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Human beings are a highly social species, and there are neural systems that have a role in enabling human beings to function as the social animals they are. They connect people into smaller or larger social groups; and at least some of these groups have a unity that lets the united human beings function as one. That this is so has implications for an array of philosophical and theological issues, including the notion of a people, the concomitant notions of a people’s communal guilt and communal shame, the notion of the church as the body of Christ, the understanding of human perfection as a likeness to a triune God, and many other such issues. What is required to elucidate these issues is a metaphysics that can explain the nature of a united something-or-other that includes human persons as constituents. This article explores these issues and outlines the nature of the needed metaphysics.
Macroscopic, modular, morphologically simple skeletons occur in the uppermost Mural Formation (Cambrian, Epoch 2, Bonnia–Olenellus Biozone), west-central Alberta and adjacent east-central British Columbia. They represent organisms that lived almost exclusively in reefal environments dominated by archaeocyaths. Some were attached to archaeocyaths or less commonly other surfaces, and some grew downward, apparently from overhangs or cavities in reefs. Qualitative and quantitative data from a large number of specimens, most of which were serially thin sectioned, indicate that they represent a single, remarkably variable species. The skeletal structure ranges among specimens from entirely cerioid to partially to entirely labyrinthine with irregularly incomplete walls. There is also a wide range of variability in growth form among skeletons, in module size and wall thickness among and within skeletons, in module shape within skeletons, and in number and location of projections extending from the wall into some modules. Module increase occurred by peripheral expansion at the basal surface of the skeleton and longitudinal fission involving projections from the wall as module size increased during vertical growth. Walls of skeletons, now composed of calcite cement, were probably originally aragonite. Modular skeletons from the uppermost Mural Formation are assigned to Rosellatana jamesi Kobluk, 1984a, previously represented only by a few cerioid specimens from correlative strata in the Rosella Formation of north-central British Columbia. The skeletal structure and types of module increase in R.jamesi, and a few similar but less well-known Cambrian taxa from elsewhere in North America, suggest a general biologic affinity with hypercalcified sponges.
To create a simple simulated tonsil-tying model to help trainees gain surgical skills during limited training opportunities.
Methods
A tonsil-tying trainer was constructed using basic hospital items that are easily attainable in a basic hospital setting. Feedback was obtained from consultants, registrars and senior house officers.
Results
A simple, low-cost and effective low-fidelity model for deep knot tying in tonsillectomy is presented. The model is modifiable for the progressing trainee and allows a degree of objective feedback with the potential for subjective feedback from a trainer. The model is easy to prepare using typical basic hospital ward equipment.
Conclusion
This model provides practice of placing a Boyle–Davis gag, and the use of tools and a head light. It is adjustable for tonsil-tying practice at a variety of depths with different vessel sizes and conditions (e.g. bleeding). Lastly, basic objective feedback without significant technical challenges is possible.
Retropharyngeal and parapharyngeal infections can be managed surgically or conservatively. A trial of medical treatment before considering computed tomography (CT) imaging may be appropriate.
Methods
This is a retrospective review of patients with retropharyngeal and parapharyngeal infections between October 2022 and April 2023. Descriptive and statistical analysis compared surgically and conservatively managed patients.
Results
There were 33 patients (median age 58 months). CT imaging was acquired for 30 of 33 patients (90.9 per cent) and 25 had a CT scan within 24 hours of presentation. Fourteen patients (42.4 per cent) were managed surgically. The mean duration of antibiotics for surgically and conservatively managed patients was not significantly different (19.9 vs 21.4 days, p = 0.73). Larger lesions were observed on the CT scans of surgically treated patients (22.8 vs 15.6 mm, p = 0.01).
Conclusion
Management of paediatric retropharyngeal and parapharyngeal infections can be surgical or conservative. We propose a management algorithm that allows an initial trial of intravenous antibiotics before CT imaging for selected patients.
