Quercetin, a vital flavonoid found in many medicinal plants, has shown anti-inflammatory, anti-cancerous, anti-aging, anti-tumour, anti-viral, anti-fungal, anti-bacterial, anti-obesity, anti-diabetic, and anti-protozoal activity. However, very little is known of its anthelmintic activity; there is no literature against tapeworm infection so far. The present study was performed to expose its cestocidal role by using the zoonotic tapeworm Hymenolepis diminuta as a parasite model. The parasite was exposed to different concentrations of 0.125, 0.25, 0.5, 1, 2.5, 5, 10, 20, and 40 mg/mL Quercetin prepared in RPMI 1640, with 1% Tween 20. Another set of parasites was treated with a standard dose of Praziquantel (0.001 mg/ml), and another set of parasites was kept as control. All experiments were maintained at 37°C ± 1°C in the incubator. Quercetin activity was assessed through viability test, and time of motility was observed through paralysis. After the experiment, worms were processed for light and electron microscopic analysis to observe the post-treatment effect on their tegument. Dose-dependent efficacy was observed in all the treatments. Time of paralysis and time of mortality for 20 mg/mL Quercetin dose was 1.40±0.03h and 2.35±0.03h, respectively, which is at par with the drug Praziquantel. Histological study showed constrictions in the tegument, while extensive damage in suckers and neck region with deformed and shrunken proglottids, sloughed-off microtriches and undistinguished nucleus with loss of envelope architecture were observed in treated parasites under electron microscopic studies, which indicates the negative activity of Quercetin on the parasite thus suggesting its cestocidal activity.

The new mineral tarutinoite, ideally Ag3Pb7Bi7S19, was found in a fragment of a drill core extracted at the 178.5 m level of borehole #4604 at the Tarutinskoe (Tarutino) copper-skarn deposit, Chelyabinsk Oblast, Southern Urals, Russia. It occurs as anhedral grains up to 0.10 × 0.05 mm intergrown with hessite and galena in magnetite and calcite. Tarutinoite is grey, opaque with metallic lustre, brittle tenacity and uneven fracture. No cleavage and parting are observed. The Vickers’ micro-indentation hardness (VHN, 25 g load) is 178 kg/mm2 (range 165–194, n = 4), corresponding to a Mohs’ hardness of 3.5–4, and calculated density is 7.180 g/cm3. In reflected light, tarutinoite is greyish-white, very weakly bireflectant and non-pleochroic. Under crossed polarisers the new mineral exhibits moderate anisotropy, in grey and dark grey tones with bluish tints. The reflectance values for wavelengths recommended by the Commission on Ore Mineralogy of the International Mineralogical Association are (Rmin/Rmax, %): 45.5/47.9 (470 nm), 43.5/45.0 (546 nm), 43.3/44.1 (589 nm) and 41.8/42.5 (650 nm). The chemical composition (wt.%, electron microprobe data, mean of 7 spot analyses) is Cu 0.30, Ag 8.33, Cd 0.04, Pb 37.12, Bi 37.52, S 15.15, Se 0.40, Te 0.66, total 99.52. The empirical formula calculated on the basis of 36 atoms per formula unit is (Ag3.01Cu0.18)Σ3.19(Pb6.98Cd0.01)Σ6.99Bi7.00(S18.42Se0.20Te0.20)Σ18.82. Tarutinoite is monoclinic, space group C2/m, with a = 13.5447(12), b = 4.1027(3), c = 32.481(4) Å, β = 96.433(9)°, V = 1793.6(3) Å3 and Z = 2. The strongest lines of the powder X-ray diffraction pattern [d, Å (I, %) (hkl)] are: 16.15 (48) (0 0 2), 3.407 (69) (1 1 –5), 3.328 (95) (2 0 –9), 3.042 (65) (2 0 –10), 2.941 (100) (3 1 2), 2.910 (55) (3 1 –4), 2.053 (44) (0 2 0). The crystal structure of tarutinoite was refined to R1 = 0.1349 for 2024 reflections with Fo > 4σ(Fo) and 84 refined parameters. The new mineral is the first 7,8L member of the lillianite homologous series. It is named after its type locality.

