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Cognitive decline presents individual and societal challenges, underscoring the importance of identifying risk factors to inform interventions for older adults. This cross-sectional study examined how physical activity (PA), perceived stress, and social support were related to cognitive function, with mild behavioral impairment (MBI) as a mediator, among 410 Thai older adults. Structural equation model revealed that perceived stress was associated with increased MBI (p < .001), which was directly related to cognitive function (p < .05). Higher social support was associated with lower MBI (p < .05), while moderate-to-vigorous PA was related to reduced MBI (p < .001) and improved cognitive function (p < .001). MBI mediated the associations of perceived stress (indirect effect = −0.244) and moderate-to-vigorous PA (indirect effect = 0.08) with cognitive function. Perceived stress–MBI relationship was stronger in participants with chronic diseases (∆χ2 = 4.236; p = 0.025). Findings support developing interventions to mitigate MBI, with input from health care professionals.
Forecasting of armed conflicts is a critical area of research with the potential to save lives and mitigate suffering. While existing forecasting models offer valuable point predictions, they often lack individual-level uncertainty estimates, limiting their usefulness for decision-making. Several approaches exist to estimate uncertainty, such as parametric and Bayesian prediction intervals, bootstrapping, quantile regression, but these methods often rely on restrictive assumptions, struggle to provide well-calibrated intervals across the full range of outcomes, or are computationally intensive. Conformal prediction offers a model-agnostic alternative that guarantees a user-specified level of coverage but typically provides only marginal coverage, potentially resulting in non-uniform coverage across different regions of the outcome space. In this article, we introduce a novel extension called bin-conditional conformal prediction (BCCP), which enhances standard conformal prediction (SCP) by ensuring consistent coverage rates across user-defined subsets (bins) of the outcome variable. We apply BCCP to simulated data as well as the forecasting of fatalities from armed conflicts, and demonstrate that it provides well-calibrated uncertainty estimates across various ranges of the outcome. Compared to SCP, BCCP offers improved local coverage, though this comes at the cost of slightly wider prediction intervals.
Protein-losing enteropathy associated with failing Fontan circulation remains a significant challenge in long-term, single-ventricle circulation management. Evidence is very limited regarding medical therapies associated with a reduction in disease severity and morbidity outside of cardiac transplantation. We report a novel experience with remission of recalcitrant protein-losing enteropathy after treatment of Cryptosporidium gastroenteritis with a combination of antimicrobials including nitazoxanide, paromomycin, and azithromycin.
Although Adolphe Sax’s serpentine invention hailed from Belgium, and then France, saxophones today are widely perceived as symbols of United States-led popular modernity. This image’s strength occludes a largely unknown antipodean precursor: the instrument debuted in British colonial Australia before being first heard across the Atlantic. This article foregrounds the goldrush-era Australian introduction of an instrument otherwise known as a ‘turkophone’, by enigmatic French musician Charles Jean-Baptiste Soualle, known in his orientalist stage persona as ‘Ali Ben Sou Alle’, from December 1852 to July 1855.
This article establishes the European origins of Soualle’s act and examines its effusive Australian reception through a historical musicology lens, before discussing the cultural dynamics key to this episode’s geographic context. While a Saidian, Orientalism-inspired critique sheds some light on the appeal of ‘Ali Ben Sou Alle’ to Australian audiences, Soualle’s local success was perhaps most notably underwritten by geopolitical events. For example, the 1853 outbreak of the Crimean War, which pitted the allied imperial French, British, and Ottoman powers against Tsarist Russia, challenged a nascent Australia’s sense of itself and place in the world, and provided Soualle an opportune, sympathetic platform from which to compose and perform. Remarkably, given characterizations the instrument signified in the Jazz Age decades hence, Soualle’s saxophone also embodied notions of freedom for its mid-nineteenth-century Australian audiences.
This episode, and its thematic resonances, offers insights into histories of touring musicians, understandings of music and coloniality, musical globalism, and the saxophone’s symbolic malleability prior to its rise to worldwide prominence.
Current political developments worldwide illustrate that research on democratic backsliding is as important as ever. A recent exchange in Political Science & Politics (February 2024) highlighted again that the measurement of democracy remains a challenge. With many democracy indicators consisting of subjective assessments rather than factual observations, trends in democracy over time could be due to human biases in the coding of these indicators rather than empirical facts. This article leverages two cutting-edge Large Language Models (LLMs) for the coding of democracy indicators from the V-Dem project. With access to huge amounts of information, these models may be able to rate the many “soft” characteristics of regimes at substantially lower costs. Whereas LLM-generated codings largely align with expert coders for many countries, we show that when these models deviate from human assessments, they do so in different but consistent ways. Some LLMs are too pessimistic and others consistently overestimate the democratic quality of these countries. Although the combination of the two LLM codings can alleviate this concern, we conclude that it is difficult to replace human coders with LLMs because the extent and direction of these attitudes is not known a priori.
