In the mid-fourteenth century, the Jochid ulus went through a phase of extreme political turbulence. Following the death of the last Batuid khan Berdibek (r. 1357–1359), during the next two decades, circa 1360–1380, a high number of power contenders rose at both the central and the local levels of the ulus. This article aims to map and exemplify those attempts as part of the broader theoretical discussion concerning the scope and depth of the khanate's crisis. It does so by combining an overall, bird's-eye perspective on the political history of the ulus by zooming in on the regional history, as well as through the analysis of both written primary and numismatic sources. None of the multiple patterns of reaction to the dying-out of the Batuid lineage clearly contradicted the idea of the khanate's unity and the overarching ‘Chinggisid principle’. At this point in time, the ulus still followed the centrifugal logic of the Chinggisid rule. At the same time, the crisis of the Jochid ulus of the mid-fourteenth century indeed prepared the very ground for the power division between the still-existing branches of the Jochid family and the break-up of the Jochid power domain of the fifteenth century that followed the last unification attempt of the ulus under Toqtamïsh (r. 1380–1406).

This paper compares the views of Hegel and Schelling regarding the problem of individuation, i.e. the question of what makes an individual (a) numerically distinct from others and (b) the very individual it is. My focus is on how Hegel approaches this problem in his metaphysics and how that relates to Schelling’s views as articulated in his ‘negative philosophy’. While Hegelians like Robert Stern and Karen Ng are optimistic that Hegel can solve the problem of individuation, I argue that Schelling puts forward an objection that both challenges Hegel’s account and provides a rationale for taking seriously Schelling’s own insistence on a pre-logical dimension of being.

Proton acceleration in a near-critical-density gas driven by a light spring (LS) pulse with a helical structure in its intensity profile is investigated using three-dimensional particle-in-cell simulations. Compared with other pulse modes with the same laser power, such as the Gaussian pulse or the donut Laguerre–Gaussian (LG) pulse, the LS structure significantly enhances the peak intensity and drives a stronger longitudinal acceleration field and transverse focusing field. Both the high intensity and helical structure of the LS pulse contribute to the formation of a bubble-like structure with a fine electron column on the axis, which is critical for stable proton acceleration. Therefore, it is very promising to obtain ultra-high-energy protons using LS pulses with a relatively lower power. For example, by using LS pulses with the same power of 4.81 PW, the proton in the gas can be accelerated up to 8.7 GeV, and the witness proton can be accelerated to 10.6 GeV from 0.11 GeV, which shows the overwhelming advantage over the Gaussian and LG pulse cases.

This article presents a description of German schon and noch as nontemporal scalar focus operators. Both items operate in a scalar model of sufficiency and signal that the focus value yields a more informative proposition than all alternatives under consideration; that is, they are special cases of scalar additives. Where the two expressions differ is in the complementary perspectives they evoke. Schon relates to higher alternatives. Noch relates to lower alternatives, but brings about an inverse (i.e., antonymically ordered) scalar model. The use of schon and noch as scalar sufficiency operators is traced back to an amalgamation of two other uses of the same items. The descriptive findings contribute to the advancement of our cross-linguistic understanding of scalar focus operators and raise fundamental questions pertaining to the typological and theoretical status of scale reversal phenomena.*

Randomised controlled trials are the ‘gold standard’ approach in nutrition research to show a causal relationship between a dietary intervention and clinically relevant outcomes at the population level. Here we review why different study designs are needed to establish the efficacy of dietary interventions at the individual level and to better account for relevant factors that can also influence the outcomes. Over the past decade, precision nutrition approaches have been developed as a new way to measure the effectiveness of dietary interventions at the individual and population level. Precision nutrition aims to determine the individual factors that are associated with differences in responses to dietary interventions. This is complex, typically needing studies with a large number of participants and using advanced statistical approaches and machine-learning algorithms to identify predictors that can explain why individuals do or do not respond to consuming specific foods, meals or diets, for a given outcome. N-of-1 study designs, which are new to nutrition science, offer a robust alternative approach to assess how an intervention and everyday behaviours affect individual health outcomes. They utilise repeated measures within individuals, rather than baseline and end measures in a larger number of participants, to provide the statistical power required to determine an individual’s responsiveness to an intervention. The adoption of new study designs and modelling approaches, particularly the N-of-1 approach, to examine responses to interventions within individuals, will help to further the understanding of the relationships between diet and health within individuals more effectively and accurately.