In public life, the problem of civility is often presented as a choice over whether citizens should recover social norms of civility to sustain politics in the face of polarization or else contest demands for civility to politicize social inequalities. Political theorists often respond by treating this as an epistemological problem requiring conceptual clarification. By distinguishing between civility as politeness and civility as public-mindedness, for instance, they promise to clarify when it is appropriate to conform to social norms and when it might be morally permissible to be rude or disrespectful. While valid in its own terms, such an approach presupposes an impoverished conception of both the subject and the politics of civility. Rather than ask when and why we should choose to be civil (or not), in this article we ask: what is produced when citizens are civil or uncivil within a given situation? We consider this by turning to two feminist interlocutors: Anna Julia Cooper and Hannah Gadsby. Engaging with their reflections on and interventions within situations in which civility rises to the level of explicit attention provides the basis for a more adequate understanding of the subject of civility. Cooper and Gadsby each highlight how the subject does not simply choose whether to conform to social norms but is both constituted by the situation within which they act while also constituting the situation of which they are a part. This opens the way to a more adequate understanding of the politics of civility. As an embodied negotiation of social norms and political principles, Cooper and Gadsby show how this involves reading situations, expanding situations to interpellate others, and disclosing the limits of a situation.

Many Americans express a mix of conservative and liberal views across issues. Prior research indicates these voters are cross-pressured. A recent, influential article “Moderates” (Fowler et al. 2023) argues that these voters instead largely have centrist views on individual issues. To reach this conclusion, “Moderates” develops a method to determine which voters’ views are well-summarized by liberal-conservative ideology. “Moderates” finds that most voters’ views are. It therefore concludes that the large number of such voters with centrist estimated ideologies—“moderates”—must hold centrist views on issues. We show that this method systematically overstates how many voters’ views are well-summarized by liberal-conservative ideology: it assumes voters’ views are unless they either answer questions randomly or form a single cluster with distinctive views. In simulations, we show this problem is large. The article’s core conclusion that many voters who express a mix of conservative and liberal views can be inferred to support centrist policies therefore remains in doubt.

Let X be a smooth projective variety defined over a number field K. We give an upper bound for the generalised greatest common divisor of a point $x\in X$ with respect to an irreducible subvariety $Y\subseteq X$ also defined over K. To prove the result, we establish a rather uniform Riemann–Roch-type inequality.

Conducting elite interviews presents well-documented challenges, often linked to dynamics that are influenced by researchers’ status. This aspect of positionality is sometimes characterized as “insider” or “outsider” status, but scholars have noted the lack of nuance in this rigid binary. Drawing on experiences during interviews with policy elites—primarily in England—this article describes the author’s “in-betweener” status and reviews four methodological considerations from this perspective, highlighting the challenges and opportunities associated with different points on the insider–outsider spectrum. These observations are meant to stimulate reflexivity among researchers regardless of their status.

This note seeks to bring awareness to the wide variety of archival documents available for research in urban history in Kumase, Ghana’s second city and capital of the historic Asante Kingdom. We draw mainly on our experiences researching the history of Jackson Park, one of colonial Kumase’s earliest public parks.

Much scholarly attention has been paid to how great powers have used development finance as a tool for projecting power and shaping the international order, with less given to how smaller countries navigate these dynamics. This article investigates the conditions under which Latin American countries borrow from institutions led by the declining hegemon, the United States, or the rising power, China. Specifically, it uses mixed methods to analyze 518 loans from the World Bank and Chinese banks, and interviews with policymakers in Ecuador to highlight the mechanisms of decisions, outline interactions between different factors, and identify factors that cannot be readily tested statistically. Results show that countries are diversifying their development finance between the two great powers, motivated by domestic political considerations such as party ideology and economic development priorities, as well as by international structures including the balance of power and the borrowing country’s foreign policy alignment with the United States.

