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For coherent systems with components and active redundancies having heterogeneous and dependent lifetimes, we prove that the lifetime of system with redundancy at component level is stochastically larger than that with redundancy at system level. In particular, in the setting of homogeneous components and redundancy lifetimes linked by an Archimedean survival copula, we develop sufficient conditions for the reversed hazard rate order, the hazard rate order and the likelihood ratio order between two system lifetimes, respectively. The present results substantially generalize some related results in the literature. Several numerical examples are presented to illustrate the findings as well.
This article presents two related arguments. First, the limits of doctrinal analysis cut deeper than many EU lawyers realise. Most would probably accept that legal doctrine does not determine every legal dispute, but lawyers studying EU institutional balance often still assume that it can be deduced from the positive law what is good institutional practice. This paper argues instead that the allocation of EU institutional authority cannot be determined by the exercise of legal judgement, but instead requires the exercise of political judgement on the relative merits of different institutions. Second, this means that political and normative discourses and disciplines cannot be assumed to fall outside the domain of legal scholarship. What we need instead is a distinctive kind of legal scholarship that interweaves doctrinal analysis with normative political theory, broadly conceived. I will argue that political theory, in addition to evaluative value, has adjudicative value, provided that our theories are sensitive to the EU’s social and political setting and the constraints this setting imposes on what is realistically feasible.
Can trust norms within the African moral system support data gathering for Generative AI (GenAI) development in African society? Recent developments in the field of large language models, such as GenAI, including models like ChatGPT and Midjourney, have identified a common issue with these GenAI models known as “AI hallucination,” which involves the presentation of misinformation as facts along with its potential downside of facilitating public distrust in AI performance. In the African context, this paper frames unsupportive data-gathering norms as a contributory factor to issues such as AI hallucination and investigates the following claims. First, this paper explores the claim that knowledge in the African context exists in both esoteric and exoteric forms, incorporating such diverse knowledge as data could imply that a GenAI tailored for Africa may have unlimited accessibility across all contexts. Second, this paper acknowledges the formidable challenge of amassing a substantial volume of data, which encompasses esoteric information, requisite for the development of a GenAI model, positing that the establishment of a foundational framework for data collection, rooted in trust norms that is culturally resonant, has the potential to engender trust dynamics between data providers and collectors. Lastly, this paper recommends that trust norms in the African context require recalibration to align with contemporary social progress, while preserving their core values, to accommodate innovative data-gathering methodologies for a GenAI tailored to the African setting. This paper contributes to how trust culture within the African context, particularly in the domain of GenAI for African society, propels the development of Afro-AI technologies.
This project developed and validated an automated pipeline for prostate treatments to accurately determine which patients could benefit from adaptive radiotherapy (ART) using synthetic CTs (sCTs) generated from on-treatment cone-beam CT (CBCT) images.
Materials and methods:
The automated pipeline converted CBCTs to sCTs utilising deep-learning, for accurate dose recalculation. Deformable image registration mapped contours from the planning CT to the sCT, with the treatment plan recalculated. A pass/fail assessment used relevant clinical goals. A fail threshold indicated ART was required. All acquired CBCTs (230 sCTs) for 31 patients (6 who had ART) were assessed for pipeline accuracy and clinical viability, comparing clinical outcomes to pipeline outcomes.
Results:
The pipeline distinguished patients requiring ART; 74·4% of sCTs for ART patients were red (failure) results, compared to 6·4% of non-ART sCTs. The receiver operator characteristic area under curve was 0·98, demonstrating high performance. The automated pipeline was statistically significantly (p < 0·05) quicker than the current clinical assessment methods (182·5s and 556·4s, respectively), and deformed contour accuracy was acceptable, with 96·6% of deformed clinical target volumes (CTVs) clinically acceptable.
Conclusion:
The automated pipeline identified patients who required ART with high accuracy while reducing time and resource requirements. This could reduce departmental workload and increase efficiency and personalisation of patient treatments. Further work aims to apply the pipeline to other treatment sites and investigate its potential for taking into account dose accumulation.
