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The aim of this study is to analyse the changing patterns in the transmission of COVID-19 in relation to changes in Vietnamese governmental policies, based on epidemiological data and policy actions in a large Vietnamese province, Bac Ninh, in 2021. Data on confirmed cases from January to December 2021 were collected, together with policy documents. There were three distinct periods of the COVID-19 pandemic in Bac Ninh province during 2021. During the first period, referred to as the ‘Zero-COVID’ period (01/04–07/04/2021), there was a low population vaccination rate, with less than 25% of the population receiving its first vaccine dose. Measures implemented during this period focused on domestic movement restrictions, mask mandates, and screening efforts to control the spread of the virus. The subsequent period, referred to as the ‘Transition’ period (07/05–10/22/2021), witnessed a significant increase in population vaccination coverage, with 80% of the population receiving their first vaccine dose. During this period, several days passed without any reported COVID-19 cases in the community. The local government implemented measures to manage domestic actions and reduce the time spent in quarantine, and encouraged home quarantining for the close contacts of cases with COVID-19. Finally, the ‘New-normal’ stage (10/23–12/31/2021), during which the population vaccination coverage with a second vaccine dose increased to 70%, and most of the mandates for the prevention and control of COVID-19 were reduced. In conclusion, this study highlights the importance of governmental policies in managing and controlling the transmission of COVID-19 and provides insights for developing realistic and context-specific strategies in similar settings.
This paper investigates an operation mechanism for mutual aid platforms to develop more sustainably and profitably. A mutual aid platform is an online risk-sharing platform for risk-heterogeneous participants, and the platform extracts revenues by charging participants commission and subscription fees. A modeling framework is proposed to identify the optimal commissions and subscriptions for mutual aid platforms. Participants are divided into different types based on their loss probabilities and values derived from the platform. We present how these commissions and subscriptions should be set in a mutual aid plan to maximize the platform’s revenues. Our analysis emphasized the importance of accounting for risk heterogeneity in mutual aid platforms. Specifically, different types of participants should be charged different commissions/subscriptions depending on their loss probabilities and values on the platform. Participants’ shared costs should be determined based on their loss probabilities. Adverse selection occurs on the platform if participants with different risks pay the same shared costs. Our results also show that the platform’s maximum revenue will be lower if the platform charges the same fee to all participants. The numerical results of a practical example illustrate that the optimal commission/subscription scheme and risk-sharing rule result in considerable improvements in platform revenue over the current scheme implemented by the platform.
An outbreak of SARS-CoV-2 was confirmed after an academic party in Helsinki, Finland, in 2022. All 70 guests were requested to fill in follow-up questionnaires; serologic analyses and whole-genome sequencing (WGS) were conducted when possible.
Of those participating – all but one with ≥3 vaccine doses – 21/53 (40%) had test-confirmed symptomatic COVID-19: 7% of those with earlier episodes and 76% of those without. Half (11/21) were febrile, but none needed hospitalisation. WGS revealed subvariant BA.2.23.
Compared to vaccination alone, our data suggest remarkable protection by hybrid immunity against symptomatic infection, particularly in instances of recent infections with homologous variants.
Consider a Brownian motion on the circumference of the unit circle, which jumps to the opposite point of the circumference at incident times of an independent Poisson process of rate $\lambda$. We examine the problem of coupling two copies of this ‘jumpy Brownian motion’ started from different locations, so as to optimise certain functions of the coupling time. We describe two intuitive co-adapted couplings (‘Mirror’ and ‘Synchronous’) which differ only when the two processes are directly opposite one another, and show that the question of which strategy is best depends upon the jump rate $\lambda$ in a non-trivial way. We also provide an explicit description of a (non-co-adapted) maximal coupling for any jump rate in the case that the two jumpy Brownian motions begin at antipodal points of the circle.
Undirected, binary network data consist of indicators of symmetric relations between pairs of actors. Regression models of such data allow for the estimation of effects of exogenous covariates on the network and for prediction of unobserved data. Ideally, estimators of the regression parameters should account for the inherent dependencies among relations in the network that involve the same actor. To account for such dependencies, researchers have developed a host of latent variable network models; however, estimation of many latent variable network models is computationally onerous and which model is best to base inference upon may not be clear. We propose the probit exchangeable (PX) model for undirected binary network data that is based on an assumption of exchangeability, which is common to many of the latent variable network models in the literature. The PX model can represent the first two moments of any exchangeable network model. We leverage the EM algorithm to obtain an approximate maximum likelihood estimator of the PX model that is extremely computationally efficient. Using simulation studies, we demonstrate the improvement in estimation of regression coefficients of the proposed model over existing latent variable network models. In an analysis of purchases of politically aligned books, we demonstrate political polarization in purchase behavior and show that the proposed estimator significantly reduces runtime relative to estimators of latent variable network models, while maintaining predictive performance.
