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The study of memory resilience and cognitive aging remains in its early stages. Nevertheless, growing evidence suggests that a lifetime of literacy engagement and continued reading in older age confer significant cognitive benefits. High literacy levels are associated with increased cognitive reserve; which may offer a buffer against age-related memory decline. Once forgetfulness begins to interfere with daily functioning, this additional reserve may help avid readers maintain cognitive performance. In people at elevated risk for age-related memory disorders, such reserve may even delay or mitigate the onset of full-blown dementia.
Behavioral and psychological symptoms of dementia (BPSD) are common in hospitalized older people and challenge acute care delivery.
Objective
This study sought to identify available quality indicators (QIs) for BPSD, establish priorities, and explore perceived facilitators and barriers to their use.
Methods
We conducted a cross-sectional electronic survey among physicians, nurses, and administrators in Quebec acute care hospitals (January–February 2025). The survey included open-ended questions analysed using Donabedian’s structure–process–outcome model.
Findings
Fifty-five respondents generated 677 responses, yielding 59 themes, 44 deemed priorities. Key QIs included delirium screening, restraint and antipsychotic use, length of stay, adverse events, and resource availability. Participants emphasized the need for standardized, clinically meaningful QIs. Reported barriers included staffing shortages, fragmented technological systems, and limited institutional prioritization, while facilitators included leadership commitment, interdisciplinary support, and structured training.
Discussion
Embedding standardized QIs into electronic health records may enhance benchmarking, guide improvement, and promote safer dementia care.
Neuropsychological (NP) tests are multi-domain in execution. Reliance on a single score representing specific domains obscures the detection of subtle cognitive changes and increases risk of inaccurate assessment. Rooted in the Boston Process Approach (BPA), the Framingham Heart Study (FHS) captures multi-dimensional errors and process features within and across NP tests. We examined these BPA variables in community-dwelling older adults.
Methods:
We analyzed data from 2363 dementia-free participants aged 60 and above. Exploratory and confirmatory factor analyses used Kemeny covariance structures. Measurement invariance was estimated across age, sex, and education groups. We assessed the impact of demographics on latent factors, and the ability of these factors to predict future conversion to all-cause dementia. We trained machine learning (ML) models to compare NP and BPA data.
Results:
Participants were older adults (mean age 71.5 ± 8.7 years), primarily female (54.2%), and non-Hispanic White (96.5%). The bifactor model was the only model with adequate fit (CFI = 0.96, RMSEA = 0.03). General and specific factors captured ability for accurate and strategic responses, test-specific variance, and nuanced executive and semantic processes distributed across tests. Higher general ability and stronger verbatim story recall were associated with a reduced likelihood of developing all-cause dementia (general: OR = 0.15, 95% CI [0.12–0.86]; recall: OR = 0.24, 95% CI [0.23–0.90]) over a median of 5.2 years. With NP/BPA data, ML models identified >99% of 222 converters.
Conclusions:
This study highlights the strengths of NP/BPA data. Multidimensional cognitive features may enhance sensitivity to early changes predictive of incipient dementia.
Early-onset frontotemporal dementia (EO-FTD) presents before age 65 and is frequently misdiagnosed as psychiatric or behavioural disorders, delaying care.
Objective
This scoping review synthesizes research on EO-FTD’s earliest cognitive symptoms from patients, companions (family and friends), healthcare professionals, and cognitive tests to promote early detection.
Methods
A systematic search of six databases (Medline, Embase, CINAHL, PsycInfo, Scopus, and Proquest Dissertations and Theses) identified 2197 studies of which 16 met inclusion criteria, encompassing 663 EO-FTD participants.
Findings
A total of 35 unique cognitive symptoms were identified. Memory, attention, and executive dysfunction were most frequently reported. Symptom terminology varied widely, often mirroring cognitive test phrasing, limiting clinical applicability. Many studies relied on cognitive test scores rather than detailed symptom descriptions, with patient and companion reports underrepresented.
Discussion
The findings underscore the need for standardized nomenclature, improved assessment tools, and greater inclusion of patient and companion perspectives to enhance EO-FTD early diagnosis and intervention strategies.
To evaluate the feasibility and preliminary efficacy of a clinical program designed to teach informal caregivers of older Veterans with pain and mild-to-moderate dementia or mild cognitive impairment (MCI), pain management, pain coping and pain communication skills.
