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Maya Blue is a unique hybrid pigment created by combining organic indigo with the inorganic clay mineral palygorskite. First used for architectonic decoration in the Terminal Preclassic, it became widespread in the Late Classic on figurines, murals, and elite ceramics. Unlike indigo, it is notable for its durability and resistance to degradation by acids, alkalines, organic solvents and fading. The authors analyzed 17 samples of Maya Blue on pottery from the Late-Terminal Classic periods, a.d. 680–860, from Buenavista del Cayo, Belize. Using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS), it was determined that the palygorskite in these samples likely came from Sacalum, Yucatan, some 375 km away. The authors suggest several routes by which palygorskite might have been transported from Yucatán to Buenavista. The pigment or knowledge of how to produce it likely was conveyed through high-status exchanges rather than commercial trade. Maya Blue held significant cultural and religious importance. It symbolized water and rain and was associated with the god Chaahk. Maya Blue appeared initially at Buenavista on architecture and rare imported ceramics but its use gradually increased on locally produced Belize Valley wares. Use at Buenavista peaked in the early 9th century before disappearing around a.d. 860. The study demonstrates the potential of trace element analysis in identifying long-distance social interactions in ancient Mesoamerica.
We present the first results of a pilot ‘TASmanian Search for Inclined Exoplanets’ (TASSIE) program. This includes observations and analysis of five short-period exoplanet candidates using data from TESS and the Harlingten 50 cm telescope at the Greenhill Observatory. We describe the instrumentation, data reduction process and target selection strategy for the program. We utilise archival multi-band photometry and new mid-resolution spectra to determine stellar parameters for five TESS Objects of Interest (TOIs). We then perform a statistical validation to rule out false positives, before moving on to a joint transit analysis of the remaining systems. We find that TOI3070, TOI3124 and TOI4266 are likely non-planetary signals, which we attribute to either short-period binary stars on grazing orbits or stellar spots. For TOI3097, we find a hot sub-Jovian to Jovian size planet (R3097Ab = 0.89 ± 0.04 RJ, P3097Ab = 1.368386 ± 0.000006 days) orbiting the primary K dwarf star in a wide binary system. This system shows indications of low metallicity ([Fe/H] ≈ −1), making it an unlikely host for a giant planet. For TOI3163, we find a Jovian-size companion on a circular orbit around a late F dwarf star, with R3163b = 1.42 ± 0.05RJ and P3163b = 3.074966 ± 0.000022 days. In future, we aim to validate further southern giant planet candidates with a particular focus on those residing in the sub-Jovian desert/savanna.
The Australian SKA Pathfinder (ASKAP) offers powerful new capabilities for studying the polarised and magnetised Universe at radio wavelengths. In this paper, we introduce the Polarisation Sky Survey of the Universe’s Magnetism (POSSUM), a groundbreaking survey with three primary objectives: (1) to create a comprehensive Faraday rotation measure (RM) grid of up to one million compact extragalactic sources across the southern ∼ 50 per cent of the sky (20,630 deg2); (2) to map the intrinsic polarisation and RM properties of a wide range of discrete extragalactic and Galactic objects over the same area; and (3) to contribute interferometric data with excellent surface brightness sensitivity, which can be combined with single-dish data to study the diffuse Galactic interstellar medium. Observations for the full POSSUM survey commenced in May 2023 and are expected to conclude by mid-2028. POSSUM will achieve an RM grid density of around 30–50 RMs per square degree with a median measurement uncertainty of ∼1 rad m−2. The survey operates primarily over a frequency range of 800–1088 MHz, with an angular resolution of 20″ and a typical RMS sensitivity in Stokes Q or U of 18 μJy beam−1. Additionally, the survey will be supplemented by similar observations covering 1296–1440 MHz over 38 per cent of the sky. POSSUM will enable the discovery and detailed investigation of magnetized phenomena in a wide range of cosmic environments, including the intergalactic medium and cosmic web, galaxy clusters and groups, active galactic nuclei and radio galaxies, the Magellanic System and other nearby galaxies, galaxy halos and the circumgalactic medium, and the magnetic structure of the Milky Way across a very wide range of scales, as well as the interplay between these components. This paper reviews the current science case developed by the POSSUM Collaboration and provides an overview of POSSUM’s observations, data processing, outputs, and its complementarity with other radio and multi-wavelength surveys, including future work with the SKA.
