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The effect of dietary intake on body weight may vary based on individual genetic differences. However, children are rarely used in such investigations. The aim was to identify possible genetic moderation through polygenic scores (PGS) for BMI, of the association between dietary intakes and BMI in children. The study sample included children who were part of a French-Canadian birth-cohort study. BMI data was available on seven occasions between ages 4 and 13 years. FFQ (juice and fruit drinks, sweets and snack foods, meats, and fruits and vegetables) and 24-h dietary recall (proteins, lipids, carbohydrates, total energy) data were available up to 4 years. Linear mixed models were used to account for repeated BMI measurements. The consumption of juice and fruit drinks (in girls), sweets and snack foods, fruits and vegetables, proteins, lipids, carbohydrates and total energy were associated with BMI. Associations with BMI increased with age (kg/m2 per year) for fruits and vegetables (β: −0.03, 95%CI: −0.06;−0.01), lipids (β: 0.11, 95%CI: 0.01;0.22), carbohydrates (β: 0.05, 95%CI: 0.01;0.08), and total energy (β: 0.07, 95%CI: 0.02;0.12), and with higher values of a PGS (kg/m2 per SD) for proteins (β: 0.54, 95%CI: 0.03;1.06), lipids (β: 0.63, 95%CI: 0.12;1.13), and total energy (β: 0.32, 95%CI: 0.06;0.58). Using longitudinal data, we showed that the associations between specific dietary intakes and BMI may vary depending on age and genetic susceptibility in childhood.
Front-of-package labelling informs consumers about the ‘healthiness’ of foods based on different classification schemes. These schemes reflect competing worldviews for assessing a food’s healthiness, represented by nutrient-, food- or diet-based indices. The Health Star Rating scheme (HSR) has been criticised for failing to appropriately score unhealthy products. Updates to the HSR algorithm were implemented over a two-year period from November 2020. This study investigated alignment between a nutrient-based scheme (HSR), food-based scheme (Nova food processing system) and diet-based scheme (Australian Dietary Guidelines (ADG)).
Setting:
Mintel Global New Products Database
Participants:
Retail foods displaying HSR launched or updated onto the Australian market between November 2020 and June 2023.
Design:
Products were categorised according to the ADG and Nova, descriptive statistics performed for each category and proportion displaying HSR ≤ 2·0 and ≥ 2·5 calculated for discretionary foods, five food group foods, ultra-processed foods (UPF) and non-UPF. Agreement between categories obtained by Kappa.
Results:
Median HSR for UPF and discretionary foods were 3·5 and 2·5, respectively, and 73·7 % of UPF and 58·2 % of discretionary foods displayed HSR ≥ 2·5. Agreement between HSR and Nova was none to slight (k = 0·09, P < 0·001) and HSR and ADG was fair (k = 0·38, P < 0·001). Between 2020–2023, the proportion of UPF displaying HSR ≥ 2·5 increased from 60·2 % to 78·5 % and for discretionary foods 47·0 % to 62·5 %.
Conclusion:
The HSR algorithm calculates ‘healthy’ HSR (≥ 2·5) for a high proportion of UPF and discretionary foods. The HSR’s nutrient-based approach to translate food-and diet-based nutrition recommendations into accurate food ‘healthiness’ assessments is still problematic.
To examine the prevalence, financial value and marketing leveraging methods of food sponsorship agreements and food service contracts in Canadian recreation and sport facilities (RSF).
Design:
Cross-sectional survey using descriptive analysis. RSF managers and directors reported the number, value and types of marketing leveraging methods used in food-related sponsorship agreements and food service contracts.
Setting:
Publicly funded RSF in nine Canadian provinces that provide indoor sport programming for children and youth.
Participants:
Eighty-six RSF representatives completed the survey (response rate: 73·9 %). Most facilities were municipally owned and located in urban settings; over 70 % served children under 13 years of age.
Results:
Food sponsorship agreements and food service contracts were reported by 36·5 % and 65·5 % of RSF, respectively. Financial donations were included in 88·6 % of sponsorship agreements and 27·4 % of contracts. Sponsors contributed a median of 25·0 % (IQR: 13·9–83·3 %) of total sponsorship income, with a median annual donation per sponsor of $500 (IQR: $288–$1375). Nearly all agreements and contracts included at least one food marketing leveraging method. Branded signage was the most common in sponsorship agreements (64·6 %), while equipment donation was the most common in food service contracts (52·2 %).
