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An important parameter characterising the synchronisation of turbulent flows is the threshold coupling wavenumber. This study investigates the relationship between the threshold coupling wavenumber and the leading Lyapunov vector using large eddy simulations and the SABRA model. Various subgrid-scale stress models, Reynolds numbers and different coupling methods are examined. A new scaling relation is identified for the leading Lyapunov exponents in large eddy simulations, showing that they approximate those of filtered direct numerical simulations. This interpretation provides a physical basis for results related to the Lyapunov exponents of large eddy simulations, including those related to synchronisation. Synchronisation experiments show that the peak wavenumber of the energy spectrum of the leading Lyapunov vector coincides with the threshold coupling wavenumber, in large eddy simulations of box turbulence with standard Smagorinsky or dynamic mixed models as well as in the SABRA model, replicating results from direct numerical simulations of box turbulence. Although the dynamic Smagorinsky model exhibits different behaviour, the totality of the results suggests that the relationship is an intrinsic property of a certain class of chaotic systems. We also confirm that conditional Lyapunov exponents characterise the synchronisation process in indirectly coupled systems as they do in directly coupled ones, with their values insensitive to the nature of the master flow. These findings advance the understanding of the role of the Lyapunov vector in the synchronisation of turbulence.
We audited family caregivers’ hand hygiene (HH) and masking practices at a pediatric tertiary care center during a period of increased community viral circulation and an enteric outbreak. Observed HH rates were below 5%, whereas masking was above 90%. Awareness of practices can inform strategies in caregiver infection prevention education.
Despite previous observational studies suggesting that malnutrition could be involved in venous thromboembolism (VTE), definitive causality still lacks high-quality research evidence. This study aims to explore the genetic causal association between malnutrition and VTE. The study was performed using summary statistics from genome-wide association studies for VTE (cases = 23 367; controls = 430 366). SNP associated with exposure was selected based on quality control steps. The primary analysis employed the inverse variance weighted (IVW) method, with additional support from Mendelian randomisation (MR)-Egger, weighted median and weighted mode approaches. MR-Egger, leave-one-SNP-out analysis and MR pleiotropy residual sum and outlier (MR-PRESSO) were used for sensitivity analysis. Cochran’s Q test was used to assess heterogeneity between instrumental variables (IV). IVW suggested that overweight has a positive genetic causal effect on VTE (OR = 1·1344, 95 % CI = 1·056, 1·2186, P < 0·001). No genetic causal effect of malnutrition (IVW: OR = 0·9983, 95 % CI = 0·9593, 1·0388, P = 0·9333) was found on VTE. Cochran’s Q test suggests no possible heterogeneity in both related exposures. The results of the MR-Egger regression suggest that the analysis is not affected by horizontal pleiotropy. The results of the MR-PRESSO suggest that there are no outliers. The results revealed a statistical genetic association where overweight correlates with an increased risk of VTE. Meanwhile, no genetic causal link was observed between malnutrition and VTE. Further research is warranted to deepen our understanding of these associations.
Estimation of near-wall turbulence in channel flow from outer observations is investigated using adjoint-variational data assimilation. We first consider fully resolved velocity data, starting at a distance from the wall. By enforcing the estimated flow to exactly satisfy the Navier–Stokes equations, we seek a statistically stationary turbulent state that reproduces the instantaneous outer measurements. Such an estimated state provides full access to the unknown near-wall turbulence, including the wall shear stresses and pressure. When the first observation is within 50 viscous units from the wall, the correlation coefficient between the true and estimated state exceeds 95 %. As the observations are further separated from the wall, at 90 viscous units, the accuracy of the assimilated wall stresses decreases to 40 % at the wall. This trend is nearly independent of the Reynolds number. The Fourier spectrum of the estimation error is qualitatively consistent with the coherence spectrum between the outer and the inner state variables: observed long wavelength structures in the outer flow have deeper coherence into the unobserved near-wall region and, therefore, the error is lowest at large scales. Nevertheless, the adjoint-variational approach provides a more rigorous quantification of the capacity to accurately predict the instantaneous near-wall turbulence from outer measurements. Lastly, we demonstrate the robustness of the estimation accuracy using filtered and sub-sampled outer observations.
