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Microorganism motility often takes place within complex, viscoelastic fluid environments, e.g. sperm in cervicovaginal mucus and bacteria in biofilms. In such complex fluids, strains and stresses generated by the microorganism are stored and relax across a spectrum of length and time scales and the complex fluid can be driven out of its linear response regime. Phenomena not possible in viscous media thereby arise from feedback between the swimmer and the complex fluid, making swimming efficiency co-dependent on the propulsion mechanism and fluid properties. Here, we parameterize a flagellar motor and filament properties together with elastic relaxation and nonlinear shear-thinning properties of the fluid in a computational immersed boundary model. We then explore swimming efficiency, defined as a particular flow rate divided by the torque required to spin the motor, over this parameter space. Our findings indicate that motor efficiency (measured by the volumetric flow rate) can be boosted or degraded by relatively moderate or strong shear thinning of the viscoelastic environment.
The new mineral vadlazarenkovite, ideally Pd8Bi1.5Te1.25As0.25, was discovered in a heavy concentrate obtained from ore samples collected at the Anomal’noe occurrence, Konder alkaline-ultrabasic massif, Khabarovsk Krai, Far East, Russia. It occurs as anhedral grains up to 0.15 × 0.15 mm, intergrown with vysotskite and associated with numerous platinum-group element (PGE) bearing minerals (arsenopalladinite, ezochiite, hollingworthite, kotulskite, norilskite, polarite, skaergaardite, sobolevskite, sperrylite, törnroosite, zvyagintsevite etc.). Vadlazarenkovite is grey, opaque with metallic lustre, has brittle tenacity and uneven fracture. No cleavage and parting are observed. The Vickers’ micro-indentation hardness (VHN, 50 g load) is 424 kg/mm2 (range 406–443, n = 4), corresponding to a Mohs’ hardness of 4.5–5. Dcalc. = 11.947 g/cm3. In reflected light, vadlazarenkovite is white with a pale creamy hue. The bireflectance is weak in air and noticeable in oil immersion. In crossed polars the new mineral exhibits distinct anisotropy in grey tones. The reflectance values for wavelengths recommended by the Commission on Ore Mineralogy of the International Mineralogical Association are (Rmin/Rmax, %): 47.2/47.8 (470 nm), 49.1/50.8 (546 nm), 50.7/52.6 (589 nm) and 52.4/54.6 (650 nm). The chemical composition (wt.%, electron microprobe data, mean of 6 analyses) is: Pd 63.67, Ag 2.21, As 1.27, Sb 0.60, Te 11.26, Pb 2.56, Bi 19.95, total 101.51. The empirical formula calculated on the basis of 11 atoms per formula unit is (Pd7.87Ag0.27)Σ8.14(Bi1.26Te1.16As0.22Pb0.16Sb0.06)Σ2.86. Vadlazarenkovite is trigonal, space group R$\bar 3$c, a = 7.7198(2), c = 43.1237(11) Å, V = 2225.66(13) Å3 and Z = 12. The strongest lines of the powder X-ray diffraction pattern [d, Å (I, %) (hkl)] are: 2.308 (55) (1 1 15); 2.262 (100) (2 0 14); 2.232 (70) (3 0 0); and 2.040 (70) (1 1 18). The crystal structure of vadlazarenkovite was refined to R1 = 0.0267 for 761 reflections with Fo > 4σ(Fo). The new mineral is isotypic with mertieite. It honours Professor Vadim Grigorievich Lazarenkov (1933–2014) for his outstanding contributions to the geology, geochemistry and mineralogy of platinum-group elements.
This paper presents a dual-band bandpass filter with regular harmonic suppression. The proposed third-order filter consists of two microstrip stepped impedance resonators and single substrate integrated waveguide resonator. The mismatches in their higher order resonant frequencies are utilized to suppress the regular harmonics. The passbands are centered at f1 = 2.4 GHz and f2 = 3.5 GHz with fractional bandwidths of 5% and 7.5%, respectively. The measured midband insertion and return losses are better than 2.55 and 14.5 dB for the first, whereas for the second band, they are better than 1.95 and 14 dB. The filter offers at least 33 dB suppression of first three higher order regular harmonics of f1 and f2.
From 1860 to 1900, a modern system of property rights emerged in the International Settlement in Shanghai. This paper examines the largely overlooked process by which the Shanghai Municipal Council (SMC) brought about a system of well-functioning property rights through land surveys, mapping, and assessments. These methods worked hand-in-hand with road planning and construction in facilitating the expansion of the International Settlement to the Chinese-controlled area. Colonial officials, merchants, and Chinese intellectuals worked collectively and sometimes separately to generate knowledge about land and property by translating terms in the Chinese tradition. It argues that the efforts in institution-building and translation helped normalize the definition of property rights as things exclusively owned, strengthening the SMC's control over the land in Shanghai. These processes illuminate the relationship between empire-making and property rights by showing how property rights emerged and functioned in a semi-colonial context where multiple foreign authorities coexisted with the local government. The relatively secure system of property rights, which both foreign and Chinese merchants exploited, formed the foundation of a prosperous Shanghai in the twentieth century.
