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Cavitation bubble pulsation and liquid jet loads are the main causes of hydraulic machinery erosion. Methods to weaken the load influences have always been hot topics of related research. In this work, a method of attaching a viscous layer to a rigid wall is investigated in order to reduce cavitation pulsations and liquid jet loads, using both numerical simulations and experiments. A multiphase flow model incorporating viscous effects has been developed using the Eulerian finite element method (EFEM), and experimental methods of a laser-induced bubble near the viscous layer attached on a rigid wall have been carefully designed. The effects of the initial bubble–wall distance, the thickness of the viscous layer, and the viscosity on bubble pulsation, migration and wall pressure load are investigated. The results show that the bubble migration distance, the normalised thickness of the oil layer and the wall load generally decrease with the initial bubble–wall distance or the oil-layer parameters. Quantitative analysis reveals that when the initial bubble–wall distance remains unchanged, there exists a demarcation line for the comparison of the bubble period and the reference period (the bubble period without viscous layer under the same initial bubble–wall distance), and a logarithmic relationship is observed that $\delta \propto \log_{10} \mu ^*$, where $\delta =h/R_{max}$ is the thickness of the viscous layer h normalised by the maximum bubble radius $R_{max}$, $\mu ^* = \mu /({R_{max }}\sqrt {{\rho }{{\mathop {P}\nolimits } _{{atm}}}})$ is the dynamic viscosity $\mu$ normalised by water density $ \rho $ and atmospheric pressure $P_{atm}$. The results of this paper can provide technical support for related studies of hydraulic cavitation erosion.
Individuals can intentionally process task-relevant information while ignoring task-irrelevant information. This study aims to investigate how to promote forgetting of task-irrelevant information through noninvasive brain stimulation, utilizing direct suppression and thought substitute inhibition mechanisms.
Methods
Participants were cued to either remember task-relevant information while forgetting task-irrelevant information (IR condition) or to forget task-irrelevant items while remembering task-relevant information (IF condition). High-frequency rTMS was applied to activate the left ventrolateral prefrontal cortex (VLPFC, n = 32), right dorsolateral prefrontal cortex (DLPFC, n = 32), or vertex cortex (control condition, n = 32).
Results
Compared to vertex stimulation, (1) The Left VLPFC stimulation promoted the memory of task-relevant information in the IR condition, and resulted in a memory deficit for the task-irrelevant information in the IF condition (active forgetting). (2) The Right DLPFC stimulation promoted the forgetting of task-irrelevant information in the IF condition (active forgetting) and facilitated the memory of task-relevant information in the IR condition.
Conclusions
Stimulating left VLPFC or right DLPFC can promote active forgetting. Noninvasive brain stimulation can effectively regulate memory control.
Conceptual innovation is highly prized in Western Anglophone philosophy. Yet it often stems from a relatively narrow tradition that takes little account of contributions from other cultures and philosophical practices. We illustrate this point using the example of work done by Dalit feminists on identifying and addressing hermeneutical injustice. Despite their relevance, Dalit feminist contributions are virtually unknown and remain unrecognized in Anglophone philosophical discussions of hermeneutical injustice. This article aims to investigate the reasons for this neglect. One potential reason is the generally low status accorded to experiential knowledge in epistemology, which is pivotal to Dalit feminist accounts. Another reason concerns systematic bias against non-Western philosophy, which may reflect prejudicial stereotypes and the privileging of existing disciplinary norms. We argue that these reasons may explain the exclusion of Dalit feminists’ scholarship. In light of this, we offer two modest suggestions. First, philosophers should cultivate greater openness to citing texts by non-philosophers where these texts are relevant to the topic at hand. Second, we argue that a more embedded and extensive practice of cross-cultural philosophy or comparative philosophy is needed. These two suggestions may reduce neglect of philosophically rich traditions such as Dalit feminism.
This article explores the relationship between Hessenberg varieties associated with semisimple operators with two eigenvalues and orbit closures of a spherical subgroup of the general linear group. We establish the specific conditions under which these semisimple Hessenberg varieties are irreducible. We determine the dimension of each irreducible Hessenberg variety under consideration and show that the number of such varieties is a Catalan number. We then apply a theorem of Brion to compute a polynomial representative for the cohomology class of each such variety. Additionally, we calculate the intersections of a standard (Schubert) hyperplane section of the flag variety with each of our Hessenberg varieties and prove that this intersection possesses a cohomological multiplicity-free property.