Conclusions and Implications:
Food sponsorship and service agreements are prevalent in Canadian RSF and include financial and in-kind contributions that may benefit facilities. However, the marketing leveraging methods used – such as branded signage and product provision – may also increase children’s exposure to food marketing. Greater monitoring and evaluation of these marketing practices are needed, especially in the context of proposed national marketing restrictions.
Consumer enthusiasm in plant-based eating has resulted in the rapid expansion of plant-based meat (PBM) products. The extensive processing required to simulate meat warrants further investigation regarding PBMs nutritional quality and healthiness, particularly considering the health halo that has surrounded these products. An online audit of dominant UK supermarkets evaluated PBM (n = 209) against ‘standard’ (n = 2143) and ‘reduced’ (e.g. low fat) meat equivalents (n = 100), across eight product categories. This evaluation included NOVA categorisation, Nutritional Profiling Model (NPM) classification, on-pack claims, micronutrient content and product affordability. PBM products were typically more favourable than ‘standard’ meat equivalents for energy density, dietary fibre, total and saturated fat content. However, they contained significantly higher salt in most product categories. Differences between PBM and ‘reduced’ meat comparators were more nuanced. PBM products were significantly more expensive than ‘standard’ meat equivalents in four of the eight product categories (p < .05). Few PBM and zero meat-based products reported micronutrient information. While all PBM and most meat-based products were characterised as ultra-processed, PBM products demonstrated a lower (‘healthier’) NPM score compared to ‘standard’ meat equivalents across all product categories (p ≤ .001). Although no significant differences were detected between PBM and ‘reduced’ meat-based products, a greater proportion of PBM products were classified as ‘healthier’ according to NPM compared to ‘standard’ and ‘reduced’ meat equivalents. Thus PBM products may offer healthier alternatives with the potential to synergistically support public and planetary health. Future manufacturing practices should consider cost-effective fortification and reformulation strategies to improve nutritional quality and affordability of PBMs.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading chronic liver disease worldwide. While total SFA intake has been linked to MASLD, the contribution of specific SFA and the mechanism underlying the SFA-MASLD association remain unclear. This study evaluated the associations of individual SFA with MASLD and the mediating roles of insulin resistance (IR) and serum albumin. We used data from seven National Health and Nutrition Examination Survey (NHANES) cycles (2005–2018) in a cross-sectional analysis. Associations between individual SFA and MASLD were estimated via logistic regression with restricted cubic splines (RCS). Weighted quantile sum (WQS) and quantile g-computation (QGC) models assessed the mixture associations. Mediation analysis evaluated the proportions of these associations accounted for by serum albumin and IR. Compared with the reference group, the highest tertile of intake was associated with increased odds of MASLD for C4:0 (OR = 1·12, 95 % CI 1·01, 1·25), C6:0 (OR = 1·15, 95 % CI 1·04, 1·28), C14:0 (OR = 1·20, 95 % CI 1·08, 1·33), C16:0 (OR = 1·24, 95 % CI 1·12, 1·38) and C18:0 (OR = 1·25, 95 % CI 1·12, 1·39). RCS models revealed largely linear dose–response relationships. Both WQS and QGC indicated a positive joint association of SFA with MASLD, with C16:0 identified as a major contributor. Among SFA significantly associated with MASLD, IR accounted for 30·0–47·4 % of the associations, while serum albumin accounted for 5·9–8·0 %. Higher intakes of short- and long-chain SFA, both individually and collectively, are associated with higher odds of MASLD. IR and serum albumin may partially explain these associations. These findings support the development of precision dietary strategies targeting specific SFA for MASLD prevention.
