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This paper focuses on the concept of delaying laminar–turbulent transition in hypersonic boundary layers by stabilising fundamental resonance (FR), a key nonlinear mechanism in which finite-amplitude Mack modes support the rapid growth of oblique perturbations. As a pioneering demonstration of this control strategy, we introduce surface heating applied exclusively during the nonlinear phase. Unlike traditional control methods that target the linear phase, the suppressive effect of surface heating on secondary instability modes during FR is evident across various Reynolds numbers, wall temperatures and fundamental frequencies, as confirmed by direct numerical simulations (DNS) and secondary instability analyses (SIA). To gain deeper insights into this control concept, an asymptotic analysis is conducted, revealing an almost linear relationship between the suppression effect and the heating intensity. The asymptotic predictions align overall with the DNS and SIA calculations. The asymptotic theory reveals that the suppression effect of FR is primarily influenced by modifications to the fundamental-mode profile, while mean-flow distortion has a comparatively modest yet opposing impact on this process. This research presents a promising approach to controlling transition considering the nonlinear evolution of boundary-layer perturbations, demonstrating advantages over conventional methods that are sensitive to frequency variations.
Idiopathic normal pressure hydrocephalus (iNPH) is characterized by gait disturbances, cognitive impairment and urinary dysfunction. Early diagnosis is essential to ensure timely shunt treatment. However, patient identification remains challenging due to limited studies, mostly from Asia and Europe, which restrict generalizability to other geographic areas. Moreover, demographic factors (age, sex, education) influence cognitive and gait performance in other neurological conditions, but their impact on iNPH remains unclear. This study aimed to characterize the demographic, vascular, cognitive and gait profiles of iNPH patients in Eastern Quebec (Canada) and determine how demographic factors influence performance outcomes.
Methods:
A retrospective chart review was conducted on 175 patients diagnosed with probable iNPH at a specialized neurology center in Eastern Quebec. Demographic data, vascular risk factors and cognitive and gait outcomes were extracted from medical records. Descriptive statistics were used to characterize the sample, and multiple linear regressions assessed the effect of demographic factors on performance outcomes.
Results:
The cohort had a mean age of 73.9 years and a mean education level of 11.9 years. Age and education significantly predicted over half of the cognitive test results, while age was the only significant predictor of gait. Hypertension (58%) and hyperlipidemia (47%) were more prevalent than diabetes (26%), differing from previous studies where diabetes was the second most reported vascular risk factor after hypertension.
Conclusions:
Clinical heterogeneity characterizes iNPH patients in Eastern Quebec. Differences in the prevalence of vascular risk factors compared to previous studies may reflect geographic variability in the clinical presentation of this condition.
This study examined whether supplementation with collagen peptides (CP) affects appetite and post-exercise energy intake in healthy active females. In this randomised, double-blind cross-over study, fifteen healthy females (23 (sd 3) years) consumed 15 g/d of CP or a taste matched non-energy control (CON) for 7 d. On day 7, participants cycled for 45 min at ∼55 % Wmax, before consuming the final supplement. Sixty-min post supplementation an ad libitum meal was provided, and energy intake recorded. Subjective appetite sensations were measured daily for 6 d (pre- and 30 min post-supplement) and pre (0 min) to 280 min post-exercise on day 7. Blood glucose and hormone concentrations (total ghrelin, glucagon-like peptide-1 (GLP-1), and peptide YY (PYY), cholecystokinin (CCK), dipeptidyl peptidase-4 (sDPP-4), leptin, and insulin) were measured fasted at baseline (day 0), then pre-breakfast (0 min), post-exercise (100 min), post-supplement (115, 130, 145, 160 min) and post-meal (220, 280 min) on day 7. Ad libitum energy intake was ∼10 % (∼41 kcal) lower in the CP trial (P = 0·037). There was no difference in gastrointestinal symptoms or subjective appetite sensations throughout the trial (P ≥ 0·412). Total plasma GLP-1 (AUC, CON: 6369 (sd 2330); CP: 9064 (sd 3021) pmol/l; P < 0·001) and insulin (+80 % at peak) were higher after CP (P < 0·001). Plasma ghrelin and leptin were lower in CP (condition effect; P ≤ 0·032). PYY, CCK and glucose were not different between CP and placebo (P ≥ 0·100). CP supplementation following exercise increased GLP-1 and insulin concentrations and reduced ad libitum energy intake at a subsequent meal in physically active females.