We use Stein’s method to establish the rates of normal approximation in terms of the total variation distance for a large class of sums of score functions of samples arising from random events driven by a marked Poisson point process on $\mathbb{R}^d$. As in the study under the weaker Kolmogorov distance, the score functions are assumed to satisfy stabilisation and moment conditions. At the cost of an additional non-singularity condition, we show that the rates are in line with those under the Kolmogorov distance. We demonstrate the use of the theorems in four applications: Voronoi tessellations, k-nearest-neighbours graphs, timber volume, and maximal layers.
We consider infinitely wide multi-layer perceptrons (MLPs) which are limits of standard deep feed-forward neural networks. We assume that, for each layer, the weights of an MLP are initialized with independent and identically distributed (i.i.d.) samples from either a light-tailed (finite-variance) or a heavy-tailed distribution in the domain of attraction of a symmetric $\alpha$-stable distribution, where $\alpha\in(0,2]$ may depend on the layer. For the bias terms of the layer, we assume i.i.d. initializations with a symmetric $\alpha$-stable distribution having the same $\alpha$ parameter as that layer. Non-stable heavy-tailed weight distributions are important since they have been empirically seen to emerge in trained deep neural nets such as the ResNet and VGG series, and proven to naturally arise via stochastic gradient descent. The introduction of heavy-tailed weights broadens the class of priors in Bayesian neural networks. In this work we extend a recent result of Favaro, Fortini, and Peluchetti (2020) to show that the vector of pre-activation values at all nodes of a given hidden layer converges in the limit, under a suitable scaling, to a vector of i.i.d. random variables with symmetric $\alpha$-stable distributions, $\alpha\in(0,2]$.
We consider a class of weakly interacting particle systems of mean-field type. The interactions between the particles are encoded in a graph sequence, i.e. two particles are interacting if and only if they are connected in the underlying graph. We establish a law of large numbers for the empirical measure of the system that holds whenever the graph sequence is convergent to a graphon. The limit is the solution of a non-linear Fokker–Planck equation weighted by the (possibly random) graphon limit. In contrast with the existing literature, our analysis focuses on both deterministic and random graphons: no regularity assumptions are made on the graph limit and we are able to include general graph sequences such as exchangeable random graphs. Finally, we identify the sequences of graphs, both random and deterministic, for which the associated empirical measure converges to the classical McKean–Vlasov mean-field limit.
We develop a novel Monte Carlo algorithm for the vector consisting of the supremum, the time at which the supremum is attained, and the position at a given (constant) time of an exponentially tempered Lévy process. The algorithm, based on the increments of the process without tempering, converges geometrically fast (as a function of the computational cost) for discontinuous and locally Lipschitz functions of the vector. We prove that the corresponding multilevel Monte Carlo estimator has optimal computational complexity (i.e. of order $\varepsilon^{-2}$ if the mean squared error is at most $\varepsilon^2$) and provide its central limit theorem (CLT). Using the CLT we construct confidence intervals for barrier option prices and various risk measures based on drawdown under the tempered stable (CGMY) model calibrated/estimated on real-world data. We provide non-asymptotic and asymptotic comparisons of our algorithm with existing approximations, leading to rule-of-thumb principles guiding users to the best method for a given set of parameters. We illustrate the performance of the algorithm with numerical examples.
The impact of hepatitis B virus (HBV) infection on clinical outcomes of coronavirus disease 2019 (COVID-19) remains unclear. The aim of this study is to explore this impact. For this systematic review and meta-analysis, we searched PubMed, Web of Science, Embase, Cochrane library, China National Knowledge Infrastructure (CKNI), China Science and Technology Journal Database (VIP), and Wan Fang database for articles between 1 January 2020 and 1 February 2023. We used the Newcastle–Ottawa Quality Assessment to evaluate the study’s quality. A random-effects meta-analysis was performed utilising the rates of severe/critical illness and death in COVID-19 patients with and without HBV infection. Eighteen studies with a total of 40,502 participants met the inclusion criteria. The meta-analysis showed that compared to those without HBV infection, COVID-19 patients with HBV were at increased risk of mortality (OR = 1.65, I2 = 58%, and 95% CI 1.08–2.53) and severity (OR = 1.90, I2 = 44%, and 95% CI 1.62–2.24). The region and gender may influence the outcomes of COVID-19 patients with HBV infection, but it requires more global data to confirm. In conclusion, HBV infection is significantly linked to an increased risk of severity and mortality in COVID-19.
We show that the size-Ramsey number of the $\sqrt{n} \times \sqrt{n}$ grid graph is $O(n^{5/4})$, improving a previous bound of $n^{3/2 + o(1)}$ by Clemens, Miralaei, Reding, Schacht, and Taraz.
