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As a wave of backsliding has swept across both new and established democracies, scholars have sought to identify formal and informal institutions that can act as guardrails of democracy. But while informal norms, party structures, and formal institutions such as separation of powers have all been singled out as potential bulwarks against democratic backsliding, the literature has had less to say about what role, if any, federalism might play in stopping democracies from sliding into autocracy. While some constitutional designers and scholars have argued that federalism can help to prevent the emergence of a national tyranny, most contemporary research has emphasized the damaging effects federalism can have on democracy. In this article, we assess the relationship between federalism and threats posed by national rulers, with quantitative analysis of that relationship in countries around the world and with structured, focused comparative case studies in the United States, Brazil, Venezuela, and India. Our quantitative analysis finds no systematic relationship between federalism and backsliding, while our comparative case studies support our argument that federalism is only likely to serve as a bulwark against autocratic threats posed by national rulers under a limited set of conditions.
While scholars consider the global democratic deficit a key issue, we know little about citizens’ perceptions in this regard. To what extent and why do citizens perceive global democratic deficiencies? I conceptualize deficiencies absolutely and relatively—theorizing countries, knowledge, and framing as explanatory factors. Between 2018 and 2021, I conducted survey experiments on around 42,000 respondents in 17 highly diverse countries. Contrary to many scholarly assessments, I find that most people do not perceive major global democratic deficiencies, in the sense that global governance is generally not perceived as highly undemocratic in absolute terms and more democratic than developing democracies. However, the results vary by the object and aspect of inquiry: World politics (versus international organizations) and input (versus output) are perceived as less democratic. Plus, neither gains in relevant knowledge nor common framings affect public perceptions, which are thus quite robust. These findings add novel evidence to debates about global governance.
The “gender gap” in voting is one of the most well-documented findings in survey research across democracies. However, gender gap research has traditionally assumed that everyone is either a man or a woman, which does not account for the growing number of people who identify as nonbinary. How do nonbinary people differ from men and women in their party identification and voting behavior? We answer this question using data from the 2021 Canadian Election Study online panel, which has a large enough subsample of nonbinary respondents to identify gaps in party identification and voting behavior. Nonbinary people are much less likely to identify with and vote for the Liberal Party or Conservative Party and much more likely to identify with and vote for the social democratic New Democratic Party (NDP) than both men and women. Many of these gaps persist even when restricting the analysis to LGBTQ respondents, adjusting for demographic variables that predict nonbinary identity, and adjusting for issue attitudes. Nonbinary people’s distinctiveness from men and women suggests that researchers need to add nonbinary response options to gender questions and, wherever possible, incorporate nonbinary people into analyses of gender and politics.
One potential solution to the rising threat of antibacterial drug resistance is the application of therapeutic clays to treat wound infections. Clays with antibacterial activity have been identified from a range of sources with their antibacterial properties often attributed to the release of toxic metal ions such as Fe(II) and Al(III). Here, clays from Afghanistan, Azerbaijan and Bangladesh that are utilized for washing and healing purposes were examined. Their antibacterial activities were assessed in suspension and as aqueous leachates against representative Gram-negative, Escherichia coli, and Gram-positive, Bacillus subtilis, bacteria. The majority of the clays conferred no deleterious effect and, in fact, tended to promote bacterial growth, likely as a result of released organic and inorganic nutrients. However, one of the clays, obtained from the Dhaka region of Bangladesh, displayed significant bactericidal activity against E. coli and B. subtilis as a clay suspension but not as an aqueous leachate. Further experiments confirmed that contact between clay and the bacteria was necessary for most of the antibacterial effects. Detailed analysis of bulk and <2 μm clay fraction mineralogy and geochemistry revealed no single defining parameter or mineral component that could be used to easily distinguish natural clays with antibacterial properties from those without. Overall, the results suggest a mechanism of antibacterial action of the Dhaka clay that arises from acidic conditions, likely enabled by the absence of calcite in the bulk clay, metal release, the presence of interstratified chlorite-smectite, and direct clay–bacteria interactions.