We characterize four fruitful and underappreciated epistemic roles played by the concept of an individualized niche in contemporary biology, utilizing results of a qualitative empirical study conducted within an interdisciplinary biological research center. We argue that the individualized niche concept (1) shapes the research agenda of the center, (2) facilitates explaining core phenomena related to interindividual differences, (3) helps with managing individual-level causal complexity, and (4) promotes integrating local knowledge from ecology, evolutionary biology, behavioral biology, and other biological fields. We thereby also challenge arguments that the niche concept is superfluous in ecology.
This project documents the current archaeological record of the Qaraçay River Basin in western Azerbaijan. Integrating intensive pedestrian survey, satellite imagery analysis and topographic mapping, the study identified 85 kurgans, six necropolises and nine sites from the Chalcolithic or medieval periods. The authors believe this demonstrates the potential for further archaeological studies in the region.
The influence of the SNP rs174575 (C/G) within the fatty acid desaturase 2 gene on the levels of long-chain PUFA was determined through statistical meta-analysis. Six databases were searched to retrieve the relevant literature. Original data were analysed using Stata 17·0, encompassing summary statistics, tests for heterogeneity, assessment of publication bias, subgroup analysis and sensitivity analysis. A total of ten studies were identified and grouped into twelve trials. Our results showed that individuals who carried the minor G allele of rs174575 had significantly higher dihomo-γ-linolenic acid levels (P = 0·005) and lower arachidonic acid levels (P = 0·033) than individuals who were homozygous for the major allele. The subgroup analysis revealed that the G-allele carriers of rs174575 were significantly positively correlated with linoleic acid (P = 0·002) and dihomo-γ-linolenic acid (P < 0·001) and negatively correlated with arachidonic acid (P = 0·004) in the European populations group. This particular SNP showed a potential association with higher concentrations of dihomo-γ-linolenic acid (P = 0·050) and lower concentrations of arachidonic acid (P = 0·030) within the breast milk group. This meta-analysis has been registered in the PROSPERO database (ID: CRD42023470562).
This paper makes the case for a discursive understanding of ontological security and demonstrates the utility of such an approach in an analysis of European Parliament (EP) debates between 1990 and 2020. We argue that articulations of ontological (in)security operate through the (re)inscription of a set of metanarratives in what we call ‘discursive nodal points’. Building on an extensive analysis of EP debates over 30 years, we demonstrate that in contrast to the prevailing view of the European Union (EU) as an ‘anxious community’, at least on the political level, EU actors remain surprisingly confident in the European project. While they do invoke challenges to the EU, they see these as incentives to strengthen the integration project and often consider operating in crisis mode as an essential EU characteristic. In doing so, they draw on modernist metanarratives of progress, control, and power to construct an ontologically secure EU. We argue that the future ontological security of the EU will partly depend on allowing for more ambiguity in this modernist narrative without accepting a nationalist counter-narrative that undermines the idea of European integration.
This article addresses the recent interest in Black Internationalism in the history of political thought and related fields by engaging with a portion of W. E. B. Du Bois’s (1868–1963) work. It examines in particular how Du Bois treats Africa in his published and unpublished writings from the 1910s to the 1940s in light of the challenges of world war and continued imperial expansionism in the global South. I argue that through a rhetorical framing of problems on the continent, and by situating Africa in relation to global economic problems as well as the goal of long-lasting peace, Du Bois comes up with novel approaches to war and empire, as well as solutions to the problems that they pose. I conclude by reflecting on how he can contribute to debates on Black Internationalism today.
Immigration policies designed to deter people from seeking asylum are gaining traction in many Western nations, with the UK recently attempting to establish an offshore immigration processing centre in Rwanda. This letter outlines emerging evidence from Australia on the negative long-term psychological effects of offshore processing on people seeking asylum.
The Cardiovascular Health Diet Index (CHDI) is a diet quality score based on the dietary guidelines of the American Heart Association for cardiovascular health but with some adaptations, such as red meat, dairy products, beans and ultra-processed foods in its components. The CHDI has shown good relative validity parameters; however, its association with health outcomes is still unclear. Thus, our aim was to investigate the association between the CHDI score with subclinical atherosclerosis. Data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) cohort were used. Subclinical atherosclerosis was assessed by measuring coronary artery calcification at baseline (2008–2010) and second wave (2012–2014) and carotid intima-media thickness at baseline and at the third wave (2017–2019). The CHDI score (ranges from 0 to 110 points) was applied to dietary data obtained from an FFQ at baseline. Poisson regression with robust variance, linear regression and linear mixed-effects models were used to evaluate the association of the CHDI score with coronary artery calcification incidence (n 2224), coronary artery calcification progression (n 725) and changes in carotid intima-media thickness (n 7341) over time, respectively. After a median 8-year follow-up period, a 10-point increase in the CHDI score was associated with a decrease in carotid intima-media thickness of 0·002 mm (95 % CI –0·005, –0·001). No association was observed between the CHDI score and coronary artery calcification incidence and progression after a 4-year follow-up period. Higher scores in the CHDI were prospectively associated with decreased subclinical atherosclerosis after an 8-year follow-up period.