As the use of computational text analysis in the social sciences has increased, topic modeling has emerged as a popular method for identifying latent themes in textual data. Nevertheless, concerns have been raised regarding the validity of the results produced by this method, given that it is largely automated and inductive in nature, and the lack of clear guidelines for validating topic models has been identified by scholars as an area of concern. In response, we conducted a comprehensive systematic review of 789 studies that employ topic modeling. Our goal is to investigate whether the field is moving toward a common framework for validating these models. The findings of our review indicate a notable absence of standardized validation practices and a lack of convergence toward specific methods of validation. This gap may be attributed to the inherent incompatibility between the inductive, qualitative approach of topic modeling and the deductive, quantitative tradition that favors standardized validation. To address this, we advocate for incorporating qualitative validation approaches, emphasizing transparency and detailed reporting to improve the credibility of findings in computational social science research when using topic modeling.
We introduce a family of polynomials, which arise in three distinct ways: in the large N expansion of a matrix integral, as a weighted enumeration of factorizations of permutations, and via the topological recursion. More explicitly, we interpret the complex Grassmannian $\mathrm {Gr}(M,N)$ as the space of $N \times N$ idempotent Hermitian matrices of rank M and develop a Weingarten calculus to integrate products of matrix elements over it. In the regime of large N and fixed ratio $\frac {M}{N}$, such integrals have expansions whose coefficients count factorizations of permutations into monotone sequences of transpositions, with each sequence weighted by a monomial in $t = 1 - \frac {N}{M}$. This gives rise to the desired polynomials, which specialise to the monotone Hurwitz numbers when $t = 1$. These so-called deformed monotone Hurwitz numbers satisfy a cut-and-join recursion, a one-point recursion, and the topological recursion. Furthermore, we conjecture on the basis of overwhelming empirical evidence that the deformed monotone Hurwitz numbers are real-rooted polynomials whose roots satisfy remarkable interlacing phenomena. An outcome of our work is the viewpoint that the topological recursion can be used to “topologise” sequences of polynomials, and we claim that the resulting families of polynomials may possess interesting properties.
Antimicrobial prescribing differences between physicians and nurse practitioners (NPs) remain poorly characterized. We compared prescribing practices at a safety-net hospital. NPs adhered more to pneumonia guidelines, while physicians had better adherence for abdominal and urinary infections. Ineffective therapy was more common for NPs. These gaps highlight important stewardship opportunities.
Morphological matrices (MMs) have traditionally been used to generate concepts by combining different means. However, exploring the vast design space resulting from the combinatorial explosion of large MMs is challenging. Additionally, all alternative means are not necessarily compatible with each other. At the same time, for a system to achieve long-term success, it is necessary for it to be flexible such that it can easily be changed. Attaining high system flexibility necessitates an elevated compatibility with alternative means of achieving system functions, which further complicates the design space exploration process. To that end, we present an approach that we refer to as multi-objective technology assortment combinatorics. It uses a shortest-path algorithm to rapidly converge to a set of promising design candidates. While this approach can take flexibility into account, it can also consider other quantifiable objectives such as the cost and performance of the system. The efficiency of this approach is demonstrated with a case study from the automotive industry.
The escalating presence of microplastics (<5 mm) in drinking water presents urgent environmental and health challenges, yet the United Nations Environment Programme’s (UNEP) Global Plastics Treaty draft texts, including UNEP/PP/INC.5/4 and the Chair’s Text, lack robust provisions to address this issue. This Letter to the Editor analyzes deficiencies in the treaty’s approach, identifying critical gaps in standardized terminology, globally consistent monitoring methodologies, comprehensive source control and enforceable international regulations. Leveraging insights from California’s innovative microplastics monitoring framework, which employs spectroscopy-based detection and provisional health thresholds, we highlight scalable solutions for global policy. Key obstacles include technological disparities, economic reliance on plastic production, limited toxicological data and geopolitical barriers to unified action. We propose targeted strategies for the Intergovernmental Negotiating Committee (INC-5.2), including adopting precise microplastics definitions, establishing universal detection protocols, regulating both primary and secondary microplastic sources and supporting research and capacity-building in low-resource regions. These measures aim to enhance the treaty’s ability to mitigate microplastic pollution in drinking water, fostering science-driven global cooperation to protect ecosystems and public health.