As herbicide resistance continues to render commonly used rice herbicides ineffective, alternative sites of action are paramount to maintaining yield and producer profitability. Combining a slow-release formulation and a fenclorim seed treatment might allow the safe use of S-metolachlor in rice. Experiments were initiated in 2022 and 2023 near Colt, AR, on a silt loam soil to evaluate crop safety using a capsule suspension (CS) formulation of S-metolachlor and a fenclorim seed treatment in rice. The first experiment assessed the tolerance of two cultivars (‘Diamond’ and ‘DG263L’) to three rates (0.42, 0.84, and 1.68 kg ai ha−1) of a CS S-metolachlor at a delayed preemergence (DPRE) application timing in conjunction with a fenclorim seed treatment. The second experiment evaluated a 1- to 2-leaf (EPOST) application of a CS S-metolachlor at 0.56 and 1.12 kg ai ha−1 to fenclorim-treated rice. Fenclorim reduced injury and partially protected rice yield when S-metolachlor was applied DPRE at 1.68 kg ai ha−1 in both years. However, in one year, under adverse conditions, rice yields were only 65% and 66% of the nontreated control for fenclorim-treated ‘Diamond’ and ‘DG263L’, respectively. An EPOST application of S-metolachlor at 1.12 kg ai ha−1 resulted in 44% to 51% visible injury 35 d after treatment. Relative rice yields were 88% and 89% of the nontreated weed-free treatment in 2022 and 2023, respectively. Fenclorim provided enhanced crop safety at both the 0.84 and 1.68 kg ai ha−1 rates of S-metolachlor. However, the potential for reduced yield can arise when unfavorable conditions occur soon after application. An EPOST application timing of CS S-metolachlor at 0.56 kg ai ha−1 may be a viable option in rice, but 1.12 kg ai ha−1 is too high on a silt loam soil, resulting in significant rice injury.
To assess associations between dietary fat quality indices and risk of pre-diabetes and type 2 diabetes mellitus (T2DM) among Iranian adults.
Design:
Daily intakes of fatty acids were estimated using a validated FFQ with 168 food items. Adjusted hazard ratios (HR) and 95 % CI for pre-diabetes and T2DM were calculated across tertile categories of dietary fat quality indices including the atherogenic index, thrombogenic index, health-promoting index, ratio of PUFA to SFA (PUFA:SFA) and ratio of hypo- and hypercholesterolaemia (h:H).
Setting:
Tehran Lipid and Glucose Study.
Participants:
Iranian men and women.
Results:
The mean (sd) age of the 2042 pre-diabetes-free participants in pre-diabetes analysis was 38·84 (12·97), and 55·2 % were women. In T2DM analysis, the mean (sd) age of the 2295 T2DM-free participants was 40·06 (13·42), and 54·6 % of them were women. In the crude model, the PUFA:SFA ratio was positively associated with T2DM incidence (HR = 1·43; 95 % CI 1·04, 1·98). However, after adjustment for confounding variables, there were no significant associations between dietary fat quality indices and risk of pre-diabetes and T2DM.
Conclusions:
We found no significant association between fat quality indices and risk of pre-diabetes and T2DM. Further prospective and clinical trial studies are needed to clarify the issue.
Markers of inflammation and cannabis exposure are associated with an increased risk of mental disorders. In the current study, we investigated associations between cannabis use and biomarkers of inflammation.
Methods
Utilizing a sample of 914 participants from the Avon Longitudinal Study of Parents and Children, we investigated whether interleukin-6 (IL-6), tumor necrosis factor α (TNFα), C-reactive protein (CRP), and soluble urokinase plasminogen activator receptor (suPAR) measured at age 24 were associated with past year daily cannabis use, less frequent cannabis use, and no past year cannabis use. We adjusted for a number of covariates including sociodemographic measures, body mass index, childhood trauma, and tobacco smoking. We found evidence of a strong association between daily or near daily cannabis use and suPAR.
Results
We did not find any associations between less frequent cannabis use and suPAR. We did not find evidence of an association between IL-6, TNFα or CRP, and cannabis use.
Conclusions
Our finding that frequent cannabis use is strongly associated with suPAR, a biomarker of systemic chronic inflammation implicated in neurodevelopmental and neurodegenerative processes is novel. These findings may provide valuable insights into biological mechanisms by which cannabis affects the brain and impacts the risk of serious mental disorders.