To manage anaerobic digestion residues (digestate) sustainably, it is important to determine their agricultural properties. In the present study, the effects of two digestate fractions (solid and liquid) on processing tomato yield parameters, quality traits, health-related compounds and some fruit physiological disorders were evaluated. The solid and liquid digestate fractions were compared with chemically fertilized and unfertilized control to evaluate the potential of the digestate as a fertilizer. A 2-year experiment was conducted in a randomized complete block design, with three replications and using two tomato varieties: cv. ‘Arte F1’ and cv. ‘Zeplin F1’. The results indicated that (1) compared with chemical fertilizer, the solid digestate produced equal or even better results in terms of fruit size, yield parameters (solid digestate treatment increased the total fruit weight per plant by an average of 30.7, 8.2 and 22.4% in 2019 and 25.3, 14.2 and 17.9% in 2022 compared with control, chemical fertilizer and liquid treatments, respectively) and percentage of fruit affected by sunscald and blossom-end rot in both years; (2) use of liquid digestate led to similar or significantly higher fruit size, yield parameters and percentage of fruit affected by sunscald and blossom-end rot than control in both years and (3) use of both solid and liquid digestate fractions significantly maintained or improved fruit quality in terms of colour traits, pericarp thickness, dry matter content, total soluble solid content, titratable acidity, pH, vitamin C and antioxidant activity. However, the effects of solid and liquid digestate fractions varied with year and variety.

The study analyses in situ CO2 mole fraction, 14CO2, and fossil based excess CO2 mole fraction (Cfoss) data at Hegyhátsál (HUN) rural monitoring station (Central Europe) supplemented by passive monitoring of 14C content of tree-rings. Through the observed period (2014–2020) we focused on revealing trends in atmospheric CO2 and 14C levels, particularly during the year of the first COVID lockdown, in comparison to the preceding five years. In addition, monthly integrated samples of atmospheric CO2 and tree-rings from the six years were subjected to 14C analysis. The passive tree-ring measurements focuses on two major urban areas (Budapest and Debrecen) in Hungary, along with the rural monitoring site. Results show a steady increase in CO2 levels at HUN between 2014 and 2020. The calculated fossil based excess CO2 concentrations for the initial year of COVID are in good agreement with the previous five-year averages both at 115 m and 10 m elevations. These results also show seasonal variations of CO2 mole fractions, peaking in winter and decreasing in summer. Tree-ring results from Debrecen show a good alignment with the results of the atmospheric monitoring station, and it does not show a significant fossil contribution in the urban background area during the vegetation periods. Tree-ring results from Budapest show a stronger fossil contribution compared to the Debrecen ones. Our atmospheric CO2 results do not show a large decrease in fossil CO2 atmospheric contribution during the first lockdown. We found that the use of this passive CO2 monitoring technique can provide a valuable tool for investigating such differences.

Extreme weather events caused by climate change, such as drought and heavy rainfall, will further increase in Central Europe in the near future. Resilient crop production requires in-depth knowledge of soil moisture (SM), its spatial and temporal variability and the dynamics of agriculturally used land. In the current study, different SM estimation methods, including measurement and simulation-based methods, were evaluated over a 17-ha experimental arable crop field with respect to their abilities to capture the spatial and temporal SM dynamics of within-field areas and their related uncertainty and spatial representativeness. The high-spatial resolution in-situ topsoil moisture measurements (50 m grid) were compared with the estimated SM from satellite-based remote sensing (S1ASCAT) and the simulated SM from three different crop water balance models (Agricultural Risk Information System [ARIS], AquaCrop and DSSAT). The evaluation revealed that the spatial variability in the experimental field obtained from the reference could not be captured by the alternative methods investigated because of the limitations of the grid size-related soil map information. Nevertheless, the analysis revealed a very good temporal correlation of SM dynamics with the field area average across all approaches, with AquaCrop and ARIS at a soil depth of 0–10 cm and S1ASCAT soil–water index 05 achieving a R2 and a Kling–Gupta efficiency >0.80. These results indicate the added value of complementary methods for estimating SM to reduce spatial and temporal uncertainties in the estimated topsoil water content.

