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Women with polycystic ovary syndrome (PCOS) experience higher rates of depression and anxiety. There is limited research relating to perinatal mental health in women with PCOS. Studies suggest PCOS is associated with a higher prevalence of perinatal mental health disorders. Perinatal guidelines currently do not recognise PCOS as a risk factor for perinatal mental health disorders. We aimed to prospectively assess the prevalence of mental health disorders in pregnant women with PCOS.
Methods:
Consenting pregnant women, with and without PCOS, were invited to participate. Standardised validated questionnaires were carried out including Generalised Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire-9 (PHQ-9) and Edinburgh Postnatal Depression Scale (EPDS).
Results:
Fifty-one with PCOS and 49 without PCOS responded. Pregnant women with PCOS had a higher mean (SD) anxiety score (GAD-7) than those without PCOS (8.2 [6.7] vs. 5.89 [4.7], p = 0.04). Pregnant women with PCOS had higher mean (SD) depression scores than those without PCOS on EPDS (9.1 [6.4] vs. 6.4 [4.5], p = 0.02) but not PHQ-9 score (median (IQR) 4 (3–9) vs. 4 (2–7.5), p = 0.25). Women with PCOS were more likely to experience moderate/severe anxiety (PCOS 34%, control 20%) and moderate/severe depression (PCOS 34%, control 20%) symptoms than women without PCOS. Twenty-nine percent of pregnant women with PCOS had an EPDS score >13 showing significantly higher rates of severe depression (PCOS 29%, control 12%, p = 0.03).
Conclusion:
Our findings suggest a higher prevalence of perinatal depression and anxiety in women with PCOS. Our findings may suggest increased need for screening for mental health disorders in women with PCOS.
In this work we study features of inertia-gravity wave turbulence in the rotating shallow water equations. On examining the dynamics of waves with varying rotation rates, we find that the turbulent cascade of waves is strongest at low rotation rates, forming a $k^{-2}$ energy spectrum, and a rich distribution of shocks in physical space. At high rotation rates, the forward cascade of waves weakens along with a steeper energy spectra and vanishing of shocks in physical space. The wave cascade is seen to be scale-local, resulting in a noticeable time interval for energy to get transferred from domain scale to dissipative scale. Furthermore, we find that the vortical flow has a non-negligible effect on the wave cascade, especially at high rotation rates. The vortical flow assists in the forward cascade of waves and shock formation at high rotation rates, while the waves by themselves in the absence of the vortical flow lack a forward cascade and shock formation at such high rotation rates. On investigating the physical space structures in the vortical flow and their connections to the wave cascade, we find that strain-dominant regions, that are located around the boundaries of coherent vortices, are the physical space regions that contribute majorly to the forward cascade of waves. Our results in general highlight intriguing features of dispersive inertia-gravity wave turbulence that are qualitatively similar to those seen in three-dimensional homogeneous isotropic turbulence and are beyond the predictions of asymptotic resonant wave interaction theory.
This paper presents advances towards the data-based control of periodic oscillator flows, from their fully developed regime to their equilibrium stabilized in closed loop, with linear time-invariant (LTI) controllers. The proposed approach directly builds upon the iterative method of Leclercq et al. (J. Fluid Mech., vol. 868, 2019, pp. 26–65) and provides several improvements for an efficient online implementation, aimed at being applicable in experiments. First, we use input–output data to construct an LTI mean transfer functions of the flow. The model is subsequently used for the design of an LTI controller with linear quadratic Gaussian synthesis, which is practical to automate online. Then, using the controller in a feedback loop, the flow shifts in phase space and oscillations are damped. The procedure is repeated until equilibrium is reached, by stacking controllers and performing balanced truncation to deal with the increasing order of the compound controller. In this article, we illustrate the method for the classic flow past a cylinder at Reynolds number $Re=100$. Care has been taken such that the method may be fully automated and hopefully used as a valuable tool in a forthcoming experiment.
The results of an experimental investigation of smooth-body adverse pressure gradient (APG) turbulent boundary layer flow separation and reattachment over a two-dimensional ramp are presented. These results are part of a larger archival smooth-body flow separation data set acquired in partnership with NASA Langley Research Center and archived on the NASA Turbulence Modeling Resource website. The experimental geometry provides initial canonical turbulent boundary layer growth under nominally zero pressure gradient conditions prior to encountering a smooth, two-dimensional, backward facing ramp geometry onto which a streamwise APG that is fully adjustable is imposed. Detailed surface and off-surface flow field measurements are used to fully characterize the smooth-body APG turbulent boundary layer separation and reattachment at multiple spanwise locations over the ramp geometry. Unsteady aspects of the flow separation are characterized. It is shown that the first and second spatial derivatives of the streamwise static surface pressure profile are sufficient to determine key detachment and reattachment locations. The imposed streamwise APG gives rise to inflectional mean velocity profiles and the associated formation of an embedded shear layer, which is shown to play a dominant role in the subsequent flow development. Similarity scaling is developed for both the mean velocity and turbulent stresses that is found to provide self-similar collapse of profiles for different regions of the ramp flow. Despite the highly non-equilibrium flow environment, a new similarity scaling proved capable of providing self-similar turbulent stress profiles over the full streamwise extent of flow separation and downstream reattachment.
