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We give explicit presentations of the integral equivariant cohomology of the affine Grassmannians and flag varieties in type A, arising from their natural embeddings in the corresponding infinite (Sato) Grassmannian and flag variety. These presentations are compared with results obtained by Lam and Shimozono, for rational equivariant cohomology of the affine Grassmannian, and by Larson, for the integral cohomology of the moduli stack of vector bundles on .
Psychological therapies can be effective in reducing symptoms of depression and anxiety in people living with dementia (PLWD). However, factors associated with better therapy outcomes in PLWD are currently unknown.
Aims
To investigate whether dementia-specific and non-dementia-specific factors are associated with therapy outcomes in PLWD.
Method
National linked healthcare records were used to identify 1522 PLWD who attended psychological therapy services across England. Associations between various factors and therapy outcomes were explored.
Results
People with frontotemporal dementia were more likely to experience reliable deterioration in depression/anxiety symptoms compared with people with vascular dementia (odds ratio 2.98, 95% CI 1.08–8.22; P = 0.03) or Alzheimer's disease (odds ratio 2.95, 95% CI 1.15–7.55; P = 0.03). Greater depression severity (reliable recovery: odds ratio 0.95, 95% CI 0.92–0.98, P < 0.001; reliable deterioration: odds ratio 1.73, 95% CI 1.04–2.90, P = 0.04), lower work and social functioning (recovery: odds ratio 0.98, 95% CI 0.96–0.99, P = 0.002), psychotropic medication use (recovery: odds ratio 0.67, 95% CI 0.51–0.90, P = 0.01), being of working age (recovery: odds ratio 2.03, 95% CI 1.10–3.73, P = 0.02) and fewer therapy sessions (recovery: odds ratio 1.12, 95% CI 1.09–1.16, P < 0.001) were associated with worse therapy outcomes in PLWD.
Conclusions
Dementia type was generally not associated with outcomes, whereas clinical factors were consistent with those identified for the general population. Additional support and adaptations may be required to improve therapy outcomes in PLWD, particularly in those who are younger and have more severe depression.
The optimal management of a patent ductus arteriosus in a population of preterm infants is controversial. Traditionally, when the patent ductus arteriosus does not close either with conservative treatment or in response to pharmacological therapy, the only option is surgical closure. However, transcatheter occlusion might provide a therapeutic alternative.
Methods:
We searched PubMed, Embase, and Cochrane databases for non-randomised and randomised controlled trials that compared transcatheter percutaneous closure of patent ductus arteriosus with surgical ligation in low-birth-weight preterm infants (<2,500 g). A random-effects model was used for outcomes with high heterogeneity.
Results:
We included twelve studies comprising 4,668 low-birth-weight preterm infants, of whom 966 (20.7%) were in the transcatheter percutaneous closure group, and 3,702 (79.3%) patients were included in the surgical group. All-cause mortality (OR 0.28; 95% confidence interval 0.18–0.423; p < 0.00001; I2 = 0%) and haemodynamic instability (OR 0.10; 95% confidence interval 0.05–0.21; p < 0.001; I2 = 14%) were significantly lower in the transcatheter percutaneous closure group. There was no significant difference between transcatheter and surgical patent ductus arteriosus closure for the outcomes of bronchopulmonary dysplasia (0.93; 95% confidence interval 0.46–1.87; p = 0.83; I2 = 0%) and major complications (OR 0.76; 95% confidence interval 0.34–1.69; p = 0.51; I2 = 43%).
Conclusion:
These findings suggest that transcatheter patent ductus arteriosus closure in preterm infants under 2,500 g is a safe and effective alternative to surgical treatment. There was a substantial reduction in all-cause mortality and haemodynamic instability with transcatheter intervention compared to surgical closure.
In this article, we construct some examples of noncommutative projective Calabi–Yau schemes by using noncommutative Segre products and quantum weighted hypersurfaces. We also compare our constructions with commutative Calabi–Yau varieties and examples constructed in Kanazawa (2015, Journal of Pure and Applied Algebra 219, 2771–2780). In particular, we show that some of our constructions are essentially new examples of noncommutative projective Calabi–Yau schemes.