The planetary health diet (PHD) is a mostly plant-based diet that aims to optimise human health while minimising the environmental impact of food production. Limited data exist on whether the PHD fulfils key nutritional requirements during pregnancy. This research aimed to examine the PHD in early pregnancy and how it aligns with daily nutrient intake and European Food Safety Authority (EFSA) dietary guidelines. Pregnant women (n 678) from two Irish cohorts (ROLO and MicrobeMom) were analysed, and PHD index (PHDI) scores were assigned based on data from 3-d food diaries. Women were dichotomised by the median score to create a ‘High PHDI’ (> 88·99) and a ‘Low PHDI’ group (≤ 88·99). Differences in nutrient intakes and adherence to dietary guidelines between ‘High’ and ‘Low’ PHDI groups were explored. Compared with those with a ‘Low’ score, those with a ‘High’ PHDI score reported higher intakes of dietary fibre (g/d) (17·32 (13·39, 21·08) v. 21·74 (18·28, 25·88), P < 0·001), Fe (mg/d) (10·48 (8·48, 12·82) v. 12·06 (9·48, 14·60), P < 0·001), folate (µg dietary folate equivalent per d) (250·73 (193·88, 312·45) v. 279·57 (219·43, 356·81), P < 0·001) and Ca (mg/d) (837·75 (695·36, 1056·72) v. 956·57 (751·84, 1155·03), P < 0·001). A greater proportion of women in the ‘High PHDI’ group met EFSA recommendations for dietary fibre intake (10·3 % v. 28·9 %, P < 0·001). The PHD may support maternal nutritional adequacy in pregnancy while promoting environmental sustainability. Our findings provide valuable insights that can inform future dietary recommendations for pregnancy, contributing to both maternal health and planetary well-being.
The purpose of this systematic review and meta-analysis was to investigate the effects of hesperidin supplementation on inflammatory and oxidative stress biomarkers in human adults. A systematic literature search was conducted in PubMed, EMBASE and Cochrane Central Register of Controlled Trials from inception to 4 January 2025 to identify eligible randomised controlled trials. Ten randomised controlled trials with a total of 532 participants were included. The results indicated that hesperidin supplementation significantly reduced the serum levels of C-reactive protein or high-sensitivity C-reactive protein (SMD: –0·43; 95 % CI –0·71, –0·15; P = 0·002) and TNF-α (SMD: –0·51; 95 % CI –0·95, –0·07; P = 0·02) in adults, while no significant beneficial effect of hesperidin on IL-6 was observed (SMD: –0·25; 95 % CI –0·52, 0·01; P = 0·06). In addition, hesperidin intake showed a beneficial impact on the IL-6 level in patients with diseases (type 2 diabetes and myocardial infarction) (SMD: –0·38; 95 % CI –0·72, –0·04; P = 0·03) yet not in healthy adults without diagnosed diseases. Our findings demonstrated that hesperidin supplementation could lower the serum levels of C-reactive protein or high-sensitivity C-reactive protein and TNF-α in adults.
Vitamin D has been associated with depression, potentially via anti-inflammatory mechanisms, yet data are scarce, particularly in adolescence. We investigated (1) whether lower vitamin D status is associated with greater depression severity and (2) whether this association is statistically moderated by inflammation in patients of a child and adolescent psychiatry department. At admission, fasting morning venous blood was drawn. Serum vitamin D (25-hydroxy-cholecalciferol (25(OH)D)) and C-reactive protein (CRP) were analysed in all participants (n 465 (64·7 %♀; 11·3–18·9 years)). In a subsample (n 177), we additionally measured tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ) and interleukin (IL)-1β, IL-6, IL-8 and IL-10. Depression severity was assessed by the Beck Depression Inventory II (BDI-II) (n 450), the Diagnostic System for Mental Disorders in Childhood and Adolescence via self-assessment (DISYPS Self) (n 441) and parent-assessment (DISYPS Proxy) (n 422). Overall, 43·2 % (n 201) were at risk for vitamin D deficiency (< 30 nmol/l), and 73·5–83·2 % – depending on assessment tool – showed at least mild depression. Linear regression revealed an inverse association between 25(OH)D and BDI-II in both crude and CRP-adjusted full-sample models. Logistic regressions showed a robust inverse association between 25(OH)D and DISYPS Proxy, but not for DISYPS Self. Although 25(OH)D was inversely correlated with some pro-inflammatory markers, neither their inclusion in regression models nor formal mediation analyses supported inflammation as a mediator of the vitamin D–depression association. Overall, our results suggest that vitamin D relates modestly to both depression and inflammation in adolescence. However, based on the measured parameters, we cannot confirm that anti-inflammatory effects are the link between vitamin D and depression.
To analyse food and nutrition labelling policies in Mongolia, with the aim to identify key facilitators and barriers in the policy process and to propose priority actions to address these challenges.
Design:
A qualitative study utilising semi-structured individual interviews explored opinions and views of policy stakeholders on Mongolian food and nutrition labelling policies.
