To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
We consider an $\mathrm{M}/\mathrm{G}/\infty$ queue with infinite expected service time. We then provide the transience/recurrence classification of the states (the system is said to be at state n if there are n customers being served), observing also that here (unlike irreducible Markov chains, for example) it is possible for recurrent and transient states to coexist. We also prove a lower bound on the growth speed in the transient case.
Tetralogy of Fallot patients face an elevated risk of developing chylothorax and pleural effusions post-surgery. This patient group exhibits risk factors known to compromise the lymphatic system, such as elevated central venous pressure, pulmonary flow changes, and hypoxia. This study investigates the morphology and function of the lymphatic system in tetralogy of Fallot patients through lymphatic magnetic resonance imaging and near-infrared fluorescence imaging, respectively.
Methods:
Post-repair tetralogy of Fallot patients aged 6–18 years were recruited, along with age and gender-matched controls. Magnetic resonance imaging was used to assess the morphology of the thoracic lymphatic vessels and the thoracic, while near-infrared fluorescence imaging was used to assess lymphatic activity utilising lymph rate, velocity, and pressure.
Results:
Nine patients and 10 controls were included. Echocardiography revealed that 2/3 of the patients had moderate-severe pulmonary regurgitation, while none displayed signs of elevated central venous pressure. Magnetic resonance imaging identified three patients with type 3 (out of 4 types) lymphatic abnormalities, while controls had none. The thoracic ducts showed severe (one patient) and moderate (one patient) tortuosity. Mean thoracic duct diameters were 3.3 mm ±1.1 in patients and 3.0 mm ± 0.8 in controls (p-value = 0.53). Near-infrared fluorescence imaging revealed no anomalous patterns.
Conclusion:
Despite no presence of clinical lymphatic disease, 3/9 of the repaired tetralogy of Fallot patients exhibited lymphatic morphological abnormalities. The significance of these anomalies remains uncertain currently. Further research is needed to determine whether these lymphatic alterations in this patient cohort are a result of congenital malformations, haemodynamic shifts, or prenatal and early-life saturation levels.
We numerically study the influence of a soluble surfactant on the microjetting mode of the liquid–liquid flow focusing configuration. The surfactant adsorbs on the interface next to the feeding capillary and accumulates in front of the emitted jet, significantly lowering the surface tension there. The resulting Marangoni stress substantially alters the balance of the tangential stresses at the interface but does not modify the interface velocity. The global stability analysis at the minimum flow rate stability limit shows that the Marangoni stress collaborates with soluto-capillarity to stabilize the microjetting mode. Our analysis unveils the noticeable effect of the Marangoni stress associated with the surface tension perturbation. Surfactant diffusion and desorption hardly affect the stability limit. Transient numerical simulations show how subcritical and supercritical base flows respond to a spatially localized initial perturbation. Our parametric study indicates that the minimum flow rate ratio depends on the adsorption constant and the surfactant concentration through the product of these two variables. The surfactant stabilizing effect increases with the outer stream flow rate. We show that surfactants not only stabilize the microemulsion resulting from the jet breakup in hydrodynamic focusing, but also allow for the reduction of droplet size. Our findings advance the fundamental understanding of the complex role of surfactants in tip streaming via hydrodynamic focusing. In particular, our results contradict the common assumption that adding surfactant favours tip streaming simply because it reduces the meniscus tip surface tension.
This essay challenges the ethnocentrism of the dominant literature on hikmet-i cedide, or the new philosophy, in the late Ottoman Empire. Hikmet-i cedide was “new” in the sense that it did not confine itself to theological discussions and interpretations of holy books. Instead, it found its source of inspiration in the principles of modern Western philosophy, and especially the philosophy of the Enlightenment and Auguste Comte’s positivism. The dominant literature reduces this hikmet-i cedide to the philosophical writings of Muslim/Turkish intellectuals. Problematizing such ethnocentrism, this essay gives an account of hikmet-i cedide from the perspective of Ottoman–Armenians’ early engagement with positivism and the political philosophy of the Enlightenment. It argues that Armenians’ philosophical discourses in the second half of the nineteenth century were characterized by a belief that the principles of the new philosophy were the sine qua non for national survival in the multi-ethnic and multi-religious context of the Empire. They were also characterized by a commitment to reconciling modern Western philosophy with religious attachments. However, this characterization should not be thought to be confined to so-called “Armenian philosophy” but may be generalized to broader late Ottoman thought.