Given a positive integer m, let $\mathbb {Z}_m$ be the set of residue classes mod m. For $A\subseteq \mathbb {Z}_m$ and $n\in \mathbb {Z}_m$, let $\sigma _A(n)$ be the number of solutions to the equation $n=x+y$ with $x,y\in A$. Let $\mathcal {H}_m$ be the set of subsets $A\subseteq \mathbb {Z}_m$ such that $\sigma _A(n)\geq 1$ for all $n\in \mathbb {Z}_m$. Let
Ding and Zhao [‘A new upper bound on Ruzsa’s numbers on the Erdős–Turán conjecture’, Int. J. Number Theory20 (2024), 1515–1523] showed that $\limsup _{m\rightarrow \infty }\ell _m\le 192$. We prove
Microorganisms symbiotic with insects, whether permanently or temporarily, play a crucial role in the nutrition, development, reproduction, defence, and metamorphosis regulation. In some Lepidoptera, oviposition-deterrent pheromones (ODPs) on egg surface were used by pregnant females to modify the behaviour of conspecifics to avoid excessive competition for limited resources. In this study, we constructed four different Spodoptera litura groups, including, OH, OA, SH, and OA, which either feed on different hosts or grow in different environments. The 16S rDNA libraries of microbes from the egg surface of the four groups were constructed and sequenced. According to alpha and beta diversity indices, the microbes in environments and diets considerably influenced the richness, diversity, and community compositions of the microbiota on egg surfaces. The quantity of the main ODP components and the corresponding oviposition-deterrent activity among four groups were significantly differed among the four groups. The result of this study revealed that altering of microbes in environments or diets considerably changed the contents of ODP and oviposition-deterrent activity. As ODPs impart oviposition-deterrent activity towards closely related species, the findings of this study suggest that we should pay more attention to the role of symbiotic microorganisms in changing the ability of insects, especially sympatric species, to occupy the optimal niche when developing novel pest-control strategies.
where ɛ is apositive parameter, $0 \lt s \lt 1$, $2 \leqslant p \lt q \lt \min\{2p, N / s\}$, $0 \lt \mu \lt sp$, $(- \Delta)_t^s$$(t \in \left\{p,q\right\})$ is the fractional t-Laplace operator, the reaction term $f : \mathbb{R} \mapsto \mathbb{R}$ is continuous, and the potential $V \in C (\mathbb{R}^N , \mathbb{R})$ satisfying a local condition. Using a variational approach and topological tools (the non-standard C1-Nehari manifold analysis and the abstract category theory), multiplicity of positive solutions and concentration properties for the above problem are established. Our results extend and complement some previous contributions related to double phase variational integrals.
The causal relevance of local flow conditions in open-channel turbulence is analysed using ensembles of interventional experiments in which the effect of perturbing the flow within a small cell is monitored at some future time. When this is done using the relative amplification of the perturbation energy, causality depends on the flow conditions within the cell before it is perturbed, and can be used as a probe of the flow dynamics. The key scaling parameter is the ambient shear, which is also the dominant diagnostic variable for wall-attached perturbations. Away from the wall, the relevant variables are the streamwise and wall-normal velocities. Causally significant cells are associated with sweeps that carry the perturbation towards the stronger shear near the wall, whereas irrelevant ones are associated with ejections that carry it towards the weaker shear in the outer layers. Causally significant and irrelevant cells are themselves organised into structures that share many characteristics with classical sweeps and ejections, such as forming spanwise pairs whose dimensions and geometry are similar to those of classical quadrants. At the wall, this is consistent with causally significant configurations in which a high-speed streak overtakes a low-speed one, and causally irrelevant ones in which the two streaks pull apart from each other. It is argued that this is probably associated with streak meandering.