Community detection is a set of algorithms developed in network science to find meaningful sub-groups within larger groups. This article (1) outlines and evaluates the method and (2) shows how it can enrich ongoing debates about European integration. To this end, it uses the example of the approximation of laws, an enduring topic in European legal studies.
Selection of effective herbicide strategies (i.e., one-pass versus two-pass and timing [preemergence versus postemergence]) is of great importance to corn growers. Field studies were conducted to evaluate overall end-of-season weed control efficacy of multiple herbicide strategies in conventional tillage corn production systems. These studies were carried out over six site-years at four locations in Wisconsin: Arlington (2018 and 2019), Brooklyn (2019), Lancaster (2019), and Janesville (2018 and 2019). Herbicide strategy treatments included one-pass preemergence, one-pass postemergence, two-pass preemergence followed by (fb) postemergence, and two-pass preemergence fb postemergence with layered residual herbicides. The weed species present at the experimental site-years included common lambsquarters, giant foxtail, giant ragweed, velvetleaf, and waterhemp. Except Arlington-2019, the herbicide strategy was not as influential for the site-years infested with common lambsquarters, giant foxtail, velvetleaf, and waterhemp species (e.g., Arlington-2018, Brooklyn-2019, Lancaster-2019), as effective overall end-of-season control (>90%) was achieved regardless of the herbicide strategy, and no significant differences were observed in the combined weed biomass across strategies. A two-pass strategy (e.g., preemergence followed by postemergence, or preemergence followed by postemergence with layered residual herbicides) was necessary for effective overall end-of-season control at the site-years infested with giant ragweed (Janesville-2018 and -2019). Weed interference reduced corn yield by 11% to 75% across site-years. Although certain weed communities can be effectively controlled by a one-pass herbicide strategy, two-pass strategies provided the greatest and most consistent overall end-of-season weed control and corn yield across all site-years, regardless of weed species composition and environmental conditions. Hence, a two-pass herbicide strategy is recommended for conventional-tillage corn production in Wisconsin to ensure effective end-of-season weed control while protecting yield potential of the crop, particularly in fields infested with moderate to high density of troublesome weeds such as giant ragweed.
This article traces the emergence of a new type of economist in interwar France—the conjuncturist—through a study focusing on Alfred Sauvy and Robert Marjolin. We argue that these neglected figures helped to shape a new, autonomous, field of expertise that consisted of diagnosing and forecasting the economic situation to guide public decision making. As we show, the history of the conjuncturists is closely linked to that of the Popular Front in general, and to its emblematic law on the forty-hour week in particular. By becoming the most vocal opponents of this law, the conjuncturists fomented an open mutiny against the very government that had given them their first prominent position, in order to obtain the repeal of the forty-hour week, which Sauvy achieved in November 1938. Although the Popular Front was by then a thing of the past, and a future war with Germany had become the most likely outcome, the figure of the conjuncturist had succeeded in firmly occupying the institutional landscape of 1940s France—a form of economic expertise that was henceforth inseparable from political activity itself.
The China Rural Hypertension Control Project (CRHCP) is a nonphysician-led community-based hypertension intervention program that has demonstrated clear benefits in improving blood pressure (BP) control and reducing the incidence of cardiovascular disease events among hypertensive patients in rural areas of China. However, it is currently unclear whether the benefits of the CRHCP outweigh its costs, and whether promoting this project in China is justifiable from a perspective of healthcare system.
Methods
We employed a Markov model to forecast the anticipated 20-year costs and effectiveness of the CRHCP trial. Cost data for this study was gathered from public records or published papers, whereas clinical data was extracted from the CRHCP trial. Our primary outcome measure was the incremental cost-effectiveness ratio, expressed in Chinese Yuan (CNY) per quality-adjusted life-year (QALY), representing the additional cost per additional QALY gained.
Results
Over a span of 20 years, the cost for a rural hypertensive individual in China who received intensive BP intervention by a nonphysician community healthcare provider would amount to 25,129 CNY, yielding an effectiveness of 8.19 QALY. In contrast, if usual care was provided, the cost would be 26,709 CNY with an effectiveness of 7.94 QALY. The CRHCP program demonstrated lower costs and greater effectiveness for rural hypertensive individuals in China.