J. L. Austin argues that ordinary language should be used to identify when it is appropriate or inappropriate to make, accept, or reject knowledge claims. I criticize Austin's account. In our ordinary life, we often accept justifications rooted in racism, sexism, ableism, and classism as reasons to dismiss knowledge claims or challenges, despite the fact such reasons are not good reasons. Austin's Ordinary Language Epistemology (OLE) inadvertently classifies the discounting of knowledge claims in classic cases of epistemic injustice as legitimate ordinary maneuvers. I provide recommendations for revision of OLE and offer a means of distinguishing between dismissals in cases of epistemic injustice and their legitimate counterparts.
In recognition of an increasing number of high-consequence infectious disease events, a group of subject-matter experts identified core safety principles that can be applied across all donning and doffing protocols for personal protective equipment.
In this case report, we describe a woman with advancing dementia who still retained decisional capacity and was able to clearly articulate her request for deactivation of her implanted cardiac pacemaker—a scenario that would result in her death. In this case, the patient had the autonomy to make her decision, but clinicians at an outside hospital refused to deactivate her pacemaker even though they were in unanimous agreement that the patient had capacity to make this decision, citing personal discomfort and a belief that her decision seemed out of proportion to her suffering. We evaluated her at our hospital, found her to have decision-making capacity, and deactivated her pacer resulting in her death about 9 days later. While some clinicians may be comfortable discussing patient preferences for device deactivation in patients who are imminently dying, we can find no reports in the literature of requests for device deactivation from patients with terminal diagnoses who are not imminently dying.
The Holocene is a critical period for understanding the East Asian monsoon system (EAM) over long timescales, but high-precision dating and high-resolution records from the Holocene epoch at monsoonal margins of East Asia are lacking. Here, on the basis of closely spaced radiocarbon and optically stimulated luminescence dating results obtained from a typical loess–paleosol sequence on the northern Chinese Loess Plateau (CLP), we provide an independent age-based, high-resolution depositional record of East Asian summer (EASM) and winter monsoons (EAWM) variations over the past ~14 ka. We find that both the EASM and EAWM simultaneously strengthened sometime during the Holocene optimum (~7–5 ka BP), with greater seasonality, and weakened during the Late Holocene. These findings are counterintuitive to our understanding of the EAM variations based on loess records at suborbital scales during interglacial periods, providing an alternative scenario of the monsoon system evolution. We postulate that high-latitude forcing and surface feedbacks, such as vegetation change, have modulated the EAM variations during the Holocene warmth.
Stray light from the sun is one of the most significant factors affecting image quality for the optical system of a spacecraft. This paper proposes a method to design a deployable supporting mechanism for the sunshield based on origami. Firstly, a new type of space mechanism with single-closed loop was proposed according to thick-panel origami, and its mobility was analysed by using the screw theory. In order to design a deployable structure with high controllability, the tetrahedral constraint was introduced to reduce the degree of freedom (DOF), and a corresponding deployable unit named tetrahedral deployable unit (TDU) was obtained. Secondly, the process to constructing a large space deployable mechanism with infinite number of units was explained based on the characteristics of motion and planar mosaic array, and kinematics analysis and folding ratio of supporting mechanism were conducted. A physical prototype was constructed to demonstrate the mobility and deployment of the supporting mechanism. Finally, based on the Lagrange method, a dynamic model of supporting mechanism was established, and the influence of the torsion spring parameters on the deployment process was analysed.
While experiments on elections represent a popular tool in social science, the possibility that experimental interventions could affect who wins office remains a central ethical concern. I formally characterize electoral experimental designs to derive an upper bound on aggregate electoral impact under different assumptions about interference. I then introduce a decision rule based on comparison of this bound to predicted election outcomes to determine whether an experiment should be implemented. Researchers can mitigate the possibility of affecting aggregate outcomes by reducing the saturation of treatment or focusing experiments in districts and electoral systems where treated voters are less likely to be pivotal. These conditions identify novel trade-offs between adhering to ethical commitments and the statistical power and external validity of electoral experiments. More broadly, this paper shows that the formalization of an ethical objective facilitates a closer mapping between ethical considerations and experimental design than is currently practiced.
As the scientific community becomes aware of low replicability rates in the extant literature, peer-reviewed journals have begun implementing initiatives with the goal of improving replicability. Such initiatives center around various rules to which authors must adhere to demonstrate their engagement in best practices. Preliminary evidence in the psychological science literature demonstrates a degree of efficacy in these initiatives. With such efficacy in place, it would be advantageous for other fields of behavioral sciences to adopt similar measures. This letter provides a discussion on lessons learned from psychological science while similarly addressing the unique challenges of other sciences to adopt measures that would be most appropriate for their field. We offer broad considerations for peer-reviewed journals in their implementation of specific policies and recommend that governing bodies of science prioritize the funding of research that addresses these measures.