Setting:
Ulaanbaatar city, Mongolia
Participants:
Eighteen policy stakeholders, including government officials, representatives of consumer organisations and food producers.
Results:
Food labelling regulations in Mongolia were developed as part of broader reforms of the food system control to respond to changes related to the country’s transition to a market economy. Government leadership, along with technical support from international agencies, facilitated the development of these regulations. Key barriers identified in policy development were industry opposition, lack of consumer engagement, disruptions from government changes and funding shortages. Policy implementation was hindered by delays in operational regulations, inadequate infrastructure and limited knowledge and funding.
Conclusions:
To date, the development and implementation of food and nutrition labelling policies in Mongolia have been limited and insufficient. Given the health and nutritional impacts of the nutrition transition, prioritising nutrition labelling policies is essential and should emphasise consumer needs. Key actions should include the establishment of clear regulations, active stakeholder engagement, well-resourced implementation, capacity building among regulators and producers, and consumer education.
There is growing public health interest in ultra-processed foods (UPF), but limited research exploring consumers’ perceptions of these foods in the United States. We aimed to characterise consumers’ beliefs about UPF, the association between perceived food processing and perceived food healthfulness and alignment between consumers’ perceptions and objective measures of food processing and healthfulness.
Design:
In a cross-sectional survey, participants answered questions regarding their beliefs about UPF. They rated the healthfulness and processing levels of a random selection of ten out of forty possible foods. We used descriptive statistics to examine participant beliefs about UPF. We used linear regression models to test associations between perceived processing and perceived healthfulness and between objective and perceived measures of food healthfulness and processing.
Setting:
We fielded an online survey in the USA in November 2023.
Participants:
This study included US adults aged ≥ 18 years (n 4455).
Results:
Fifty-four percent of participants correctly identified UPF as ‘Food products submitted to a series of industrial processing’ and 52 % correctly identified UPF as, ‘Food products that contain artificial ingredients’. However, one-third of participants believed UPF were genetically modified products. While foods with higher perceived processing tended to have lower perceived healthfulness and individuals perceived UPF as more processed and less healthful than minimally processed foods, healthfulness perceptions better aligned with Food Compass 2.0, a measure that integrates food processing and nutrient-profile.
Conclusions:
Educational and policy efforts (e.g. food labeling) are needed to help consumers distinguish UPF and holistically assess the healthfulness of foods and beverages.
Iodine is a component of thyroid hormones and essential for neurological development. To evaluate the iodine nutritional status of pregnant women residing in Veneto and the possible role of thyroglobulin (Tg) as a proxy. 528 pregnant women in the third trimester of pregnancy were consecutively enrolled in this cross-sectional study and were asked to provide an early-morning spot urine sample (for UI/Creat) and a blood sample (for thyroid function and Tg). They also completed a questionnaire. Infant anthropometric data at birth were obtained. Median UI/Creat was 112·8 μg/g. 34·1 % of women had a UI/Creat ≥ 150 μg/g. Iodised salt (IS) was used by 76·9 % of women, iodine-containing supplements (ICS) by 74·2 % and cow’s milk was regularly consumed by 46·0 %. At multivariable analysis, consumption of regular cow’s milk and ICS were significant predictors of UI/Creat ≥ 150 μg/g (OR 1·57, 95 % CI: 1·06, 2·32 and OR: 2·83, 95 % CI: 1·66, 4·82, respectively). The median Tg value was lower among the iodine-sufficient than among the iodine-deficient women (P = 0·005). At multiple linear regression analysis, Tg was among the factors associated with weight (β = –81·83, P < 0·001) and length (β = –0·3, P < 0·01) at birth, although weakly. Tg was a factor associated with pre-term delivery (OR: 1·52, 95 % CI: 1·20, 1·92). Regular use of cow’s milk and ICS is a factor associated with UI/Creat ≥ 150 μg/g. Tg was associated with iodine status and pregnancy outcomes, although it had only a modest discriminative ability for sufficiency.