This article examines the empire-wide legal professional community that emerged for the first time in Chinese history during the Qing period (1644–1911). By analyzing a wide range of archival records and primary sources, this study provides valuable insights into the dynamic configurations of late imperial China’s legal culture and juridical field, as well as the thousands of legal specialists who shaped them. The findings challenge much of the received wisdom about late imperial China, which has too often been assumed as a Confucian society that discouraged the use of law and legal expertise and was therefore unlikely to have witnessed so many Confucian literati becoming legal specialists, both within and outside the judicial system.
Elites were pivotal for Latin America’s modernization, yet granular evidence of their industrial entrepreneurship is limited. I study Antioquia, an early center of industrialization, from the late nineteenth to early twentieth centuries. Analyzing elite interactions via newfound archival data and exploiting unexpected deaths as exogenous shocks, I find global connectivity—not local—drove industrial entrepreneurship. This suggests diverse resources unavailable in markets but accessible through global connections were crucial in forming industrial ventures. Thus, this paper depicts how social capital shapes elite outcomes.
COVID-19 changed the epidemiology of community-acquired respiratory viruses. We explored patterns of respiratory viral testing to understand which tests are most clinically useful in the postpandemic era.
Methods:
We conducted a retrospective observational study of discharge data from PINC-AI (formerly Premier), a large administrative database. Use of multiplex nucleic acid amplification respiratory panels in acute care, including small (2–5 targets), medium (6–11), and large panels (>11), were compared between the early pandemic (03/2020–10/2020), late pandemic (11/2020–4/2021), and prepandemic respiratory season (11/2019 - 02/2020) using ANOVA.
Results:
A median of 160.5 facilities contributed testing data per quarter (IQR 155.5–169.5). Prepandemic, facilities averaged 103 respiratory panels monthly (sd 138), including 79 large (sd 126), 7 medium (sd 31), and 16 small panels (sd 73). Relative to prepandemic, utilization decreased during the early pandemic (62 panels monthly/facility; sd 112) but returned to the prepandemic baseline by the late pandemic (107 panels monthly/facility; sd 211). Relative to prepandemic, late pandemic testing involved more small panel use (58 monthly/facility, sd 156) and less large panel use (47 monthly/facility, sd 116). Comparisons among periods demonstrated significant differences in overall testing (P < 0.0001), large panel use (P < 0.0001), and small panel use (P < 0.0001).
Conclusions:
Postpandemic, clinical use of respiratory panel testing shifted from predominantly large panels to predominantly small panels. Factors driving this change may include resource availability, costs, and the clinical utility of targeting important pathogenic viruses instead of testing “for everything.”
John Stuart Mill does not contradict himself in On Liberty with respect to the issue of piecework, contrary to Dale E. Miller's charge that he does. Miller fails to understand that the liberty principle (LP) limits society's authority to regulate trade in that society has no legitimate authority to prohibit or make unduly expensive a buyer's post-trade use of his purchased product in self-regarding ways. LP gives an employer who has purchased labor under a trade contract in a free and fair competitive labor market a right to conclude a separate mutually consensual self-regarding piecework contract with any skilled worker already in his employ.