‘Positional goods’, a term coined by Fred Hirsch, is an important concept in economics, social sciences and philosophy; however, it is used in different ways. This paper recovers Hirsch’s concept of positional goods as scarce goods that are fixed or near-fixed in supply and argues for the usefulness of this concept. Hirsch’s concept may have explanatory power beyond the concept used by most economists – that of Robert Frank. Moreover, Hirsch’s concept is more explanatorily basic and useful than the concept used by most philosophers – that of Brighouse and Swift.
This study is to evaluate the results obtained in a group of implanted otosclerotic patients and compare them with a matching group of non- otosclerosis cochlear implant patients.
Methods
Pre-operative computed tomographic scans, intra-operative findings, type of electrode used and difficulties of 17 patients with otosclerosis were documented. Post-operative complications, facial nerve stimulation, electrode dislocation and audiological and speech outcomes were documented and the data analysed.
Results
Surgical difficulties were directly related to the advanced stage of the disease. No major complications were reported in this cohort. No significant difference was found between both groups one year after surgery; the mean pure tone average was 35 dB ± 4.43, speech reception threshold was 40 ± 4.96 and speech discrimination score was 80 per cent ± 12.55 in the otosclerotic group.
Conclusion
Cochlear implantation is a safe and effective management for advanced otosclerosis patients even after stapes surgery.
This study explores whether DNA methylation (DNAm) mediates the association between lean body mass (LBM) and cognition, as well as whether LBM mediates the association between DNAm and cognition. Based on the data of 59 monozygotic twin pairs, mediation analyses were performed using causal inference test method and mediation analyses. Average causal mediation effect (ACME), average direct effect (ADE), and total effect (TE) were calculated. Among the CpGs associated with LBM, five located within PDGFRB and RP11 genes (ACME: −0.0972−0.0463, |ACME/ADE|: 10.44%−18.30%) negatively mediated the association between LBM and cognition, while one in the PAX2 gene (ACME: 0.3510, |ACME/TE|: 11.84%) positively mediated the association. Besides, the methylation risk score (MRS) of RP11 gene (ACME: −0.0517, |ACME/ADE|: 10.64%) and MRS of all CpGs (ACME: −0.0511, |ACME/ADE|: 10.53%) negatively mediated the association of LBM with cognition. For another, LBM negatively mediated the association between the DNAm level of one CpG within UBXN6 and cognition (ACME: −0.0732, |ACME/TE|: 20.78%), while positively mediated the association between the DNAm level of four CpGs within FOXI2 and cognition (ACME: 0.2812−0.4496, |ACME/TE|: 18.15%−27.29%). It was found the DNAm in PDGFRB, RP11 and PAX2 partially mediates the association between LBM and cognition, and the association between DNAm in UBXN6 and FOXI2 with cognition is also partially mediated by LBM.
This paper revisits the relationship between tax evasion and tax rates in a heterogeneous-agent, incomplete-markets model. Extending the foundational works of Allingham and Sandmo (1972) and Yitzhaki (1974), we explore how financially constrained households use tax evasion to mitigate the adverse effects of market imperfections. We show that deterrence policies, such as audit probabilities and penalties, exacerbate the effects of borrowing constraints. Importantly, increasing income tax rates can sometimes alleviate these negative impacts when individuals evade taxes. We identify three mechanisms shaping underreporting: the direct effect, the threshold effect, and the income effect. These help explain when and why the Yitzhaki puzzle arises. Numerical results reveal a non-monotonic relationship between tax rates and underreporting, underscoring the relative strength of these effects and offering fresh insights into the Yitzhaki puzzle.
Gel’fand–Dorfman algebras (GD algebras) give a natural construction of Lie conformal algebras and are in turn characterized by this construction. In this article, we define the Gel’fand–Dorfman bialgebra (GD bialgebra) and enrich the above construction to a construction of Lie conformal bialgebras by GD bialgebras. As a special case, Novikov bialgebras yield Lie conformal bialgebras. We further introduce the notion of the Gel’fand–Dorfman Yang–Baxter equation (GDYBE), whose skew-symmetric solutions produce GD bialgebras. Moreover, the notions of $\mathcal {O}$-operators on GD algebras and pre-Gel’fand–Dorfman algebras (pre-GD algebras) are introduced to provide skew-symmetric solutions of the GDYBE. The relationships between these notions for GD algebras and the corresponding ones for Lie conformal algebras are given. In particular, there is a natural construction of Lie conformal bialgebras from pre-GD algebras. Finally, GD bialgebras are characterized by certain matched pairs and Manin triples of GD algebras.
