Background: This project aims to bridge the gap between clinical data being collected at a local hospital to be used for research. Methods: 1.5T high-resolution anatomical MRI scans were collected from ten participants who were already undergoing clinical, imaging, and neurological assessment as part of their standard-of-care. Additional statistical models were used to examine the relationship between grey matter (using voxel-based morphometry [VBM]) and scores on the Toronto Cognitive Assessment (TorCA). Results: There was a lack of consistency in MRI scanning protocols and inconsistent reporting of clinical and neuropsychological data across participants. No significant relationship was found using the p-corrected images at p < 0.05. When viewing uncorrected images at a threshold of p < 0.001, we found a significant positive correlation between TorCA scores in the areas of the bilateral superior frontal gyrus, frontal pole, brain stem, and left putamen. Conclusions: Although no significant relationship was found between VBM metrics and TorCA scores, this project represents a crucial step in connecting health research with clinical practice where neuroimaging and neuropsychological assessments are already being collected. This project also informed our research team of areas that are needing to be streamlined and operationalized in future strategies for data collection and input.

This article demonstrates how mediatization facilitates the (re)production of mock language. Through an examination of Chinese netizens’ reactions to a series of viral internet commercials that feature three Hong Kong actors speaking nonstandard Mandarin, it uncovers the processes whereby Gangpu (Hong Kong Mandarin) has become increasingly perceived in China as funny. The vast scale of uptake formulations enabled by mediatization has made it possible for Chinese netizens to engage in a collaborative effort not only in highlighting certain features of Gangpu and certain elements of the commercials but also in presenting them in ways that evoke specific meanings and interpretations. Ultimately, it is through the parodic revoicing of Hong Kong celebrities speaking nonstandard Mandarin that this non-native variety has come to be keyed as humorous. This study shows that we gain a better understanding of how mock practices reinforce and build on each other by tracing their uptake and circulation. (Mediatization, mock language, parody, listening subject, Mandarin Chinese, Hong Kong, China)*

Background: Neuromodulation unit placement can provide efficacious control of many neurological conditions. They are high risk for infection with a historic infection rate as high as 10%. Treatment of infection requires surgical removal and a long course of systemic antibiotics. <font size=”1”> </font>At our center, one surgeon uses antibacterial envelopes with all implanted neuromodulation devices. Methods: We conducted a retrospective cohort study of consecutive implantable pulse generator (IPG) and intrathecal pump unit implantation with an antibacterial envelope at our center. This cohort was then compared to a historical cohort of consecutive patients undergoing IPG or pump placement or revision prior to the use of the envelopes. Results: IPG: There were 18 (11.9%) class I infections in the pre-envelope cohort compared with 5 (2.1%) in the post-envelope cohort. The absolute risk reduction (ARR) with the use of antibacterial envelopes was 9.85% (95% confidence interval (CI) 4.3-15.4%, p<0.01).

Pump: There were 6 (14.6%) class I infections in the pre-envelope cohort compared with 1 (1.7%) in the post-envelope cohort. The ARR with the use of antibacterial envelopes was 12.9% (95% confidence interval 1.6-24.3, p<0.05). Conclusions: Based on our results, we recommend usage of antibacterial envelopes to reduce infection rates in neuromodulation surgery. Further study is needed.

Hanscam and Buchanan (2023) give us an insightful comparative analysis of Hadrian's Wall and the US/Mexico border wall. Their analysis shows how critically to study and use these long walls in an explicitly political archaeology. I have engaged in archaeology as political action (McGuire 2008), and have researched the materiality of the US/Mexico border while doing humanitarian work along that border (McGuire 2013). Hanscam and Buchanan deftly employ archaeology as a political tool to challenge capitalist ideologies about borders. They plead for a politically relevant archaeology that engages the past to address modern issues. Without such relevance, they fear that archaeology will be made redundant. I emphatically agree with them that an activist archaeology makes our discipline more relevant. I fear, however, that these politics may be our demise rather than our salvation.

