For a uniformly locally finite metric space
$(X, d)$, we investigate coarse flows on its uniform Roe algebra
$\mathrm {C}^*_u(X)$, defined as one-parameter groups of automorphisms whose differentiable elements include all partial isometries arising from partial translations on X. We first show that any flow
$\sigma $ on
$\mathrm {C}^*_u(X)$ corresponds to a (possibly unbounded) self-adjoint operator h on
$\ell _2(X)$ such that
$\sigma _t(a) = e^{ith} a e^{-ith}$ for all
$t \in \mathbb {R}$, allowing us to focus on operators h that generate flows on
$\mathrm {C}^*_u(X)$.
Assuming Yu’s property A, we prove that a self-adjoint operator h on
$\ell _2(X)$ induces a coarse flow on
$\mathrm {C}^*_u(X)$ if and only if h can be expressed as
$h = a + d$, where
$a \in \mathrm {C}^*_u(X)$ and d is a diagonal operator with entries forming a coarse function on X. We further study cocycle equivalence and cocycle perturbations of coarse flows, showing that, under property A, any coarse flow is a cocycle perturbation of a diagonal flow. Finally, for self-adjoint operators h and k that induce coarse flows on
$\mathrm {C}^*_u(X)$, we characterize conditions under which the associated flows are either cocycle perturbations of each other or cocycle conjugate to each other. In particular, if
$h - k$ is bounded, then the flow induced by h is a cocycle perturbation of the flow induced by k.