Edited by
David Mabey, London School of Hygiene and Tropical Medicine,Martin W. Weber, World Health Organization,Moffat Nyirenda, London School of Hygiene and Tropical Medicine,Dorothy Yeboah-Manu, Noguchi Memorial Institute for Medical Research, University of Ghana,Jackson Orem, Uganda Cancer Institute, Kampala,Laura Benjamin, University College London,Michael Marks, London School of Hygiene and Tropical Medicine,Nicholas A. Feasey, Liverpool School of Tropical Medicine
Despite declining trends, pneumonia remains the most important infectious cause of serious illness and death in young children globally. It is estimated that pneumonia causes almost 800,000 deaths in children under 5 years of age each year, nearly all of which are preventable. Pneumonia is generally a more common cause of death in those countries that have the highest infant mortality rates. Risk factors are malnutrition, HIV infection or exposure and indoor or outdoor air pollution. Lack of access to basic medical care is behind most pneumonia deaths (UNICEF & World Health Organization 2013). This remains a problem in many African countries. Untreated, the case-fatality rate is particularly high in the first year of life.
Edited by
David Mabey, London School of Hygiene and Tropical Medicine,Martin W. Weber, World Health Organization,Moffat Nyirenda, London School of Hygiene and Tropical Medicine,Dorothy Yeboah-Manu, Noguchi Memorial Institute for Medical Research, University of Ghana,Jackson Orem, Uganda Cancer Institute, Kampala,Laura Benjamin, University College London,Michael Marks, London School of Hygiene and Tropical Medicine,Nicholas A. Feasey, Liverpool School of Tropical Medicine
The mortality rate of children less than 5 years of age has decreased by 60% since 1990, with the Millennium Development Goals having been a powerful drive for improvement. However, the reduction has not been evenly distributed throughout the world (UN IGME 2020). Sub-Saharan Africa remains the region with the highest under-5 mortality rate in the world, where 1 child in every 13 dies before celebrating their 5th birthday (UN IGME 2020).
Insight in nonverbal correlates of paranoid ideation can potentially help improve diagnostic procedures and guide interventions. The aim was to systematically evaluate the scientific evidence investigating nonverbal correlates of paranoid ideation.
Methods
The review follows the PRISMA guidelines. Databases PsycINFO, PubMed, Web of Science, and Cinahl were searched for studies concerning the use of standardized instruments for both verbal and nonverbal measurements of paranoid ideation in adult participants. Quality of studies was evaluated using the Effective Public Health Practice Project tool. Data were systematically extracted and summarized thematically and narratively. This review was registered with PROSPERO (CRD42022288001).
Results
The search strategy yielded 3962 results of which 22 papers met inclusion criteria. Half (n = 11) of the included articles included patients with a diagnosis on the psychosis spectrum, the other articles (n = 11) studied healthy populations. Identified nonverbal categories were spatial behavior (n = 6), brain region activity (n = 5), visual perception (n = 5), stress physiology (n = 4), information processing (n = 3), and aggression (n = 1). Some studies investigated multiple nonverbal categories.
Conclusions
Evidence was strongest for spatial behavior and brain region activity as nonverbal correlates of paranoid ideation. Evidence for stress physiology, information processing, and aggression as potential nonverbal correlates was less robust, due to inconsistent findings and small numbers of publications. Using nonverbal methods to assess paranoid ideation requires more investigation and evaluation. The integration of nonverbal assessments might offer new diagnostic possibilities that move beyond traditional verbal methods.
We present the Evolutionary Map of the Universe (EMU) survey conducted with the Australian Square Kilometre Array Pathfinder (ASKAP). EMU aims to deliver the touchstone radio atlas of the southern hemisphere. We introduce EMU and review its science drivers and key science goals, updated and tailored to the current ASKAP five-year survey plan. The development of the survey strategy and planned sky coverage is presented, along with the operational aspects of the survey and associated data analysis, together with a selection of diagnostics demonstrating the imaging quality and data characteristics. We give a general description of the value-added data pipeline and data products before concluding with a discussion of links to other surveys and projects and an outline of EMU’s legacy value.
