We present the case of an infant with Kawasaki disease following persistent complete atrioventricular block, which is a rare cardiovascular complication associated with Kawasaki disease. We offer the importance of careful electrocardiography monitoring during the acute phase of Kawasaki disease.

Pulmonary arteriovenous fistulas are a frequent complication after a Kawashima procedure. We present a 15-year-old patient with a significant left pulmonary arteriovenous fistula managed via embolisation using three Micro Vascular Plugs. This technique achieved effective occlusion through the left internal jugular vein, since these are low-profile flexible devices that accommodate through an acute angle without long and stiff sheath.

TNF-α polymorphisms may influence dyslipidaemia, but their role remains unclear. This case–control study investigated associations between TNF-α gene polymorphisms (–1031T/C, −863C/A, −857C/T, −308G/A and −238G/A) and dyslipidaemia in 595 participants (162 cases, 433 controls) from the Chaoshan region of China. Anthropometric, biochemical and genetic data were analysed using χ2 tests and logistic regression, with the false discovery rate (FDR) method applied to correct for multiple comparisons. Results revealed that only the −1031T/C and −863C/A polymorphisms were significantly associated with dyslipidaemia. Carriers of the TC + CC genotype for −1031T/C (OR = 0·48; 95 % CI: 0·30, 0·78; PFDR = 0·006) and the CA + AA genotype for −863C/A (OR = 0·41; 95 % CI: 0·24, 0·70; PFDR = 0·004) had lower odds of dyslipidaemia. Protective effects were observed for the C allele at −1031T/C (OR = 0·58, PFDR = 0·012) and the A allele at −863C/A (OR = 0·47, PFDR = 0·004). Stratified analyses showed that these associations were significant in males but not females. Functional annotation linked these TNF-α gene polymorphisms to transcription factors (e.g. HNF-1A, STAT1β) in the adipogenesis pathway. This study reveals genetic associations between TNF-α polymorphisms and dyslipidaemia, particularly in males, and provides mechanistic insights into their role in transcriptional regulation.

Transcatheter closure of patent ductus arteriosus has an established safety and efficacy in childhood using coils. However, complications and unexpected events are infrequently reported, such as haemolysis, embolisation, and stenosis of the left pulmonary artery or descending aorta. In the current work, we report an unusual obstacle that occurred upon the release of a patent ductus arteriosus coil in a child. Abnormal straightening of the coils on the pulmonary side was encountered, with failure of recoil of the patent ductus arteriosus windings noticed upon the coil release. However, the coil was successfully snared, and another was deployed with an uneventful recovery.

The famous Catholic pilgrimage site at Lourdes, France, until fairly recently displayed hundreds of discarded crutches as testament to miraculous cures. It has, though, never displayed a wooden leg. Hence the Wooden Leg Problem (WLP) for believers in miracles: if God can cure paralysis, why does He seem never to have given an amputee back their lost limb? The WLP is a severe challenge for believers in miracles and must be confronted head-on. Yet there does not appear to be any systematic analysis of the problem, at least as formulated here, in the literature on miracles or philosophy of religion generally. I discuss ten possible solutions to the WLP on behalf of the believer in miracles. Although some are stronger than others, all but the final one seem too weak to solve the problem. It is the final one – the ‘how do you know?’ solution – that I endorse and examine in some depth. This solution, I argue, shows that the WLP does not move the epistemological dial when it comes to belief or disbelief in miracles.

Iron deficiency has been associated with heart failure severity and mortality in children and adults. Intravenous iron therapy has been associated with improved outcomes for adults with heart failure. However, little is known about its impact and safety in children. We performed a single-centre review of all intravenous iron sucrose infusions prescribed to hospitalised patients ≤ 21 years of age with a primary cardiac diagnosis from 2020 to 2022. Ninety-one children (median age 6 years, weight 18 kg) received 339 iron sucrose infusions with a median dose of 6.5 mg/kg [5.1 mg/kg, 7.0 mg/kg]. At initial infusion, the majority (n = 63, 69%) had CHD, 70 patients (77%) were being managed by the advanced cardiac therapy team for heart failure, 13 (14%) were listed for heart transplant, 32 (35%) were on at least one vasoactive infusion, and 5 (6%) were supported with a ventricular assist device. Twenty infusions (6%) were associated with 27 possible infusion-related adverse events in 15 patients. There were no episodes of anaphylaxis or life-threatening adverse events. The most common adverse events were hypotension (n = 12), fever (n = 5), tachycardia (n = 3), and nausea/vomiting (n = 3). Eight of 20 infusion-related adverse events required intervention, and two infusions were associated with escalation in a patient’s level of care. Following intravenous iron repletion, patients’ serum iron, serum ferritin, transferrin saturation, and haemoglobin increased (p < 0.05 for all). In children hospitalised with cardiac disease, intravenous iron sucrose repletion is safe and may improve haemoglobin and iron parameters, including transferrin saturation and ferritin levels.