Many political scientists hold that vitriolic speech against high-profile women has only negligible effects on other women in politics. They also contend that the prevalence of such vitriol is consistent with gender bias having no significant negative impact on most women in politics. This article argues that these sanguine positions rest on inadequate and untested assumptions regarding misogyny, and the role it plays in politics. In the service of putting us in a position to test the relationship between gendered discourse in particular elections and the structural obstacles faced by women in politics, this article develops a conceptualization of political misogyny: nasty claim-making that instills repugnant connotations into women’s collective political identities (e.g., their partisan identities). Attention is also paid to how political misogyny can distribute hatred burdens disproportionately among different groups of women.
Victimization is often associated with increased political participation, and victims are influential political actors in many countries around the world. Yet for victims, activism is costly: they tell and re-tell painful stories, face searing criticism, and work to exhaustion—all at one of the worst moments of their lives. So why do they do it? Based on ethnographic research with Families for Safe Streets, a group of victims-turned-activists in New York City, this article advances a new explanation for victims’ participation in politics. I propose that for some victims, meaning-making is an in-process benefit of activism. My inductive research suggests three ways victims find meaning in politics. First, through their activism, victims can re-conceptualize the losses and harms they have suffered as policy problems, rather than random, inexplicable events. Victims may also seek to help others by changing laws to prevent similar tragedies from recurring, and some victims see their activism as a way of fulfilling important obligations to their communities, their families, and their deceased relatives.
The serotonin 4 receptor (5-HT4R) is a promising target for the treatment of depression. Highly selective 5-HT4R agonists, such as prucalopride, have antidepressant-like and procognitive effects in preclinical models, but their clinical effects are not yet established.
Aims
To determine whether prucalopride (a 5-HT4R agonist and licensed treatment for constipation) is associated with reduced incidence of depression in individuals with no past history of mental illness, compared with anti-constipation agents with no effect on the central nervous system.
Method
Using anonymised routinely collected data from a large-scale USA electronic health records network, we conducted an emulated target trial comparing depression incidence over 1 year in individuals without prior diagnoses of major mental illness, who initiated treatment with prucalopride versus two alternative anti-constipation agents that act by different mechanisms (linaclotide and lubiprostone). Cohorts were matched for 121 covariates capturing sociodemographic factors, and historical and/or concurrent comorbidities and medications. The primary outcome was a first diagnosis of major depressive disorder (ICD-10 code F32) within 1 year of the index date. Robustness of the results to changes in model and population specification was tested. Secondary outcomes included a first diagnosis of six other neuropsychiatric disorders.
Results
Treatment with prucalopride was associated with significantly lower incidence of depression in the following year compared with linaclotide (hazard ratio 0.87, 95% CI 0.76–0.99; P = 0.038; n = 8572 in each matched cohort) and lubiprostone (hazard ratio 0.79, 95% CI 0.69–0.91; P < 0.001; n = 8281). Significantly lower risks of all mood disorders and psychosis were also observed. Results were similar across robustness analyses.
Conclusions
These findings support preclinical data and suggest a role for 5-HT4R agonists as novel agents in the prevention of major depression. These findings should stimulate randomised controlled trials to confirm if these agents can serve as a novel class of antidepressant within a clinical setting.
Clozapine-induced inflammation, such as myocarditis and pneumonia, can occur during initial titration and can be fatal. Fever is often the first sign of severe inflammation, and early detection and prevention are essential. Few studies have investigated the effects of clozapine titration speed and concomitant medication use on the risk of clozapine-induced inflammation.
Aims
We evaluated the risk factors for clozapine-associated fever, including titration speed, concomitant medication use, gender and obesity, and their impact on the risk of fever and the fever onset date.