During nematode surveys conducted to investigate the biodiversity of plant-parasitic nematodes in Mediterranean olive groves with different management strategies (organic and conventional), a nematode population of the genus Neothada was detected in southern Spain. Application of integrative taxonomical approaches clearly demonstrated that it is a new species described herein as Neothada olearum sp. nov., also representing the first report of the genus in Spain. The new species is amphimictic, characterised by a short body (563–774 μm); cuticle widely annulated (2.5–3.0 μm); total number of body annuli 214–226; 16 longitudinal ridges giving a tessellate body surface; stylet without distinct basal knobs (9.0–11.0 μm); and tail elongate-conoid, with tip bluntly rounded. The results of molecular analysis of D2-D3 28S rRNA, ITS rRNA, partial 18S rRNA, and cytochrome oxidase c subunit 1 (COI) gene sequences support for the new species status and clearly separated from N. major and other species within Neothada. Phylogenetic analyses of ribosomal and mitochondrial markers of this study suggested that Neothada is a monophyletic genus, clearly separated from Thada.
To mitigate the risk of harm to themselves or others, people with mental disorders may require compulsory admission to hospital for in-patient treatment. In England and Wales this is authorised under the Mental Health Act 1983 (MHA). Patients have the right to appeal against this involuntary detention at a hearing before the First-tier Tribunal (Health Education and Social Care Chamber) Mental Health, and psychiatrists may be called on to provide written and oral evidence to the tribunal. The purpose of this article is to help psychiatrists, particularly trainees, understand the sections of the MHA involved, the patient’s right of appeal, the role of the tribunal, their own role as a professional witness, and how to improve the quality of evidence they provide.
How do authoritarian actors navigate the liberal international order, adopting democratic facades without committing to democratic principles? And why is it so difficult for the international normative system to debunk their pretence when it comes to the use of democratic values? This paper explores this question by introducing ‘profilicity’ and ‘performativity’ as key concepts to understand how autocratic regimes build powerful profiles within a liberal system that values authenticity. Unlike conventional theories, which assume that engagement with liberal norms requires genuine commitment, profilicity reveals that strategic image-building can be just as effective. Through this lens, we see how autocracies exploit liberalism’s own ideals, using performative adaptation to secure status and reshape norms. This paper suggests that the liberal order’s emphasis on sincerity may itself be a strategic weakness, one that autocratic actors skilfully navigate in a world increasingly driven by profiles over principles.
Associational life in Cape Town is a mechanism for migrants from the eastern Democratic Republic of Congo (DRC) to find belonging in South Africa. We trace the internal politics of associational membership from 2000 to 2019 to illustrate how membership in eastern Congolese associations has minimized community ties to other foreign Africans and South Africans. An increase in election violence in the DRC, divided into pro- and anti-combattant camps, and the threat of xenophobic violence in South Africa have led to a closing of ranks that presumes only other eastern Congolese can be trusted. In tracing gender, class and language cleavages, we find that eastern DRC associational life reproduces the xenophobia associational membership is intended to ameliorate.
Microbiomes are communities of microorganisms that form close associations with metazoan hosts and have important roles in host biological processes. With the advent of Next Generation Sequencing, the microbiomes of myriad animals and plants have been described. However, the microbiomes of parasites have received little attention, which is surprising considering their ecological and medical importance. This study characterizes, for the first time, the microbiome of Dujardinascaris helicina, a gastrointestinal nematode parasite of the American crocodile. Dujardinascaris helicina were isolated from crocodiles residing in two geographically separated habitats across Belize. Using 16S sequencing, we compare β-diversity between sampling locations using generalized linear mixed modeling. Our results show that D. helicina microbiomes differ in composition depending on location. We also show that D. helicina microbiomes show strong shifts toward consolidation of specific taxa when proximity to human modified environments increases.