Conclusion
Our study indicates that the implementation of the CRHCP program among rural hypertensive individuals in China resulted in increased effectiveness and reduced costs. From the perspective of Chinese healthcare system, the CRHCP program proves to be cost-saving within the current healthcare landscape.
In Southern Africa, feed gaps towards the end of the cool–dry season are a challenge that needs addressing by the timely growth of suitable forage species. Therefore, we assessed the adaptation of the species vetch (Vicia villosa Roth) and Egyptian clover (Trifolium alexandrinum L.) with one cultivar of each. A fully irrigated experiment consisting of a factorial combination of species, sowing dates (early, late) and sites (warm and hot environments) was conducted across two separate cool–dry seasons. Data were collected at successive harvest dates (hd1, hd2 and hd3) i.e. about 50, 70 and 90 days after sowing, respectively. The accumulated aboveground biomass was affected by the effect of site × sowing date irrespective of harvest date. At hd3, aboveground biomass was further affected by the effect of site × species. Site-specific sensitivity to temperature, photoperiod and soil type influenced the vegetative development of the selected species. Early sowing compared to late sowing achieved about 60% higher biomass accumulation. The species effect was major with higher vetch biomass than clover (2943 v. 961 DM kg/ha), and (1459 v. 1066 DM kg/ha) at the warm and hot sites, respectively. Moreover, clover showed a lower DM response to irrigated water (4.7 against 13.5 kg DM/ha/mm) as compared to vetch. Thus, vetch was the better-adapted crop providing adequate biomass across harvest dates and under different environments. Adoption of these species to alleviate feed gaps is possible when irrigated; however, implementation of the genetic variability of cultivars should also be assessed.
The molecular mechanism of olfaction, namely, how we smell with limited olfactory receptors to recognize exceedingly diverse and large numbers of scents remains unknown despite the recent advances in chemistry, chemical, structural, and molecular biology. Olfactory receptors are notoriously difficult to study because they are fully embedded in the cell membrane. After decades of efforts and significant funding, there are only three olfactory receptor structures known. To understand olfaction, we carried out the structural bioinformatic study of six human olfactory receptors including OR51E1, OR51E2, OR52cs, OR1A1, OR1A2, TAAR9, and their AlphaFold3 predicted water-soluble QTY variants with odorants. We applied the QTY code to replace leucine (L) with glutamine (Q), isoleucine (I) and valine (V) with threonine (T), and phenylalanine (F) with tyrosine (Y) only in the transmembrane helices. Therefore, these QTY variants become water-soluble. We also present the superimposed structures of native olfactory receptors and their water-soluble QTY variants. The superimposed structures show remarkable similarity with RMSDs between 0.441 and 1.275 Å despite significant changes to the protein sequence of the transmembrane domains (43.03%–50.31%). We also show the differences in hydrophobicity surfaces between the native olfactory receptors and their QTY variants. Furthermore, we also used AlphaFold3 and molecular dynamics to study the odorant octanoate with OR1A2 and spermidine with TAAR9. Our bioinformatics studies provide insight into the differences between the hydrophobic helices and hydrophilic helices, and will likely further stimulate designs of water-soluble integral transmembrane proteins and other aggregated proteins.
Surface acoustic wave (SAW) resonator-based compact multi-band bandpass filters (BPFs) with quasi-elliptic transfer functions (TF) and reconfigurable reflective or quasi-reflectionless characteristics are reported. They utilize bandpass-type multi-resonant acoustic wave lumped resonator (AWLR) stages, shaped by multiple in-parallel cascaded distinct SAW resonators and one lumped-element (LE) inductor. By incorporating resistively-terminated bandstop-type AWLR stages at the Radio Frequency (RF) input/output, their power reflection response can be tailored to be quasi-reflectionless. The multi-band BPF can be expanded to TF with: i) a high number of passbands by increasing the number of the acoustic wave resonators (AWRs) in the AWLR stages, and ii) higher selectivity by cascading bandpass-type AWLRs stages using impedance inverters, and iii) symmetric quasi-reflectionless characteristics. For N in-series cascaded stages, each comprising K distinct AWRs, K passbands with enhanced fractional bandwidth (FBW) can be created, with overall TF having N•(K) poles and N•(K+1) transmission zeros (TZs). The operating principles of the multi-band BPF concept are provided through detailed design examples. The concept is demonstrated through detailed design examples, with three multi-band BPF prototypes manufactured and characterized, exhibiting dual-/triple-band centered between 1029.8 and 1039.9 MHz, FBWs> 0.4kt2, and effective Q-factors> 5,000. The quasi-reflectionless prototype showed a maximum reflection of -11.5 dB.