We analyze the effects of limited investor attention on the stock market reaction to innovation announcements and develop a new measure of patents’ economic value. We hypothesize that, when some investors pay delayed attention to innovation announcements, there will be a post-announcement drift in addition to the announcement effect, with the former decreasing and the latter increasing in investor attention. Using media coverage and abnormal Google search volume as investor attention proxies, we find consistent evidence. Our new attention-weighted measure of patents’ economic value has greater predictive power for future firm performance than measures based on the announcement effect alone.
In this article, we study the Johnson homomorphisms of basis-conjugating automorphism groups of free groups. We construct obstructions for the surjectivity of the Johnson homomorphisms. By using it, we determine their cokernels of degree up to four and give further observations for degree greater than four. As applications, we give the affirmative answer to the Andreadakis problem for the basis-conjugating automorphism groups of free groups at degree four. Moreover, we calculate twisted first cohomology groups of the braid-permutation automorphism groups of free groups.
This study explores the relationships between board internationalization, board size, and strategic change of firms from emerging markets. Building upon resource dependency theory (RDT), this study proposes that board internationalization has a positive impact on strategic change. A higher level of nationality heterogeneity on the board of directors, an organization receives more diverse perspectives and experiences from foreign directors. This, in turn, influences firms to identify areas of improvement and engage in strategic change. In addition, conventional wisdom suggests that board size per se has a negative relationship with strategic change. However, this study proposes that large board sizes together with board internationalization can foster strategic change. In other words, board size and board internationalization can jointly counteract the inertial nature of a large board, resulting in strategic change. The analyses of 255 publicly listed firms from nine emerging countries for the 2013–2018 financial years confirm these predictions.
This paper tests for the cyclical implications of the external constraint in Argentina from 1930 to 2018, and investigates the responses of GDP, real wages, trade balance, and external debt to external trade shocks using a recursive vector-autoregressive model. Moreover, considering the shift in development strategy in 1976, marked by the transition from state-led industrialization to deregulation and trade openness, changes in external vulnerability are analyzed.
Results confirm a trade balance bottleneck hindering future growth, and that external debt fails to spur short-term growth or improve the purchasing power of the population, thereby confirming the vicious cyclical dynamics of stop-and-go and go-and-crash for the entire period. Also, real external vulnerability grew significantly after 1976, as evidenced by the fact that the cumulative impact of movements in the terms of trade and external demand rose from explaining 30% to 43% of GDP variation.
where $(m_0, m_1, \ldots , m_v) \in \mathbb {N}^{v+1}$, $m_0 = \sum _{i=1}^{v} m_i$ and $v \ge 2$, we estimate lower and upper bounds of the supremum of the Hausdorff dimension of sets on the real line that uniformly avoid nontrivial zeros of any f in $\mathcal {G}$.