Phoretic particles are often used as a simple model for experimental and theoretical studies of active matter. We develop a computational framework to resolve hydrodynamic and chemical interactions of multiple self-propelling phoretic particles suspended in two-dimensional Stokes flow. The proposed method is precise enough to resolve correctly the subtle transitions between different modes of spontaneous locomotion for a single particle, and fast and versatile enough to study multiparticle dynamics in periodic or confined domains. The particles are modelled as chemically active rigid circles, which can emit or absorb a solute into surrounding fluid. The interaction between particles and solute induces a slip flow on particle surfaces, and the solute is advected by the fluid flow and diffuses with a constant diffusivity. A fast boundary integral method is proposed to solve fluid–structure interaction in Stokes flow. Acceleration of this method is provided by splitting the velocity field due to a set of point forces into a short-range part with singularity and a long-range part which is sufficiently smooth, thanks to an Ewald-like decomposition. An overlapping mesh method is employed for advection–diffusion of the solute with moving boundaries. The idea is to decompose the computational domain into several overlapping subdomains, and body-fitted meshes are used to ensure sharp resolution of boundary conditions. The framework is validated separately for the Stokes problem and the advection–diffusion problem, reaching relatively high order of accuracy. We apply our framework to several practical problems, such as a single particle in a channel and particle suspensions, showing rich sets of behaviours.
The relationship between salinity-driven (SD) and particle-driven (PD) gravity currents has long been a focal point of geophysical research. This study investigates salinity–particle dual-driven gravity currents using a direct numerical simulation discrete element method. The transition regime from SD to PD currents is explored. The results show that the transition is related to interfacial instability and material transport dynamics. During this transition, the enhancement of particle sedimentation weakens the interfacial stratification and heightens its susceptibility to shear instability. Consequently, the instability generates a series of billows that encourages fluid dilution, further amplifying the particle sedimentation effect. The transition regime is closely associated with this positive closed-loop feedback mechanism. It supplies sufficient energy at the slumping stage to maintain the front velocity of particle-dominated currents comparable to that of salinity-dominated currents. The interfacial vortices will expand spatially by the centrifugal forces on the particles, leading to a reduction in detrainment.
In the 1880s, Sievers proposed that in Old English words such as *feorhes, the loss of the post-consonantal *h caused compensatory lengthening of the vowel: fēores. Since there are no unambiguous traces of this sound change in later English, widespread analogical restitution of the short vowels was assumed (e.g. from feorh). The evidence for this lengthening is largely metrical. I argue that while Sievers is correct that words like <feores> often need to scan with a heavy initial syllable, this need not be explained by a general lengthening in the language at large. Indeed, the distribution of where heavy scansions are required in verse is typical for metrical archaisms: late prehistoric metrical values of words preserved for poetic convenience. Just as wundor ‘marvel’ can continue to be scanned as monosyllabic *wundr, or contracted hēan can scan as disyllabic *hēahan, so can light-syllabled feores continue to scan as heavy *feorhes. The same sets of poems that prefer non-epenthesized or non-contracted forms also prefer the heavy scansions of feores-type words. If heavy scansions of feores-words are seen as a matter of poetic convention, then the hypothesis of compensatory lengthening in the language generally is left without evidence and should be rejected.
Student debt heavily shapes the life decisions and outlook of those living with it. This article examines the relationship between undergraduates’ views of President Joe Biden’s actions on student debt and their support for him in the 2024 election prior to his dropping out of the race. Using a representative survey from a large private university in the Northeast, we assess how student views of Biden’s handling of student loan relief correlated with voting intentions among registered student voters. Our analysis reveals that students who believed the Biden administration adequately addressed student debt were significantly more likely to support him compared to those who believed he had done too little. Additionally, our findings suggest that whereas increased student debt relief could have bolstered Biden’s support among liberal and very liberal students, its impact on moderate and conservative students was more limited. This study highlights the electoral implications of student debt relief policies, particularly in shaping young voters’ preferences, and it underscores the potential for targeted economic benefits to influence voter behavior in a highly polarized political environment.