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Loss of skeletal muscle strength and mass (sarcopenia) is common in older adults and associated with an increased risk of disability, frailty and premature death. Finding cost-effective prevention and treatment strategies for sarcopenia for the growing ageing population is therefore of great public health interest. Although nutrition is considered an important factor in the aetiology of sarcopenia, its potential for sarcopenia prevention and/or treatment is still being evaluated. Nutrition research for sarcopenia utilises three main approaches to understand muscle-nutrition relationships, evaluating: single nutrients, whole foods and whole diet effects – both alone or combined with exercise. Applying these approaches, we summarise recent evidence from qualitative and quantitative syntheses of findings from observational and intervention studies of healthy older adults, and those with sarcopenia. We consider protein supplements, whole foods (fruits and vegetables) and the Mediterranean diet as exemplars. There is some evidence of beneficial effects of protein supplementation ≥ 0·8 g/kg body weight/d on muscle mass when combined with exercise training in intervention studies of healthy and sarcopenic older adults. In contrast, evidence for effects on muscle function (strength and physical performance) is inconclusive. There is reasonably consistent epidemiological evidence suggesting benefits of higher fruits and vegetables consumption for better physical performance. Similarly, higher adherence to the Mediterranean diet is associated with beneficial effects on muscle function in observational studies. However, intervention studies are lacking. This review discusses how current evidence may inform the development of preventive and intervention strategies for optimal muscle ageing and nutritional public policy aimed at combatting sarcopenia.
Two-dimensional (2-D) quadrant analysis is generally used for investigating flow and sediment dynamics around a rigid structure in open channel flows. Given that particle distribution around rigid obstacles is not spatially uniform and changes in time, while vortices evolve to become three-dimensional (3-D) structures, 2-D quadrant analysis might be unsuitable to completely determine the sediment transport. Hence, 3-D quadrant and 3-D octant analyses should be considered, using the 3-D instantaneous velocity data and relative 3-D bursting process to define sediment transport surrounding the submerged square and circular cylinders. The turbulent kinetic energy (TKE), transition probabilities, occurrence probabilities, stress fraction and angles of inclination of 3-D bursting events are considered to quantify the coherent structures surrounding the cylinders and their interaction with bed particles. Experiments were conducted at the Hydraulics and Water Resources Engineering Laboratory, School of Infrastructure, Indian Institute of Technology, Bhubaneswar, Odisha, India, and velocity data were recorded at different cross-sections around the submerged cylinders using an acoustic Doppler velocimeter. Results show that the TKE is greater for internal ejection, external ejection, and internal sweep, external sweep in the upstream of the circular and square cylindrical structures. On the other part, the TKE is significant for internal ejection, external ejection, and internal sweep, external sweep in the downstream of the aligned square cylindrical structures, which justifies the highest scour depth that occurred upstream of the circular and square cylindrical structures and downstream of the aligned square cylindrical structure. The transition probability of the bursting events was determined using the Markov process from the measured velocity data to investigate the consecutive occurrence of bursting events. Further, the importance of sweeps and ejections on sediment erosion surrounding the cylinders within the scour hole at various stages of its development was investigated via 3-D quadrant analysis of the bursting occurrences. The outcomes show that external sweep and internal ejection events are active mechanisms for bed particle transport surrounding the cylinder. The maximum transition probability values are found around aligned cylindrical structures in comparison with the circular and square cylindrical structures in the transverse direction. This depicts the formation of a trailing vortex on both sides of the aligned square cylindrical object. The results reveal that the effect of inclination angles with respect to the water flow is greater for internal ejection and external sweep from upstream to downstream within the scour hole surrounding the cylindrical structures at various phases of development as horseshoe vortices and downflow develop upstream of the cylindrical structures while trailing vortices and wake vortices form at the top and downstream of the cylindrical structures. Internal and external ejection have a higher stress fraction than an internal and external sweep for square cylinders with alignment angles of 0°, 20° and circular cylinders over underdeveloped and developed scoured beds, respectively. With the higher percentage of fractional contributions for internal sweeps, the external sweep is predicted close to the cylindrical objects in comparison with the internal ejection and external ejection events because of the formation and warping of the horseshoe vortex close to the cylindrical objects, suggesting a significant probability of 3-D bursting occurrences with sediment movement near the cylindrical structures.
