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Community biology labs are locally organized spaces for research, tinkering and innovation, which are important for improving the accessibility of biological research and the transferability of scientific knowledge. These labs promote citizen science by providing resources and education to community members. For community labs to deliver consistent and reliable results, they would ideally be based on an adaptive and robust foundation: an Enterprise Systems Thinking (EST) framework. This paper follows a descriptive methodology to apply EST to conceptualize the optimal functioning of community biology labs. EST approaches can increase the overall understanding of the community lab system’s context and performance. This supportive tool can aid in successful stakeholder engagement and communications within the lab’s complex structure. It is also adaptive and can be adjusted as Community Bio labs expand in scale and are newly introduced to local communities. The result of this paper is the development of a framework that may help enhance existing community laboratory organizational approaches so that they may provide consistent accessibility, innovation and education to local communities.
Comics are one of the paradigmatic forms of hybrid media, and coming up with a satisfactory definition for it has been difficult. Cowling, S. & Wesley D. C. (2022) take a functional approach and offer an Intentional Picture-Reading View which defines comics as something that is “aptly intended to be picture-read.” I show that the view is extensionally inadequate as is because formally ambitious prose and concrete poetry, too, are aptly intended to be picture-read. The way forward, I argue, is to look at more medium-specific non-depictive images (such as speech balloons and panels) to set comics apart from other hybrid media.
Edited by
Ottavio Quirico, University of New England, University for Foreigners of Perugia and Australian National University, Canberra,Walter Baber, California State University, Long Beach
We propose an unsupervised, corpus-independent method to extract keywords from a single text. It is based on the spatial distribution of words and the response of this distribution to a random permutation of words. Our method has three advantages over existing unsupervised methods (such as YAKE). First, it is significantly more effective at extracting keywords from long texts in terms of precision and recall. Second, it allows inference of two types of keywords: local and global. Third, it extracts basic topics from texts. Additionally, our method is language-independent and applies to short texts. The results are obtained via human annotators with previous knowledge of texts from our database of classical literary works. The agreement between annotators is moderate to substantial. Our results are supported via human-independent arguments based on the average length of extracted content words and on the average number of nouns in extracted words. We discuss relations of keywords with higher-order textual features and reveal a connection between keywords and chapter divisions.
The chapter discusses constitutional rules on political and electoral systems and political parties. While constitutions in Anglophone African countries are maximalist, Francophone Africa countries tend to be constitutionally minimalist on electoral and political party regulation, leaving key aspects of electoral systems for presidents, legislature and election management bodies to statutory regulation, which has led to instances of controversial and regressive reforms. Despite the differences, however, the relevant constitutional rules have remained relatively stable, and democratic backsliding often happens through irregular processes and legal reform, rarely through constitutional change, except presidential term limits. Fundamentally, the chapter argues that the winner-takes-all nature of politics constitutes the principal scourge of democratization in Africa, incentivizing attempts to manipulate and violate electoral and party rules. Accordingly, to enable progress in constitutional democracy, ensure stability of the rules of the game, and preclude abusive changes, constitution makers should recognize the manifestations of and tackle winner-takes-all politics, including through the recognition and empowerment of opposition groups.
Ministry of Health (MOH) Malaysia stakeholders seek primary care access to sodium-glucose cotransporter 2 inhibitor (SGLT2i). Addressing this required a complex decision, selecting among three SGLT2i for two different indications and two practice settings. The options include expanding the existing SGLT2i (empagliflozin) in the MOH Medicines Formulary to primary care and/or having dapagliflozin and/or luseogliflozin as alternatives. This study aimed to conduct a multiple health technology assessment (HTA) to determine the SGLT2i of choice for the MOH setting.
Methods
The clinical benefits of SGLT2i were assessed through a systematic literature review and affordability was assessed through the development of three budget impact analysis models simulating seventy scenarios. Each model varied by prescribing indications, restrictions, and SGLT2i involved (M1: glycemic control, HbA1c between 6.5 percent and 10 percent, empagliflozin–dapagliflozin–luseogliflozin; M2: cardiovascular benefits, HbA1c less than 10 percent, empagliflozin-dapagliflozin; M3: a composite of M1 and M2). The outcome of the HTA was presented to the MOH decision-makers.
Results
Although there was no significant difference in glycemic control between the SGLT2i, differences exist in cardiovascular benefits conferred. Despite having scenarios with lower net budget impact (NBI) in the M1, M2, and M3 models, decision-makers decided to expand empagliflozin use to primary care setting and add dapagliflozin for hospital-only setting for both indications [NBI of $4.38 mil] due to empagliflozin’s advantage in reducing risk for cardiovascular death and prior experience of its use in MOH.
Conclusions
The multiple HTA approach guided the complex decision-making process by providing a holistic understanding of the decision’s impact.
Early worsening of plasma lipid levels (EWL; ≥5% change after 1 month) induced by at-risk psychotropic treatments predicts considerable exacerbation of plasma lipid levels and/or dyslipidaemia development in the longer term.
