Pregnant women are exposed to various contaminants through foods, with environmental toxicants and aflatoxin (AF) being among the major food contaminants. Therefore, this review was conducted for a better perspective on the AF exposure during pregnancy or infancy, highlighting how exposure through the mother (via placenta and breast milk) and directly through infant foods ultimately affects infant health. The literature suggests that AF exposure during pregnancy may lead to maternal anaemia, premature delivery, pregnancy loss or decreased number of live births. AF crosses through the placenta and also passes through breast milk. AF exposure during pregnancy may also lead to deleterious effects on the fetus or infants such as reduced fetal growth, low birth weight, impairment of linear or long bone growth and developmental delay such as small head circumference and reduced brain size, stillbirth or fetal death. It may also have an adverse effect on some organs and organ systems, causing aberrations such as neonatal jaundice and disrupting hormone synthesis. In the Indian context, there are limited clinical studies to assess the health effects of AF exposure during pregnancy. For the first time, we have made an attempt to estimate the AF exposure by calculating the AF estimated daily intake using the empirical formulae based on several reported studies. However, more research needs to be undertaken to understand the AF exposure outcomes during pregnancy. The data presented in this review warrant more clinical studies in India on maternal AF exposure to elucidate the birth outcomes and associated infant health outcomes.

E-sports has become popular among young people in recent years. The online nature of esports might contribute to differences in the dietary habits and lifestyles of university students who engage in this activity. The study aimed to compare the dietary habits, adherence to the Mediterranean diet and sleep duration of esports players (ESp) and non-eSports players (nESp) university students in Türkiye. The study was designed as a cross-sectional analysis, and data were collected through an online form. The form consisted of questions on socio-demographic characteristics, dietary habits, food frequency, physical activity, sleep duration and the Mediterranean Diet Adherence Scale. The study included 115 ESp participants (mean age: 20·5 (sd 1·5) years) and 110 nESp participants (mean age: 21·0 (sd 1·5) years). The ESp group had significantly higher rates of alcohol (45·2 % v. 15·5 %) and energy drink (34·8 % v. 12·7 %) consumption compared with the nESp group (P < 0·001). A significantly higher proportion of ESp skipped breakfast compared with nESp (68·3 % v. 46·2 %) (P = 0·004). The adherence rates to the Mediterranean diet were comparable between the two groups, with 30·4 % of ESp and 36·4 % of nESp adhering to the dietary pattern. Although physical activity, sleep duration and Mediterranean diet adherence were similar between groups, esports players reported higher consumption of alcohol, energy drinks and processed foods, which might increase the risk of obesity and metabolic disorders. These findings highlight the need for targeted nutritional guidance and health promotion strategies to support healthier lifestyle behaviours among ESp.

Healthy ageing and longevity have emerged as urgent public health priorities amid global population ageing and declining birth rates. This review synthesises empirical evidence highlighting the essential role of diet and nutrition in preventing chronic diseases and supporting functional independence in later life. The review was organised using a problem-solving approach to address three core questions: ‘What’ evidence links food and nutrition with positive health outcomes; ‘Why’ do specific dietary components affect biological ageing – via mechanisms such as nutrient sensing, inflammation modulation and caloric restriction; and ‘How’ culturally tailored, person-centred dietary interventions should be developed for better adoption. Findings from centenarian populations suggest that low-energy (i.e. foods with low energy density, such as fruit and vegetables, whole grains), nutrient-rich and diverse diets may help prevent or delay age-related diseases, supporting the notion that food could be used as medicine. Moreover, addressing barriers such as food insecurity and limited access to culturally appropriate healthy food options, particularly in low-income and rural communities, is crucial for achieving equitable health outcomes. Finally, the review calls for integrating personalised nutrition strategies into clinical care and public health initiatives. These efforts can enhance healthspan, improve quality of life and reduce the broader social and economic burdens associated with ageing populations.

