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We give a construction of integral local Shimura varieties which are formal schemes that generalise the well-known integral models of the Drinfeld p-adic upper half spaces. The construction applies to all classical groups, at least for odd p. These formal schemes also generalise the formal schemes defined by Rapoport-Zink via moduli of p-divisible groups, and are characterised purely in group-theoretic terms.
More precisely, for a local p-adic Shimura datum $(G, b, \mu)$ and a quasi-parahoric group scheme ${\mathcal {G}} $ for G, Scholze has defined a functor on perfectoid spaces which parametrises p-adic shtukas. He conjectured that this functor is representable by a normal formal scheme which is locally formally of finite type and flat over $O_{\breve E}$. Scholze-Weinstein proved this conjecture when $(G, b, \mu)$ is of (P)EL type by using Rapoport-Zink formal schemes. We prove this conjecture for any $(G, \mu)$ of abelian type when $p\neq 2$, and when $p=2$ and G is of type A or C. We also relate the generic fibre of this formal scheme to the local Shimura variety, a rigid-analytic space attached by Scholze to $(G, b, \mu , {\mathcal {G}})$.
This article offers an intersectional and temporospatial analysis of female visibility during religious activity in urban spaces in Republican Rome. The focus is on the regular religious activity of prominent female religious officials – Vestals, flaminica Dialis, and regina sacrorum – and collectives of women – married and enslaved women – as religious activity and roles could empower some women, and provide regular opportunities for visibility in the city. I argue that such an approach and focus reshape our understanding of the visibility of women in urban spaces, challenging traditional scholarly views of female domesticity and invisibility. A temporospatial lens reveals that women of various roles and statuses were regularly visible in a wide array of urban spaces, seemingly irrespective of their public, private, or sacred nature. There appears to have been limited spatial segregation by gender. Instead, a woman’s intersectional statuses and temporality were key dimensions differentiating female visibility. There was no singular gendered rhythm, but plural rhythms in interaction and conflict, and female religious officials played key roles in directing these rhythms and bringing harmony to the religious calendar. Futurity and the preservation of the community lay at the core of this female religious activity. Ultimately, time’s place was pivotal.
Sheath-ends are poorly represented in works regarding weaponry of the Cimmerian period (10th–7th century BC), despite forming an important component, particularly among the melee weapons of the time. There are several reasons for this neglect: until recently, the number of known sheath-ends was quite small, thus making it impossible to speak of types, variants or cultural affiliations; also, most of the previously published sheath-ends are spread over a large territory and were published many decades ago. Therefore, some of them may be unknown to researchers due to the age of publications, as well as linguistic and cultural barriers. Over the past few years, a larger number of new sheath-ends has emerged. Some of them belong to previously known types, others are completely new. Their analysis is here conducted using the comparative method. The total number of sheath-ends now known makes it possible to begin a discussion about their types, chronology and origins, which will undoubtedly develop as new finds appear.
This study demonstrated the incidences of hospital-acquired colonization by extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E), carbapenem-resistant Enterobacterales (CRE), and vancomycin-resistant enterococci (VRE) of 22%, 8%, and 8% among hematologic malignancy patients. Difference in time to colonization detection between VRE (14 d) and ESBL-E and CRE (7 d) may inform appropriate surveillance measures.
The essence of the Metaverse lies in the inter-subjectivity revealed by phenomenology. The many-worlds model reveals the significance of interaction and communication for digital human existence. The Metaverse exhibits a rhizomatic structure of narrative from multiple small universe interpretations, particularly the cross-embedding and close coupling between digital relational orders and analog legal orders formed through interface revolution. Virtuality-reality interfacing permits rational design based on exchange concepts, yielding twelve fundamental digital-age juridical propositions from subject interaction ordering mechanisms. These propositions indicate that with consumer sovereignty and distributed autonomous organizations, the Metaverse will transform order principles. A corridor system connecting cyberspace to off-chain society will be built using code and smart contracts as dual interfaces, producing varied relationship-law combinations.