Developed sequential order statistics (DSOS) are very useful in modeling the lifetimes of systems with dependent components, where the failure of one component affects the performance of remaining surviving components. We study some stochastic comparison results for DSOS in both one-sample and two-sample scenarios. Furthermore, we study various ageing properties of DSOS. We state many useful results for generalized order statistics as well as ordinary order statistics with dependent random variables. At the end, some numerical examples are given to illustrate the proposed results.
The aim of this study is to evaluate the infection risk of aircraft passengers seated within and beyond two rows of the index case(s) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza A(H1N1)pdm09 virus, and SARS-CoV-1. PubMed databases were searched for articles containing information on air travel–related transmission of SARS-CoV-2, influenza A(H1N1)pdm09 virus, and SARS-CoV-1 infections. We performed a meta-analysis of inflight infection data. In the eight flights where the attack rate could be calculated, the inflight SARS-CoV-2 attack rates ranged from 2.6% to 16.1%. The risk ratios of infection for passengers seated within and outside the two rows of the index cases were 5.64 (95% confidence interval (CI):1.94–16.40) in SARS-CoV-2 outbreaks, 4.26 (95% CI:1.08–16.81) in the influenza A(H1N1)pdm09 virus outbreaks, and 1.91 (95% CI:0.80–4.55) in SARS-CoV-1 outbreaks. Furthermore, we found no significant difference between the attack rates of SARS-CoV-2 in flights where the passengers were wearing masks and those where they were not (p = 0.22). The spatial distribution of inflight SARS-CoV-2 outbreaks was more similar to that of the influenza A(H1N1)pdm09 virus outbreaks than to that of SARS-CoV-1. Given the high proportion of asymptomatic or pre-symptomatic infection in SARS-CoV-2 transmission, we hypothesised that the proximity transmission, especially short-range airborne route, might play an important role in the inflight SARS-CoV-2 transmission.
A testing rate for measles above 80% is required by the WHO European Region Measles Elimination strategy to verify elimination. To comply with this rate, we explored factors associated with the return of oral fluid kits (OFK) by suspected measles cases. We described the cases and conducted a mixed-effects analysis to assess the relationship between socio-demographic and public health management characteristics and the likelihood of returning an OFK to the reference laboratory. Of 3,929 cases who were sent a postal OFK, 2,513 (67%) returned the kit. Adjusting for confounding, registration with a general practitioner (GP) (aOR:1.48, 95%CI:1.23–1.76) and living in a less deprived area (aOR:1.35, 95%CI:1.04–1.74) were associated with an increased likelihood of returning the OFK. The odds of returning the OFK also increased if the HPT contacted the parents/guardians of all cases prior to sending the kit and confirmed their address (aOR:2.01, 95%CI:1.17–3.42). Cases notified by a hospital (aOR:1.94, 95%CI:1.31–2.87) or GP (aOR:1.52; 95%CI:1.06–2.16) also had higher odds of returning the OFK. HPTs may want to consider these factors when managing suspected cases of measles since this may help in increasing the testing rates to the WHO-recommended level.
While finite element (FE) modeling is widely used for ultimate strength assessments of structural systems, incorporating complex distortions and imperfections into FE models remains a challenge. Conventional methods typically rely on assumptions about the periodicity of distortions through spectral or modal methods. However, these approaches are not viable under the many realistic scenarios where these assumptions are invalid. Research efforts have consistently demonstrated the ability of point cloud data, generated through laser scanning or photogrammetry-based methods, to accurately capture structural deformations at the millimeter scale. This enables the updating of numerical models to capture the exact structural configuration and initial imperfections without the need for unrealistic assumptions. This research article investigates the use of point cloud data for updating the initial distortions in a FE model of a stiffened ship deck panel, for the purposes of ultimate strength estimation. The presented approach has the additional benefit of being able to explicitly account for measurement uncertainty in the analysis. Calculations using the updated FE models are compared against ground truth test data as well as FE models updated using standard spectral methods. The results demonstrate strength estimation that is comparable to existing approaches, with the additional advantages of uncertainty quantification and applicability to a wider range of application scenarios.
We consider the simple random walk on the d-dimensional lattice $\mathbb{Z}^d$ ($d \geq 1$), traveling in potentials which are Bernoulli-distributed. The so-called Lyapunov exponent describes the cost of traveling for the simple random walk in the potential, and it is known that the Lyapunov exponent is strictly monotone in the parameter of the Bernoulli distribution. Hence the aim of this paper is to investigate the effect of the potential on the Lyapunov exponent more precisely, and we derive some Lipschitz-type estimates for the difference between the Lyapunov exponents.