Method
We conducted a case-control study. The medical records of 539 Japanese participants with treatment-resistant schizophrenia at 21 hospitals in Japan who received clozapine for the first time between 2010 and 2022 were retrospectively investigated. Of these, 512 individuals were included in the analysis. Individuals were divided into three groups according to the titration rate recommended by international guidelines for East Asians: the faster titration group, the slower titration group and the ultra-slower titration group. The use of concomitant medications (such as antipsychotics, mood stabilisers, hypnotics and anxiolytics) at clozapine initiation was comprehensively investigated. Logistic regression analysis was performed to identify the explanatory variables for the risk of a fever of 37.5°C or higher lasting at least 2 days.
Results
Fever risk significantly increased with faster titration, male gender and concomitant use of valproic acid or quetiapine. No increased fever risk was detected with the use of other concomitant drugs, such as olanzapine, lithium or orexin receptor antagonists. Fever onset occurred significantly earlier with faster titration. Multivariate analysis identified obesity as being a factor that accelerated fever onset.
Conclusion
A faster titration speed and concomitant treatment with valproic acid and quetiapine at clozapine initiation increased the risk of clozapine-associated fever. Clinicians should titrate clozapine with caution and consider both the titration speed and concomitant medications.
Introducing an international relations perspective into the literature on anti-immigrant attitudes, we hypothesize that immigrants from rival countries will be shunned and immigrants from allied countries preferred, especially by respondents who identify more strongly with the nation. We fielded a forced-choice conjoint experiment in 22 countries, whereby respondents chose between applicants for permanent resident status with randomized attributes. We identified rival and allied countries of origin for each surveyed country, with one such pair sharing a similar racial and cultural make-up as the majority of respondents, and one pair being more dissimilar. We find that discrimination against immigrants from rival states is so pronounced that it results in a net preference for racially and culturally dissimilar immigrants. Since we fielded the surveys amidst the Russian invasion of Ukraine, we are able to leverage exogenous changes in the intensity of one rivalry, providing further evidence for the proposed mechanism.
This study reflects on the field research interruptions that occurred around the world with the onset of the COVID-19 pandemic. Based on my experience of in-person and remote fieldwork with vulnerable populations and sensitive research topics during this time, I introduce a “zig-zagging approach” that can be used as a research adaptivity strategy in times of disruption. I argue that “zig-zagging your way through the field” is a legitimate strategy as long as researchers acknowledge that changing from in-person to remote fieldwork (and vice versa) will alter various aspects of their relationship with the field including;(1) perception of positionality and authenticity; (2) processes of trust building and security challenges; and (3) experience of ethnographic immersion and observation. I offer mitigation strategies to reduce the impact of change and also discuss aspects that cannot be mitigated when working with vulnerable populations or sensitive research topics. I conclude on why going back—and forth (i.e., zig-zagging)—should become a practical solution when all else fails.
Plea bargaining figures heavily in criminal justice systems in the United States and, increasingly, around the globe. Conventional wisdom holds that plea bargaining generates efficiency gains for all parties, while sorting the guilty from the innocent. We build a series of formal models to consider the relationship between a defendant’s guilt and her likelihood of pleading guilty. In an inversion of the conventional wisdom, we show that under a range of empirically plausible scenarios—for example, if criminals are more risk-seeking than the wrongfully accused, or if prosecutors derive a career benefit from trial wins—the innocent are more likely than the guilty to plea bargain.
A long-standing debate in political psychology considers whether individuals update their beliefs and attitudes in the direction of evidence or grow more confident in their convictions when confronted with counter-attitudinal arguments. Though recent studies have shown that instances of the latter tendency, which scholars have termed attitude polarization and “belief backfire,” are rarely observed in settings involving hot-button issues or viral misinformation, we know surprisingly little about how participants respond to information targeting deeply held attitudes, a key condition for triggering attitude polarization. We develop a tailored experimental design that measures participants’ core issue positions and exposes them to personalized counter-attitudinal information using the large language model GPT-3. We find credible evidence of attitude polarization, but only when arguments are contentious and vitriolic. For lower valence counter-attitudinal arguments, attitude polarization is not detected. We conclude by discussing implications for the study of political cognition and the measurement of attitudes.