In p-adic Hodge theory and the p-adic Langlands program, Banach spaces with $\mathbf {Q}_p$-coefficients and p-adic Lie group actions are central. Studying the subrepresentation of G-locally analytic vectors, $W^{\mathrm {la}}$, is useful because $W^{\mathrm {la}}$ can be studied via the Lie algebra $\mathrm {Lie}(G)$, which simplifies the action of G. Additionally, $W^{\mathrm {la}}$ often behaves as a decompletion of W, making it closer to an algebraic or geometric object.
This article introduces a notion of locally analytic vectors for W in a mixed characteristic setting, specifically for $\mathbf {Z}_p$-Tate algebras. This generalization encompasses the classical definition and also specializes to super-Hölder vectors in characteristic p. Using binomial expansions instead of Taylor series, this new definition bridges locally analytic vectors in characteristic $0$ and characteristic p.
Our main theorem shows that under certain conditions, the map $W \mapsto W^{\mathrm {la}}$ acts as a descent, and the derived locally analytic vectors $\mathrm {R}_{\mathrm {la}}^i(W)$ vanish for $i \geq 1$. This result extends Theorem C of [Por24], providing new tools for propagating information about locally analytic vectors from characteristic $0$ to characteristic p.
We provide three applications: a new proof of Berger-Rozensztajn’s main result using characteristic $0$ methods, the introduction of an integral multivariable ring $\widetilde {\mathbf {A}}_{\mathrm {LT}}^{\dagger ,\mathrm {la}}$ in the Lubin-Tate setting, and a novel interpretation of the classical Cohen ring $\mathbf {{A}}_{\mathbf {Q}_p}$ from the theory of $(\varphi ,\Gamma )$-modules in terms of locally analytic vectors.
Recently, autonomous aerial systems have received unparalleled popularity and applications as varied as they are innovative in the civil domain. The unmanned aerial vehicle (UAV) is now the subject of intensive research in both aeronautical and automotive engineering.
This paper presents a new, robust gain-scheduled adaptive control strategy for a class of UAV with linear parameter varying (LPV) models. The proposed controller synthesis involves a set of pre-tuned linear quadratic regulator (LQR) combined with fractional-order PID controllers supervised with an adaptive switching law. The main innovation in this work is the enhancement of the classical gain-scheduling adaptive control robustness for systems with LPV models by combining a set of robust LQR + fractional-order PID compensators. The stability of the resulting controller is demonstrated and its efficiency is validated using a numerical simulation example on a civilian UAV system airspeed and altitude control to illustrate its practical efficiency and achieved robustness.
The COVID-19 pandemic exacerbated psychological distress, but limited information is available on the shifts in mental health symptoms and their associated factors across different stages. This study was conducted to more reliably estimate shifts in mental health impacts and to identify factors associated with symptoms at different pandemic stages.
Methods
We performed a national repeated cross-sectional study at stable (2021), recurrence (2022), and end-of-emergency (2023) stages based on representative general national population with extensive geographic coverage. Anxiety, depression, post-traumatic stress disorder (PTSD) and insomnia symptoms were evaluated by GAD-7, PHQ-9, IES-R and ISI scales, respectively, and their associated factors were identified via multivariable linear regression.
Results
Generally, 42,000 individuals were recruited, and 36,218, 36,097 and 36,306 eligible participants were included at each stage. The prevalence of anxiety, depression and insomnia symptoms increased from 13.7–16.4% at stable to 17.3–22.2% at recurrence and decreased to 14.5–18.6% at end of emergency, while PTSD symptom continuously increased from 5.1% to 7.6% and 9.2%, respectively (all significant, P < 0.001). Common factors associated with mental health symptoms across all stages included centralized quarantine, frontline work and residence in initially widely infected areas. Centralized quarantine was linked to anxiety, depression, PTSD and insomnia during the stable, recurrence and end-of-emergency stages. Frontline workers exhibited higher risks of anxiety, depression and insomnia throughout these stages. Individuals in initially widely infected areas were more likely to experience depression and PTSD, particularly during the stable and recurrence stages. Stage-specific risk factors were also identified. Lack of outdoor activity was associated with anxiety, depression and insomnia during the stable and recurrence stages. Residents in high-risk areas during the recurrence stage correlated with increased anxiety and insomnia. Suspected infection was tied to anxiety and insomnia in the recurrence and end-of-emergency stages, while the death of family or friends was linked to PTSD during recurrence and to depression, PTSD and insomnia at the end-of-emergency stage.