Multimodal imaging is crucial for diagnosis and treatment in paediatric cardiology. However, the proficiency of artificial intelligence chatbots, like ChatGPT-4, in interpreting these images has not been assessed. This cross-sectional study evaluates the precision of ChatGPT-4 in interpreting multimodal images for paediatric cardiology knowledge assessment, including echocardiograms, angiograms, X-rays, and electrocardiograms. One hundred multiple-choice questions with accompanying images from the textbook Pediatric Cardiology Board Review were randomly selected. The chatbot was prompted to answer these questions with and without the accompanying images. Statistical analysis was done using X2, Fisher’s exact, and McNemar tests. Results showed that ChatGPT-4 answered 41% of questions with images correctly, performing best on those with electrocardiograms (54%) and worst on those with angiograms (29%). Without the images, ChatGPT-4’s performance was similar at 37% (difference = 4%, 95% confidence interval (CI) –9.4% to 17.2%, p = 0.56). The chatbot performed significantly better when provided the image of an electrocardiogram than without (difference = 18, 95% CI 4.0% to 31.9%, p < 0.04). In cases of incorrect answers, ChatGPT-4 was more inconsistent with an image than without (difference = 21%, 95% CI 3.5% to 36.9%, p < 0.02). In conclusion, ChatGPT-4 performed poorly in answering image-based multiple-choice questions in paediatric cardiology. Its accuracy in answering questions with images was similar to without, indicating limited multimodal image interpretation capabilities. Substantial training is required before clinical integration can be considered. Further research is needed to assess the clinical reasoning skills and progression of ChatGPT in paediatric cardiology for clinical and academic utility.
Studies concerning twins with a sociological focus are scarce in Hungary as well as international research, although the number of twin births has increased dramatically worldwide. The raising and education of twins are tasks demanding special attention from both the family and institutions. In our study we examine these aspects, looking back from adulthood, using the narrow scope of the available data from research based on the ‘Hungarostudy 2021’ database (N total: 7000; n twins: 106). Our results, corresponding to the hypotheses of educational sociology, demonstrate how the relationships between family size and school career and increasing number of siblings reduces the chances of high educational attainment. A regression analysis confirmed that both the number of siblings and a later position in the birth order reduces the chance of obtaining a higher education. For the second child in a family, the chance of earning a university degree is reduced to to 0.743. The role of a large family concerning higher education showed a stronger relationship in the case of twins compared to nontwins. For twins, the sibling pattern has a decisive effect in educational attainment. Twins themselves have a 1.449 times higher chance of obtaining a higher education compared to nontwins (p = 0.101), and fraternal twins have half (0.517) the chance of obtaining a higher education compared to identical twins; but both results are not significant (p = 0.156).
People are frequently concerned about the impressions they make on others (referred to as metaperceptions), but their insights are often inaccurate. Illustrating the phenomenon called the liking gap, speakers interacting in their first language (L1) and second language (L2) tend to underestimate how much they are liked by their interlocutor, and these judgments often predict their desire to engage in future interaction and collaboration. To understand the scope of this bias and its consequences, we focused on L1–L2 dyadic interaction, examining metaperception as a potential barrier to conversations between university students. We recruited 58 previously unacquainted university students to perform a 10-min academic discussion task between one L1 and one L2 speaker. Afterward, the speakers (a) assessed each other’s interpersonal liking, speaking skill, and interactional behavior; (b) provided their metaperceptions of their interlocutor’s assessments of the same dimensions; and (c) estimated their interest in future interaction with the same interlocutor. All speakers showed a reliable metaperception bias to underestimate their interpersonal liking, speaking skill, and interactional behavior. However, only L1 speakers’ desire to engage in future interaction was associated with their metaperceptions of interpersonal liking. We discuss implications of this finding for understanding and promoting academic communication.
Electrocardiograms are frequently obtained in infants and children. Training specific to paediatric electrocardiogram interpretation is necessary given that cardiac physiology and electrocardiogram findings in children are different than adults and change throughout infancy and childhood. Distributed practice may be an effective method to improve paediatric residency electrocardiogram education efforts.