In this paper it is shown that a modal detuned instability of periodic near-wall streaks originates a large-scale structure in the bulk of the turbulent channel flow. The effect of incoherent turbulent fluctuations is included in the linear operator by means of an eddy viscosity. The base flow is an array of periodic two-dimensional streaks, extracted from numerical simulations in small domains, superposed to the turbulent mean profile. The stability problem for a large number of periodic units is efficiently solved using the block-circulant matrix method proposed by Schmid et al. (Phys. Rev. Fluids, vol. 2, 2017, 113902). For friction Reynolds numbers equal or higher than $590$, it is shown that an unstable branch is present in the eigenspectra. The most unstable eigenmodes display large-scale modulations whose characteristic wavelengths are compatible with the large-scale end of the premultiplied velocity fluctuation spectra reported in previous computational studies. The wall-normal location of the large-wavelength near-wall peak in the spanwise spectrum of the eigenmode exhibits a power-law dependence on the friction Reynolds number, similarly to that found in experiments of pipes and boundary layers. Lastly, the shape of the eigenmode in the streamwise-wall-normal plane is reminiscent of the superstructures reported in the recent experiments of Deshpande et al. (J. Fluid Mech., vol. 969, 2023, A10). Therefore, there is evidence that such large-wavelength instabilities generate large-scale motions in wall-bounded turbulent flows.
Solving the three-dimensional boundary layer equations carries theoretical significance and practical applications, which also poses substantial challenges due to its inherent complexity. In this paper, the laminar boundary layer equations for the symmetry plane of three-dimensional bodies are derived in an orthogonal curvilinear coordinate system associated with the principal curvatures. The derivation of the boundary layer equations is based not only on the common symmetric properties of the flow, as given by Hirschel et al. (Three-Dimensional Attached Viscous Flow, 2014, Academic Press, pp. 183–187), but also incorporates the geometric symmetry properties of the body. The derived equations are more representative and simplified. Notably, these equations can degenerate to a form consistent with or equivalent to the commonly used boundary layer equations for special bodies such as flat plates, cones and spheres. Furthermore, for hypersonic flows, the crossflow velocity gradient at the boundary layer edge on the symmetry plane is derived based on Newtonian theory. Subsequently, this parameter can provide the necessary boundary condition needed for solving the boundary layer equations using existing methods. Finally, as examples, the equations developed in this paper are solved using the difference-differential method for several typical three-dimensional blunt shapes that appeared on hypersonic vehicles. They prove to be useful in the analysis and interpretation of boundary layer flow characteristics in the symmetry plane of blunt bodies.
Background: Congenital cardiac care involves multiple stakeholders including patients and their families, surgeons, cardiologists, anaesthetists, the wider multidisciplinary team, healthcare providers, and manufacturers, all of whom are involved in the decision-making process to some degree. Game theory utilises human behaviour to address the dynamics involved in a decision and what the best payoff is depending on the decision of other players. Aim: By presenting these interactions as a strategic game, this paper aims to provide a descriptive analysis on the utility and effectiveness of game theory in optimising decision-making in congenital cardiac care. Methodology: The comprehensive literature was searched to identify papers on game theory, and its application within surgery. Results: The analysis demonstrated that by utilising game theories, decision-making can be more aligned with patient-centric approaches, potentially improving clinical outcomes. Conclusion: Game theory is a useful tool for improving decision-making and may pave the way for more efficient and improved patient-centric approaches.
We use Stein’s method to obtain distributional approximations of subgraph counts in the uniform attachment model or random directed acyclic graph; we provide also estimates of rates of convergence. In particular, we give uni- and multi-variate Poisson approximations to the counts of cycles and normal approximations to the counts of unicyclic subgraphs; we also give a partial result for the counts of trees. We further find a class of multicyclic graphs whose subgraph counts are a.s. bounded as $n\to \infty$.
The Energy Charter Treaty (ECT) is one of the best-known and most controversial of the international investment treaties. The energy transition necessary to achieve the Paris Agreement climate target will require large and sustained flows of investment capital. Scholars, environmentalists, industry representatives, and governmental officials have intensively debated the modernization of the ECT. The main point of contention is whether the ECT can facilitate the energy transition or whether it entrenches fossil lock-in in unsustainable and unjust ways. This article proposes a comprehensive and integrated approach to the ECT, guided by the theoretical matrix of Earth system law scholarship. Our analysis reveals that the ECT cannot address contemporary socio-ecological challenges, but rather it remains a sectoral piece of a supranational economic constitution far removed from the most pressing exigencies of the Anthropocene.