When turbulent convection interacts with a turbulent shear flow, the cores of convective cells become aligned with the mean current, and these cells (which span the height of the domain) may interact with motions closer to the solid boundary. In this work, we use coupled Eulerian–Lagrangian direct numerical simulations of a turbulent channel flow to demonstrate that, under conditions of turbulent mixed convection, interactions between motions associated with ejections and low-speed streaks near the solid boundary and coherent superstructures in the interior of the flow interact and lead to significant vertical transport of strongly settling Lagrangian particles. We show that the primary suspension mechanism is associated with strong ejection events (canonical low-speed streaks and hairpin vortices characterised by $u'\lt 0$ and $w'\gt 0$, where $u'$ and $w'$ are the streamwise and vertical turbulent velocity fluctuations), whereas secondary suspension is strongly associated with large-scale plume structures aligned with the mean shear (characterised by $w'\gt 0$ and $\theta '\gt 0$, where $\theta$ represents temperature fluctuations). This coupling, which is absent in the limiting cases (pure channel flow or free convection) is shown to lead to a sudden increase in the interior concentration profiles as ${Ri}_\tau$, the friction Richardson number, increases, resulting in concentrations that are larger by roughly an order of magnitude at the channel midplane.
It is generally accepted that the evolution of the deep-water surface gravity wave spectrum is governed by quartet resonant and quasi-resonant interactions. However, it has also been reported in both experimental and computational studies that non-resonant triad interactions can play a role, e.g. generation of bound waves. In this study, we investigate the effects of triad and quartet interactions on the spectral evolution, by numerically tracking the contributions from quadratic and cubic terms in the dynamical equation. In a finite time interval, we find that the contribution from triad interactions follows the trend of that from quartet resonances (with comparable magnitude) for most wavenumbers, except that it peaks at low wavenumbers with very low initial energy. This result reveals two effects of triad interactions. (1) The non-resonant triad interactions can be connected to form quartet resonant interactions (hence exhibiting the comparable trend), which is a reflection of the normal form transformation applied in wave turbulence theory of surface gravity waves. (2) The triad interactions can fill energy into the low-energy portion of the spectrum (low wavenumber part in this case) on a very fast time scale, with energy distributed in both bound and free modes at the same wavenumber. We further analyse the latter mechanism using a simple model with two initially active modes in the wavenumber domain. Analytical formulae describing the distribution of energy in free and bound modes are provided, along with numerical validations.
Thermal Marangoni effects play important roles in bubble dynamics such as bubbles generated by water electrolysis or boiling. As macroscopic bubbles often originate from nucleated nanobubbles, it is crucial to understand how thermocapillarity operates at the nanoscale. In this study, the motion of transient bulk gas nanobubbles in water driven by a vertical temperature gradient between two solid plates is investigated using molecular dynamics simulations and analytical theory. The simulation results show that due to the thermal Marangoni force, nanobubbles move towards the hot plate at a constant velocity, similar to the behaviour of macroscale gas bubbles. However, unlike macroscale gas bubbles whose thermal conductivity and viscosity are negligible compared to those of water, the thermal conductivity and viscosity of nanoscale gas bubbles are significantly increased due to their large gas density. The thermal resistance and the slip length are also found to matter at the liquid–gas interface, though they decrease with increasing gas densities. The previous thermocapillary theory for macroscale bubbles is extended by considering all these nanoscopic effects. Expressions of the Marangoni force and the drag force are derived. By balancing the Marangoni force and the drag force, the theoretical velocity of the nanobubble migration in a thermal gradient is obtained. When using the measured transport properties of liquid, gas, and their interfaces, the theoretically obtained velocity is consistent with the result of the molecular simulations. We find that the slip length is too small to have considerable effects on nanobubble motions in the current liquid–gas system.
