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The remains of black henbane (Hyoscyamus niger) are relatively common at archaeological sites as it grows naturally around settlements in north-western Europe. All parts of the plant may be used as a medicine or a narcotic but its natural prevalence in built environments makes it difficult to interpret any intentionality behind its presence in the archaeological record. Evidence of the deliberate collection and use of black henbane seeds in the Roman Netherlands is presented here for the first time. Examination of Classical texts and interrogation of the archaeobotanical data allow the authors to place the discovery at Houten-Castellum of a hollowed bone containing hundreds of black henbane seeds within the context of the wider Roman understanding of the plant and its properties.
L'une des fonctions des institutions publiques des démocraties libérales est de formuler des recommandations à l'attention des décideurs. Or, les institutions publiques savent que leurs recommandations seront souvent ignorées en partie par le décideur. Cette situation de « conformité partielle » aux recommandations soulève plusieurs problèmes de nature philosophique pour les institutions. En nous appuyant sur une analyse de 570 recommandations tirées de 40 documents et rapports du secteur public québécois, nous identifions deux enjeux entourant la structure des recommandations issues du secteur public.
Persistent pulmonary hypertension of the newborn is a life-threatening condition that affects about 1–2 per 1,000 live births worldwide. Bosentan is an oral dual endothelin receptor antagonist that may have a beneficial effect on persistent pulmonary hypertension of the newborn by reducing pulmonary vascular resistance and improving oxygenation. However, its role in persistent pulmonary hypertension of the newborn remains unclear.
Objectives:
To systematically evaluate the efficacy and safety of bosentan as an adjuvant therapy for persistent pulmonary hypertension of the newborn in newborns.
Methods:
We searched six English and two Chinese databases from their inception to 1 January 2023 following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We included randomised controlled trials and retrospective studies that compared bosentan with placebo or other drugs for persistent pulmonary hypertension of the newborn in newborns. We performed a meta-analysis using random-effects models and assessed the risk of bias and heterogeneity in the included studies.
Results:
We included 10 studies with a total of 550 participants. Bosentan significantly reduced the treatment failure rate (relative risk = 0.25, P < 0.001), pulmonary artery pressure (mean difference = −11.79, P < 0.001), and length of hospital stay (mean difference = −1.04, P = 0.003), and increased the partial pressure of oxygen (mean difference = 10.02, P < 0.001) and blood oxygen saturation (SpO2) (mean difference = 8.24, P < 0.001) compared with a placebo or other drugs. The occurrence of adverse reactions was not significantly different between bosentan and a placebo or other drugs.
Conclusions:
Bosentan is effective in the treatment of persistent pulmonary hypertension of the newborn but adverse reactions such as abnormal liver function should be observed when using it.
How knowledge is created, accessed, stored and disseminated has become a major focus of study when assessing the success or failure of industrial clusters. Marshall (1890; 225) initiated this debate when he noted: ‘The mysteries of the trade become no mysteries; but are as it were in the air’. In the edited collection by Wilson, Corker and Lane (2022), emphasis has been placed on the links between knowledge, knowledge flows and how innovation systems evolve and adapt. This paper builds on their work examining how tacit and codified knowledge is created and disseminated across a cluster. Bathelt et al (2004) have demonstrated how successful clusters build effective ‘global pipelines’ to access knowledge generated elsewhere, prompting us to think how a business history analysis can incorporate these concepts and how these processes have worked in practice. The paper analyses two English clusters and the processes involved in the formation of a common body of knowledge, a ‘knowledge-cum-industrial zeitgeist’ which explains the cluster’s performance. Specifically, it proposes a model that links internally-generated knowledge and ‘global pipelines’ that clusters develop to tap into externally-generated knowledge, which through effective feedback into the ‘local buzz’ results in further innovation and strengthens the cluster’s competitive advantage.
We aim to analyze the efficacy and safety of TMS on cognition in mild cognitive impairment (MCI), Alzheimer’s disease (AD), AD-related dementias, and nondementia conditions with comorbid cognitive impairment.