Across Latin American countries, there is remarkable heterogeneity in abortion legislation, ranging from full prohibition to legal elective abortion.1 However, abortion policy does not seem to clearly map onto implementation on the ground. On the one hand, even in countries with very restrictive abortion laws, (clandestine) abortion rates are comparatively high, and legislation that criminalizes abortion is rarely enforced (Blofield 2006; Htun 2003). On the other hand, in countries that allow abortion under all or some circumstances, access to abortion is not guaranteed. In Argentina, for instance, different reports have stressed the difficulty in accessing abortion procedures both before and after legalization was enacted in early 2021.2
In vitro production of porcine embryos is a complicated process that includes in vitro maturation (IVM), in vitro fertilization (IVF) and in vitro culture (IVC). Insufficient cytoplasmic maturation, slow zona reaction and improper embryo culture conditions will compromise the efficiency of porcine embryo production in vitro. Previous studies have shown that insulin-transferrin-selenium (ITS) in IVM or IVC medium could improve porcine oocyte maturation, decrease polyspermy fertilization and promote subsequent embryonic development in vitro. However, the effect of ITS both in IVM and IVC media on porcine embryo production in vitro hasn’t been elucidated. In this study, we found that 1.0% ITS supplementation in IVM/IVC media promoted the expansion of cumulus cells, raised mitochondrial membrane potential, increased ATP content and reduced ROS level in matured oocytes, improved blastocyst rate and the cell number of blastocyst, simultaneously. In conclusion, the IVM/IVC media supplemented with 1.0% ITS can improve the efficiency of porcine embryo production in vitro.
A model is formulated of a two-dimensional migrating, or swimming, inviscid bubble in a viscous fluid whose unsteady displacement is caused by the spreading over its surface of an initial distribution of insoluble surfactant. Assuming small capillary and Reynolds numbers, and a linear equation of state giving the surface tension as a function of surfactant concentration, the quasi-steady Stokes flow around the bubble is found analytically and explicit formulas are determined for the time-dependent bubble speed and its final overall displacement. At infinite surface Péclet number this is done using a complex version of the method of characteristics to solve a complex partial differential equation of Burgers type. For a finite non-zero surface Péclet number, the problem is shown to be linearizable by a complex variant of the classical Cole–Hopf transformation. The formulation allows general statements to be made on the bubble speed and its total net displacement in terms of the initial surfactant distribution. A weak finite-time singularity in the surface activity associated with an isolated clean point on the bubble surface is also identified and studied in detail.
This article examines recent measures undertaken by major commercial banks to mitigate and address human rights risks associated with their financial dealings in the arms industry. By reviewing the corporate policies of 20 leading banks that provide financing to top arms manufacturing and exporting companies, the article provides insights into three significant aspects of banks’ efforts: the development of defence sector policies, the implementation of risk assessments for adverse human rights impacts, and the application of exclusion clauses. These measures highlight the increasing recognition by banks of the need to address the ethical, social and human rights implications of financing arms deals, contributing to the broader regulatory and normative framework governing the arms industry.
New limit theory is provided for a wide class of sample variance and covariance functionals involving both nonstationary and stationary time series. Sample functionals of this type commonly appear in regression applications and the asymptotics are particularly relevant to estimation and inference in nonlinear nonstationary regressions that involve unit root, local unit root, or fractional processes. The limit theory is unusually general in that it covers both parametric and nonparametric regressions. Self-normalized versions of these statistics are considered that are useful in inference. Numerical evidence reveals interesting strong bimodality in the finite sample distributions of conventional self-normalized statistics similar to the bimodality that can arise in t-ratio statistics based on heavy tailed data. Bimodal behavior in these statistics is due to the presence of long memory innovations and is shown to persist for very large sample sizes even though the limit theory is Gaussian when the long memory innovations are stationary. Bimodality is shown to occur even in the limit theory when the long memory innovations are nonstationary. To address these complications, new self-normalized versions of the test statistics are introduced that deliver improved approximations that can be used for inference.
In this paper, we establish a new version of one-dimensional discrete improved Hardy’s inequality with shifts by introducing a shifting discrete Dirichlet’s Laplacian. We prove that the general discrete Hardy’s inequality as well as its variants in some special cases admit improvements. Further, it is proved that two-variable discrete $p$-Hardy inequality can also be improved via improved discrete $p$-Hardy inequality in one dimension. The result is also extended to the multivariable cases.
In this article, we consider some critical Brézis-Nirenberg problems in dimension $N \geq 3$ that do not have a solution. We prove that a supercritical perturbation can lead to the existence of a positive solution. More precisely, we consider the equation:
where $B \subset \mathbb{R}^N$ is a unit ball centred at the origin, $N\geq 3$, $r=\vert x \vert$, $\alpha \in (0,\min\{N/2,N-2\})$, λ is a fixed real parameter and $q\in [2,2^*]$. This class of problems can be interpreted as a perturbation of the classical Brézis–Nirenberg problem by the term rα at the exponent, making the problem supercritical when $r \in (0,1)$. More specifically, we study the effect of this supercritical perturbation on the existence of solutions. In particular, when N = 3, an interesting and unexpected phenomenon occurs. We obtain the existence of solutions for λ in a range where the Brézis–Nirenberg problem has no solution.