Conclusions
Mental health symptoms increased when pandemic recurred, and could remain after end-of-emergency, requiring prolonged interventions. Several key factors associated with mental symptoms and their variations were identified at different pandemic stages, suggesting different at-risk populations.
This article investigates how early modern migrants articulated identification with their host society in the context of the late eighteenth-century Dutch Republic, a period preceding modern nationalism. Drawing on a unique dataset derived from the Prize Papers – a collection of testimonies from captured sailors interrogated by British Admiralty courts – we analyze migrants’ declarations of sovereign allegiance. We assess how factors such as duration of residence, local citizenship (poorterschap), occupational rank, and marital status influenced migrants’ identification with their adopted polity. Using logistic regression, we find that civic institutional embeddedness, reflected in city citizenship, and occupational rank, especially among ship captains, significantly predicted identification with the Dutch Republic. In contrast, duration of residence and marital status had weak and statistically insignificant effects. Our findings highlight that pre-national forms of identification were deeply embedded in civic and institutional contexts rather than simply reflecting modern nationalist sentiments. By combining quantitative analysis with targeted archival research into individual biographies, this study demonstrates the complex interplay between institutional opportunities and personal networks in shaping migrants’ allegiances, thereby offering a nuanced historical perspective relevant to contemporary debates on civic integration.
Healthcare has deleterious impacts on the environment through production of massive amounts of waste leading to generation of greenhouse gas (GHG) emissions. Single-use materials used for preparation and administration of intravenous (IV) medications are a large component of hospital waste. Transitioning medications from the IV-to-oral (PO) route, called switch therapy, may be a means of decreasing unnecessary waste and associated emissions arising from hospital care.
Methods:
This was a retrospective cohort study involving adult patients receiving IV antimicrobials with a highly bioavailable PO equivalent at a large academic medical center. For a randomly selected subset of patients, the mean number of IV days of therapy (DOT) for which PO therapy could have been administered based on our institution’s policy was determined for each antimicrobial. This proportion was applied to the full cohort to estimate the total unnecessary IV DOT. A GHG emissions estimation tool was used to estimate the emissions generated from the excess antimicrobials.
Results:
During the study period, 15,037 IV DOT were administered, of which 9,694 DOT (64%) were estimated to be unnecessary. This was estimated to have generated 2,049 kilograms of total waste and 0.353 metric tons of carbon dioxide equivalents, equivalent to 904 miles driven.
Conclusions:
Optimizing IV-to-PO antimicrobial switch policies may be an effective way to decrease hospital environmental impact through reduction of single-use supply waste and associated emissions. Future work should prioritize evaluating other potential antimicrobial stewardship interventions as a means to reduce GHG emissions.
Clostridioides difficile infection (CDI) is common among patients undergoing hematopoietic stem cell transplantation (HSCT). Oral vancomycin prophylaxis may effectively prevent CDI in certain populations. We investigated the effectiveness of oral vancomycin primary prophylaxis in preventing CDI in HSCT patients.
Methods:
We searched six databases from inception to March 21, 2025, for studies comparing the incidence of CDI in HSCT patients who received oral vancomycin primary prophylaxis versus those who did not. We built a Bayesian random-effects model for meta-analysis. The primary outcome was the incidence of CDI. Secondary outcomes included incidence of positive vancomycin-resistant Enterococcus cultures, blood stream infections, graft-vs-host disease, and length of hospital stay. We also assessed for heterogeneity and publication bias using Robust Bayesian Meta-Analyses.
Results:
Six studies met inclusion criteria with a total of 1,236 patients. Four of the studies were of fair to good quality. Oral vancomycin primary prophylaxis reduced the incidence of CDI during hospitalization (OR 0.31; 95%CrI 0.16–0.59). Studies were weakly heterogeneous but had strong publication bias. Oral vancomycin primary prophylaxis reduced the odds of CDI by 12% after accounting for publication bias (OR 0.88; 95%CrI 0.32–1.16), although this reduction was not statistically significant. Secondary outcomes were similar in both groups.