Methods
Twenty caregivers of older Veterans with pain and dementia or MCI and the Veterans themselves participated in a 5-session program taught by trained Veterans Affairs (VA) clinicians. All sessions were conducted remotely using video-technology, with caregivers and Veterans. Two sessions were conducted with individual Veteran-caregiver dyads, and three sessions were conducted with caregiver groups. Caregivers and Veterans completed baseline and post-intervention measures. Qualitative interviews of 10 caregivers who completed the program were also conducted and focused on identifying themes related to caregiving for their loved ones with pain and dementia and related to participating in the program.
Results
The program was well received and almost all caregivers identified videoconferencing as the preferred venue for participating in such a program. They most valued learning about dementia and participating with other caregivers. Pre-post analyses revealed significant improvements in perceived caregiving competence and self-efficacy for managing pain. Challenges encountered included scheduling related to caregivers’ multiple competing responsibilities and lack of familiarity with tele-conferencing technology.
Significance of results
Patients with pain and mild to moderate dementia or MCI have been relatively ignored in current literature. Our preliminary findings suggest that a program delivered by trained healthcare professionals to caregivers and Veterans using tele-conferencing could benefit caregivers.
Around 10% of people living with dementia (PLWD) will experience a deterioration in their condition that will require urgent (‘crisis’) community support or an in-patient psychiatric admission. We have previously shown that people at high risk of a crisis event can be identified at the point of diagnosis. How the idea that someone is at increased risk of experiencing a crisis event in their care is best communicated is not known. Here, we describe the analysis of interviews with clinicians and PLWD, to understand their perspective and the co-production of tools designed to support risk communication.
Aims
To explore multistakeholder perspectives (healthcare professionals, carers, PLWD; n = 12) on the communication of risk of future in-patient psychiatric admission or enhanced ‘crisis’ community care and develop tools to support communication.
Method
This pilot study used an experience-based, co-design approach. Reflexive thematic analysis was used to analyse transcripts, leading to co-development of draft educational materials.
Results
We identified five themes that inform how risk should be communicated. Participants underlined the importance of timing, setting and follow-up appointments. Digital tools were considered essential, but they were not seen as a substitute to face-to-face appointments. Individual preferences varied, highlighting the need for patient-centred communication. The findings led to the co-development of clinician guidelines and educational materials.
Conclusions
Risk communication in dementia is complex and must be personalised to be most effective. Our findings may have relevance for the communication of other areas of risk in dementia beyond risk of care crises.
This study aimed to make a head-to-head comparison of the diagnostic accuracy and cross-cultural applicability of abbreviated 20-item versions of the Copenhagen Cross-Linguistic Naming Test (C-CLNT20) and Naming Assessment in Multicultural Europe (NAME20).
Methods:
The present study was conducted in a multicultural and multilingual patient sample from memory clinics across five European countries. Receiver operating characteristic curve analysis was used to assess the diagnostic accuracy of C-CLNT20 and NAME20 in classifying dementia and mild cognitive impairment (MCI). Binary logistic regression analysis was performed to evaluate the influence of demographic and cultural factors on diagnostic accuracy.
Results:
C-CLNT20 and NAME20 showed acceptable diagnostic accuracy for dementia with areas under the curve (AUC) of .75 and .82, respectively, but had low accuracy for MCI (AUC of .64 and .62, respectively). Compared to C-CLNT20, NAME20 had slightly higher, but statistically non-significant, AUCs for dementia in both in the full sample and in participants with immigrant background. The diagnostic accuracy of the C-CLNT20 and NAME20 was not significantly influenced by education and immigrant status in the full sample, or by acculturation and use of an interpreter in participants with immigrant background.
Conclusion:
Both C-CLNT20 and NAME20 are promising brief alternatives to the full versions of the naming tests when time is limited. They also present a promising alternative to other established naming tests by maintaining diagnostic accuracy while showing minimal cross-cultural and cross-linguistic bias.
Gothic Dementia: Troubled Minds in Gothic Timelines introduces Gothic studies as a valuable lens through which to critically consider how we think about dementia. It argues that the Gothic's foundational narrative techniques can model approaches to similar dementia symptoms, such as chronological confusion, fragmentation, cyclical storytelling, repetition, unreliable narrators, unstable identities, uncanny behaviours, and Otherness. If we can navigate these challenging narrative elements in literature, can we navigate similar challenging dementia signs using interpretive strategies? Gothic Dementia considers this question in two ways: (1) through Gothic literary elements that correlate to characteristics of dementia and (2) through contentious horror film depictions of characters with dementia and their caregivers. Reading Gothic works and horror films within the context of dementia studies—and vice versa—can contribute valuable insights into a feared disease that threatens the core of who we imagine ourselves and others to be.