Aims
We aimed to determine which clinical and genetic risk factors could predict EWL.
Method
Predictive values of baseline clinical characteristics and dyslipidaemia-associated single nucleotide polymorphisms (SNPs) on EWL were evaluated in a discovery sample (n = 177) and replicated in two samples from the same cohort (PsyMetab; n1 = 176; n2 = 86).
Results
Low baseline levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C) and triglycerides, and high baseline levels of high-density lipoprotein cholesterol (HDL-C), were risk factors for early increase in total cholesterol (P = 0.002), LDL-C (P = 0.02) and triglycerides (P = 0.0006), and early decrease in HDL-C (P = 0.04). Adding genetic parameters (n = 17, 18, 19 and 16 SNPs for total cholesterol, LDL-C, HDL-C and triglycerides, respectively) improved areas under the curve for early worsening of total cholesterol (from 0.66 to 0.91), LDL-C (from 0.62 to 0.87), triglycerides (from 0.73 to 0.92) and HDL-C (from 0.69 to 0.89) (P ≤ 0.00003 in discovery sample). The additive value of genetics to predict early worsening of LDL-C levels was confirmed in two replication samples (P ≤ 0.004). In the combined sample (n ≥ 203), adding genetics improved the prediction of new-onset dyslipidaemia for total cholesterol, LDL-C and HDL-C (P ≤ 0.04).
Conclusions
Clinical and genetic factors contributed to the prediction of EWL and new-onset dyslipidaemia in three samples of patients who started at-risk psychotropic treatments. Future larger studies should be conducted to refine SNP estimates to be integrated into clinically applicable predictive models.
Trade secrets raise three primary issues. First, if an entity is forced to share trade secrets to expedite development and to expand the supply of needed products, must or should the government compensate the rights holder? Although this chapter addresses this question, it is largely unnecessary to answer it. This is because compensation is not required under international law, and because reasonable compensation should normally be provided for compelled trade secret sharing. Second, does international law prohibit governments from compelling the sharing of trade secrets, including by compulsory licensing? The short answer is no. Third, what authorities currently exist or could be adopted for governments to compel the sharing of trade secrets? The chapter provides general overview of a range of existing authorities, as well as a framework for addressing the latter two questions and for understanding the complexity of the first question.
Navigating the complexities of language diversity is a central challenge in developing robust natural language processing systems, especially in specialized domains like banking. The Moroccan Dialect of Arabic (Darija) serves as a common language that blends cultural complexities, historical impacts, and regional differences, which presents unique challenges for language models due to its divergence from Modern Standard Arabic and influence from French, Spanish, and Tamazight. To tackle these challenges, this paper introduces Darija Banking, a novel Darija dataset aimed at enhancing intent classification in the banking domain. DarijaBanking comprises over 1800 parallel high-quality queries in Darija, Modern Standard Arabic (MSA), English, and French, organized into 24 intent classes. We experimented various intent classification methods, including full fine-tuning of monolingual and multilingual models, zero-shot learning, retrieval-based approaches, and Large Language Model prompting. Furthermore, we propose BERTouch, a BERT-based language model fine-tuned on intent detection in Darija, which outperforms state-of-the-art models, including OpenAI’s GPT-4, achieving F1 scores of 0,98 and 0,96 on both Darija and MSA, respectively. The results provide insights into enhancing Moroccan Darija banking intent detection systems, highlighting the value of domain-specific data annotation and balancing precision and cost-effectiveness.
Edited by
Ottavio Quirico, University of New England, University for Foreigners of Perugia and Australian National University, Canberra,Walter Baber, California State University, Long Beach
This chapter maintains that the International Court of Justice (ICJ) may usefully intervene in the complex and multifaceted litigation that has developed before national and international tribunals, as well as human rights treaty bodies, concerning national climate policies adopted to implement international obligations. By considering the rationale and nature of climate litigation, the chapter seeks to point out what international law rules the ICJ should take into account (especially clarifying their existence and scope) in order to make a real contribution to national and international jurisprudence.
This chapter identifies three distinct reasons why China took a middle-of-the-road position in the debate on the COVID-19 TRIPS waiver at the WTO. It also recounts the country’s more assertive position in the run-up to the adoption of the Ministerial Decision on the waiver. Drawing eight lessons from the international debate on the waiver and the subsequent Ministerial Decision, the chapter offers insights into the future role China can or will play in future international policy debates at the intersection of intellectual property and public health, including during the next pandemic.
This article explores the potential barriers for emerging composers to constructing and maintaining a career in the field of composition in Scotland, viewed through the lens of both those early in their careers and the experience of others who have worked professionally for many years. Thirty-nine composers responded to a survey that highlighted the role of educational mentoring, the need for monetary stability and the challenges faced by female and older emerging composers. The professional lives of current Scottish composers have been seldom studied, and the purpose of this investigation is to explore, inform and provide suggestions for future consideration.
