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Two-dimensional simulations are conducted to investigate the direct initiation of cylindrical detonation in hydrogen/air mixtures with detailed chemistry. The effects of hotspot condition and mixture composition gradient on detonation initiation are studied. Different hotspot pressures and compositions are first considered in the uniform mixture. It is found that detonation initiation fails for low hotspot pressures and the critical regime dominates with high hotspot pressures. Detonation is directly initiated from the reactive hotspot, whilst it is ignited somewhere beyond the non-reactive hotspots. Two cell diverging patterns (i.e. abrupt and gradual) are identified and the detailed mechanisms are analysed. Moreover, cell coalescence occurs if many irregular cells are generated initially, which promotes the local cell growth. We also consider non-uniform detonable mixtures. The results show that the initiated detonation experiences self-sustaining propagation, highly unstable propagation and extinction in mixtures with a linearly decreasing equivalence ratio along the radial direction, i.e. 1 → 0.9, 1 → 0.5 and 1 → 0. Moreover, the hydrodynamic structure analysis shows that, for the self-sustaining detonations, the hydrodynamic thickness increases at the overdriven stage, decreases as the cells are generated and eventually becomes almost constant at the cell diverging stage, within which the sonic plane shows a ‘sawtooth’ pattern. However, in the detonation extinction cases, the hydrodynamic thickness continuously increases, and no ‘sawtooth’ sonic plane can be observed.
After the coup attempt on July 15, 2016, the Turkish state started to produce a new official history of the event as a narrative of popular resistance against a military coup for the sake of democracy. This narrative with a religious aura was supported by “democracy watch” meetings and new commemoration days, museums, and monuments across Turkey. It was based on four concepts, symbolized by the Rabia sign: one nation, one homeland, one flag, and one state. However, the use of the Rabia sign has fallen from grace recently, creating a critical gap or “glitch” in the mnemonic infrastructure. This paper offers a visual categorization of July 15 monuments across Turkey and positions them in the historiography of Turkish national monuments. Finally, Rabia monuments are analyzed as a case study to show part of the complex (trans)national narratives of the “New Turkey.”
To systematically review the methodology, performance, and generalizability of diagnostic models for predicting the risk of healthcare-facility–onset (HO) Clostridioides difficile infection (CDI) in adult hospital inpatients (aged ≥18 years).
Background:
CDI is the most common cause of healthcare-associated diarrhea. Prediction models that identify inpatients at risk of HO-CDI have been published; however, the quality and utility of these models remain uncertain.
Methods:
Two independent reviewers evaluated articles describing the development and/or validation of multivariable HO-CDI diagnostic models in an inpatient setting. All publication dates, languages, and study designs were considered. Model details (eg, sample size and source, outcome, and performance) were extracted from the selected studies based on the CHARMS checklist. The risk of bias was further assessed using PROBAST.
Results:
Of the 3,030 records evaluated, 11 were eligible for final analysis, which described 12 diagnostic models. Most studies clearly identified the predictors and outcomes but did not report how missing data were handled. The most frequent predictors across all models were advanced age, receipt of high-risk antibiotics, history of hospitalization, and history of CDI. All studies reported the area under the receiver operating characteristic curve (AUROC) as a measure of discriminatory ability. However, only 3 studies reported the model calibration results, and only 2 studies were externally validated. All of the studies had a high risk of bias.
Conclusion:
The studies varied in their ability to predict the risk of HO-CDI. Future models will benefit from the validation on a prospective external cohort to maximize external validity.
This study examined absorbed organic residues in pottery to assess differences in subsistence practices in Roman Britain. Through this approach, we investigated foodways at a major urban site and a range of small towns, villas and farmsteads within its hinterland. The study revealed that consumption at Cirencester differed remarkably to consumption at other sites in the surrounding hinterland, with a greater contribution from pigs and/or chickens. Dairy products were a key contributor to the diet at rural sites, including a high-status villa. We contend that both findings are the result of extensification of food production. Thus, we show how reconstructing broad culinary patterns can reveal possible responses of inhabitants to the challenges of feeding the increasing population of Roman Britain.