Idiopathic normal pressure hydrocephalus (iNPH) is a neurological disorder affecting older adults for which symptoms may improve following shunting; however, the criteria for surgical referral remain unclear. While most studies rely on fixed cut-off scores for cognitive and gait tests, the present study examined decision-making based on clinical judgment to identify which factors influence referral. A secondary objective was to compare pre- and post-CSF tap test (CSF-TT) changes between the shunt and no shunt groups.
Methods:
This retrospective study included 175 patients assessed at CHU de Québec – Hôpital de l’Enfant-Jésus. Based on a combination of objective test results and clinical judgment, patients were categorized as referred (n = 119) or not referred (n = 56) for shunt surgery. Logistic regression identified the variables influencing referral decisions. Mixed-effects ANOVA models for repeated measures were conducted to compare pre- and post-CSF-TT changes in gait and cognitive performance between shunt and no shunt groups.
Results:
Three change indices significantly predicted referral: the 10-Meter Walk Test (normal pace), the Trail Making Test Condition 5 and the Berg Balance Scale. Higher education positively influenced referral. While most gait and balance measures showed significant improvement following CSF-TT, cognitive tests appeared less responsive to the procedure.
Conclusion:
Although this study employed a clinically grounded approach based on clinical judgment rather than fixed thresholds, the findings align with prior literature identifying gait and balance as robust indicators. This study reinforces the need to shift from rigid threshold-based criteria toward individualized, clinically grounded decision-making models that can better capture the heterogeneity of iNPH presentations.
The USA has among the highest levels of mental illness of all countries, together with the most treatment. We seek happiness through mechanisms that produce pleasure, most of which are not effective. Those lower down in the hierarchy use more destructive means to gain gratification, thereby becoming worse off. Americans may suffer more pain than people in other rich nations, especially social pain in response to chronic stressors present here. We consume 80% of the world’s opioids Smartphone use, especially among youth, may be harmful for mental health. Evolutionary pressures make us live to reproduce and nurture the progeny until they can have children. Various mental illnesses that don’t impact propagation can manifest, especially in later life, such as anxiety to cope with danger. Mental health is political, like other aspects of health
Lewy bodies (LBs) are the main pathological feature of the neurodegenerative diseases Parkinson’s disease and Dementia with LBs. Since their discovery over 100 years ago, it is only in the last three decades, that, a wealth of genetic, pathological and pre-clinical evidence puts the spotlight on accumulated α-Synuclein (α-Syn) as the main component of LBs and implicated as a driver of these diseases. This has catapulted clinical trials for these diseases focussing on strategies to remove, reduce, disaggregate and prevent propagation of α-Syn. Advances in technical approaches have started to build a bigger picture of the complexity of LBs extending beyond α-Syn. There is still much to be learned about the processes underlying the formation and structure of LBs and their relationship to neurodegeneration. This will likely impact upon how we target these diseases therapeutically, diagnose them and build clinical trials. Here, we will discuss LBs in the context of α-Syn and other features, modelling strategies and how to direct research moving forwards in order to get clinical results. A more complete understanding of LBs and potential novel targets that drive their formation will likely lead to better outcomes in LB diseases.
People living with dementia (PLWD) want – and have the right – to participate in research that impacts them. However, barriers in legislation, institutional practices, and/or biases may jeopardize inclusion.
Objective and Methods
Interviews with 33 Canadian dementia researchers were conducted to explore understandings of research consent with regard to dementia, research practices, and approaches in everyday research contexts.
Findings
Analysis of these interviews revealed challenges in negotiating the space between best practices and institutional requirements; gaps in knowledge, procedures, and guidelines on inclusion and consent; tensions regarding who should be involved in decision making; and how assumptions of presumed incapacity and/or the ‘protection’ of vulnerable groups create and/or sustain the exclusion of PLWD from research.
Discussion
Moving forward, findings suggest that advancing the meaningful inclusion of PLWD in Canadian dementia research will require clear, consistent standardized guidelines, flexible and ongoing consent processes, accessibility accommodations, and a stronger focus on rights-based practices.
The arguments of this book are intended to tackle the social injustices faced by people living with dementia, yet reflecting on the author’s social position reveals a tension. As the author is not a member of the social group this book concerns, they are engaging in an act of speaking for others: a practice that has received significant criticism, given the risks of contributing to oppression and stigma through misrepresentation. With this concern in mind, this chapter engages in a reflective exercise about the content of the book, highlighting ways in which the author’s social position may have negatively influenced its content and setting out the steps the author has taken to try to address this.