Edited by
Ottavio Quirico, University of New England, University for Foreigners of Perugia and Australian National University, Canberra,Walter Baber, California State University, Long Beach
The lawfulness of carbon border adjustment measures (CBAMs) under general international economic law and particular economic agreements is explored; specifically, if their international lawfulness can be determined by thinking of them as countermeasures necessary to implement climate change obligations. As there are no non-discriminatory obligations under customary international law, it is argued that CBAMs are lawful under general international law, but under particular international economic agreements they can be seen as countermeasures lawfully taken in response to breaching the obligation to curb GHG emissions, allowing their justification as a breach of primary non-discriminatory economic obligations, particularly the national treatment principle under the GATT and GATS. This shifts the burden of proving necessity/proportionality to the State in breach of the obligation. CBAMs are fundamentally lawful measures and can only give rise to compensation if it they are unnecessary/disproportionate. This chapter also assesses whether they can be thought of as erga omnes contractantes obligations under international economic agreements, particularly the GATT and the GATS.
Edited by
Ottavio Quirico, University of New England, University for Foreigners of Perugia and Australian National University, Canberra,Walter Baber, California State University, Long Beach
This chapter discusses the building blocks of the European Union’s strategy for climate neutrality. Carbon pricing in the EU is described, focusing on the EU ETS and on the forthcoming CBAM. Then the roles of electrification and clean molecules in the future European energy system are discussed. Finally, sustainable finance priorities, capacities, and regulatory instruments put forward by the EU are reviewed, before a brief conclusion.
Edited by
Ottavio Quirico, University of New England, University for Foreigners of Perugia and Australian National University, Canberra,Walter Baber, California State University, Long Beach
Metabolic dietary patterns, including the Empirical Dietary Index for Hyperinsulinaemia (EDIH) and Empirical Dietary Inflammatory Pattern (EDIP), are known to impact multiple chronic diseases, but the role of the colonic microbiome in mediating such relationships is poorly understood. Among 1,610 adults with faecal 16S rRNA data in the TwinsUK cohort, we identified the microbiome profiles for EDIH and EDIP (from food frequency questionnaires) cross-sectionally using elastic net regression. We assessed the association of the dietary pattern-related microbiome profile scores with circulating biomarkers in multivariable-adjusted linear regression. In addition, we used PICRUSt2 to predict biological pathways associated with the enriched microbiome profiles, and further screened pathways for associations with the dietary scores in linear regression analyses. Microbiome profile scores developed with 32 (EDIH) and 15 (EDIP) genera were associated with higher insulin and homeostatic model assessment of insulin resistance. Six genera were associated with both dietary scores: Ruminococcaceae_UCG-008, Lachnospiraceae_UCG-008, Defluviitaleaceae_UCG-011 Anaeroplasma, inversely and Negativibacillus, Streptococcus, positively. Further, pathways in fatty acid biosynthesis, sugar acid degradation, and mevalonate metabolism were associated with insulinaemic and inflammatory diets. Dietary patterns that exert metabolic effects on insulin and inflammation may influence chronic disease risk by modulating gut microbial composition and function.
Edited by
Ottavio Quirico, University of New England, University for Foreigners of Perugia and Australian National University, Canberra,Walter Baber, California State University, Long Beach
It is, by now, beyond dispute that climate change presents the single greatest environmental challenge of our times. It is equally likely that this challenge will only be met by sustained and iterative cycles of global policy formation, administrative rule-making, regulatory action, and impact assessment. The second and third of these steps, broadly speaking, constitute the process of policy implementation. While the scholarly study of policy implementation is not new, it has yet to receive serious attention in the area of climate change regulation. The reasons for this are relatively simple.
First, the policy formation stage is still ongoing. As the recent meeting of the Conference of the Parties to the United Nations Framework Convention on Climate Change (UNFCCC) in Dubai vividly demonstrates, major outstanding disagreements on the basic structure of global climate policy remain.1
Edited by
Ottavio Quirico, University of New England, University for Foreigners of Perugia and Australian National University, Canberra,Walter Baber, California State University, Long Beach
This chapter aims to inform reflection on business self-regulation (or corporate social responsibility, CSR) in addressing climate change by drawing on developments in ‘business and human rights’ and the experience accumulated in the European Union (EU). Despite dissimilarities in addressing the environmental and human right impacts of business operations, there are commonalities around incentives, impacts and regulatory dynamics of CSR that help clarify its expected place in global governance. This analysis revisits long-standing claims about CSR in light of current legal and market evolutions. The main finding is that the notion of CSR has been fundamentally transformed in the last 20 years. What is the change, what are the drivers enabling such change, and what are the expected impacts on corporate compliance and sustainability performance? The analysis contributes to the regulatory governance area, including regarding climate change, and promotes cross-fertilisation among the social and environmental areas in CSR.