Vaccination is crucial to fighting the coronavirus disease (COVID-19) pandemic. A large body of literature investigates the effect of the initiation of the COVID-19 vaccination in case numbers in Turkey, including the resistance and willingness to taking the vaccine. The effect of early relaxation in the Turkish public with the initiation of vaccination on new daily cases is unknown.
Methods:
This study performs an event study analysis to explore the pre-relaxation effect of vaccination on the Turkish public by using daily data of new cases, stringency index, and residential mobility. Two events are comparatively defined as the vaccination of the health personnel (Event 1) and the citizens age 65 and over (Event 2). The initial dates of these events are January 13 and February 12, 2021, respectively. The length of the estimation window is determined as 14 days for the 2 events. To represent only the early stages of the vaccination, the study period ends on April 12, 2021. Thus, whereas the event window of Event 1 includes 90 observations, Event 2 covers 60 observations.
Results:
While average values of residential mobility, stringency index, and daily numbers of cases are 15.36, 71.03, and 11 978.93 in the estimation window for Event 1, these averages are 8.89, 70.88, and 17 303.20 in the event window. For Event 2, the same average values are 9.14, 69.38, and 7 664.93 in the estimation window and 8.25, 71.12, and 22 319.10 in the event window. When 14-day abnormal growth rates of the daily number of cases for Event 1 and Event 2 are compared, it is observed that Event 1 has negative growth rates initially and reaches a 7.59% growth at most. On the other hand, Event 2 starts with a 1.11% growth rate, and having a steady increase, it reaches a 23.70% growth in the last 14 days of the study period.
Conclusion:
The preliminary result shows that, despite taking more strict governmental measures, while residential mobility decreases, the daily number of COVID-19 cases increases in the early stages of vaccination compared to short pre-periods of it. This indicates that the initiation of vaccination leads to early behavioral relaxation in public. Moreover, the effect of Event 2 on the case numbers is more significant and immediate, compared to that of Event 1, which may be linked to the characteristic of the Turkish culture being more sensitive to the older adult population.
Helicity, an invariant under ideal-fluid (Euler) evolution, has a topological interpretation in terms of writhe and twist for a closed vortex tube, but accurately quantifying twist is challenging in viscous flows. With a novel helicity decomposition, we present a framework to construct the differential twist that establishes the theoretical relation between the total twisting number and the local twist rate of each vortex surface. This framework can characterize coiling vortex lines and internal structures within a vortex – important in laminar–turbulence transition, and in vortex instability, reconnection and breakdown. As a typical example, we explore the dynamics of vortex rings with differential twist via direct numerical simulation (DNS) of the Navier–Stokes equations. Two twist waves with opposite chiralities propagate towards each other along the ring and then collide whence the local twist rate rapidly surges. Local vortex surfaces are squeezed into a disk-like dipole structure containing coiled vortex lines, leading to vortex bursting. We derive a Burgers-equation-like model to quantify this process, which predicts a bursting time that agrees well with DNS.
Conduct problems and head injuries increase the risk of delinquency and share a bidirectional association. However, how they link across development is unknown. The present study aimed to identify their linked developmental pathways and associated risk factors. Latent class analysis was modeled from Millennium Cohort Study data (n = 8,600) to identify linked pathways of conduct problem symptoms and head injuries. Head injuries were parent-reported from ages 3 to 14 and conduct problems from ages 3 to 17 using the Strengths and Difficulties Questionnaire (SDQ). Multinomial logistic regression then identified various risk factors associated with pathway membership. Four distinct pathways were identified. Most participants displayed low-level conduct problem symptoms and head injuries (n = 6,422; 74.7%). Three groups were characterized by clinically relevant levels of conduct problem symptoms and high-risk head injuries in childhood (n = 1,422; 16.5%), adolescence (n = 567; 6.6%), or persistent across development (n = 189; 2.2%). These clinically relevant pathways were associated with negative maternal parenting styles. These findings demonstrate how pathways of conduct problem symptoms are uniquely linked with distinct head injury pathways. Suggestions for general preventative intervention targets include early maternal negative parenting styles. Pathway-specific interventions are also required targeting cumulative risk at different ecological levels.