Accumulating evidence suggests that rapid eye movement sleep (REM) supports the consolidation of extinction memory. REM is disrupted in posttraumatic stress disorder (PTSD), and REM abnormalities after traumatic events increase the risk of developing PTSD. Therefore, it was hypothesized that abnormal REM in trauma-exposed individuals may pave the way for PTSD by interfering with the processing of extinction memory. In addition, PTSD patients display reduced vagal activity. Vagal activity contributes to the strengthening of memories, including fear extinction memory, and recent studies show that the role of vagus in memory processing extends to memory consolidation during sleep. Therefore, it is plausible that reduced vagal activity during sleep in trauma-exposed individuals may be an additional mechanism that impairs extinction memory consolidation. However, to date, the contribution of sleep vagal activity to the consolidation of extinction memory or any emotional memory has not been investigated.
Methods
Trauma-exposed individuals (n = 113) underwent a 2-day fear conditioning and extinction protocol. Conditioning and extinction learning phases were followed by extinction recall 24 h later. The association of extinction recall with REM characteristics and REM vagal activity (indexed as heart rate variability) during the intervening consolidation night was examined.
Results
Consistent with our hypotheses, REM disruption was associated with poorer physiological and explicit extinction memory. Furthermore, higher vagal activity during REM was associated with better explicit extinction memory, and physiological extinction memory in males.
Conclusions
These findings support the notion that abnormal REM, including reduced REM vagal activity, may contribute to PTSD by impairing the consolidation of extinction memory.
Seventeen putative resistant late watergrass populations [Echinochloa phyllopogon (Stapf.) Koso-Pol.; syn.: Echinochloa oryzicola (Vasinger) Vasinger] originating from rice (Oryza sativa L.) monoculture fields in northern Greece were examined for possible evolution of multiple resistance to acetolactate synthase (ALS) and acetyl-CoA carboxylase (ACCase) inhibitors and auxin herbicides in rate–response pot assays. Most of the populations were highly cross-resistant to the ALS-inhibiting herbicides bispyribac-Na, imazamox, penoxsulam, and nicosulfuron + rimsulfuron, whereas three of them were also multiple resistant to both ALS and the auxin mimic quinclorac. In addition, two E. phyllopogon populations were found to be multiple resistant to the ALS and ACCase inhibitors cycloxydim, cyhalofop-butyl, profoxydim, and quizalofop-P-ethyl. Amplification and sequencing of the ACCase gene fragment from eight surviving profoxydim-treated plants of the two multiple-resistant E. phyllopogon populations to ALS- and ACCase-inhibiting herbicides, revealed an Ile to Leu substitution at codon 1781 of the ACCase enzyme. However, amplification and sequencing of the ALS gene fragment in the same E. phyllopogon plants sequenced for ACCase revealed a Trp to Leu substitution at codon 574 of the ALS enzyme in three out of the eight sequenced plants. These results strongly support the evidence of coexisting E. phyllopogon multiple target-site resistance to ALS and ACCase inhibitors, which is reported for the first time.
Antimicrobial resistance (AMR) has become a worldwide growing concern over the past decades. Thus, encouraging manufacturers to develop new antibiotics is needed. We hypothesised that transparency on the regulatory appraisals of antibiotics would provide an incentive to pharmaceutical development. We thus aimed at reporting the French health technology assessment (HTA) opinions and reimbursement decision on antibiotics to those German (G-BA) and English (NICE) HTA bodies.