It remains unclear whether cognitive reserve can attenuate dementia risk among people with different genetic predispositions.
Aims
We aimed to examine the association between cognitive reserve and dementia, and further to explore whether and to what extent cognitive reserve may modify the risk effect of genetic factors on dementia.
Method
Within the UK Biobank, 210 631 dementia-free participants aged ≥60 years were followed to detect incident dementia. Dementia was ascertained through medical and death records. A composite cognitive reserve indicator encompassing education, occupation and multiple cognitively loaded activities was created using latent class analysis, categorised as low, moderate and high level. Polygenic risk scores for Alzheimer's disease were constructed to evaluate genetic risk for dementia, categorised by tertiles (high, moderate and low). Data were analysed using Cox models and Laplace regression.
Results
In multi-adjusted Cox models, the hazard ratio (HR) of dementia was 0.66 (95% confidence interval (CI) 0.61–0.70) for high cognitive reserve compared with low cognitive reserve. In Laplace regression, participants with high cognitive reserve developed dementia 1.62 (95% CI 1.35–1.88) years later than those with low cognitive reserve. In stratified analysis by genetic risk, high cognitive reserve was related to more than 30% lower dementia risk compared with low cognitive reserve in each stratum. There was an additive interaction between low cognitive reserve and high genetic risk on dementia (attributable proportion 0.24, 95% CI 0.17–0.31).
Conclusions
High cognitive reserve is associated with reduced risk of dementia and may delay dementia onset. Genetic risk for dementia may be mitigated by high cognitive reserve. Our findings underscore the importance of enhancing cognitive reserve in dementia prevention.
Youth with different developmental disorders might experience challenges when dealing with facial emotion recognition (FER). By comparing FER and related emotional and cognitive factors across developmental disorders, researchers can gain a better understanding of challenges and strengths associated with each condition. The aim of the present study was to investigate how social anxiety and executive functioning might underlie FER in youth with and without autism spectrum disorders (ASD) and specific learning disorders (SLD). The study involved 263 children and adolescents between 8 and 16 years old divided into three groups matched for age, sex, and IQ: 60 (52 M) with ASD without intellectual disability, 63 (44 M) with SLD, and 140 (105 M) non-diagnosed. Participants completed an FER test, three executive functions’ tasks (inhibition, updating, and set-shifting), and parents filled in a questionnaire reporting their children’s social anxiety. Our results suggest that better FER was consistent with higher social anxiety and better updating skills in ASD, while with lower social anxiety in SLD. Clinical practice should focus on coping strategies in autistic youth who could feel anxiety when facing social cues, and on self-efficacy and social worries in SLD. Executive functioning should also be addressed to support social learning in autism.
In recent debates about the replication crisis, two positions have been dominant: one that focuses on methodological reforms and one that focuses on theory building. This paper takes up the suggestion that there might be a deeper difference in play, concerning the ways the very subject matter of psychology is construed by opposing camps, i.e., in terms of stable effects versus in terms of complexity. I argue that each gets something right, but neither is sufficient. My analysis suggests that the context sensitivity of the psychological subject matter needs to be front and center of methodological and theoretical efforts.
We propose a linearized deterministic model for predicting coherent structures in the wake of a floating offshore wind turbine subject to platform motions. The model's motion-to-wake predictive capability is achieved through two building blocks: a motion-to-forcing (M2F) part and a forcing-to-wake (F2W) part. The M2F model provides a unified framework to parameterize the effects of arbitrary floating wind turbine motions as unsteady loads of a fixed actuator disk, requiring only the radial distribution of the aerodynamics force coefficient on the blade as input. The F2W model is derived based on a bi-global resolvent model obtained from the linearized Navier–Stokes equations, using the time-averaged wake of a fixed wind turbine as input. In addition to its capability of predicting sensitive frequency ranges, the model excels linear stability analysis by providing spatial modes of the wake response in a motion-specific and phase-resolved manner. The model successfully predicts the wake pulsing mode induced by surge, as well as the similarity and difference of the wake meandering modes caused by sway and yaw. Large-eddy simulations under different inflow turbulence intensities (TIs) and length scales are further conducted to analyse the wake meandering triggered by the simultaneous excitation of free-stream turbulence and sway motion. The results show distinct frequency signatures for the wake dynamics induced by ambient turbulence and sway motion. The inflow TI is found to have a stabilizing effect on the wake, reducing the motion-induced wake responses. Such a stabilizing effect is captured satisfactorily with the proposed model, provided that the effective viscosity is calibrated properly using the data from the fixed turbine wake under the corresponding turbulent inflow.