The cardiovascular adaptations associated with structured exercise training in Fontan patients remain unknown. We hypothesised that short-term training causes cardiac remodelling and parallel improvement in maximal exercise capacity (VO2 max) in these patients.
Methods and Results:
Five patients, median age 19.5 (17.6–21.3) years, with a history of Fontan operation meeting inclusion/exclusion criteria, participated in a 3-month training programme designed to improve endurance. Magnetic resonance images for assessment of cardiac function, fibrosis, cardiac output, and liver elastography to assess stiffness were obtained at baseline and after training. Maximal exercise capacity (VO2 max) and cardiac output Qc (effective pulmonary blood flow) at rest and during exercise were measured (C2H2 rebreathing) at the same interval. VO2 max increased from median (IQR) 27.2 (26–28.7) to 29.6 (28.5–32.2) ml/min/kg (p = 0.04). There was an improvement in cardiac output (Qc) during maximal exercise testing from median (IQR) 10.3 (10.1–12.3) to 12.3 (10.9–14.9) l/min, but this change was variable (p = 0.14). Improvement in VO2 max correlated with an increase in ventricular mass (r = 0.95, p = 0.01), and improvement in Quality-of-life inventory (PedsQL) Cardiac scale scores for patient-reported symptoms (r = 0.90, p = 0.03) and cognitive problems (r = 0.89, p = 0.04). The correlation between VO2 max and Qc showed a positive trend but was not significant (r = 0.8, p = 0.08). No adverse cardiac or liver adaptations were noted.
Conclusion:
Short-term training improved exercise capacity in this Fontan pilot without any adverse cardiac or liver adaptations. These results warrant further study in a larger population and over a longer duration of time.
Diets and dietary constituents that we consume have a considerable impact on disease risk. Intriguingly these effects may be modulated to some extent by sex. Lack of female representation in nutritional studies as well as a lack of stratification by sex has and continues to limit our understanding of these sex × diet interactions. Here we provide an overview of the current and available literature describing how exposure to certain dietary patterns (Western-style diet, Mediterranean diet, vegetarian/vegan, ketogenic diet) and dietary constituents (dietary fibre, PUFA and plant bioactive) influences disease risk in a sex-specific manner. Interestingly, these sex differences appear to be highly disease-specific. The identification of such sex differences in response to diet stresses the importance of sex stratification in nutritional research.
The confluence of rapid population aging and the overwhelming desire of older adults to age in place begs the question: Do our cities support the health and well-being of aging populations? Using a neighbourhood-by-neighbourhood approach, this macro-scale investigation explores the “double risk” that many older adults live with – the potential of being disadvantaged by socio-demographic risk factors (being older, living alone, low income) and by living in an unsupportive built environment. It is an integration of what we know about supportive built form for older adults and applies this knowledge to Canadian cities, using a spectrum approach to classifying built environments. We found that most older adults with socio-demographic risk factors are living in unsupportive built environments in Canada; however, the distribution between built environments along the spectrum and between municipalities reveals a variegated landscape of double risk. Previous research suggests that unsupportive built environments can be supplemented with services, small-scale improvements in the built environment, and larger-scale retrofitting of neighbourhoods. Since the spatial distribution of vulnerability varies greatly within the 33 Canadian cities analysed, it highlights the need for this kind of inquiry to target age-friendly policy interventions.