A decade ago, it seemed that America’s punitive system of mass incarceration was on the precipice of a transformation, stimulated by a legitimacy crisis as great as any in a century. A decade later, far more modest steps toward reform have been accomplished, and mass incarceration in the United States has proven stubbornly resilient. While overall imprisonment rates are modestly lower, there is little evidence of improving prison conditions or a fundamental reorientation of the use of prolonged incarceration. This prompts a deeply historical question, to which answers, of necessity, must be speculative. What makes the carceral state so resilient, not just in recent decades but also across centuries? Following recent law and society scholars, who have brought together the literature on the historical political-economy of punishment with new institutionalist accounts of the role of myth and ceremony in formal organizations and the bureaucratization of modern societies, this article identifies five “legal-rational myths” about crime and punishment that have perennially delayed a reckoning with its lack of alignment with central public values like respect for human dignity and racial justice. The article turns to California as the epicenter of this most recent legitimacy crisis to chart how myths work to bolster the carceral state against efforts to shrink or abolish it.

Bringing critical race theory and settler colonial theory to bear on legal mobilization scholarship, this article examines the ongoing campaign to strike down the 1978 Indian Child Welfare Act (ICWA). ICWA sought to end the forced removal of American Indian children from their tribes. If successful, the challenges to ICWA’s constitutionality stand to undermine tribal sovereignty writ large. Drawing on a content analysis of documents from 17 major court cases (2013–2023) and a unique dataset of public-facing documents from the leading ICWA challengers, I interrogate the argumentative architecture of this legal mobilization. I find that the campaign to strike down ICWA is structured around three ideological maneuvers: erasure, settler normativity, and reclassification. These maneuvers scaffold a fourth – colorblindness – and the claim that ICWA is an unconstitutional race-based statute. I show how ICWA adversaries use these ideological maneuvers to legitimate white possession of Indigenous children and delegitimize tribal sovereignty. While existing work tends to treat colorblind racism and settler colonialism as analytically distinct, these findings shed light on the linkages between the two. They also marshal empirical analysis to illustrate how the embeddedness of settler colonialism and racism in the law enables broad claims to and defense of whiteness as property.

This study examines the representation of Jamaican Creole and cultural stereotypes about Jamaicans in the BBC Three sketch Jamaican Countdown, produced for the British show Famalam. The parody, which sharply contrasts with the original intellectual and orderly game show Countdown, employs features of Jamaican Creole for comedic effect. However, it has faced criticism for reinforcing cultural stereotypes about Jamaicans. This article focuses on the linguistic features – phonetic, morphosyntactic and lexical – used in the sketch. Through qualitative methods, it examines these features and investigates how linguistic and visual elements contribute to the portrayal of cultural stereotypes. The results show that Jamaican Countdown introduces complex indexical relationships by enriching the portrayal of Jamaicans in popular culture but also perpetuating stereotypes. The sketch contrasts the original British game show’s formality with a sexualized, unruly Jamaican parody, which exhibits various semiotic resources to both parody and reinforce cultural stereotypes.

This commentary responds to Carona & Atanázio's discussion of Sylvia Plath's novel The Bell Jar in this issue of BJPsych Advances. Although I agree with their emphasis on empathy and sensitivity in medical practice, I argue that they overlook the broader insights of the medical humanities. By examining themes of suicide and patriarchy in The Bell Jar, I highlight how the novel itself, and the humanities scholars who have studied it, provide a counternarrative to the biomedical model, urging a more holistic understanding of psychological distress. I advocate engaging with Plath's work beyond diagnostic criteria, appreciating its cultural and structural dimensions.

Let $(X, \Delta )$ be a klt threefold pair with nef anti-log canonical divisor $-(K_X+\Delta )$. We show that $\kappa (X, -(K_X+\Delta ))\geq 0$. To do so, we prove a more general equivariant non-vanishing result for anti-log canonical bundles, which is valid in any dimension.