Mandatory calorie labelling was introduced in out-of-home (OOH) food sector outlets during 2022 in England. Previous research in North America has found that labelled energy content can be underestimated for packaged and quick-serve foods, but no study has evaluated the accuracy of OOH food sector menu calorie labelling in response to the mandatory policy introduced in England. N 295 menu items from a range of outlet types (e.g. cafes, pubs, restaurants) and menu categories (e.g. starters and sides, main, dessert) were sampled. Bomb calorimetry was used to quantify energy content, and the reported energy content on menus was recorded. Consistency of measured energy was assessed by sampling the same items across outlets of the same business (n 50 menu items). Differences between reported and measured energy content were tested through Wilcoxon signed rank tests, and a linear model examined correlates of the difference. Mean measured kilocalories (kcal) were significantly lower than reported kcal (–16·70 kcal (±149·19), V = 16 920, P < 0·01 and r = 0·182). However, both over- (23 % of menu items) and under-estimation (11 %) by > 20 % of measured energy content were common, and the averaged absolute percentage difference between reported and measured values was 21 % (±29 %). Discrepancy between measured and reported energy content was more common in some outlet types (pubs), and reported energy content was substantially different (> 20 %) to measured energy content for 35 % of sampled menu items. There may be significant inaccuracies in reported energy content of calorie labelled menu items in English food outlets subject to mandatory calorie labelling.

Vitamin D deficiency is common in the UK, especially in certain ethnic minority populations. There is limited information on childhood vitamin D status in the UK, or factors associated with vitamin D deficiency. Using a cross-sectional study of 4650 children of South Asian, Black African and Caribbean and White European origins (9–10 years old) surveyed between 2004 and 2007, we investigated measurements of circulating 25(OH)D concentrations (a measure of vitamin D status) and anthropometric measurements. Overall, 68 % of children had 25(OH)D concentrations ≤ 50 nmol/L and were either insufficient (25–50 nmol/L) (45 %) or deficient (< 25 nmol/L) (23 %). Mean 25(OH)D concentrations were lowest in South Asian (especially Bangladeshi) children, intermediate in Black African and Caribbean and highest in White European children. Mean values were ≤ 50 nmol/L for all children during the winter months and ≤ 50 nmol/L throughout the year for South Asian, Black African and Caribbean children. In analyses adjusted for season, age, sex, ethnicity, socio-economic status and fat mass index, girls had a higher risk of being vitamin D deficient or insufficient (OR 1·49, 95 % CI 1·32, 1·68) compared with boys. South Asian children (OR 25·49, 95 % CI 19·95, 32·57) and Black African and Caribbean children (OR 10·31, 95 % CI 10·31, 17·52) had the highest risks of being deficient or insufficient compared with White European children. Childhood vitamin D deficiency was common in this study population. In the UK, targeted and novel interventions are needed to increase 25(OH)D concentrations, particularly South Asian and Black African and Caribbean children and reduce the health risks associated with low vitamin D status.

The effects of high plant-based proteins (PP) used as alternative protein sources in aquafeeds on muscle cellularity and myogenic factors of rainbow trout, Oncorhynchus mykiss, remain unclear. This study explored muscle fibre growth phases and the impact of two additive mixtures (A) in high-PP diets on muscle physiology. Over a seven-month trial, 2000 fish (2·22 g) were divided into four groups (five replicates each) and fed isonitrogenous (fry, 46 %; fingerling, 44 %; and grow-out, 42 % crude protein) and isolipidic (20 % lipid) diets: control (30 % fishmeal), PP, PP + A1 (krill meal, taurine, selenium) and PP + A2 (proline, hydroxyproline, vitamin C). Sampling for muscle histology and myogenic gene expression was conducted at ten sampling points from Day 0 to Day 214. Muscle histology (fibre distribution: small, 0–20 μm; small-medium, 20–60 μm; large-medium, 60–100 μm and large, ≥ 100 μm diameter) revealed four growth phases: hyperplasia (2·2–15 g), hypertrophy (15–50 g), hyperplasia (50–150 g) and hypertrophy (150–350 g). MyoD2 and myogenic regulatory factor 4 (MRF4) were upregulated during hyperplasia, while myostatin 1 (MSTN1)/myostatin 2 (2) and reduced Paired box 7 indicating growth inhibition and fewer satellite cells. The PP diet without additives altered fibre recruitment, while PP + A2 enhanced hypertrophy, increasing large (> 100 μm) fibres. Additive mixtures modulated myogenic gene expression, with PP + A2 promoting MyoD2, myogenin and MRF4 and reducing MEF2A/C, contrary to known hypertrophy markers. PP + A1 and PP + A2 diets reduced MSTN1 expression, potentially mitigating growth inhibition. Additive supplementation in PP diets alleviates negative impacts on muscle cellularity and myogenic regulation. The identified growth phases provide insights for precision nutrition, supporting improved feeding strategies for sustainable aquaculture.