People from different ethnic minorities in the UK are experiencing a steeper increase in dementia diagnosis compared to their white counterparts but are more likely to have a higher risk of dementia, to be diagnosed at a younger age and to die earlier from the condition. These disparities suggest the need for urgent interventions to prevent and reduce dementia risk. Despite the significant presence of Chinese people in the UK, there has been little dementia research involving them, so this study is the first in the UK to focus on Chinese communities living in five major cities. Using a cultural adaptation theoretical framework, we adapted Alzheimer’s Research UK’s virtual dementia prevention campaign Think Brain Health to meet the needs of Chinese people. We used a mixed methods approach to evaluate knowledge of dementia and brain health activities, and intention regarding help-seeking. We performed descriptive, chi-square and thematic analysis; 54 Chinese people completed the intervention, with 85 per cent aged over 60 years. Over half (56%) could not speak, read or write in English. Our results showed significant improvements in knowledge of dementia and brain health, and an improved intention to seek help and information. All participants reported a positive experience of the culturally tailored intervention and valued working with dementia researchers who were able to deliver the intervention in Chinese languages. Future work involving Chinese communities in the UK will need to identify an appropriate but non-stigmatizing Chinese term for dementia.
Recently, former colonial powers in the Global North have begun addressing their colonial pasts through their foreign policies. Some of these states pursue a feminist foreign policy (FFP). However, to date, only one FFP makes explicit mention of colonial legacies: that of Germany, adopted in 2021. How does German FFP discourse address this and what political work does this do? Contributing to critiques of coloniality in FFP, we analyze the discursive representation of Germany’s colonial past in foreign policy texts since 2021. Drawing on the socio-critical concepts theater of reconciliation by Max Czollek and remembrance superiority by Mohamed Amjahid, we find that the discourse powerfully establishes gendered notions of caring, responsible, and reflexive German statehood. This organizes how Germany’s engagement with its colonial past is told and which forms of engagement with former colonies are rendered intelligible. We argue that German FFP erases colonial structures that permeate German foreign policy and reproduces coloniality through discursive representations.
Anesthesiologists are broadly trained members of the health care workforce, managing patients daily using advanced stabilization/resuscitative techniques. They work in a collaborative, team-based model and lead multidisciplinary teams. Their work includes prioritizing patients according to the complexities of their disease presentations, and threats to life and limb. Trauma care is a regular part of the anesthesiologist’s job. The presence of anesthesiologists is required in hospitals to achieve the designation “level 1” trauma center. Anesthesiology is a specialty known for promoting safe practice principles and improving quality of care, utilizing crisis resource management and implementing cognitive aids. Despite these skillsets, anesthesiologists are generally overlooked in disaster preparedness. The number of trained anesthesiologists is similar to that of emergency medicine physicians, and they are nearly twice as abundant as general surgeons. In countries outside the US, anesthesiologists are often included in the pre-hospital team.
The purpose of this article is to emphasize the skillsets of anesthesiologists and to advocate for their inclusion in disaster preparedness teams. Due to their presence and comfort throughout the hospital system, broad training in emergent and elective cases, resuscitation skills, procedural skills, communication skills, daily triage, and team management, anesthesiologists should be considered essential leaders during mass casualty incident preparation and response.
In a combined experimental and numerical effort, we investigate the generation and reduction of airfoil tonal noise. The means of noise control are streak generators in the form of cylindrical roughness elements. These elements are placed periodically along the span of the airfoil at the mid-chord streamwise position. Experiments are performed for a wide range of Reynolds numbers and angles of attack in a companion work (Alva et al., AIAA Aviation Forum, 2023). In the present work, we concentrate on numerical investigations for a further investigation of selected cases. We have performed wall-resolved large-eddy simulations for a NACA 0012 airfoil at zero angle of attack and Mach 0.3. Two Reynolds numbers (${0.8\times 10^{5}}$ and ${1.0 \times 10^{5}}$) have been investigated, showing acoustic results consistent with experiments at the same Reynolds but lower Mach numbers. Roughness elements attenuate tones in the acoustic field and, for the higher Reynolds number, suppress them. Through Fourier decomposition and spectral proper orthogonal decomposition analysis of streamwise velocity data, dominating structures have been identified. Further, the coupling between the structures generated by the surface roughness and the instability modes (Kelvin–Helmholtz) of the shear layer has been identified through stability analysis, suggesting stabilisation mechanisms by which the sound generation by the airfoil is reduced by the roughness elements.