Delving into fraternal succession, intermarriage practices, and levirate marriages of the Northern Qi dynasty (550–577), this article demonstrates that these practices served as pillars of stability for the imperial family. In this exploration, Empress Dowager Lou 婁太后 (501–562) emerges as the central figure behind these practices, playing a pivotal role in their implementation and wielding immense power as kingmaker. Starting from before the official reign of the Northern Qi, she personally chose her husband, laid the groundwork for him to become regent of the preceding Eastern Wei (534–550) court, and controlled the succession system to seat her own sons as emperors of the Northern Qi. Drawing on her Xianbei 鮮卑 roots, Empress Dowager Lou enforced an agenda of Inner Asian practices and politics in her pursuit to consolidate the rule and identity of the Northern Qi imperial family.

Globalization leads to the emergence of new factors that threaten security and the rule of law in Kazakhstan, which necessitates the constant improvement of the personnel qualifications in internal affairs bodies. The purpose of this study was to cover the vectors of updating the legal support for the professional training of law enforcement officers in Kazakhstan. The following methods of scientific research were employed in this study: analysis; synthesis; comparison; deduction; generalization; and formal–legal. It was found that a major part of the future development of the Republic of Kazakhstan is to uphold the principles of justice, protection of society and the rule of law. The effectiveness of ensuring these indicators depends on the level of competence of law enforcement officers, whose activities are aimed at preventing the commission of crimes, their investigation and protection of public safety in general. The study proved that changes in legal, political and socio-economic relations contribute to the emergence of new threats facing society. Thus, the complexity of law enforcement operations is increasing, which demonstrates the need to constantly update the knowledge and skills of internal affairs personnel in Kazakhstan. As a result, the study highlighted the priority of improving the curricula and standards by which police education and training are delivered. It was established that the improvement of legal support of professional training of personnel of internal affairs bodies should be provided based on several approaches, namely legislative, educational, scientific and personal. The results should be used to develop and update the educational policies in the field of professional development of police officers in the Republic of Kazakhstan.

The article explores the interplay between imperialism and ethnonationalism, revealing how these seemingly conflicting ideologies coalesced in Russian political thought. The period of 1989–1994 saw a struggle between civic nationalism, which sought to redefine Russia within its existing borders, and imperialist-nationalist currents that viewed Soviet disintegration as a geopolitical catastrophe. Within this ideological conflict, the “time bomb” metaphor emerged as a potent rhetorical device, encapsulating anxieties about territorial fragmentation and national decline. The study identifies Russian émigré intellectual Gleb Rahr as a key figure in introducing the metaphor, later popularized by figures such as Dmitry Rogozin and Vladimir Putin.

This article deals with Hecataeus of Miletus fr. 310 Jacoby, featuring a curious list of islands located along the Nile, and bearing Greek names such as Ephesus, Chios, Lesbos, Kypros and Samos. Scholars generally assume the list, composed in the late sixth or early fifth century, represents joint Greek emporia established on Egyptian soil, thereby serving as a reliable testimony to the emergence of collective Greek identities during the late Archaic period. The composition of the list, along with the contemporary historical, cultural and archaeological contexts of its place names, is examined with particular emphasis on the collective identities of the islanders. On this basis, it is contended that the list lacks any evidence pertaining to Greek commercial footholds or collective identities in Egypt. Rather, fr. 310 serves as a practical navigational mnemonic, delineating culturally familiar geographical landmarks to assist Greek sailors in traversing a complex foreign river passage. The fragment now emerges as a valuable historical document, illuminating Greek navigational knowledge and practices during the late Archaic period.

We show that on every affine Weyl group natural random walks are noise sensitive in total variation.