Conclusion:
Oral vancomycin primary prophylaxis prevented CDI in HSCT patients without significantly affecting secondary outcomes. However, after controlling for publication bias, these findings were no longer significant. Further studies are needed to provide stronger evidence for or against this intervention, assess long-term safety, and assess potential effects on antimicrobial resistance.
Cultural transfers between metropolitan cores and colonial peripheries, have been a constant feature of the history of modern nationalism. Anti-colonial movements also influenced to some extent the development and strategies of European national movements before 1939. After 1945, and with particular intensity following the Algerian War of Independence, claims for national self-determination from the colonial possessions of the European empires also influenced the development of regional and national movements within Western Europe. This was flanked by the adoption of Marxist-Leninist and New Left doctrines by the post-war generation leading Western European minority nationalisms. The article deals with the reformulation of national self-determination in Europe under the influence of anti-colonial thought, particularly since the adoption of the theories of “internal colonialism”, and the new dimension given to the theory of national liberation by authors such as Frantz Fanon. It also looks at the emergence of radical ethno-nationalist parties in the 1960s and their commitment to this new wave of anti-colonial self-determination. Finally, the attempts of some of these movements to articulate a transnational programme will be analysed.
Disability and inclusivity are progressive topics that have evolved in response to societal experiences, as evidenced by the social model of disability, which has been endorsed as a replacement for the conventional individual model of disability. However, many still regard disability as an individual rather than an environmental problem, which fosters stigmatization of people with disabilities. Addressing this requires deeper knowledge to inform experience design that raises awareness of disability and the importance of social inclusion. The authors conducted a co-design experiment focusing on how to fill the communication gap between deaf and hearing people. Six teams, each comprising one deaf and two hearing participants, were observed to identify the salient characteristics of two contrastive approaches: LESS, a deaf-oriented audio environment with decreased audio stimuli, and MORE, a hearing-oriented audio environment with no decreased auditory stimuli. The results were cross-analyzing quantitative and qualitative data with interaction mapping. The analysis found that the LESS approach helps people feel no barriers, while the MORE approach enables them to challenge prior understandings of the issue. This study will contribute to designing an experience-based awareness-raising activity, suggesting where the gap exists and how it should be filled in the context of diversity, equity and inclusion.
Kawasaki disease is a self-limiting vasculitis of unknown aetiology, and coronary artery lesions are its most common and serious complication. The Systemic Immune-Inflammation Index is a new biomarker of inflammation that may have prognostic value in Kawasaki disease. This study evaluated patients with Kawasaki disease and the prognostic role of Systemic Immune-Inflammation Index in coronary involvement. A total of 62 children with Kawasaki disease and 49 healthy controls were included. Systemic Immune-Inflammation Index was calculated as: neutrophils × platelets/lymphocytes). Systemic Immune-Inflammation Index was also significantly higher in Kawasaki disease patients than controls (2373 ± 2040 vs. 300 ± 218, p < 0.001). Subgroup analysis of the Kawasaki disease patients showed that Systemic Immune-Inflammation Index was significantly higher in patients with coronary artery lesions than in those without (p < 0.05). In conclusion, Systemic Immune-Inflammation Index is a composite inflammatory biomarker easily obtained from routine blood parameters and may be an independent predictor of coronary artery involvement in Kawasaki disease.
Francisco Suárez (1548–1617), one of the most important early modern scholastic philosophers, had considerable influence not only on canonical early modern philosophers such as Descartes and Leibniz, but even more so on subsequent scholastic philosophers and theologians. His Metaphysical Disputations of 1597 was intended to provide the reader with a complete grounding in metaphysics and is one of the most detailed, comprehensive elaborations of an Aristotelian metaphysics ever published. This Critical Guide offers fourteen new essays on a wide range of topics in the Metaphysical Disputations, including Suárez's metaphysics of modality, his nominalism, and his accounts of the categories, prime matter, falsity, time, and causation. The volume will be valuable for scholars and students of early modern scholasticism, and also for those researching later thinkers whose work was influenced by Suárez.