Wind tunnel experiments are performed in both neutral and stable boundary layers to study the effect of thermal stability on the wake of a single turbine and on the wakes of two axially aligned turbines, thereby also showing the influence of the second turbine on the impinging wake. In the undisturbed stable boundary layers, the turbulence length scales are significantly smaller in the vertical and longitudinal directions (up to 50 % and $\approx$40 %, respectively), compared with the neutral flow, while the lateral length scale is unaffected. The reductions are larger with the imposed inversion of a second stable case, except in the near-wall region. In the neutral case, the length scales in the wake flow of the single turbine are reduced both vertically and laterally (up to 50 % and nearly 40 %, respectively). While there is significant upstream influence of a second turbine (on mean and turbulence quantities), there is virtually no upstream effect on vertical length scales. However, curiously, the presence of the second turbine aids length-scale recovery in both directions. Longitudinally, each turbine contributes to successive reduction in coherence. The effect of stability on the turbulence length scales in the wake flows is non-trivial: at the top of the boundary layer, the reduction in the wall-normal length scale is dominated by the thermal effect, while closer to the wall, the wake processes strongly modulate this reduction. Laterally, the turbines’ rotation promotes asymmetry, while stability opposes this tendency. The longitudinal coherence, significantly reduced by the wake flows, is less affected by the boundary layer's thermal stability.
We present sound and complete sequent calculi for the modal mu-calculus with converse modalities, aka two-way modal mu-calculus. Notably, we introduce a cyclic proof system wherein proofs can be represented as finite trees with back-edges, i.e., finite graphs. The sequent calculi incorporate ordinal annotations and structural rules for managing them. Soundness is proved with relative ease as is the case for the modal mu-calculus with explicit ordinals. The main ingredients in the proof of completeness are isolating a class of non-wellfounded proofs with sequents of bounded size, called slim proofs, and a counter-model construction that shows slimness suffices to capture all validities. Slim proofs are further transformed into cyclic proofs by means of re-assigning ordinal annotations.
In this article, we study the behaviour of the Abels–Garcke–Grün Navier–Stokes–Cahn– Hilliard diffuse-interface model for binary-fluid flows, as the diffuse-interface thickness passes to zero. For the diffuse-interface model to approach a classical sharp-interface model in the limit $\varepsilon \to +0$, the so-called mobility parameter $m$ in the diffuse-interface model must scale appropriately with the interface-thickness parameter $\varepsilon$. In the literature various scaling relations in the range $o(1)$ to $O(\varepsilon ^3)$ have been proposed, but the optimal order to pass to the limit has not been explored previously. Our primary objective is to elucidate this optimal order of the $m$–$\varepsilon$ scaling relation in terms of the rate of convergence of the diffuse-interface solution to the sharp-interface solution. Additionally, we examine how the convergence rate is affected by a sub-optimal parameter scaling. We centre our investigation around the case of an oscillating droplet. To provide reference limit solutions, we derive new analytical expressions for small-amplitude oscillations of a viscous droplet in a viscous ambient fluid in two dimensions. For two distinct modes of oscillation, we probe the sharp-interface limit of the Navier–Stokes–Cahn–Hilliard equations by means of an adaptive finite-element method. The adaptive-refinement procedure enables us to consider diffuse-interface thicknesses that are significantly smaller than other relevant length scales in the droplet-oscillation problem, allowing an exploration of the asymptotic regime.
This paper investigates the effect of anisotropic turbulence on generating leading-edge aerofoil–turbulence interaction noise. Thin aerofoil theory is used to model an aerofoil as a semi-infinite plate, and the scattering of incoming turbulence is solved via the Wiener–Hopf technique. This theoretical solution encapsulates the diffraction problem for gust–aerofoil interaction and is integrated over a wavenumber–frequency spectrum to account for general incoming anisotropic turbulence. We develop a novel axisymmetric wavenumber–frequency model that captures the wall-normal variation in turbulence characteristics, differing from previous approaches. Then, the method of Gaussian decomposition, in which the generalised spectra are approximated through the weighted sum of individual Gaussian eddy models, is applied to fit the turbulence model to experimental data. Comparisons with experimental data show good agreement for a range of anisotropic ratios.