Previous studies highlighted the health benefits of coffee and tea, but they only focused on the comparisons between different consumptions. Consequently, the association estimate lacked a clear interpretation, as the substitution of beverages and distribution of doses were not explicitly prescribed. We focused on the ‘relative association’ to ascertain the optimal consumption strategy (including total intake and optimal allocation strategy) for coffee, tea and plain water associated with decreased mortality. Self-reported coffee, tea and plain water intake were used from the UK Biobank. Within a compositional data analysis framework, a multivariate Cox model was used to assess the relative associations after adjusting for a range of potential confounders. The lower mortality risk was observed with at least approximately 7–8 drinks/d of total consumption. When the total intake > 4 drinks/d, substituting plain water with coffee or tea was linked to reduced mortality; nevertheless, the benefit was not seen for ≤ 4 drinks/d. Besides, a balanced consumption of coffee and tea (roughly a ratio of 2:3) associated with the lowest hazard ratios of 0·55 (95 % CI 0·47, 0·64) for all-cause mortality, 0·59 (95 % CI 0·48, 0·72) for cancer mortality, 0·69 (95 % CI 0·49, 0·99) for CVD mortality, 0·28 (95 % CI 0·15, 0·52) for respiratory disease mortality and 0·35 (95 % CI 0·15, 0·82) for digestive disease mortality than other combinations. These results highlight the importance of the rational combination of coffee, tea and plain water, with particular emphasis on ensuring adequate total intake, offering more comprehensive and explicit guidance for individuals.

Personalised nutrition aims to deliver targeted advice to promote dietary behaviours that are beneficial to health based on individual characteristics. Given the financial implications (for providers and participants) of characterising, developing, implementing, communicating and supporting individual behaviour change there remains potential for personalised nutrition to widen health inequalities within populations. Some commentators promote a universal approach to achieve wider population-level benefit. Universal approaches attempt to provide a whole systems perspective with individual outcomes, potentially smaller in scale, impacting at the population level. In the UK the national food-based guidance, the Eatwell Guide, is used to communicate advice on diet consistent with UK government dietary recommendations based on robust, independent assessment of the best available evidence by the Scientific Advisory Committee on Nutrition. Effort was taken in ensuring all UK government recommendations in 2016 (when the UK’s national food-based guidance was last reviewed following changes in dietary recommendations on carbohydrates and sugars) could be achieved at a population level based on available and recognised foods. There is evidence that moving towards a diet consistent with national food-based guidelines has positive benefits for health and the environment. There is debate about the cost of a healthy diet and the impact of including elements of sustainability elements. This commentary considers how developments in healthy eating indices may be beneficial as a universal approach could provide opportunities to support individuals move towards healthier diets. It also raises questions about the evidence requirements and timing of any future amendments to the UK’s Eatwell Guide.

Few studies have examined the effects of early-life nutrition interventions on adolescent physical activity (PA). We aimed to examine the long-term effects of small-quantity lipid-based nutrient supplements (SQ-LNS) on adolescent PA and sedentary behaviour (SB) and to describe current adolescent PA and SB levels in this cohort. In the International Lipid-Based Nutrient Supplements (iLiNS)-DYAD-Ghana trial, 1320 mothers were enrolled and randomly assigned to one of three conditions: (1) daily iron and folic acid during pregnancy and placebo (calcium) from birth to 6 months postpartum (IFA), (2) multiple micronutrient supplements during pregnancy to 6 months postpartum (MMN) or (3) SQ-LNS during pregnancy to 6 months postpartum (LNS). Infants from mothers in the LNS group received SQ-LNS designed for children from 6 to 18 months. We recruited 11–13-year-old adolescents of mothers enrolled in the iLiNS-DYAD-G trial for a 7-d PA and SB assessment using accelerometers (n 305) and self-reported PA and SB (n 508). We compared the LNS with non-LNS (IFA+MMN) groups using ANCOVA models for the following outcomes: mean vector magnitude counts per minute, PAQ-C score and percentage of time in SB, light PA and moderate-to-vigorous PA (MVPA). There were no significant differences between the LNS and non-LNS groups in any PA outcome in minimally or fully adjusted models. Only approximately 50 % of adolescents met the PA recommendation of 60 min/d MVPA, with males more active than females; however, there is room for improvement. SQ-LNS in early life does not appear to have a sustained impact on PA or SB.