In a world demanding climate action, the oil-rich Gulf states face a defining crossroads: can they transform economies built on fossil fuels into resilient, climate-aligned powerhouses? This timely and original study offers a rigorous, multidimensional analysis of how Saudi Arabia, the United Arab Emirates, and Qatar are navigating the high-stakes transition to decarbonization. Weaving together historical political economy, postcolonial state formation, economic pressures, geopolitical realignments, and environmental imperatives, it explores the difficult trade-offs and strategic decisions forging the region's trajectory. Through incisive analysis, it reveals emerging policy innovations, evolving social contracts, and institutional strategies that are redefining the Gulf's energy future—while critically evaluating the macroeconomic consequences of climate-driven transformation. Essential reading for policymakers, financiers, energy professionals, multilateral institutions, and scholars, The Gulf's Climate Reckoning offers an intellectual and strategic framework for understanding the Gulf's climate-industrial transformation and its far-reaching implications for the emerging global energy and governance landscape.
This Element discusses the presence of ruins in contemporary environmental imagination. Contemporary ruins, much more than those that served as constituents of Romantic and Gothic aesthetics, simultaneously express a fascination with and a dread of the non-human agencies at play in the world, while also countering the nostalgic dimension of traditional representations of ruins. The contemporary success of ruins can be connected to the sense of planetary precarity induced by anthropogenic climate change, and to the widespread presence of eco-anxiety in the public conscience. Moreover, at the centre of ruins' aesthetic power is the interaction of human and non-human forces, and in the process of ruination, buildings and monuments find new meaning thanks to the intervention of external agents that human civilization has long attempted to tame or eliminate and that make a disturbing return as soon as anthropic activity ceases.
Musica Elettronica Viva (MEV) enjoys cult status in the history of avant-garde music in the second half of the twentieth century. Founded in Rome at the turn of 1966 and 1967 on the initiative of the American composer and pianist Frederic Rzewski, MEV, together with the Gruppo di Improvvisazione Nuova Consonanza (GINC), introduced free improvisation to the European continent. However, many aspects of the group’s early years remain obscure, particularly with regard to their first performances and their transition to improvisation. Drawing on previously unpublished archives, in particular those of Frederic Rzewski preserved in Brussels, this article clarifies these aspects by establishing a precise chronology from 1966 to 1968. Far from following the aesthetics of GINC, MEV seems to have been more influenced by the Living Theatre, whose Artaudian and political approach encouraged its shift towards musical spontaneity and audience participation. This study thus offers a new perspective on the origins of MEV and its place within the Italo-American avant-garde of the period.
In many economies, youth unemployment rates over the past two decades have exceeded 10 percentage points, highlighting that not all youth successfully transition successfully from schooling to employment. Equally disturbing are the high rates of young adults not observed in employment, education, or training, a rate commonly referred to as “NEET.” There is not a single pathway for successful transitions. Understanding these pathways and the influences of geographic location, employment opportunities, and family and community characteristics that contribute to positive transitions is crucial. While abundant data exists to support this understanding, it is often siloed and not easily combined to inform schools, communities, and policymakers about effective strategies and necessary changes. Researchers prefer working with datasets, while many stakeholders favor results presented through storytelling and visualizations. This paper introduces YouthView, an innovative online platform designed to provide comprehensive insights into youth transition challenges and opportunities. YouthView integrates information from datasets on youth disadvantage indicators, employment, skills demand, and job vacancy at regional levels. The platform features two modes: a guided storytelling mode with selected visualizations, and an open-ended suite of exploratory dashboards for in-depth data analysis. This dual approach enables policymakers, community organizations, and education providers to gain a nuanced understanding of the challenges faced by different communities. By illuminating spatial patterns, socioeconomic disparities, and relationships between disadvantage factors and labor market dynamics, YouthView facilitates informed decision-making and the development of targeted interventions, ultimately contributing to improved youth economic outcomes and expanded opportunities in areas of greatest need.