Social scientists often classify text documents to use the resulting labels as an outcome or a predictor in empirical research. Automated text classification has become a standard tool since it requires less human coding. However, scholars still need many human-labeled documents for training. To reduce labeling costs, we propose a new algorithm for text classification that combines a probabilistic model with active learning. The probabilistic model uses both labeled and unlabeled data, and active learning concentrates labeling efforts on difficult documents to classify. Our validation study shows that with few labeled data, the classification performance of our algorithm is comparable to state-of-the-art methods at a fraction of the computational cost. We replicate the results of two published articles with only a small fraction of the original labeled data used in those studies and provide open-source software to implement our method.
This article presents Latinx political thought as a distinctive tradition in political theory that reworks central concepts in response to historical experiences of conquest, colonialism, migration, and transnational politics. In reconstructing this tradition, we argue that its problem space converges with US-based Latin American political thought. The article first traces a genealogy of Latinx political theory and then explores three realms of theorizing around which Latinx and Latin American political thought cluster: sovereignty and state violence, peoplehood, and transnationalism. We explain how the surveyed works disrupt and enrich political theory accounts of these problems. In arguing for the recognition of this field as a tradition, the article also aims to make it intelligible as an area of concentration for PhD students in political science.
I draw together theories of partisan polarization and motivated reasoning, which suggest that partisanship shapes information processing, and theories of accountability, which argue voters hold elected officials accountable through promise fulfillment. Here, I ask how partisanship influences voter understanding of promise fulfillment and accountability and if voters assess promises through a partisan lens. Two original survey experiments test how respondents react to promise fulfillment on the issues of immigration and human trafficking. I demonstrate that co-partisans differentiate between kept and broken promises, but out-partisans do not. Despite partisan differences, respondents evaluate promise-keeping when asked about accountability but not when asked about approval. Thus, even when voters recognize broken promises, accountability is influenced by partisanship. Immigration, a more polarized issue, is more likely to prime a partisan response than human trafficking, a less polarized issue. Future work must account for partisanship in accountability and what this means for our understanding of fundamental democratic principles.
Urbanisation is taking place worldwide and rates of mental illness are rising. There has been increasing interest in ‘nature’ and how it may benefit mental health and well-being.
Aims
To understand how the literature defines nature; what the characteristics of the nature intervention are; what mental health and well-being outcomes are being measured; and what the evidence shows, in regard to how nature affects the mental health and well-being of children and adolescents.
Method
A meta-review was conducted, searching three databases for relevant primary and secondary studies, using key search terms including ‘nature’ and ‘mental health’ and ‘mental well-being’. Inclusion criteria included published English-language studies on the child and adolescent population. Authors identified the highest quality evidence from studies meeting the inclusion criteria. Data were extracted and analysed using descriptive content analysis.
Results
Sixteen systematic reviews, two scoping reviews and five good quality cohort studies were included. ‘Nature’ was conceptualised along a continuum (the ‘nature research framework’) into three categories: a human-designed environment with natural elements; a human-designed natural environment; and a natural environment. The nature ‘intervention’ falls into three areas (the ‘nature intervention framework’): access, exposure and engagement with nature, with quantity and quality of nature relevant to all areas. Mental health and well-being outcomes fit along a continuum, with ‘disorder’ at one end and ‘well-being’ at the other. Nature appears to have a beneficial effect, but we cannot be certain of this.
Conclusions
Nature appears to have a beneficial effect on mental health and well-being of children and adolescents. Evidence is lacking on clinical populations, ethnically diverse populations and populations in low- and middle-income countries. Our results should be interpreted considering the limitations of the included studies and confidence in findings.