This Element develops a theory of institutional acceleration to explain the transformation to a digital economy through a cluster of frontier technologies: artificial intelligence, blockchain, quantum computing, cryptography, and low-earth orbit infrastructure. Unlike previous technological revolutions, these technologies transform not how we organise things, but how we coordinate economic activity. The authors' supertransition thesis explains why these digital technologies shouldn't be understood in isolation, but rather should be understood in how they combine to create new institutional possibilities, leading to more open, complex, and global economic systems. Drawing on evolutionary economics and institutional theory, this Element shows how this evolutionary process is reshaping our institutional economic architecture. Ultimately, institutional acceleration drives greater computation and knowledge into our economic systems.
People with disabilities face barriers to employment compared to people without disabilities, including the way in which employment opportunities are structured. The COVID-19 pandemic has opened up new ways of working (e.g. working from home), which have been trialled in a number of different locations, and these have the potential to widen employment opportunities for people with disabilities. It is therefore important to explore the extent to which job preferences differ between people with disabilities and people without disabilities, in particular for aspects such as teleworking. In total, 253 participants (62 male and 191 female) took part in a discrete choice experiment (DCE) that investigates participants’ preferences for various job aspects. These include discretionary medical leave, flexible scheduling, working from home, and the availability of part-time jobs. People with disabilities significantly prefer flexible scheduling and the availability of part-time jobs compared to people without disabilities. The results of a latent class analysis suggest it is older women with disabilities in particular, who most value increased flexible job design. An analysis of lexicographic preferences suggests that it is people who are most constrained by ‘traditional’ working conditions who benefit the most from increased flexibility, e.g. people who require teleworking or flexible scheduling. This suggests that wider adoption of these attributes by employers has the potential to go some way towards addressing the persistent disability employment gaps and related health inequalities observed in many countries around the world.
Indirect calorimetry (IC) is regarded as the benchmark for measuring resting energy expenditure (REE)(1) but validity and reliability in adults with overweight or obesity have not been systematically appraised(2). The aim of our research was to evaluate the diagnostic accuracy of IC for REE in adults with overweight or obesity. A rapid systematic review was conducted. PubMed and Web of Science were searched to December 2023. Eligible studies measured REE by IC in adults with overweight or obesity (BMI ≥ 25 kg/m2 or mean BMI > 30 kg/m2) reporting validity and/or reliability. Studies were selected using Covidence and critically appraised using the CASP diagnostic study checklist. From n = 4022 records, n = 21 studies utilising n = 13 different IC devices were included (n = 10 reported concurrent validity, n = 7 reported predictive validity, n = 7 reported reliability). A hand-held IC had poor validity and inconsistent reliability (n = 6 studies). Standard desktop-based ICs (n = 9 devices) were examined by across n = 18 studies; most demonstrated high validity, predictive ability, and good to excellent reliability. An IC accelerometer showed weak validity (n = 1 study); a body composition-based IC showed strong validity (n = 1 study); and a whole-room IC demonstrated excellent reliability (n = 1 study). Standard desktop-based IC demonstrated the most consistent validity, predictive ability, and reliability for REE in adults with overweight or obesity. Hand-held IC may have limited validity and reliability. Accelerometer, body composition-based, and whole-room IC devices require further evaluation. Inconsistent findings are attributed to differing methodologies and reference standards. Further research is needed to examine the diagnostic accuracy of IC in adults with overweight and obesity.