Despite the urgent need for plant-based dietary shifts, few studies have examined current diet trajectories using longitudinal data. This study analyzed dietary transitions of French adults over 8 years (2014-2022), assessing diet quality and the role of various socio-economic factors. Consumption data from 17 187 NutriNet-Santé cohort participants, weighted for the French Census, were collected via FFQ in 2014, 2018 and 2022. Adopting a gender-specific approach, consumption changes in twenty-three food groups were assessed over time. Diet quality was evaluated using the Comprehensive Diet Quality Index score, categorising foods into ‘healthy’ and ‘unhealthy’. Socio-economic analysis targeted four food groups (red meat (including fresh beef, pork, offal and lamb), processed meat (e.g. sausages, ham and bacon), legumes and whole-grain products), strongly linked to mortality risk and recognised as significant markers of the sustainable diet transition. All analyses were conducted using multi-adjusted mixed-effects models. Consumption of some healthy plant-based foods (nuts +59 %, legumes +22 %, whole-grain products +7 %) significantly increased over time, while consumption of some unhealthy foods (red meat −19 %, refined cereals −18 %, sweetened drinks −15 %) decreased. Conversely, consumption of prepared and mixed dishes (+16 %) and processed meat (+35 %) increased. These changes differed in magnitude between genders and translated into an improved diet quality score (Comprehensive Diet Quality Index). Occupational status was linked to longitudinal changes in food consumption, showing increased consumption of plant-based foods among students and higher socio-professional categories. Our findings provide accurate data on trends and factors for targeted initiatives, guiding strategic interventions for a sustainable dietary transition.
This article examines the online reaction to the linguistic performance of a pro-China Hong Kong singer-actor in a commercial where he speaks Hong Kong English. Paradoxically, the posters criticizing his English are Hongkongers themselves, while those showing admiration are mainland Chinese. Understanding this paradox requires an appreciation of the multiple and complex orders of indexicality through which the variety is evaluated and of the increasing use of linguistic evaluations as a proxy for political judgements in a society undergoing significant changes. An analysis of online comments and remixes associated with the commercial shows that Hong Kong social media users attribute a range of different indexical meanings to the celebrity's English to shame him for his perceived ‘betrayal’ and to reclaim a sense of social superiority over mainlanders in the face of unease about Hongkongers’ cultural distinctiveness. It unpacks complexities surrounding the deployment of language ideologies in societies experiencing sociopolitical upheavals. (Language ideologies, linguistic ridicule, orders of indexicality, polycentricity, social media, Hong Kong)*
Sperm infertility or subfertility is detrimental to the precious highland germplasm like yak whose population has been gradually declining in India. Understanding the ‘omic’ landscape of infertile or subfertile yak sperm can reveal some interesting insights. In an attempt to do the same, this study considered the semen of infertile or subfertile yak bulls for whole-genome and transcriptome evaluations. DNA sequencing revealed that the yak sperm genome contains the necessary genes to carry out all the important biological processes related to the growth, development, survival and multiplication of an organism. Interestingly, RNA Seq results highlighted that genes like VAMP7, MYLK, ARAP2 and MARCH6 showed increased expression, while biological processes related to immune response (GO:0043308, GO:0002447, GO:0002278, GO:0043307, GO:0043312, GO:0002283, GO:0043299 and GO:0002446) were significantly overrepresented. These findings hint at a possible role played by immune system in regulating infertility or subfertility in yaks. Further, in-depth studies can validate these findings and help in improving our biological understanding in this area.
The zeolitic rocks of Akrotiri, on Santorini Island (Aegean Sea, Greece), can be grouped according to the zeolite minerals present. The first group includes zeolitic rocks that contain only clinoptilolite, the second group contains clinoptilolite and mordenite and the third group contains only mordenite. Clinoptilolite accounts for up to 56 wt.% and mordenite for up to 69 wt.% of the rocks. All samples contain feldspars (8–36 wt.%), clay minerals (6–8 wt.%), quartz (3–6 wt.%), opal-CT (2 wt.%), amphibole (2–4 wt.%) and amorphous materials (4–7 wt.%). The studied samples were classified chemically as andesites or dacites. The ammonium-exchange capacity of the studied samples was 104–158 meq 100 g–1. According to Commission Implementing Regulation (EU) No. 651/2013, zeolitic rocks that contain ≥80 wt.% clinoptilolite, ≤20 wt.% clay minerals and are free of fibrous minerals and quartz can be used as feed additives in animal husbandry. Zeolites with fibrous habit (mordenite, erionite, secondarily roggianite and mazzite) and SiO2 minerals such as quartz, cristobalite and tridymite can be dangerous to both humans and animals. The mineralogical study showed that, due to their low clinoptilolite content and the presence of both quartz and fibrous mordenite, the studied zeolitic rocks do not conform with European Regulation No. 651/2013. As a result, their use as feed additives and nutrition supplements is prohibited.