The resilience of international supply chains is increasingly becoming a policy objective within international trade law making. Unilaterally, States have resorted to a myriad of trade tools to achieve this objective, including subsidizing domestic industries, facilitating critical minerals, and imposing tariffs on dominant supplying States to encourage supply diversification. In this context, the Indo-Pacific Economic Framework for Prosperity Supply Chain Agreement is the first major international trade agreement primarily aimed at achieving regional supply chain resilience. This Research Note explores the WTO compatibility of the economic interventions that underpin the Supply Chain Agreement’s ‘managed trade’ approach to supply chain resilience. First, it outlines the firm-centred governance approach that is central to supply chain management under the Supply Chain Agreement. Second, it explores the likely challenges and justifications of the envisaged interventions under GATT 1994 and Agreement on Safeguards. Finally, it reflects on the potential role of the WTO to shape cooperative supply chain governance interventions.
Parental psychopathology is a known risk factor for child autistic-like traits. However, symptom-level associations and underlying mechanisms are poorly understood.
Methods
We utilized network analyses and cross-lagged panel models to investigate the specific parental psychopathology related to child autistic-like traits among 8,571 adolescents (mean age, 9.5 years at baseline), using baseline and 2-year follow-up data from the Adolescent Brain Cognitive Development study. Parental psychopathology was measured by the Adult Self Report, and child autistic-like traits were measured by three methods: the Kiddie Schedule for Affective Disorders and Schizophrenia for DSM-5 autism spectrum disorder (ASD) subscale, the Child Behavior Checklist ASD subscale, and the Social Responsiveness Scale. We also examined the mediating roles of family conflict and children’s functional brain connectivity at baseline.
Results
Parental attention-deficit/hyperactivity problems were central symptoms and had a direct and the strongest link with child autistic-like traits in network models using baseline data. In longitudinal analyses, parental attention-deficit/hyperactivity problems at baseline were the only significant symptoms associated with child autistic-like traits at 2-year follow-up (β = 0.014, 95% confidence interval [0.010, 0.018], FDR q = 0.005), even accounting for children’s comorbid behavioral problems. The observed association was significantly mediated by family conflict (proportion mediated = 11.5%, p for indirect effect <0.001) and functional connectivity between the default mode and dorsal attention networks (proportion mediated = 0.7%, p for indirect effect = 0.047).
Conclusions
Parental attention-deficit/hyperactivity problems were associated with elevated autistic-like traits in offspring during adolescence.
There is a need for better collaborative care between services to improve healthcare provision for people with intellectual disabilities. In the UK, the learning disability psychiatry multidisciplinary team (MDT) is a specialist team responsible for providing and coordinating care for people with intellectual disabilities.
Aims
To document learning disability MDT perspectives on factors influencing healthcare quality for people with intellectual disabilities.
Method
Healthcare professionals who were members of a learning disability MDT within a National Health Service Trust in the West Midlands were purposively sampled for interview (n = 11). Participants included psychiatrists, nurses, occupational therapists and speech and language therapists. Data were analysed thematically using Braun and Clarke’s six-stage approach.
Results
Factors influencing the quality of healthcare provision included: the learning disability MDT working to overcome systemic barriers; the consequences of specific failures within mainstream healthcare services, such as diagnostic overshadowing; inadequate use of information collated in health passports; and inadequate capacity assessments of people with intellectual disabilities. Improvements in healthcare provision for people with intellectual disabilities require better accessibility to healthcare and better training for healthcare professionals so they can understand the health needs of people with intellectual disabilities.
Conclusions
A rapid review of practices around health passports for people with intellectual disabilities should be conducted. Healthcare professionals working in mainstream healthcare services need an increased awareness of the harms of diagnostic overshadowing and inadequate capacity assessments. Conclusions are based on findings from MDTs within one health board; future work may focus on understanding perspectives from different teams.
Plant-soil microbial interactions play a central role in maintaining biodiversity and coexistence in terrestrial ecosystems. However, to what extent plant-soil feedbacks (PSFs) operate in tropical Afromontane forests remains unclear. In this study, we conducted a PSF shade house experiment using six tree species exhibiting diverse life-history strategies and abundances in a sub-tropical montane forest in Nigeria. Seedlings were grown under controlled conditions in sterilised soil with or without soil inoculum collected under mature trees of each of the six species. We assessed whether conspecific tree seedlings’ performance was altered in comparison to heterospecific seedlings when grown in the soil of their adult trees. Seedling growth did not significantly differ between inocula from conspecific and heterospecific adults in five of the six species tested, indicating no evidence of PSFs. In Garcinia smeathmannii, we found a significant increase in seedling growth when grown in conspecific soil inocula. Given that no PSFs were observed in five out of six species, our study suggests that PSFs may play a limited role in the performance of some species in this Afromontane ecosystem. Nonetheless, the facilitative interaction noted in Garcinia smeathmannii indicates a nuanced ecological dynamic worth further exploration.