Radiocarbon (14C) dating of sediment deposition around Antarctica is often challenging due to heterogeneity in sources and ages of organic carbon in the sediment. Chemical and thermochemical techniques have been used to separate organic carbon when microfossils are not present. These techniques generally improve on bulk sediment dates, but they necessitate assumptions about the age spectra of specific molecules or compound classes and about the chemical heterogeneity of thermochemical separations. To address this, the Rafter Radiocarbon Laboratory has established parallel ramped pyrolysis oxidation (RPO) and ramped pyrolysis-gas chromatography-mass spectrometry (Py-GC-MS) systems to thermochemically separate distinct carbon fractions, diagnose the chemical composition of each fraction, and target suitable RPO fractions for radiocarbon dating. Three case studies of sediment taken from locations around Antarctica are presented to demonstrate the implementation of combined RPO-AMS and Py-GC-MS to provide more robust age determination in detrital sediment stratigraphy. These three depositional environments are good examples of analytical and interpretive challenges related to oceanographic conditions, carbon sources, and other factors. Using parallel RPO-AMS and Py-GC-MS analyses, we reduce the number of radiocarbon measurements required, minimize run times, provide context for unexpected 14C ages, and better support interpretations of radiocarbon measurements in the context of environmental reconstruction.
This article considers the Clive Memorial Fund and the campaigns surrounding proposed statues to Robert Clive in London and Calcutta between 1907 and 1912. The author argues that this campaign was an attempt to glorify Clive's actions, focused on the battle of Plassey and its aftermath, as foundation stones for the Indian Empire. The statues were an anxious attempt to situate Britain as a natural part of Indian history, but the campaign instead provoked a developing Indian counternarrative around resistance to colonial rule, particularly from newspapers in Bengal. Although the fund garnered support in Britain, it was greeted in India with official irritation and widespread Indian opposition, highlighting the importance of considering imperial statues in their imperial frame. This reaction, demonizing Clive's treachery and praising his opponent, Siraj-ud-Daula, the nawab of Bengal, was indicative of the place of history in both Bengali nationalism and imperial self-identity. Using newspapers in Britain and Bengal and the correspondence of the Clive Memorial Committee, the author examines the competing narratives of history that emerged in the campaigns around the fund.
The basic question of this article is whether Thomas Aquinas's doctrine of divine providence through his understanding of primary and secondary causation can be understood as a theological causal or non-causal explanation. To answer this question, I will consider some contemporary discussions about the nature of causal and non-causal explanations in philosophy of science and metaphysics, in order to integrate them into a theological discourse that appeals to the classical distinction between God as first cause and creatures as secondary causes to explain God's presence and providence in the created universe. My main argument will hold that, even if there are some philosophical models of explanation that seem to allow one to suggest that, at least partially, this doctrine could be seen as a non-causal theological explanation, there are other models that offer seemingly stronger reasons to see this doctrine in full as a causal theological explanation.
Adverse environments are linked to elevated youth antisocial behavior. However, this relation is thought to depend, in part, on genetic susceptibility. The present study investigated whether polygenic risk for antisociality moderates relations between hostile environments and stable as well as dynamic antisocial behaviors across adolescence. We derived two antisocial-linked polygenic risk scores (PRS) (N = 721) based on previous genome-wide association studies. Forms of antisocial behavior (nonaggressive conduct problems, physical aggression, social aggression) and environmental hostility (harsh parenting and school violence) were assessed at age 13, 15, and 17 years. Relations to individual differences stable across adolescence (latent stability) vs. time-specific states (timepoint residual variance) of antisocial behavior were assessed via structural equation models. Higher antisocial PRS, harsh parenting, and school violence were linked to stable elevations in antisocial behaviors across adolescence. We identified a consistent polygenic-environment interaction suggestive of differential susceptibility in late adolescence. At age 17, harsher parenting was linked to higher social aggression in those with higher antisocial PRS, and lower social aggression in those with lower antisocial PRS. This suggests that genetics and environmental hostility relate to stable youth antisocial behaviors, and that genetic susceptibility moderates home environment-antisocial associations specifically in late adolescence.