We investigate enstrophy variations by collapse of point vortices in an inviscid flow and, in particular, focus on the enstrophy dissipation that is a significant property characterising two-dimensional (2-D) turbulent flows. To reveal the vortex dynamics causing the enstrophy dissipation, we consider the dynamics of point vortices, whose vorticity is concentrated on points and dynamics on the inviscid flow, governed by the point-vortex system. The point-vortex system has self-similar collapsing solutions, which are expected to be a key to understand the enstrophy dissipation, but the collapsing process cannot be described by solutions to the 2-D Euler equations. We thus consider the 2-D filtered-Euler equations, which are a regularised model of the 2-D Euler equations, and their point-vortex solutions. The preceding studies (Gotoda and Sakajo, J. Nonlinear Sci. 2016, vol. 26, pp. 1525–1570, Gotoda and Sakajo, SIAM J. Appl. Math. 2018, vol. 78, 2105–2128) have proven that there exist three point-vortex solutions to the filtered model such that they converge to self-similar collapsing orbits in the three point-vortex system and dissipate the enstrophy at the event of collapse in the zero limit of the filter parameter. In this study, we numerically show that the enstrophy dissipation by the collapse of point vortices could occur for the four and five vortex problems in a filtered model. Moreover, we show the detailed convergence process of the point vortices for gradually decreasing filter parameters, which provides a new insight for the three vortex problem. In addition, numerical computations suggest that the enstrophy dissipation is caused by collapse of separated point vortices with the negative interactive energy.