High-energy, sugar-rich diets are associated with obesity and pancreatic disorders. We investigated the effects of consumption of a high-fat and high-fructose diet (HFFrD) on gene expression related to insulin synthesis, inflammation and apoptosis in pancreatic β-cells. Weaned Wistar rats were fed either a control diet (CD; 11 % kcal from fat and 0 % from fructose) or an HFFrD (48 % kcal from fat and 33 % from fructose) for 22 weeks; after a 6-h fast, animals were euthanised. Body weight and total fat were recorded. Serum analyses included: glucose, insulin, triacylglycerides (TAG), malondialdehyde (MDA), TNFα, IL-6, IL-10 and advanced glycation end-products (AGE). Pancreatic islets were analysed for gene expression linked to insulin synthesis, inflammation and apoptosis. Pancreatic assessments included TUNEL assay and immunohistochemistry. HFFrD increased body weight, total fat, MDA, insulin, homeostatic model assessment for insulin resistance, AGE, TAG and IL-6 concentrations in both sexes. Gene expression revealed sex-dependent differences: Glut2, Gck, Khk, Ins2 and the transcription factor Mafa were downregulated in males but upregulated in females. Pdx1 expression increased in females, whereas NeuroD1 increased in males. Pro-inflammatory markers (Il-1β, Il-6) increased in both sexes, whereas Il-10 decreased in males and increased in females. Bax/Bcl2 ratio decreased in males but increased in females; antioxidant and apoptotic markers Nrf2 and Casp3 increased in females. Endocannabinoid receptors (Cnr1, Cnr2) increased in both sexes. HFFrD altered the expression of genes involved in insulin synthesis, inflammation and apoptosis in a sex-specific manner. Compared with males, females showed lower vulnerability, possibly because of adaptive responses in insulin synthesis signalling influenced by sex hormones.
Food insecurity (FI) prevalence has increased globally, including in the USA, and disproportionately affects certain subgroups (e.g. women). Both food-related and non-food-related sociopolitical indicators may impact FI rates; however, these associations are underexplored. This study assessed select state-level sociopolitical indicators among states with higher and lower FI rates compared to the national average.
Design:
Cross-sectional
Setting:
US
Participants:
We identified twenty-five states representing lower (n 18) and higher (n 7) FI prevalence compared to the 2021–2023 US average (12·2 %) and used national data sources to characterise sixteen sociopolitical indicators (selected via prior review) across three categories: (1) proximal to FI (related to food access/income/resources), (2) inequality (contributing to disparities) and (3) tobacco/alcohol/cannabis regulation (may exacerbate/perpetuate financial constraints). We described each indicator and explored their associations (using t tests or Fisher’s tests) with state FI status (high v. low).
Results:
For proximal indicators, low-FI (v. high-FI) states had greater food environment scores, nutrition assistance programme participation, minimum wage and insured individuals. For inequality indicators, low-FI (v. high-FI) states had narrower gender wage gaps, greater racial equity and more protective policies for sexual/gender minority populations and abortion rights. For substance-related indicators, low-FI (v. high-FI) states had higher cigarette taxes and were more likely to have comprehensive smoke-free laws, legalised non-medical cannabis and provisions for expunging/pardoning prior cannabis-related convictions.
Conclusion:
Low-FI states had more sociopolitical indicators aimed at improving food access, financial resources, equality and substance use-related regulations. Findings highlight the importance of adopting a holistic, sustainable, multilevel approach to effectively address the broader determinants of FI.
To co-create with rangatahi (young people) evidence-based eating and wellbeing guidelines for young people in Aotearoa New Zealand (NZ), informed by mātauranga Māori (traditional Māori knowledge).
Design:
Rangatahi collaborated with Māori and non-Māori experts to review existing health guidelines covering sustainable eating, physical activity, screen time, sleep and mental wellbeing and develop their own set of guidelines. Peer feedback on the draft guidelines was used to produce the final guidelines. The process integrated scientific evidence with mātauranga Māori, following tikanga Māori (Māori custom) to ensure a culturally centred process.
Setting:
Wānanga (learning workshops) were held at a local marae (traditional meeting house), and feedback presentations were held in four secondary schools in Hawke’s Bay, NZ.
Participants:
Seventeen rangatahi from four schools with high Māori student enrolment participated in the wānanga, and ninety-four students provided peer feedback through surveys.
Results:
The rangatahi created ten eating and ten wellbeing guideline messages. These messages were invitational (beginning ‘Let’s try to…’) acknowledging the challenging journey for many rangatahi from current to recommended behaviours. Only one quantification (8–10 h of sleep) was included. Three eating and three physical activity guidelines incorporated the concepts of ‘mauri’ (life force). The guidelines addressed contemporary issues including sustainable eating, ultra-processed foods, social dimensions of eating and physical activity, screen time and cyberbullying. They also emphasised respect, rights and responsibilities, concluding with a motivational whakatauki (proverb) about aspirations.