Ecuador is a key area in South America when it comes to understanding the economic, social and archaeological aspects of pre-Hispanic cultures in the northwestern region of the Andes. Among the most complex societies to have inhabited this territory is the so-called Manteño culture (AD ∼800–1530), which spanned across most of Ecuador’s central Pacific coast. Ongoing research at the site of Ligüiqui (Manta, Manabí) has enabled us to obtain a more complete overview of the chronological sequence of the Manteño period as well as contributing further data on the advanced stage of social development reached during the period; characterized by the hierarchical arrangement of sites, the use of extensive settlement models, and semi-circular stone fish traps (corrales). In order to understand the role played by this coastal site in the complex Manteño culture, a detailed radiocarbon study was performed in the sequence of the Ligüiqui site. In addition, using a detailed review of available Manteño settlement radiocarbon data (13 sites and 64 dates), we established a chronostratigraphic framework for the culture. Our data indicate that Ligüiqui probably acted as a supply centre for marine-origin products from the twelfth century onwards with activity peaking during the Late Manteño period. A multisite comparison using Bayesian modeling indicates an early onset of the Manteño culture in Ligüiqui around AD 700, and a general demise in most of the sites AD ∼1500 or slightly before. This culture finally collapsed before AD ∼1600 during the early Spanish colonial period. Only one site, La Libertad, shows potential evidence of having remained a Manteño settlement after that date.

Persons living with dementia are at risk of becoming lost. While return discussions after missing incidents are common with children, these discussions are seldom done with persons living with dementia. Our objective was to describe the use of return discussions with persons living with dementia according to the literature and practice. We conducted a scoping review using 19 databases to locate scholarly and grey literature on return discussions, followed by 20 semi-structured interviews with first responders and service providers in Canada and the United Kingdom (UK). Eleven scholarly and 94 grey sources were included, most from the UK, related to missing children, none included persons with dementia. According to participants, although there was no standardized procedure, there were themes about conditions that facilitate return discussions. This was the first study to examine return discussion practice in dementia, and results can inform development of evidence-based protocols.

Bipolar disorder (BD) is a leading cause of disability and is linked to cognitive and functional impairment, increased mortality from cardiometabolic disorders and bipolar disorder suicide. Few studies in sub-Saharan Africa have explored cognitive dysfunction in bipolar disorder. Our study explores the cognitive characteristics in a bipolar patient cohort in Nigeria and assesses its association with clinical and demographic variables.

40 participants from the Bipolar Disorder Longitudinal Study, at baseline, were included in the pilot study of the BiDiLos-Ng. Using a cross-sectional design, cognitive function was assessed using the Screen for Cognitive Impairment in Psychiatry. Multiple linear regression models were used to explore associations between dependent and independent variables.

Cognitive impairment was present in 41% of the bipolar cohort, it was not associated with the frequency of mood episodes, and higher educational level was associated with higher verbal fluency test scores (p = 0.02). Being in employment (p = 0.03), younger age (p = 0.00), and lower YMRS score (p = 0.006) were associated with higher working memory test scores.

The presence of mania symptoms during the euthymic phase of BD was associated with cognitive impairment. Executive function and working memory were linked to better academic and occupational attainment.

Gambling has been Macau’s principal industry and a major source of income for the city for nearly 180 years. However, surprisingly little has been said about its urban impact and connections to a wider economy of vice, e.g. opium, pawnbroking and prostitution, which was consolidated in the second half of the nineteenth century mostly by the hands of a Chinese entrepreneurial elite. This article takes a novel approach to examining Macau’s early colonial development by historicizing the city’s modern economy from a different, mostly neglected urban angle. It shows that the development of vice businesses promoted the diversification of commercial activity, real estate development and the creation of public facilities, defining a type of ordinary urbanization, business-led rather than government-oriented, that affected Macau’s urban character and identity in durable ways.

This study investigated the impact of reading statements in a second language (L2) versus the first language (L1) on core knowledge confusion (CKC), superstition, and conspiracy beliefs. Previous research on the Foreign Language Effect (FLE) suggests that using an L2 elicits less intense emotional reactions, promotes rational decision-making, reduces risk aversion, causality bias and superstition alters the perception of dishonesty and crime, and increases tolerance of ambiguity. Our results do not support the expected FLE and found instead an effect of L2 proficiency: Participants with lower proficiency exhibited more CKC, were more superstitious and believed more in conspiracy theories, regardless of whether they were tested in L1 or L2. The study emphasises the importance of considering L2 proficiency when investigating the effect of language on decision-making and judgements: It—or related factors—may influence how material is judged, contributing to the FLE, or even creating an artificial effect.

In the development discourse, there has been a tendency to frame the Global South, especially Africa, as a perpetual recipient of ideas from the Global North. This has led to the implementing of “development” initiatives based on the unsuccessful modernization paradigm and the associated Washington Consensus. Despite the emergence of counter theories such as dependency and underdevelopment theories, they share similar assumptions with the modernization paradigm. These assumptions include the belief that historical change brings development or progress, the sidelining of noneconomic factors like ethnicity, race, and gender, and the sole emphasis on economic growth as a measure of development. Both models assume that the state should primarily drive advancement. To address the weaknesses of these development models, alternative perspectives such as women and development, women in development, and gender and development were introduced. However, these perspectives would be integrated into the mainstream development discourse, diluting their impact.