In both philosophical research and public discourse around dementia, issues of power and social status receive insufficient attention. The Introduction sets out how this book is aimed at filling this gap.
In medical ethics, there is a well-established debate about the authority of advance directives over people living with dementia, a dispute often cast as a clash between two principles: respecting autonomy and beneficence toward patients. This chapter, in highlighting underexplored issues of power and social status, argues that there need be only one principle in substitute decision-making: determining authenticity. This principle favours a substituted judgment standard in all cases and instructs decision-makers to determine what the patient would authentically prefer to happen – based not merely on the patient’s decisions but also on their present settled dispositions. Adhering to this principle entails that, in a significant range of cases, an advance directive can (and indeed ought to) be overruled.
This book makes a number of theoretical contributions to the legal and political philosophy of dementia care, which have important public policy implications. This conclusion serves as both a summary of the book and a final statement of the urgency of addressing the issues raised. It must be appreciated that contemporary Western societies, including the UK, face funding and legislative barriers to achieving the just, dementia-inclusive society. Nevertheless, by identifying an ideal to aspire to, it is hoped that this book can play some role in rectifying the severe injustices people living with dementia face.
Despite negative effects on their health and social lives, many informal carers of people living with dementia claim to be acting in accordance with a moral obligation. Indeed, feelings of failure and shame are commonly reported by those who later give up their caring responsibilities, suggesting a widespread belief that professional dementia care, whether delivered in the person’s own home or in an institutional setting, ought always to be a last resort. This chapter, however, suggests that this common intuition gets things the wrong way around. The most serious injustices engendered by present-day dementia care services are contingent on broader societal structures – they can thus be ameliorated relatively easily (if resource intensively). Informal dementia care, on the other hand, carries similar risks of injustice and is much more resistant to structural reform. While there may be moral obligations to provide informal dementia care in present-day societies, then, they arise because of the deficiencies of professional care, not the virtues of its informal counterpart.
Carers often interfere with the choices of people living with dementia. On neo-republican and (most) relational egalitarian views, interference can be justified if it tracks a person’s interests: if it does not lead to a relationship of domination. The kind of environment-shaping interventions carers often choose to pursue, however, would be considered infantilising or objectionably paternalistic in other cases. This chapter defends what it calls the indirect-first approach to dementia care, arguing that it offers the best prospects of avoiding domination.
Dietary magnesium (Mg) is a potentially modifiable factor in preventing dementia, but current evidence supporting this remains insufficient and inconclusive. This study aimed to determine whether dietary Mg is associated with the risk of dementia among middle-aged and older people. Participants of this 8-year cohort study were 13,032 community-dwelling individuals aged 40–74 years. Dietary data were collected using a validated food frequency questionnaire in 2011–2013. Mg intake was adjusted for energy intake using the residual method. The outcome was newly diagnosed dementia determined using Japan’s long-term care insurance database. Covariates included demographic characteristics, body size, lifestyles, and disease histories. Cox proportional hazard models were used to determine adjusted hazard ratios (HRs). The mean age of participants was 59.0 years. Dementia occurred in 148 males and 138 females. Lower quartiles of energy-adjusted Mg intake were associated with a higher risk of dementia (P for trend = 0.0410) in males, with the lowest quartile (Q1) having an elevated risk of dementia (HR = 1.73, 95% CI:1.07–2.83) compared to the highest quartile (Q4, reference); however, this association was not found in females. In a subgroup analysis by disease history in males, the HR of Q1 was attenuated in both subgroups; HR was 1.52 (95% CI:0.74–3.11) in those with a disease history and 1.40 (95% CI:0.73–2.69) in those without. In conclusion, low dietary Mg intake is associated with increased dementia risk in middle-aged and older Japanese males. However, this association may be partly attributable to underlying disease history.
The framework set out in this book reconceptualises the problem of dementia care as a problem of power and social exclusion. At every stage, the goal should be to empower recipients of care to meet their own needs and participate fully in social life as equals, necessitating restrictions on the power of carers and radical changes to our cultural assumptions about and depictions of dementia. Though few would disagree that Western dementia care services are in need of reform, the book’s emphasis on social equality means that the depth and character of the proposed reforms differ significantly from many of those under public discussion. Indeed, as demonstrated in this chapter, significant changes would be needed to the way the UK treats people living with dementia under the law in order to support the reforms recommended in this book.