Methods:
A pre-survey was administered to paediatric and internal medicine/paediatrics residents to ascertain baseline comfort with electrocardiogram interpretation. Subsequently, residents were emailed a clinical vignette with an associated electrocardiogram and multiple-choice question 1–2 times monthly. After submitting their answer, residents were taken to a webpage explaining key concepts explored in the clinical vignette. After 6 and 12 months, a survey was administered asking residents to again rate their confidence in the same electrocardiogram interpretation skills.
Results:
The longitudinal email-based curriculum increased exposure to electrocardiogram training. Six months of participation in the curriculum correlated with significant increases in confidence in electrocardiogram interpretation skills. While there was no further increase in confidence seen at 12 months, the improvement seen at 6 months was durable. Participation in the curriculum most significantly correlated with changes in confidence in ability to utilise a stepwise approach for electrocardiogram interpretation.
Conclusions:
The curriculum resulted in durable improvement in confidence in electrocardiogram interpretation skills for paediatric residents at our centre, suggesting that email-based distributive practice can be an effective method for skill and knowledge improvement for complex educational topics.
First branchial arch abnormalities are rare. Surgical excision is the mainstay of treatment and described in the literature. Excision can be associated with significant complications. We describe factors influencing operative and non-operative management of patients.
Methods
Case review was conducted between January 2012 and September 2022 of patients with first branchial arch abnormalities at Alder Hey Children’s Hospital, UK. Analysis of electronic patient records, operation notes and extraction of clinical outcomes were obtained.
Results
Four patients were identified with an average age of 2 years and 4 months. Three were female. Three underwent operative intervention, one of which had a recurrence post-operatively and was manged conservatively. The non-operatively managed patient remains conservatively managed with no complications.
Conclusion
First branchial arch abnormalities can be managed operatively and non-operatively, depending on patient factors. Steps to improve surgical planning such as constructive interference in steady state magnetic resonance imaging may help decision making and risk stratification of operative management.
Substance use refers to the consumption of drugs that have varying degrees of impact on a persons’ physical, mental and emotional well-being. While the adverse health effects of drugs have been extensively documented, further research is needed to understand their impact on fertility. Studies have indicated that substance use affects both the male and female reproductive systems. As substance use is more prevalent among young adults compared with the elderly, it appears that individuals of reproductive age are particularly vulnerable to the reproductive impairments associated with substance use. Although numerous studies have reported detrimental effects of substance use on pregnant women and their foetus during the post-implantation stages, there are limited studies on critical pre-implantation period and gamete stages. In this narrative review, we aimed to focus on the most significant evidence regarding the impact of substances on gametes and pre-implantation embryos.
Manuelarossiite, ideally CaPbAlF7, is a new fluoride mineral found in a specimen from a fumarole formed subsequent to the 1944 eruption of the Vesuvius volcano, Naples Province, Campania, Italy. It occurs as very rare tabular crystals, up to 0.06 × 0.04 × 0.015 mm, in the vugs of volcanic scoria, associated with cerussite. In the same scoria where manuelarossiite was found, anglesite, artroeite, atacamite, calcioaravaipaite, cerussite, challacolloite, cotunnite, hephaistosite, matlockite, napoliite and susannite were identified. Manuelarossiite is colourless with a white streak and adamantine lustre. It is brittle and has a laminated fracture. Cleavage is perfect on {001}. Dcalc = 5.095 g cm–3. The calculated mean refractive index is 1.625. The chemical composition (wt.%, electron microprobe, H2O calculated by stoichiometry) is: CaO 13.98, PbO 55.46, Al2O3 12.59, F 29.45, H2O 1.68, –O=F –12.40, total 100.76. The empirical formula calculated on the basis of 7 anions is Ca1.00Pb1.00Al1.00[F6.25(OH)0.75]Σ7.00. Raman spectroscopy confirms the limited presence of OH– groups in the mineral. Manuelarossiite is monoclinic, space group C2/m, with a = 7.6754(3), b = 7.4443(4), c = 9.2870(5) Å, β = 93.928(5)°, V = 529.39(5) Å3 and Z = 4. The strongest lines of the powder X-ray diffraction pattern [d, Å (I, %) (hkl)] are: 9.257 (57) (001); 4.537 (72) (111); 3.725 (98) (020); 3.630 (57) (20$\bar 1$); 3.588 (65) (11$\bar 2$); 3.460 (100) (021); 3.422 (63) (112); and 2.673 (65) (220). The crystal structure was refined to R1 = 0.056 for 849 reflections with F > 4σ(F). It is characterised by {001} layers formed by CaF8 polyhedra decorated on both sides by AlF6 octahedra, in turn connected to the {001} layer through edge-sharing. Successive {001} layers are bonded through Pb atoms. The new mineral honours Dr. Manuela Rossi (b. 1977) from the University of Naples for her contribution to the study of the Vesuvius volcano and its minerals.