This article is about the seminar held at Luiss University in Rome on 17 June 2024. The seminar focused on ‘The End of Christian Democracy: A New Direction for Research’ and was the first milestone and official launch of the PRIN research project ‘The End of Christian Democracy: The Collapse of a Political Dream – Voices from the Margins’, led by a consortium of four universities: Luiss, Roma Tre, Bologna and Suor Orsola Benincasa, Naples.
This paper empirically examines the dynamic relationship between stock market volatility and commodity prices through the time-varying risk aversion channel using daily data between December 31 in 1999 and June 14 in 2021. We employ a time-varying structural-form vector autoregressive model (VAR) model with (aggregate, sectoral and sixteen individual) commodity prices. The results suggest that the transmission mechanism of stock market volatility shocks on the commodity prices change over time. The negative effect of stock market volatility on commodity prices is more statistically significant in the 2008–09 Global Financial Crisis than that during the COVID-19 pandemic in 2020. Further, the effect is greater in energy commodities compared to the agricultural and metals markets. The long-lasting negative effect of risk aversion is stronger compared to that of the expected stock market volatility on the commodity price. The change in the stock-commodity transmission mechanism is likely due to changes in underlying sources of risk aversion and expected uncertainty over time.
This short contribution presents an enigmatic clay mould recovered from a tile kiln in Vindolanda's North Field. This complete mould contains an impression of Apollo in bust form, but its exact use is unclear. This paper presents the mould and discusses its potential use for the manufacture of ceramic figurines. Found in an industrial area of the site, its discovery also provides valuable evidence for craft production along this frontier and hints at a largely unknown provincial industry.
In this paper, we deal with a weighted eigenvalue problem for the anisotropic $(p,q)$-Laplacian with Dirichlet boundary conditions. We study the main properties of the first eigenvalue and a reverse Hölder type inequality for the corresponding eigenfunctions.
We extend the growth-at-risk (GaR) literature by examining US growth risks over 130 years using a time-varying parameter stochastic volatility regression model. This model effectively captures the distribution of GDP growth over long samples, accommodating changing relationships across variables and structural breaks. Our analysis offers several key insights for policymakers. We identify significant temporal variation in both the level and determinants of GaR. The stability of upside risks to GDP growth, as seen in previous research, is largely confined to the Great Moderation period, with a more balanced risk distribution prior to the 1970s. Additionally, the distribution of GDP growth has narrowed significantly since the end of the Bretton Woods system. Financial stress is consistently associated with higher downside risks, without affecting upside risks. Moreover, indicators such as credit growth and house prices influence both downside and upside risks during economic booms. Our findings also contribute to the financial cycle literature by providing a comprehensive view of the drivers and risks associated with economic booms and recessions over time.
Cementitious materials and their alkaline pore fluids can change the structure of bentonite used as a raw material for road embankments or concrete storage of garbage cans. This study investigated the alteration of montmorillonite-rich bentonite from northeast Morocco (Trebia deposit, Nador) in alkaline media rich in Ca2+, Mg2+, Na+, or K+. Specimens based on raw bentonite mixed with variable proportions of oxides (CaO, MgO) or hydroxides (NaOH, KOH) and water were prepared and aged for 28 days. Mineralogical composition by X-ray diffraction (XRD) was determined on raw bentonite and specimens to follow phase changes. Chemical composition and thermal characteristics were determined for raw bentonite and specimens by Fourier-transform infrared spectroscopy (FT-IR) and thermogravimetric/differential thermal analysis (TGA/DTA). Microstructural evolution and alteration of the external surface of bentonite were evaluated using scanning electron microscopy coupled with energy dispersive X-ray (SEM/EDX) analysis. XRD results of bentonite-CaO mixture demonstrated the formation of gels (e.g. C-S-H) and calcite. When the amount of CaO added increased, excess portlandite and the precipitation of calcite in the outer surface of bentonite occurred, stopping pozzolanic reaction and consequently decreasing the compressive strength of specimens. On the other hand, the addition of MgO allowed the formation of brucite. Sodalite and cancrinite were neoformed with the addition of 32 wt.% NaOH after 28 days of hydration. The addition of hydroxides (NaOH or KOH) to bentonite did not reveal any setting due to the absence of the formation of cementitious phases.
Polyaenus (Strat. 8.23.5) includes an armoured elephant in his description of Julius Caesar crossing a defended ford in Britain (54 b.c.) – something found nowhere in Caesar's own Bellum Gallicum. From looking at a range of loci in the Strategica dealing with Caesar's military exploits in Celtic lands, it becomes clear that, instead of being the remnant of a now-lost source tradition, Polyaenus either based the elephant vignette on an underlying narrative structure provided by the Bellum Gallicum, or a source using this work very closely. Given the overall unlikelihood of Caesar taking an elephant to Britain, Polyaenus probably inserted an elephant for rhetorical and/or didactic purposes and was perhaps influenced by Caesar's own non-literary propaganda involving elephants.