Due to the high prevalence and incidence of depression among young adults, identifying potential prevention strategies during young adulthood is of great public health importance. Indeed, dietary intake is an important determinant of mental health during this stage of the lifespan. Dietary polyphenols, present in plant and plant-derived foods, have been inversely associated with depression in older cohorts(1). However, the prospective association between polyphenol intake and depression remains unclear, particularly in young adults. As such, this study aimed to assess the prospective association between the intake of total polyphenols, polyphenol classes, and polyphenol subclasses and depressive symptoms in young adults. Data from the Raine Study Generation 2 participants at 20-, 22-, and 27-year follow-ups (n = 1,484; 52.7% female; age range: 18 to 28 years) were used. The exposure variable, polyphenol intake, was estimated from self-reported dietary intakes using the Phenol-Explorer Database. We categorised energy-adjusted polyphenol intake into quartiles. The primary outcome was self-reported depressive symptoms assessed via the 21-item Depression, Anxiety, and Stress Scale (DASS) averaged across the three timepoints. Linear mixed-effects models were used to assess the association between the polyphenol intake exposures and depressive symptoms. Sociodemographic characteristics and lifestyle- and health-related behaviours were adjusted for in multivariable models. Participants in the highest quartiles for flavonol and hydroxybenzoic acid intake had lower depressive symptoms across time than participants in the lowest quartiles [flavonols (Q4 vs Q1 model-adjusted mean difference: −1.42, 95% CI: −2.52, −0.31); hydroxybenzoic acids (Q4 vs Q1: −1.37, CI: −2.48, −0.26)]. We found little to no evidence of a prospective association between depressive symptoms and quartiles of total polyphenols, polyphenol classes, and other polyphenol subclasses. The results from the current study in combination with previous studies in the field suggest that the intake of some, but not all, polyphenol subclasses may be useful targets for novel prevention strategies for depression. However, further mechanistic studies in human populations, and prospective studies in young adults and across the lifespan are required.
Mental health problems commonly persist from childhood to adulthood. This study tested whether young adult life transitions can improve adult mental health symptoms after adjusting for childhood mental health symptoms.
Methods
The analysis uses data from the prospective, representative Great Smoky Mountains Study. Life transitions (e.g., high school completion, partnering, parenthood, and living independently) were assessed up to three times in young adulthood (ages 18 to 26; 3,241 observations). A cumulative variable counted the number of young adult transitions. Emotional, substance use, and antisocial personality symptoms were assessed at age 30 (1,154 participants or 81.2% of the original sample). Propensity models adjusted for early life adversities and psychiatric symptoms.
Results
Multiple young adult transitions were common (m = 4.62; SD = 1.57). After adjusting for childhood mental health problems and adversities, each additional transition was significantly associated with a reduction in subsequent adult emotional symptoms (β = −0.34, 95% CI: −0.59, −0.08, p = 0.01) and adult antisocial personality disorder symptoms (β = −0.08, 95% CI: −0.14, −0.02, p < 0.001. These associations were stronger in males than in females. Young adult transitions were not associated with reductions in subsequent substance use symptoms (β = −0.04; 95% CI: −0.11, 0.03, p = 0.30). Young adult transitions related to educational milestones and consistent employment were associated with the largest reductions in symptoms.
Conclusions
In this cohort study, life transitions during young adulthood were associated with reduced emotional and behavioral symptoms in adulthood. These transitions may constitute a potential mental health turning point and a specific, modifiable target for social policies.
A class of sequences called L-sequences is introduced, each one being a subsequence of a Collatz sequence. Every ordered pair $(v,w)$ of positive integers determines an odd positive integer P such that there exists an L-sequence of length n for every positive integer n, each term of which is congruent to P modulo $2^{v+w+1}$. The smallest possible initial term of such a sequence is described. If $3^v>2^{v+w}$ the L-sequence is increasing. Otherwise, it is decreasing, except if it is the constant sequence P. A central role is played by Bezout’s identity.
Selective serotonin reuptake inhibitors (SSRIs) are the preferred pharmacological treatment for obsessive–compulsive disorder (OCD). However, insufficient response is common and it remains unclear whether specific patient-level factors influence the likelihood of treatment response.
Aims
To determine the efficacy and acceptability of SSRIs in adult OCD, and to identify patient-level modifiers of efficacy.