Design:
Systematic review, Meta-Analysis
Setting:
We searched MEDLINE, Embase, Cochrane database, APA PsycINFO, Web of Science, and Scopus from January 1, 2000, to February 9, 2023.
Participants and interventions:
RCTs, open-label, and case series studies reporting cognitive outcomes following TMS intervention were included.
Measurement:
Cognitive and safety outcomes were measured. Cochrane Risk of Bias for RCTs and MINORS (Methodological Index for Non-Randomized Studies) criteria were used to evaluate study quality. This study was registered with PROSPERO (CRD42022326423).
Results:
The systematic review included 143 studies (n = 5,800 participants) worldwide, encompassing 94 RCTs, 43 open-label prospective, 3 open-label retrospective, and 3 case series. The meta-analysis included 25 RCTs in MCI and AD. Collectively, these studies provide evidence of improved global and specific cognitive measures with TMS across diagnostic groups. Only 2 studies (among 143) reported 4 adverse events of seizures: 3 were deemed TMS unrelated and another resolved with coil repositioning. Meta-analysis showed large effect sizes on global cognition (Mini-Mental State Examination (SMD = 0.80 [0.26, 1.33], p = 0.003), Montreal Cognitive Assessment (SMD = 0.85 [0.26, 1.44], p = 0.005), Alzheimer’s Disease Assessment Scale–Cognitive Subscale (SMD = −0.96 [−1.32, −0.60], p < 0.001)) in MCI and AD, although with significant heterogeneity.
Conclusion:
The reviewed studies provide favorable evidence of improved cognition with TMS across all groups with cognitive impairment. TMS was safe and well tolerated with infrequent serious adverse events.
The dynamic charge density of KZnB3O6, which contains edge-sharing BO4 units, has been characterized using laboratory and synchrotron X-ray diffraction techniques. The experimental electron density distribution (EDD) was constructed using the maximum-entropy method (MEM) from single crystal diffraction data obtained at 81 and 298 K. Additionally, MEM-based pattern fitting (MPF) method was employed to refine the synchrotron powder diffraction data obtained at 100 K. Both the room-temperature single crystal diffraction data and the cryogenic synchrotron powder diffraction data reveal an intriguing phenomenon: the edge-shared B2O2 ring exhibits a significant charge density accumulation between the O atoms. Further analysis of high-quality single crystal diffraction data collected at 81 K, with both high resolution and large signal-to-noise ratio, reveals no direct O–O bonding within the B2O2 ring. The experimental EDD of KZnB3O6 obtained aligns with the results obtained from ab-initio calculations. Our work underscores the importance of obtaining high-quality experimental data to accurately determine EDDs.
Indigenous philosophy from the 17th century and earlier is often thought to be irretrievable because of a lack of extant works. There are at least two reasons that this view is mistaken. First, it overlooks the role oral traditions play in preserving the thought of Indigenous peoples. Second, some Indigenous thinkers had their philosophical views recorded by European interlocutors shortly after contact. With these sources, the same techniques used to recover the views of philosophers like Prodicus, whose works are lost, can be applied to Indigenous thinkers. By reconstructing the philosophy of Kondiaronk, I show how this can be done.