We propose a novel time-asymptotically stable, implicit–explicit, adaptive, time integration method (denoted by the $\theta $-method) for the solution of the fractional advection–diffusion-reaction (FADR) equations. The spectral analysis of the method (involving the group velocity and the phase speed) indicates a region of favourable dispersion for a limited range of Péclet number. The numerical inversion of the coefficient matrix is avoided by exploiting the sparse structure of the matrix in the iterative solver for the Poisson equation. The accuracy and the efficacy of the method is benchmarked using (a) the two-dimensional fractional diffusion equation, originally proposed by researchers earlier, and (b) the incompressible, subdiffusive dynamics of a planar viscoelastic channel flow of the Rouse chain melts (FADR equation with fractional time-derivative of order ) and the Zimm chain solution (). Numerical simulations of the viscoelastic channel flow effectively capture the nonhomogeneous regions of high viscosity at low fluid inertia (or the so-called “spatiotemporal macrostructures”), experimentally observed in the flow-instability transition of subdiffusive flows.
Mungbean (Vigna radiata (L.) Wilczek), also known as greengram, is the most widely cultivated Asian Vigna species. Improved mungbean cultivars have a narrow genetic base that limits yield potential and they are poorly adapted to varying growth conditions in different agro-ecological conditions. The genetic potential of landrace germplasm accessions in gene- banks therefore needs to be better exploited. Germplasm core collections are made of a reduced set of representative accessions from the entire diversity maintained by genebanks. This subset of accessions can be used for testing general combining ability with local germplasm in the search for yield enhancement. Core collections also help breeders in selecting parental material that could maximize potential genetic gain from derived hybrid populations. At the National Bureau of Plant Genetic Resources (NBPGR), India, genetic enhancement/pre- breeding studies in mungbean have been initiated involving diverse parents mainly from the cultivated gene pool, using the Bureau's core collection as starting material. Germplasm enhancement aims at widening the genetic base of breeding materials by transferring desired genes from unimproved germplasm into enhanced varieties. Mild and decentralized selected material was maintained in target sites across the country. A total of 102 progenies were advanced to F5 for further selection and use by the breeders in Delhi. The genetic potential of a few selected enhanced progenies with desired plant types and better yield-related traits is presented in this paper. The study clearly demonstrates the potential of germplasm accessions conserved in genebanks for use in large-scale base-broadening efforts in mungbean.
The Marangoni flow induced by an insoluble surfactant on a fluid–fluid interface is a fundamental problem investigated extensively due to its implications in colloid science, biology, the environment and industrial applications. Here, we study the limit of a deep liquid subphase with negligible inertia (low Reynolds number, $Re\ll {1}$), where the two-dimensional problem has been shown to be described by the complex Burgers equation. We analyse the problem through a self-similar formulation, providing further insights into its structure and revealing its universal features. Six different similarity solutions are found. One of the solutions includes surfactant diffusion, whereas the other five, which are identified through a phase-plane formalism, hold only in the limit of negligible diffusion (high surface Péclet number $Pe_s\gg {1}$). Surfactant ‘pulses’, with a locally higher concentration that spreads outward, lead to two similarity solutions of the first kind with a similarity exponent $\beta =1/2$. On the other hand, distributions that are locally depleted and flow inwards lead to similarity of the second kind, with two different exponents that we obtain exactly using stability arguments. We distinguish between ‘dimple’ solutions, where the surfactant has a quadratic minimum and $\beta =2$, from ‘hole’ solutions, where the concentration profile is flatter than quadratic and $\beta =3/2$. Each of these two cases exhibits two similarity solutions, one valid prior to a critical time $t_*$ when the derivative of the concentration is singular, and another one valid after $t_*$. We obtain all six solutions in closed form, and discuss predictions that can be extracted from these results.
The tension distribution problem of cable-driven parallel robots is inevitable in real-time control. Currently, iterative algorithms or geometric algorithms are commonly used to solve this problem. Iterative algorithms are difficult to improve in real-time performance, and the tension obtained by geometric algorithms may not be continuous. In this paper, a novel tension distribution method for four-cable, 3-DOF cable-driven parallel robots is proposed based on the wave equation. The tension calculated by this method is continuous and differentiable, without the need for iterative computation or geometric centroid calculations, thus exhibiting good real-time performance. Furthermore, the feasibility and rationality of this algorithm are theoretically proven. Finally, the real-time performance and continuity of cable tension are analyzed through a specific numerical example.