An important feature of the dynamics of double-diffusive fluids is the spontaneous formation of thermohaline staircases, where wide regions of well-mixed fluid are separated by sharp density interfaces. Recent developments have produced a number of one-dimensional reduced models to describe the evolution of such staircases in the salt fingering regime relevant to mid-latitude oceans; however, there has been significantly less work done on layer formation in the diffusive convection regime. We aim to fill this gap by presenting a new model for staircases in diffusive convection based on a regularisation of the $\gamma$-instability (Radko 2003 J. Fluid Mech. vol. 805, 147–170), with a range of parameter values relevant to both polar oceans and astrophysical contexts. We use the results of numerical simulations to inform turbulence-closure parametrisations as a function of the horizontally averaged kinetic energy $e$, and ratio of the haline to thermal gradients $R_0^*$. These parametrisations result in a one-dimensional model that reproduces the critical value of $R_0^*$ for the layering instability, and the spatial scale of layers, for a wide range of parameter values, although there is a mismatch between the range of $R_0^*$ for layer formation in the model and observational values from polar oceans. Staircases form in the one-dimensional model, evolving gradually through layer merger events that closely resemble simulations.
Since the 1978 discovery of an islet “Oodaaq Island” north of Greenland, then considered to be the northernmost island in the world, multiple islets have been reported and apparently disappeared with regular intervals in the permanent sea ice-covered area offshore the northernmost part of Greenland. In this paper, we report results of comprehensive investigations at all quoted positions of reported islets, with bathymetry measurements, as well as supplementary lidar, ice thickness and gravity measurements during a helicopter reconnaissance. The bathymetry measurements confirm the non-existence of all the reported islets, and the northernmost land in the world is thus confirmed to be the moraine island “Inuit Qeqertaat” (Kaffeklubben Island) at latitude 83°39′54″ N, 30°37′45 ″ W. All reported islet positions are found at ocean depths from 26 m to 47 m, with no indications of shallow banks or submarine rocks at the reported positions. It is therefore concluded that all reported islets or new islands since 1978 have been stranded icebergs, likely originating from marine-terminating glaciers near Cape Morris Jesup, and stranded for up to several years in the relatively shallow and nearly permanently sea ice-covered areas around Inuit Qeqertaat.
This article offers an archival study of free improvisation and sibling practices at the London Musicians Collective (LMC) during this institution’s heyday in the 1970s and 80s. In the process, I seize upon Collective activities to scrutinize theories of music and democracy in contexts of improvisation, proposing that stylistic, ideological, and experiential fractures among LMC members — which were legion — index an adversarial mode of organizing that contrasts with sunnier depictions of improvisation and democratic self-determination. Such differences, I suggest, arose from fundamentally yet productively opposed articulations of subjectivity, which I regard as assuming feminist, posthuman, entrepreneurial, and other reflexive forms.
Among the artefacts recovered from Warwick, an English ship wrecked in Bermuda at the end of November 1619, was a small wooden navigational device. Discovered during the 2010 archaeological field season, the object was cleaned, analysed, and later conserved. It has been identified as an analogue navigational tool known as a plain scale. A novel instrument at the time, the device showed real-world applications of complex mathematical formulas for charting a course on a map. Its presence on Warwick is striking; it is believed to be the earliest known example of a plain scale in use on board an English ship sailing to the colonies. The goal of this paper is to present the artefact, provide its historical and archaeological background, and discuss the current body of research related to its purpose in resolving navigational problems.