Harbour seals were extensively hunted in Denmark, but have only been driven to local extinction in one larger area, the South Funen Archipelago and Little Belt, where the species has been absent throughout the 20th century. Despite high growth rates of the Danish harbour seal populations after protection from hunting in 1976, seals have only been observed sporadically in the South Funen Archipelago and Little Belt until recent years, where recolonisation now causes conflicts with fisheries. Here, we review historical sources documenting the local extinction of harbour seals in the area during the 19th century and report the results of aerial surveys of haul-out sites during moulting seasons of 2021–2023 and pupping seasons of 2022 and 2023. Historical sources reveal that seal hunting was a common practice in southern Denmark, but catches dwindled to rarities during the 19th century. During recent surveys, seals were detected at six of the identified potential haul-out sites. Around Aarø Island, an average of 141 (range: 92–186) harbour seals were recorded over four moulting season surveys, constituting the majority (90%) of the total counts of the surveyed area. During the pupping seasons, a total of five pups was encountered at two different haulouts. As none of the haulouts are protected during the pupping and breeding seasons, protective measures may support this recolonisation of the historic harbour seal breeding range.
This study investigates the impact of warfare on nuptial patterns, focusing on the trends and characteristics of age differences within marriage. Specifically, it explores the socio-demographic outcomes of the Imjin War (1592–1598) and post-war reconstruction in Korea, using the earliest extant Chosŏn household registers, compiled between 1606 and 1630. Individual-level microdata were derived involving 2,336 married couples based on 11,749 entries in these registers, covering four administrative districts located in the southeastern region of the Korean peninsula severely devastated by the war. Factors such as status, property, warfare, social practices, and legal regulations influenced spousal age differences. First, social rank and family wealth played pivotal roles, with age gaps widening as a husband's socio-economic status increased. Second, females born after 1580, whose first marriages were affected by the Imjin War and post-war circumstances, experienced an average marital age gap of about ten years. Third, this effect was further complicated by the imposition of socio-legal rules on remarriage; that is, the yangban entailed a pronounced age difference owing to the Neo-Confucian norm of chaste widowhood. This study enriches the understanding of historical marriage customs in Korea and offers insights for studies on age disparity in marriage.
The injection of ${\rm CO}_2$ into depleted reservoirs carries the potential for significant Joule–Thomson cooling, when dense, supercritical ${\rm CO}_2$ is injected into a strongly under-pressured reservoir. The resulting low temperatures around the wellbore risk causing thermal fracturing of the well/near-well region or causing freezing of pore waters or formation of gas hydrates which would reduce injectivity and jeopardise well and reservoir integrity. These risks are particularly acute during injection start-up when ${\rm CO}_2$ is in the gas stability field. In this paper we present a model of non-isothermal single-phase flow in the near-wellbore region. We show that during radial injection, with fixed mass injection rate, transient Joule–Thomson cooling can be described by similarity solutions at early times. The positions of the ${\rm CO}_2$ and thermal fronts are described by self-similar scaling relations. We show that, in contrast to steady-state flow, transient flow causes slight heating of ${\rm CO}_2$ and reservoir gas either side of the thermal front, as pressure diffuses into the reservoir. The scaling analysis here identifies the parametric dependence of Joule–Thomson cooling. We present a sensitivity analysis which demonstrates that the primary controls on the degree of cooling are reservoir permeability, reservoir thickness, injection rate and Joule–Thomson coefficient. The analysis presented provides a computationally efficient approach for assessing the degree of Joule–Thomson cooling expected during injection start-up, providing a complement to complex, fully resolved numerical simulations.