Medieval elite culture is often difficult to grasp among archaeological records from settlement sites. A silver-gilt amethyst setting, probably part of a brooch, from the moat of Castle Kolno in Poland represents an unusual high-status find from a context related to everyday activity.
Building upon an institutional perspective and the resource-based view, we theorize and address questions on what drives foreign subsidiaries of multinational enterprises (MNEs) to engage corporate social performance (CSP) strategies and how CSP contributes to the competitiveness of MNE subsidiaries in the host market. Subsequently, we theorize and explore the roles governments in home and host countries play in motivating MNE subsidiaries to adopt and implement CSP strategies and activities, and how institutional effects may be moderated by the specific resources and capabilities of MNE subsidiaries. The conceptual framework presented in this work was empirically tested using survey data collected from foreign subsidiaries of Chinese MNEs. The results, which provide broad support for most of the research hypotheses, can contribute to the stream of research on the CSP of MNE subsidiaries. More importantly, this study sheds new light on the particular importance of government pressure from both home and host countries. In particular, firm-specific resources or capabilities moderate the institutional effects (i.e., government pressure) on CSP strategies of MNE subsidiaries, ultimately enhancing the competitive advantages of these subsidiaries in the host market.
Fasciolosis, a parasitic disease of ruminants, poses significant economic and animal-health challenges in Algeria. This study aimed to assess spatial, temporal, and species-specific patterns of fasciolosis prevalence across diverse agro-climatic zones and to estimate associated economic losses. Between 2013 and 2023, eight wilayas El-Tarf, Skikda, Jijel (Region I), Blida, Mila (Region II), and M’Sila, Medea, Laghouat (Region III) were surveyed. Systematic postmortem inspections of 1,569,392 animals (349,176 cattle; 982,669 sheep; 235,639 goats; 1,882 camels; 26 horses) were performed by qualified veterinarians, with liver and bile-duct examination for Fasciola. Data on region, species, year, and season were analyzed in R 4.4.0 using ANOVA, Kruskal–Wallis, Tukey’s post hoc tests, and principal component analysis (PCA). Economic losses were calculated from condemned liver weights in Blida, Laghouat, and Jijel, converted to USD. PCA distinguished three regional prevalence profiles, with PC1 (77.7% variance) separating overall prevalence levels. Region I exhibited the highest mean prevalence (2.47%), peaking at 3.54% in 2018 – significantly greater than Region II (1.39%) and Region III (1.96%) (p < 0.01). Cattle showed the greatest infection rate (mean 4.14%), significantly higher than sheep (1.32%; p < 0.001) and goats (0.25%; p < 0.001), while horses and camels remained uninfected. Seasonal analysis revealed highest prevalence in autumn and winter (≈2.1%) versus spring (≈1.5%). Economic losses totaled USD 10.6 million in Blida, USD 1.0 million in Laghouat, and USD 142.2 million in Jijel over the study period. Targeted control strategies, adapted to regional and seasonal risk patterns, are essential. Future work should investigate environmental and management factors driving regional differences and evaluate cost-effective interventions to mitigate fasciolosis impact in Algerian livestock.
A growing demand for wheat as a staple crop leads to an expansion of its production. The consequence is land use change and short rotations for wheat. But wheat grown in short rotations causes yield decline. To secure future food supplies, a deeper understanding of the physiological processes contributing to this yield reduction is needed. Therefore, a three-year data set from a long-term field trial in Northern Germany was analysed to investigate the impact of crop rotational position (CRP) (wheat grown in the first [W1] and in the third [W3] year in self sequence after break crop) in combination with three genotypes and four rates of nitrogen (N) fertilizer on intercepted radiation by the canopy (Q), radiation use efficiency (RUE), grain yield and yield components. All genotypes showed a reduction of Q, RUE and yields in W3. The focus was further set on differences in yield formation pre- and post-anthesis. This revealed a significant interaction between CRP and genotype. An overall reduction in intercepted radiation pre-anthesis as well as in kernels/m2 in W3 suggested, that yield formation under adverse pre-crop conditions was rather ‘source limited’. A possibility to compensate this limitation might be a prolonged phase of radiation interception post-anthesis.