Conclusions:
Innovative, relevant and contemporary eating and wellbeing guidelines have been successfully co-created by rangatahi Māori for all young people across NZ.
To evaluate food marketing techniques used in Canadian recreation and sport facilities and assess the healthfulness of foods and beverages marketed by the techniques.
Design:
Cross-sectional content analysis of photographed food marketing instances coded for marketing techniques according to Health Canada’s Monitoring Protocol, developed for monitoring food marketing techniques across settings, supplemented with new inductively identified codes and sport-related marketing techniques. Healthfulness was classified as ‘of concern’ or ‘not of concern’ according to cut-offs of sodium, sugar and saturated fat established by Health Canada.
Setting:
Recreation and sport facilities in Canada
Participants:
134 facilities with 2576 food marketing instances
Results:
91·4 % of food marketing instances included at least one general marketing technique. Branded infrastructure, displays and furniture was the most prevalent (87·9 %) and appeared with another technique half of the time. Sport-related marketing appeared in 12·2 % of marketing instances, with most referring to sponsors. Most (86·5 %) marketing instances were ‘of concern’. Food marketing instances with sport-related marketing (97·6 %) were significantly more likely to be ‘of concern’ than without sport-related marketing (84·6 %) (χ2 = 20·54, P < 0·001). Three new indicators – appeals to taste, appeals to emotion, and cross-channel references – captured persuasive elements not addressed by the current monitoring protocol.
Conclusions:
This study highlights the presence of food branding and the use of sport-related marketing to promote unhealthy products/brands in recreation and sports facilities. Monitoring protocols may underestimate exposure to persuasive food marketing by overlooking subtle, symbolic and cross-channel techniques. Future research can be improved by including subtle techniques and reinforced messages across marketing channels.
Large inequalities in fruit and vegetable consumption (FVC) persist, yet it remains unclear how intersecting factors such as socio-economic status, ethnicity and sex influence FVC in the UK. Using an intersectional framework allows us to explore complex realities and double burdens faced by certain population groups.
Design:
Cross-sectional data from the UK Household Longitudinal Study Wave 9 (2017–2018) were analyzed. FVC was measured as a binary variable, indicating whether individuals met the recommended five daily portions of fruits and vegetables (400 grams in total). An intersectional Multilevel Analysis of Individual Heterogeneity and Discriminatory Accuracy was used, nesting participants into forty-eight social strata based on sex, ethnicity, age and educational level.
Setting:
United Kingdom.
Participants:
A total of 16 275 individuals from the UK Household Longitudinal Study sample were included, with one adult randomly selected per household.
Results:
Overall, 69·2 % of the sample did not meet the recommended daily FVC. Inequalities were predominantly explained by additive effects of sex, ethnicity, age and educational level. Men, individuals with lower educational levels, ethnic minority groups and younger participants were at higher risk of insufficient FVC, particularly those experiencing combinations of these factors.
Conclusions:
Low FVC across the population, combined with strong additive effects of social determinants, underscore the need for proportionate universal interventions. Policies targeting improved access to fruits and vegetables across all neighbourhoods, especially those predominantly inhabited by individuals with lower educational levels, are warranted to reduce these inequalities.
To synthesise and quantify the association between household food insecurity (HFI) and various forms of malnutrition that include stunting, wasting, underweight, overnutrition and anaemia among Indonesian children under 5 years of age.
Design:
A systematic review and meta-analysis was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. The study included literature search, screening, data extraction, quality assessment using Joanna Briggs Institute (JBI) tools and meta-analysis using Review Manager 5.4.
Setting:
Studies conducted in Indonesia, covering urban, rural and mixed settings across multiple provinces.
Participants:
Children under 5 years of age residing in Indonesia, from households assessed for food insecurity using validated tools.
Results:
A total of thirty-two studies met the inclusion criteria, of which twenty-six were eligible for meta-analysis. HFI was significantly associated with higher odds of stunting (case–control: OR = 4·66; 95 % CI: 3·39, 6·40; P < 0·001; cross-sectional: OR = 4·61; 95 % CI: 4·17, 5·11; P < 0·001), wasting (OR = 1·92; 95 % CI: 1·60, 2·32; P < 0·001), underweight (OR = 5·26; 95 % CI: 2·12, 13·04; P < 0·001) and overnutrition (OR = 1·66; 95 % CI: 1·49, 1·85; P < 0·001). Children in food-secure households had significantly lower odds of anaemia (OR = 0·41; 95 % CI: 0·30, 0·58; P < 0·001).