To describe the effects of porous roughness on turbulence, we have carried out direct numerical simulations using the lattice Boltzmann method. The simulated flows are fully developed turbulent flows in channels consisting of a solid smooth top wall and a porous bottom wall with transverse porous ribs whose heights are 10 % of the channel height. The considered ratios of the rib spacing to the rib height are $w/k\simeq 1$ and 9. The Kelvin-cell structure is applied to construct faithfully the porous media whose porosities are $\varphi \ge 0.79$. Three kinds of porous media having different permeabilities are considered. The most permeable one has an approximately one order higher permeability than that of the least permeable one. The higher permeability case is designed to have a pore scale that is the same as the rib height so that it is the most permeable case for the rib roughness with the designed porosity. In the simulations, the bulk Reynolds number is set to $Re_b=5500$, and the corresponding permeability Reynolds numbers are $Re_K=2.2\unicode{x2013}7.5$. The simulated field data and the drag coefficient, which includes both the pressure drag by the ribs and the frictional drag over the porous wall, are analysed to understand the characteristics of the permeable roughness in terms of permeability. The decomposition of the drag coefficient into the integrated laminar, rib-drag, dispersion and turbulence parts elucidates the transition mechanism between the typical d-type to k-type roughness depending on $Re_K$. By the double (time and space) averaged budget equations for the dispersion and Reynolds stresses, we explain how the energy generated by the roughness transfers to turbulence through dispersion resulting in the k-type characteristics. The nominal roughness sublayer thickness and the characteristic roughness height are introduced with the parameters obtained by fitting the velocity data to Best's and Nikuradse's logarithmic velocity formulae. Along with data in the literature, it is suggested that the ratio of the characteristic roughness height to the nominal roughness sublayer thickness becomes constant irrespective of the rib spacing in the full permeable-wall turbulence at $Re_K> 7$.
In the article ‘How to be absolutely fair, Part I: the Fairness formula’, we presented the first theory of comparative and absolute fairness. Here, we relate the implications of our Fairness formula to economic theories of fair division. Our analysis makes contributions to both philosophy and economics: to the philosophical literature, we add an axiomatic discussion of proportionality and fairness. To the economic literature, we add an appealing normative theory of absolute and comparative fairness that can be used to evaluate axioms and division rules. Also, we provide a novel definition and characterization of the absolute priority rule.
In this experimental study, the impact of symmetric local blowing on suppressing the vortex-induced noise of a circular cylinder was investigated. A highly instrumented cylinder with pressure taps and a series of blowing chambers was used to inject air along the span (seven times the cylinder diameter) at circumferential angles $\theta _{b}={\pm }41^{\circ }$, ${\pm }90^{\circ }$ and ${\pm }131^{\circ }$ corresponding to the boundary layer, shear layers on the cylinder and separated shear layers, respectively. The investigation aimed to understand the noise reduction mechanism of local blowing by conducting near-field pressure and far-field noise measurements in synchronisation with flow field velocity measurements. Near-field pressure was measured around the circumference of the cylinder using a remote-sensing technique and planar particle image velocimetry was implemented to measure the velocity of the wake flow field at a diameter-based Reynolds number of $Re=7\times 10^{4}$. The results revealed that the interaction of the rolling up separated shear layers, under the influence of high-momentum fluid travelling from the free stream to the wake, induced significant vertical flow movement in the vortex-formation region. This movement led to strong alternating surface pressure fluctuations at the cylinder's shoulders, contributing to the scattering of noise. It was demonstrated that local blowing delayed vortex shedding for all cases, except at $\theta _{b}={\pm }90^{\circ }$, which elongated the shear layers and pushed the high-momentum transfer area farther downstream. The application of local blowing at $\theta _{b}={\pm }41^{\circ }$ was particularly effective in increasing the vortex formation size due to reduced entrainment of fluid-bearing vorticity.
With the wide application of quadrotor unmanned aerial vehicles (UAVs), the requirements for their safety and reliability are becoming increasingly stringent. In this paper, based on the feedback of airframe performance health perception information and the predictive function control strategy, the autonomous maintenance of a quadrotor UAV with multi-actuator degradation is realised. Autonomous maintenance architecture is constructed by the predictive maintenance (PdM) idea and the Laguerre function model predictive pontrol (LF-MPC) strategy. Using the two-stage Kalman filter (TSKF) method, based on the established UAV degradation model, the aircraft state and actuator degradation state are predicted simultaneously. For the predictive perception of system health, on the one hand, the system health degree (HD) based on Mahalanobis distance is defined by the degree of airframe state deviation from the expected state, and then the failure threshold of the UAV is obtained. On the other hand, according to the degradation state of each actuator, a comprehensive degradation variable fused with different weight coefficients of multiple actuators degradation is used to obtain the probability density function (PDF) of remaining useful life (RUL) prediction. For the autonomous maintenance of system health, the LF-MPC weight matrixes are adjusted adaptively in real-time based on the HD evaluation, to achieve a compromise balance between UAV performance and control effect, and greatly extend the working time of UAV. Simulation results verified the effectiveness of the proposed method.