2021 marked the 30-year anniversary of the publication Fatal Years: Child Mortality in the late Nineteenth-Century United States, a pioneering work in historical demography by Samuel H. Preston and Michael R. Haines. This special issue showcases the current state of historical mortality studies through a collection of articles originally presented at two commemorative sessions at the 2021 meeting of the Social Science History Association. It provides new and more nuanced evidence on several of the major themes of Fatal Years in terms of the mortality experience and includes studies of a wide range of contexts, from North America, to Ireland, England and Wales, and continental Europe. They all bring new evidence and leverage the dramatic development that has taken place in availability of large-scale micro-level data in the 30 years since Fatal Years was published. This introduction first provides some background to the collection and then summarizes the main findings from the different articles included. Preston and Haines provide a coda to this collection with a short reflection article on researching and writing Fatal Years.

We develop a simple two-sector neoclassical growth model in which the upstream sector produces intermediate goods, and the downstream sector produces final goods with outputs from the upstream. While the downstream sector features perfect competition, firms in the upstream sector engage in Cournot competition and charge a markup. We show that the deregulation and the introduction of competition in the upstream goods sector not only increases the productivity in the sector but also has a substantial spillover effect on the productivity of the downstream sector and factor prices. We calibrate the model to the Chinese economy and use the calibrated model to quantitatively evaluate the extent to which the deregulation in the upstream market in China from 1998 to 2006 can account for the rapid economic growth and the high and rising returns to capital in China over the same period. Our quantitative experiments show that the deregulation in the upstream sector can account for a significant share of economic growth in China during the study period. In addition, our model delivers implications that are consistent with several other relevant observations in China during the same period.

Background: There remains lack of data in regards to factors influencing successful endovascular reperfusion of isolated occlusion of the M2 segment of the middle cerebral artery (MCA). In this study, we set out to investigate the variables that affect the successful endovascular reperfusion of isolated M2 segment occlusion. Methods: M2 segment occlusion was defined as isolated clot anywhere within the M2 segment of the MCA. A prediction model of successful endovascular reperfusion defined as modified Thrombolysis in Cerebral Ischemia (mTICI) score of 2b, 2c and 3 and unsuccessful endovascular reperfusion defined as mTICI score of 0, 1 and 2a was developed from demographics (age, sex) , clinical factors (NIHSS at the time of presentation to hospital), imaging characteristics (ASPECTS, ICA occlusion, presence of Intracranial arterial disease (ICAD), computed tomography perfusion (CTP)-based ischemic core and mismatch volume estimation), and treatment (alteplase/tenecteplase use and periprocedural complications) variables from 64 patients who underwent endovascular thrombectomy (EVT) at Kingston Health Science Centre between December 24, 2018 and October 18, 2022. Results: The only statistical significant predictor of successful endovascular reperfusion was CTP-based ischemic core volume (smaller core volume) (p<0.05). Conclusions: The CTP-based ischemic core volume is the most important predictor of successful endovascular reperfusion for M2 occlusion.

Background: Efgartigimod is a human IgG1 antibody Fc-fragment that reduces IgG levels through FcRn blockade. A key efficacy indicator in the treatment of IgG autoantibody-mediated generalized myasthenia gravis (gMG) is improvement in MG-ADL score. Methods: The ADAPT phase 3 trial evaluated safety and efficacy of efgartigimod in patients with gMG, including reaching and maintaining of minimal symptom expression (MSE; defined as an MG-ADL total score of 0 or 1). Results: 167 patients (AChR-Ab+, n=129; AChR-Ab-, n=38) were randomized to receive treatment cycles of 4 weekly infusions of efgartigimod or placebo. Significantly more AChR-Ab+ efgartigimod-treated patients achieved MSE during cycle 1 compared to placebo-treated patients (40.0% [n=26/65] vs 11.1% [n=7/63; P<0.0001]). In cycle 2, 31.4% (n=16/51) of AChR-Ab+ patients in the efgartigimod cohort achieved MSE compared to none in the placebo cohort. MG-ADL score improved by ≥6 points in 56.9% of AChR-Ab+ efgartigimod-treated patients compared to 20.6% of placebo-treated patients in cycle 1. Most patients achieved MSE by week 4 of a cycle, paralleling early reduction in IgG levels, and MSE duration ranged from 1 to ≥10 weeks. Adverse events were predominantly mild to moderate. Conclusions: Efgartigimod treatment resulted in more patients with AChR-Ab+ gMG achieving both MSE and clinically meaningful MG-ADL improvements.