Conclusions:
HFI is strongly associated with multiple forms of malnutrition among Indonesian children under 5 years of age. These findings highlight the urgent need for integrated, nutrition-sensitive strategies that address food security to improve child health and reduce malnutrition in Indonesia.
Multiple sclerosis (MS), known to affect many individuals, can often lead to symptoms such as fatigue, cognitive impairment and depression, thereby adversely affecting quality of life. Therefore, the aim of this planned single-centre, randomised controlled trial is to determine the effects of implementing the MIND diet or a standard diet program on quality of life, fatigue, cognition and brain fog symptoms in patients with relapsing-remitting MS (RRMS). The study will include sixty-two adult RRMS patients living in Muğla, Türkiye. Eligible patients who agree to participate will be randomly assigned, in a 1:1 ratio, to the MIND diet or standard diet group for a 12-week intervention. Participants will be monitored weekly for adherence to the interventions. Primary outcomes will include determining the effects of dietary interventions on Multiple Sclerosis Quality of Life-54, Questionnaire, Modified Fatigue Impact Scale, Brief International Cognitive Assessment for MS battery and Brain Fog Scale. Secondary outcomes will consist of blood parameters including body composition and complete blood count, biochemical parameters (fasting glucose, lipid profile, liver enzymes and albumin), C-reactive protein, thyroid hormones and folate, vitamin B12 and vitamin D levels. The results of this study may help determine the potential beneficial effects of the MIND diet on MS-related fatigue, reduced quality of life, cognitive dysfunction and brain fog, contribute to comparing these findings with existing evidence in the literature and provide up-to-date evidence. In addition, it may contribute to the development of a new nutritional therapy for MS.
Personalised nutrition has emerged as a revolutionary paradigm in nutritional science, shifting from traditional ‘one-size-fits-all’ approaches to tailored dietary recommendations. We conducted a comprehensive bibliometric analysis through a systematic search strategy capturing various conceptualisations of personalised nutrition. The analysis identified 3,159 publications demonstrating three distinct phases: an inaugural phase with minimal activity, a developmental phase showing gradual growth, and a maturation phase exhibiting exponential growth. Five distinct research clusters emerged: clinical nutrition applications for special populations, nutrigenomics and personalised dietary recommendations, metabolic health and weight management, gut microbiome and functional nutrition, and precision nutrition with multi-omics integration. Temporal analysis revealed a clear evolution from genetic foundations toward microbiome research, metabolomics, and computational approaches. Citation analysis highlighted landmark studies that established individual variability in dietary responses, the gut microbiome’s role in personalisation, and technology-enabled intervention systems as foundational to the field. The convergence of microbiome research, metabolomics, artificial intelligence (AI), and clinical applications creates promising directions for advancing personalised nutrition science. Future research must bridge the gap between mechanistic elucidation and clinical application, leveraging AI-driven predictive models and precision delivery systems to translate biological insights into effective public health strategies.
The consumption of ultra-processed food (UPF) has been linked to bone metabolism in adults, but its impact on bone mineral density (BMD) in children and adolescents remains unclear. This study analysed data from 4809 children and adolescents aged 8–19 years, drawn from the National Health and Nutrition Examination Survey (NHANES) 2011–2018. UPF intake was categorised according to the NOVA classification system, with the percentage of energy derived from UPF divided into quartiles (Q1–Q4). A weighted multiple linear regression model was used to examine the relationship between UPF intake and lumbar spine BMD (LSBMD) and subtotal BMD (SBMD). Stratified analyses were conducted to explore associations across various subgroups. The results indicated that UPF intake was positively associated with LSBMD. This association was significant in girls for both LSBMD and SBMD. Positive correlations with LSBMD also emerged in 12–15 years old and specific subgroups. Moreover, mediation analysis showed total cholesterol mediated 4·8 % of the UPF–LSBMD link, and HDL-cholesterol mediated 0·9 % of the UPF–SBMD one. These findings indicate that UPF intake is associated with increased BMD in children and adolescents. Future research should further investigate the complex effects of UPF on the health of this population.