A qualitative analysis of the Transparency Committee of the French National Authority for Health (TC-HAS) opinions regarding antibiotics assessment between 2016 and 2020 was performed. Decisions of reimbursement by TC-HAS were compared to those from G-BA and NICE when available. TC-HAS recognized a clinical benefit (CB) for 15/15 evaluated indications, a clinical added value for 9/15, and a public health interest for 8/15. Among the valued antibiotics by HAS, 5 were recommended for restricted use as a “reserve” to protect against the risk of resistance emergence. A comparison of HTA opinions was possible across HTA for only 8 antibiotics. The G-BA granted a reserve status for 4 drugs and NICE a reserve with restricted use for 5 antibiotics. Three of these antibiotics were positioned similarly by the English, German, and French HTA bodies. This qualitative analysis of HTA opinions between different European HTA bodies shows a consistent reimbursement decision of antibiotics against MDR bacteria and tuberculosis besides the differences in the applied assessment methods. This work also shows how HTA bodies could recognize a clinical added value in a context of the emergence of antibiotic resistance.
Lists have come to define terrorism. In the absence of an agreed-upon definition of what constitutes terrorism, proscription, or the inclusion of non-state armed groups on terrorist lists, has created a new category, a new reality. The material and symbolic consequences of these lists have been explored in human rights law and critical terrorism studies literature. But as the world seems to shift away from the terrorist framing, what happens to the ‘terrorists’ stuck on these lists?
Grounded in empirical research with listed non-state armed groups the article explores how listed actors themselves react to the listings. They should not be seen as mere passive recipients of these labels and lists – they are active agents and able to cope strategically with this stigma. Building on Rebecca Adler-Nissen’s work on stigma in world politics, the article shifts the focus from state to non-state actors and assesses how different listed groups cope using Adler-Nissen’s typology of stigma recognition, stigma rejection, and counter-stigmatisation. This diversity in reaction is unpacked through three case studies (ETA, Hezbollah, and FARC). While some armed groups have tried to explicitly reject the label imposed on them, others have embraced it.
The article traces what happens to the ‘terrorists’, how they are reacting, and whether they can ever escape their condition. Listing regimes have enabled the continuation of the war on terror through their embeddedness in the multilateral system, creating a permanence that can endlessly be reactivated.
The spin-down law of pulsars is generally perturbed by two types of timing irregularities: glitches and timing noise. Glitches are sudden changes in the rotational frequency of pulsars, while timing noise is a discernible stochastic wandering in the phase, period, or spin-down rate of a pulsar. We present the timing results of a sample of glitching pulsars observed using the Ooty Radio Telescope (ORT) and the upgraded Giant Metrewave Radio Telescope (uGMRT). Our findings include timing noise analysis for 17 pulsars, with seven being reported for the first time. We detected five glitches in four pulsars and a glitch-like event in PSR J1825–0935. The frequency evolution of glitches in pulsars, J0742–2822 and J1740–3015, is presented for the first time. Additionally, we report timing noise results for three glitching pulsars. The timing noise was analysed separately in the pre-glitch and post-glitch regions. We observed an increase in the red noise parameters in the post-glitch regions, where exponential recovery was considered in the noise analysis. Timing noise can introduce ambiguities in the correct evaluation of glitch observations. Hence, it is important to consider timing noise in glitch analysis. We propose an innovative glitch verification approach designed to discern between a glitch and strong timing noise. The novel glitch analysis technique is also demonstrated using the observed data.
Predation is a behavior that is commonly unsuccessful, but the cause of failure is often difficult to determine in the fossil record. Here, we report on gastropod drill holes in two Plio- and Miocene bivalve specimens from the Netherlands created from the inner side of the bivalve prey's shell, which we call reverse drill holes. These holes are unequivocally caused by failure of the gastropod drilling predators to make effective use of their chemoreception and mechanoreception sensory adaptations. We hypothesize that the diffuse nature of chemical cues emanating from dense aggregations of living prey could have confused foraging predators and stimulated them to initiate the drilling process on empty valves. Poor decision making due to hunger is an alternative hypothesis. These traces represent the first reported examples of reverse gastropod drill holes from the fossil record, and the first attributed to Naticidae. Compared to other types of failed predation (incomplete drill holes and drill holes in multiply-drilled specimens) in the two assemblages studied, reverse drill holes are rare (< 1% of drill holes). This result implies that the driller's sensory and decision-making processes were generally reliable at distinguishing dead from live prey.