Background: Prior to the pandemic, telemedicine use was limited and sparsely funded within Ontario. During the pandemic, a shift in clinical recommendations and government funding models promoted telemedicine. We aim to highlight both quantitative and qualitative aspects of the patient and provider experience over 2.5 years within a Canadian Pediatric Neurology clinic. Main objectives of the study are to assess the safety, efficiency and convenience of telemedicine. Methods: A REDCap survey was sent to all patients with a telemedicine appointment from March 2020 –September 2022 and all Pediatric Neurology providers. Survey included a 5-point Likert scale questions, open questions, and patient characteristics. Results: Responses received from 272 patients and 7 providers. 91% of patients and all providers were satisfied with telemedicine. 95% of patients and all providers felt they received or were able to provide safe/adequate care. 90% of patients and all providers reported that telemedicine was more convenient. 87% of patients and all providers were interested in future appointments via telemedicine. Conclusions: Our survey shows patients and providers had highly positive experiences with telemedicine – reporting care was adequate, safe, and more convenient. This data supports incorporating telemedicine into future care and advocates that Canadian regulations/billing codes to continue to support telemedicine.

Background: Due to high risk of recurrence and complications associated with microsurgical resection or aspiration of enlarging cystic sellar lesions, stereotactic intracavitary irradiation with 90Yttrium (90Yt) has been proposed as an alternative to mitigate these challenges. Long-term efficacy data for this procedure is lacking. Methods: We conducted a Health Canada approved, single-centre, prospective cohort study to assess the effect of 90Yt therapy on cyst volume, visual field (VF) testing and endocrine function. All patients underwent right frontal stereotactic insertion of 90Yt colloid (200 Gy cyst wall). Results: 22 patients [mean age = 63.5 (± 15.4) years] received 90Yt therapy. Mean follow-up was 52 (5-113) months. Cysts included: craniopharyngioma (86%), Rathke’s cleft cyst (9%) and cystic prolactinoma (5%). Mean cyst volume reduction was 77% at 12-months (5.2 ± 4.5 cc to 1.2 ± 1.5 cc; p = 0.002). Rate of pre- and post-op hormonal dysfunction was 59% and 68%, respectively (p = 0.50). Pre-operative VF deficits were found in 68% of patients, of which 32% normalized and 36% remained stable (p = 0.180). Worsened vision was detected in 9% of patients post-operatively. Conclusions: 90Yttrium therapy significantly reduces sellar cyst size without having a deleterious effect on vision and endocrine function.

In this paper, a notion of non-microstate bi-free entropy with respect to completely positive maps is constructed thereby extending the notions of non-microstate bi-free entropy and free entropy with respect to a completely positive map. By extending the operator-valued bi-free structures to allow for more analytical arguments, a notion of conjugate variables is constructed using both moment and cumulant expressions. The notions of free Fisher information and entropy are then extended to this setting and used to show minima of the Fisher information and maxima of the non-microstate bi-free entropy at bi-R-diagonal elements.

We are grateful for the participation of the respondents and heartened at the general agreement on the importance of a politically proactive archaeology. Inevitably, the authors offer differing perspectives on how best to achieve this goal, including the degree to which political engagement may foster the strength and relevance of the discipline (McGuire 2023), the limitations of landscape or assemblage perspectives for analysing these issues (Gardner 2023; Szary 2023), and whether or not such a call is even necessary because many archaeologists are already engaged with this type of research (Soto 2023). We appreciate the opportunity that these comments provide to us for critical reflection on our arguments; here, we briefly engage with the major themes raised as part of the ongoing dialogue.