The RDA for dietary protein is likely insufficient for individuals with cystic fibrosis (CF). This study sought to characterise protein intake and diet quality in adults with cystic fibrosis (awCF), before and after elexacaftor/tezacaftor/ivacaftor (ETI) therapy, compared with healthy controls. Dietary intake was assessed by diet diary in awCF at baseline (BL, n 40) and at follow-up > 3 months post ETI therapy (follow-up (FUP), n 40) and in age-matched healthy controls (CON, n 80) free from known disease at a single time point. Protein intake dose and daily distribution, protein quality, protein source and overall diet quality were calculated for each participant. Both CON (1·39 (sd 0·47) g·kg–1·day–1) and CF (BL: 1·44 (sd 0·52) g·kg–1·day–1, FUP: 1·12 (sd 0·32) g·kg–1·day–1) had a higher mean daily protein intake than the protein RDA of 0·75g·kg–1·day–1. There was a significant reduction in daily protein intake in the CF group at FUP (P = 0·0003, d = 0·73), with levels below the alternative suggested dietary intake of ≥ 1·2 g·kg–1·day–1. There were no sex differences or noticeable effects on protein quality or source following the commencement of ETI therapy when compared with CON (all P > 0·05), although overall diet quality decreased between time points (P = 0·027, d = 0·57). The observed reduction in daily protein intake in the present cohort emphasises the importance of ensuring appropriate dietary protein intake to promote healthy ageing in adults with CF. More research is needed to evidence base dietary protein requirements in this at-risk population.
Diet quality has been linked to socio-economic status. However, evidence within rural and regional populations is lacking. This cross-sectional study examined the relationship between diet quality and socio-economic position in adults living in rural and regional areas of Australia. The Australian Recommended Food Score (ARFS; range 0–73) measured diet quality (total and subscale scores). Area-level socio-economic position was determined by postcode-linked socio-economic index for areas (SEIFA), Index of Relative Social Advantage and Disadvantage scores, stratified into quintiles. The mean total ARFS (34·7; sd = 9·1; n 836) was classified as ‘getting there’. Findings showed significantly lower mean total ARFS between SEIFA quintile 1 (1 = lowest; mean total ARFS = 30·4; sd = 10·2; categorised as ‘needs work’) compared with all other SEIFA quintiles (F (44 831) = 8·44, P ≤ 0·001). Linear regression, adjusting for age, sex, income, education, employment status and household composition demonstrated significantly lower overall diet quality for SEIFA quintile 1 compared with SEIFA quintile 3 (B = –3·9; 95 % CI (–6·2, −1·5); P < 0·001) and lower subscale scores for vegetables (B = –1·6; 95 % CI (–2·7, −0·6); P = 0·003), fruit (B = –0·9; 95 % CI (–1·6, −0·1); P = 0·018) and grains (B = –0·6; 95 % CI (–1·3, −0·0); P = 0·050). After adjusting for individual confounders of diet quality, results indicate that lower area-level socio-economic position remained associated with poorer diet quality in this sample of rural and regional Australian adults. This suggests that broader social and environmental factors unique to these areas may impact diet quality and amplify individual barriers to achieving a healthy diet.
What is compassion? Although a fundamental value in healthcare, this concept is often misunderstood and difficult to navigate. The authors of this book aim to answer this fundamental question, as well as offer a practical approach to how to use it in medicine. Comprised of two parts, the first part of this book explores the background to compassionate healthcare, examines how it differs from other concepts and outlines its relationship to medical professionalism. The second part offers a practical guide full of strategies and exercises to assist healthcare workers in practicing compassion by cultivating mindfulness and awareness, deepening compassion in care. This book is essential reading for medical professionals and trainees across healthcare, providing a guide to incorporating compassion into daily practice to deliver better, more compassionate care for the benefit of all. This title is also available as open access on Cambridge Core.