We aimed to investigate the association between plasma advanced glycation end products (AGE) level and fat, skeletal muscle-related body composition parameters in middle-aged and elderly Chinese participants. A total of 1139 participants aged over 40 years were included in a cross-sectional study. Body composition including BMI, waist:hip ratio (WHR), fat mass index (FMI), percentage of body fat (PBF), the ratio of trunk fat to legs fat (trunk fat/legs fat), fat free mass (FFM), fat free mass index (FFMI) and skeletal muscle index (SMI) was measured using a bioelectrical impedance analyser. Plasma free and combined AGE were measured by ultra-high performance liquid chromatography-tandem MS. Multiple linear regression and weighted quantile sum regression models were used to examine the association between AGE and body composition parameters. Total exposure of plasma advanced glycation end products (AGE) was positively associated with BMI (β (95 % CI): 0·381 (0·037, 0·724), P = 0·030), FMI (β (95 % CI): 0·521 (0·241, 0·800), P = 0·001), PBF (β (95 % CI): 1·996 (1·160, 2·832), P < 0·0001), trunk fat/legs fat (β (95 % CI): 0·058 (0·036, 0·080), P < 0·001); while it was negatively associated with FFM (β (95 % CI): −1·075 (–2·028, –0·122), P = 0·027), FFMI (β (95 % CI): −0·687 (–1·076, –0·297), P = 0·001) and SMI (β (95 % CI): −1·264 (–1·767, –0·761), P < 0·001). The associations between plasma AGE and FFM and FFMI were more pronounced in those aged less than 61 years and female participants. This study provides evidence on the associations between plasma AGE and fat and skeletal muscle parameters, suggesting their potential role in the development of obesity and skeletal muscle loss.

The study aimed to develop and validate a food literacy tool for Tanzanian adults. The Tanzanian nutrition, food and health promotion experts evaluated the initial twenty-three-question food literacy tool for its relevance to the context, where its content validity was determined. The construct validity involved the analysis of food literacy information collected in a cross-sectional study involving 709 adults (484 females and 225 males) sampled from rural and urban Tanzania. Exploratory factor analysis was conducted to explore the underlying factor structure and identify the number of latent constructs. A confirmatory factor analysis using structural equation modelling verified the measurement model and confirmed the theoretical model’s validity and reliability. The descriptive statistics summarised the essential characteristics of the study sample. The final tool remained with fourteen questions after removing questions with low factor loadings < 0·5 and higher uniqueness above 0·60. The model achieved construct validity through convergent and discriminant validity and construct reliability through the composite reliability exceeding 0·60 and a Cronbach’s α value of 0·83 and above. The fourteen-question food literacy tool has been reviewed and evaluated by experts in food, nutrition and public health; therefore, it is a valid measure of food literacy among adults in Tanzania. It is suitable for designing nutrition education programmes and ensures accurate and reliable measurements for effective interventions and policy actions.

Plant-based diets may improve mental health among older adults by alleviating depression and improving life satisfaction. This study aimed to explore the associations between plant-based dietary pattern trajectories (PDPT), depression and life satisfaction in Chinese older adults. Data of participants from the 2008–2018 Chinese Longitudinal Healthy Longevity Survey were analysed. We utilised group-based trajectory modelling to identify the PDPT. Logistic and linear regression models were used to analyse the associations between PDPT, depression and life satisfaction. In total, 1835 participants were divided into three groups based on plant-based dietary index (PDI), healthy plant-based dietary index (HPDI) or unhealthy plant-based dietary index (UPDI) trajectories, respectively, and the PDPT were maintained at stable levels. PDI trajectory was not significantly associated with depression or life satisfaction. HPDI trajectory had no significant association with depression. However, compared with low HPDI trajectory, participants in the high (β = 0·185, 95 % CI: 0·032, 0·337) HPDI trajectories had higher life satisfaction. Compared with the low UPDI trajectory, participants in the high UPDI trajectory groups were associated with a higher risk of depression (OR = 1·793, 95 % CI: 1·124, 2·861). Further, the medium (β = −0·145, 95 % CI: −0·273, −0·018) and high (β = −0·335, 95 % CI: −0·478, −0·191) UPDI trajectory were associated with poor life satisfaction. Dietary interventions should be prioritised to address the persistent unhealthy dietary habits among Chinese older adults, with particular emphasis on reducing UPDI to enhance mental health by promoting intake of healthy plant-based and animal-based foods while avoiding unhealthy plant-based foods.