Nutritional care is a critical, yet often overlooked component of quality care in long-term care (LTC) that is linked to culture, socialization, and residents’ psychological and physiological well-being. Given that several COVID-19 infection control protocols affected nutritional care, this study aimed to understand employees’ experiences of these changes. Seven semi-structured interviews were conducted with Saskatchewan healthcare employees from several disciplines, all of whom had a role in supporting nutritional care in LTC. The resulting interview transcripts were analyzed using reflexive thematic analysis. Three main themes characterized the interviewees’ reflections: regression to an institutional mealtime environment, unrealistic expectations, and concern for residents. Given the centrality of nutritional care to quality of life, strategies tailored to support staff in providing relationship-centered nutritional care must be further articulated to maintain standards of care for LTC residents in future outbreaks and epidemics.
Helicity plays a key role in the evolution of vortex structures and turbulent dynamics. The helicity dynamics and vortex structures in streamwise-rotating channel turbulence are discussed in this paper using the helicity budget equation and the differentiated second-order structure function equation of helicity. Generally, rotation and Reynolds numbers exhibit opposing effects on the interscale helicity dynamics and the vortices. Under the buffer layer, the positions of the helicity peaks are proportional to the ratio between the Reynolds and rotation numbers. The mechanism is related to the opposing effects of convection and rotation. Rotation directly affects the helicity balance through the Coriolis term and corresponding pressure term. In the buffer layer, the scale helicity is negative at small scales but positive at large scales, which is mainly induced by the spatial effects (the production and the spatial turbulent convection) but reduced by interscale cascades. Examination of structures reveals the close association between scale helicity and streaks, with streak lift angles exhibiting an increase with rotation and a decrease with Reynolds numbers. In the log-law layer, the Coriolis terms and corresponding pressure terms are proportional to the rotation numbers but remain independent of the Reynolds numbers. The negative scale helicity is forward cascaded towards small scales. Generally, spanwise vortices in the log-law layer are related to sweep events and forward cascades. Our findings indicate that these spanwise vortices are suppressed by rotation but recover with increasing Reynolds numbers, aligning with the effects observed in the scale helicity balance.
Irregular cusps of an orthogonal modular variety are cusps where the lattice for Fourier expansion is strictly smaller than the lattice of translation. The presence of such a cusp affects the study of pluricanonical forms on the modular variety using modular forms. We study toroidal compactification over an irregular cusp, and clarify there the cusp form criterion for the calculation of Kodaira dimension. At the same time, we show that irregular cusps do not arise frequently: besides the cases when the group is neat or contains $-1$, we prove that the stable orthogonal groups of most (but not all) even lattices have no irregular cusp.
This paper presents a broadband circularly polarized (CP) antenna array for millimeter-wave applications, and the antenna array has the advantages of wide impedance bandwidth (IBW), novel CP design, and low profile. The antenna unit consists of a two-layer substrate and two pairs of magnetoelectric dipoles. Stepped microstrip lines coupled by rectangular slits form a feeder network for easy integration. The axial ratio bandwidth (ARBW) is extended because a pair of parasitic patches is loaded and an elliptical perturbation is added. The simulation results show that the antenna has an ARBW of 18.6% (26.4–31.9 GHz) and an IBW of 45.5% (20.6–32.7 GHz), with a gain greater than 7.11 dBic in the IBW. To improve the gain of the antenna, a 2 × 2 antenna array is designed, fabricated, and measured. The measured results show that the array has an ARBW of 16.6% (26.42–31.21 GHz), an IBW of 41.6% (22.28–33.97 GHz), a peak gain of 13.89 dBic in the IBW, the cross-polarization levels in the xoz-plane and yoz-plane are above 20 dB, and a radiation efficiency greater than 89%.