Methods
We conducted an individual patient data meta-analysis (IPDMA) of industry-sponsored short-term, randomised, placebo-controlled SSRI trials submitted for approval to the Dutch regulatory agency to obtain marketing approval for treating OCD in adults. We performed a two-stage meta-analysis, using crude data of available trials. The primary outcome was the difference in Yale–Brown Obsessive–Compulsive Scale (YBOCS) change between active treatment and placebo. Secondary outcomes were differences in response (defined as the odds ratio of ≥35% YBOCS point reduction) and acceptability (defined as the odds ratio for all-cause discontinuation). We examined the modifying effect of baseline characteristics: age, gender, illness severity, depressive symptoms, weight, illness duration and history of antidepressant use.
Results
After excluding three trials because of missing data, we analysed results from 11 trials (79% of all submitted trials, n = 2372). The trial duration ranged from 10 to 13 weeks. Mean difference of SSRIs relative to placebo was 2.65 YBOCS points (95% CI 1.85–3.46, p < 0.0001), equalling a small effect size (0.33 Hedges’ g). The odds ratio for response was 2.21 in favour of active treatment (95% CI 1.72–2.83, p < 0.0001), with a number needed to treat of seven. Patient characteristics did not modify symptom change or response. Acceptability was comparable for SSRIs and placebo.
Conclusions
Our IPDMA showed that SSRIs are well accepted and superior to placebo for treating OCD. The effects are modest and independent of baseline patient characteristics.
Posttraumatic stress disorder (PTSD) has been associated with advanced epigenetic age cross-sectionally, but the association between these variables over time is unclear. This study conducted meta-analyses to test whether new-onset PTSD diagnosis and changes in PTSD symptom severity over time were associated with changes in two metrics of epigenetic aging over two time points.
Methods
We conducted meta-analyses of the association between change in PTSD diagnosis and symptom severity and change in epigenetic age acceleration/deceleration (age-adjusted DNA methylation age residuals as per the Horvath and GrimAge metrics) using data from 7 military and civilian cohorts participating in the Psychiatric Genomics Consortium PTSD Epigenetics Workgroup (total N = 1,367).
Results
Meta-analysis revealed that the interaction between Time 1 (T1) Horvath age residuals and new-onset PTSD over time was significantly associated with Horvath age residuals at T2 (meta β = 0.16, meta p = 0.02, p-adj = 0.03). The interaction between T1 Horvath age residuals and changes in PTSD symptom severity over time was significantly related to Horvath age residuals at T2 (meta β = 0.24, meta p = 0.05). No associations were observed for GrimAge residuals.
Conclusions
Results indicated that individuals who developed new-onset PTSD or showed increased PTSD symptom severity over time evidenced greater epigenetic age acceleration at follow-up than would be expected based on baseline age acceleration. This suggests that PTSD may accelerate biological aging over time and highlights the need for intervention studies to determine if PTSD treatment has a beneficial effect on the aging methylome.
We describe Swauka ypresiana n. gen. n. sp., the second fossil gossamerwing damselfly (Odonata, Zygoptera, Epallagidae, Epallaginae) and its oldest occurrence. It is the first fossil insect reported from the Swauk Formation of central Washington State, U.S.A. It was recovered from the “Sandstone facies of Swauk Pass,” a fluvial unit, immediately below the Silver Pass Volcanic Member of the Swauk Formation, which has a U–Pb zircon CA-ID-TIMS age of 51.364 ± 0.029 Ma. The host deposits probably represent mud-dominated floodplain lake or oxbow lake environments.
International organisations recommend that patients with CHD undergo a structured transition process to prepare for lifelong cardiac care. However, there is a limited understanding of current transition practices in the United States (U.S.) from the perspective of adult CHD programs. The purpose of this study was to characterise adult CHD transition practices across the U.S.
Method:
We conducted a descriptive, cross-sectional survey of adult CHD programs in the U.S., inquiring about transition practices (preparation, transfer, and integration), resources, specialists, and barriers. We used descriptive statistics to analyse the data.
Results:
We analysed responses from 38 adult CHD programs (37% response rate). Among these, 25 (66%) of adult CHD programs reported formal transition programs and 26 (68%) reported having a transfer process to receive patients from paediatric cardiology. Reported transition program specialists were interdisciplinary. Few programs reported having psychologists or psychiatrists on their teams or offered support for patients with intellectual disability. The main barriers affecting transition were insurance and health care costs.