Surface gravity waves induce a drift on objects floating on the water’s surface. This study presents laboratory experiments investigating the drift of large two-dimensional floating objects on deep-water, unidirectional, regular waves, with wave steepness ranging from 0.04 to 0.31 (0.04 $\lt k{a_w}\lt$ 0.31, where $k$ is the wavenumber and $a_w$ the wave amplitude). The objects were carefully designed to have a rectangular cross-section with a constant aspect ratio; their size varied from 2.6 $\%$ to 27 $\%$ of the incident wavelength. We observed Lagrangian behaviour for small objects. Small and large objects exhibited fundamentally different drift behaviour at high compared with low wave steepness, with a regime shift observed at a certain size and wave steepness. The scaling of object drift with steepness depends on the relative size of the object. For small objects, drift scales with steepness squared, whereas drift becomes a linear function of steepness as the object size increases. For objects that are relatively large but smaller than 13–16% of a wavelength (low to high steepness), we provide experimental evidence supporting the mechanisms of drift enhancement recently identified by Xiao et al. (J. Fluid Mech., vol. 980, 2024, p. A27) and termed the ‘diffraction-modified Stokes drift’. This enhanced drift behaviour, compared with the theoretical Stokes drift for infinitely small fluid parcels, is attributed to changes in the objects’ oscillatory motion and local wave amplitude distribution (standing wave pattern) due to the presence of the object. In the case of larger objects, similar to Harms (J. Waterw. Port Coast. Ocean Eng., vol. 113(6), 1987, pp. 606–622), we relate the critical size at which drift is maximised to their vertical bobbing motion. We determine the domain of validity for both Stokes drift and the diffraction-modified Stokes drift model of Xiao et al. (J. Fluid Mech., vol. 980, 2024, A27) in terms of relative size and wave steepness and propose an empirical parametrisation based on our experimental data.
Oncological and functional outcomes for T1-2 N0-1 (TNMv8) p16-positive oropharyngeal squamous cell carcinoma patients were analysed according to treatment: either transoral robotic surgery (TORS) (Surgery group – TORS and neck dissection ± adjuvant radiotherapy/chemoradiotherapy) or primary radiotherapy/chemoradiotherapy (Oncology group).
Methods
Single-centre retrospective observational study.
Results
The two-year disease-free survival rate was 88 per cent for the Oncology group (n = 42) and 95 per cent for the Surgery group (n = 44). The two-year overall survival rate was 98 per cent for the Oncology group and 100 per cent for the Surgery group. The functional swallowing outcome at two years post-treatment was similar in both groups. Subgroup analysis showed patients treated with surgery-only with no adjuvant treatment had the best functional outcome whilst patients treated with surgery and post-operative chemoradiotherapy had the worst functional outcome.
Conclusion
The overall oncological and functional outcomes at two years were similar in both groups. Patients treated with surgery-only had the best functional outcome without compromised oncological outcome.
Contaminated surfaces in clinics pose a pathogen transmission risk. Far ultraviolet-C light (UVC), with a favorable safety profile for human exposure, has the potential for continuous pathogen inactivation in occupied clinical areas. This study demonstrated real-world bioburden reduction on surfaces, despite frequent contamination from routine use by staff and patients in clinics.
Is Christ hypostatically united to his human nature during Holy Saturday? If so, how, given that he is (in effect) an object whose parts are in different ‘places’? In this article, I argue that God the Son does indeed remain hypostatically united to his human nature during Holy Saturday and that this is salvifically salient. One way to construe this ongoing union through somatic death is by means of the analogy of a ‘dead limb’ – Christ’s human body being that limb. I set out several ways of making sense of this claim consistent with a broadly orthodox account of the hypostatic union as a contribution to the theology of Holy Saturday and the intermediate state more broadly.
Bupropion is not licensed as an antidepressant in the UK, limiting its use. We highlight bupropion’s distinct pharmacological profile and its potential benefits in treatment-resistant depression and people experiencing selective serotonin reuptake inhibitor-induced sexual dysfunction. The National Health Service repurposing medicines programme could improve equity of access for UK patients.