Conclusion:
Around two-thirds of respondent adult CHD programs reported the presence of formal transition programs. More resources may be needed within these programmes to support patient psychological well-being and those with intellectual disability and to address barriers related to insurance and health care costs.
Objectives/Goals: The timing of neurosurgery is highly variable for post-hemorrhagic hydrocephalus (PHH) of prematurity. We sought to utilize microvascular imaging (MVI) in ultrasound (US) to identify biomarkers to discern the opportune time for intervention and to analyze the cerebrospinal fluid (CSF) characteristics as they pertain to neurosurgical outcome. Methods/Study Population: The inclusion criteria for the study are admission to the neonatal intensive care unit (NICU) with a diagnosis of Papile grade III or IV. Exclusion criteria are congenital hydrocephalus and hydrocephalus secondary to myelomeningocele/brain tumor/vascular malformation. We are a level IV tertiary referral center. Our current clinical care pathway utilizes brain US at admission and at weekly intervals. Patients who meet certain clinical and radiographic parameters undergo temporary or permanent CSF diversion. Results/Anticipated Results: NEL was implemented at our institution for PHH of prematurity in fall 2022. To date, we have had 20 patients who were diagnosed with grade III or IV IVH, of which 12 qualified for NEL. Our preliminary safety and feasibility results as well as the innovative bedside technique pioneered at our institution are currently in revision stages for publication. Preliminary results of the MVI data have yielded that hyperemia may confer venous congestion in the germinal matrix, which should then alert the neurosurgeon to delay any intervention to avoid progression of intraventricular blood. With regard to CSF characteristics, we anticipate that protein, cell count, hemoglobin, iron, and ferritin will decrease with NEL. Discussion/Significance of Impact: The timing of PHH of prematurity is highly variable. We expect that MVI will offer radiographic biomarkers to guide optimal timing of neurosurgical intervention. A better understanding of CSF characteristics could potentially educate the neurosurgeon with regard to optimal timing of permanent CSF diversion based on specific CSF parameters.
We provide an assessment of the Infinity Two fusion pilot plant (FPP) baseline plasma physics design. Infinity Two is a four-field period, aspect ratio $A = 10$, quasi-isodynamic stellarator with improved confinement appealing to a max-$J$ approach, elevated plasma density and high magnetic fields ($ \langle B\rangle = 9$ T). Here $J$ denotes the second adiabatic invariant. At the envisioned operating point ($800$ MW deuterium-tritium (DT) fusion), the configuration has robust magnetic surfaces based on magnetohydrodynamic (MHD) equilibrium calculations and is stable to both local and global MHD instabilities. The configuration has excellent confinement properties with small neoclassical transport and low bootstrap current ($|I_{bootstrap}| \sim 2$ kA). Calculations of collisional alpha-particle confinement in a DT FPP scenario show small energy losses to the first wall (${\lt}1.5 \,\%$) and stable energetic particle/Alfvén eigenmodes at high ion density. Low turbulent transport is produced using a combination of density profile control consistent with pellet fueling and reduced stiffness to turbulent transport via three-dimensional shaping. Transport simulations with the T3D-GX-SFINCS code suite with self-consistent turbulent and neoclassical transport predict that the DT fusion power$P_{{fus}}=800$ MW operating point is attainable with high fusion gain ($Q=40$) at volume-averaged electron densities $n_e\approx 2 \times 10^{20}$ m$^{-3}$, below the Sudo density limit. Additional transport calculations show that an ignited ($Q=\infty$) solution is available at slightly higher density ($2.2 \times 10^{20}$ m$^{-3}$) with $P_{{fus}}=1.5$ GW. The magnetic configuration is defined by a magnetic coil set with sufficient room for an island divertor, shielding and blanket solutions with tritium breeding ratios (TBR) above unity. An optimistic estimate for the gas-cooled solid breeder designed helium-cooled pebble bed is TBR $\sim 1.3$. Infinity Two satisfies the physics requirements of a stellarator fusion pilot plant.