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In recent years, dangerous gas leakage events occur frequently. Rapid and accurate location of gas leakage sources by mobile robots is the key to avoid the expansion of disasters. In order to solve the problem of discontinuous gas concentration gradient and sparse gas environment in three-dimensional space, particle filter, and whale swarm optimization algorithm are integrated to locate gas source. Firstly, the Z-shape search and comb search are used to locate the plume, and then, the particle filter algorithm is combined with the whale optimization method to guide the particle movement, and the random inertial disturbance term is designed to improve the convergence speed and search accuracy of the algorithm. Experimental results in three-dimensional environment show that the proposed information-driven particle filter whale optimization hybrid algorithm effectively guides the robot in localizing gas source within a certain range, significantly enhancing both the efficiency and accuracy of localization compared to other algorithms.
We perform a detailed numerical study of modal and non-modal stability in oblique Couette–Poiseuille profiles, which are among the simplest examples of three-dimensional boundary layers. Through a comparison with the Orr–Sommerfeld operator for the aligned case, we show how an effective wall speed succinctly characterizes modal stability. Large-scale parameter sweeps reveal that the misalignment between the pressure gradient and wall motion is, in general, destabilizing. For flows that are sufficiently oblique, the instability is found to depend exclusively on the direction of wall motion and not on its speed, a conclusion supported, in part, by the perturbation energy budget and the evolution of the critical layers. Closed forms for the critical parameters in this regime are derived using a simple analysis. From a non-modal perspective, pseudoresonance is examined through the resolvent and the $\epsilon$-pseudospectra. An analysis of the unforced initial value problem shows that the maximum energy gain is highly dependent on both the magnitude and direction of the wall velocity. However, the strongest amplification is always achieved for configurations that are only weakly skewed. Finally, the optimal perturbations appear to develop via a lift-up effect enhanced by an Orr-like mechanism, the latter driven by cross-flow shear.
Species in the genus Engraulis show extensive intraspecific as well as interspecific morphological and genetic diversity. Since morphological differences do not necessarily correspond to genetic differences, it is necessary to clarify the relationship between morphological differences and genetic differences for a better understanding of the population structure. Fish morphology at a given standard length differs between cohorts of Japanese anchovy Engraulis japonicus during the early life stages in the Kii Channel, but it is unknown whether the differences are caused by genetic differences or not. The Kii Channel includes the boundary between the Pacific (southern side of the Kii Channel) and the Seto Inland Sea stocks (northern side), but stock separation is based primarily on demographic characteristics. In the present study, genetic analyses were conducted to examine the genetic differences among samples (month and area) based on mitochondrial DNA cytochrome b region (Cyt b), control region (CR) and microsatellite markers. AMOVA revealed that the percentage of genetic variation among samples was low at 0.11% for Cyt b, 0.30% for CR and 0.00% for microsatellite, and no significant genetic variation was observed among samples. Although two clades were identified in the unrooted neighbour-joining tree for Cyt b and CR, both Cyt b and CR sequences were similar between months and between areas. Accordingly, the morphological differences among cohorts can be attributed to phenotypic plasticity. Additionally, there were no genetic differences between samples from the southern side and the northern side of the Kii Channel, suggesting strong genetic connectivity in these areas.
This study examined the efficacy of a probiotic in reducing depressive symptom severity in people with subthreshold depression. In a double-blind, randomised, placebo-controlled trial, a probiotic (1 × 10^9 live cells per strain: Limosilactobacillus fermentum LF16 (DSM26956), Lacticaseibacillus rhamnosus LR06 (DSM21981), Lactiplantibacillus plantarum LP01 (LMG P-21021) and Bifidobacterium longum 04 (DSM23233)) or placebo was taken daily for 12 weeks. Data were collected at baseline, 6 and 12 weeks including psychological symptom severity (Beck Depression Inventory, BDI; Patient Health Questionnaire, PHQ; Hospital Anxiety Depression Scale, HADS; and Depression Anxiety and Stress Scale, DASS). Biomarkers of glycaemia, inflammation (high-sensitivity C-reactive protein, hs-CRP), antioxidant status (total glutathione (GSH)) and stress (cortisol awakening response, CAR) were also measured. Thirty-nine participants (nineteen probiotic; twenty placebo) were enrolled. There were no significant between-group differences in the examined psychological symptom severity scores, despite certain significant within-group changes observed in both groups from baseline to 6 and/or 12 weeks of follow-up. Regarding biomarkers, the probiotic group showed reduced hs-CRP (–1520; 95 % CI –273·7, −2766·2 ng/dl) and CAR (–0·28; 95 % CI −0·05, −0·51 μg/dl) at 12 weeks, but increased total GSH (3·9; 95 % CI 0·1, 7·5 ng/dl) at 6 weeks, compared with the placebo. The current study reported favourable decreases in depressive symptoms in both groups. Although the within-group changes observed in the probiotic group were supported by favourable inflammatory, antioxidant status and stress biomarker changes compared with the placebo, further research is required to shed more light on the role of gut microbiota modulation on emotional regulation.
The relationship between Schistosoma mansoni (Sm) and hepatocellular carcinoma (HCC) has been evaluated by many studies that point towards a co-relation between schistosomal infection and HCC. While many such studies demonstrated that Sm infection in the presence of another carcinogenic factors leads to HCC, none of these studies could conclusively prove the cancer-inducing ability of Sm in humans, independent of other carcinogenic factors. The aim of this work is to present the current understanding on the association of Sm with HCC. Many epidemiological, pathological, and clinical studies have shown the role of multiple events like chronic inflammation and fibrosis as well as hepato-toxic agents like soluble egg antigens (SEAs), which help in creating a micro-environment which is suitable for HCC development. The role of Sm infection and deposited eggs in causing persistent inflammation, advanced fibrosis, and the role of SEAs, especially IPSE/alpha-1, is emphasised. This work concludes that Sm infection has the potential to induce cancer independently but the same has not been reported in humans to date. Extensive research is required to establish a causal relationship between Sm infection and HCC induction, or a complete lack thereof. However, Sm infection definitely acts along with other carcinogenic factors to induce HCC at a much faster pace and also leads to an aggressive form of liver cancer, which the other carcinogenic factor could not have achieved alone.
This article presents a comprehensive evaluation of two nuclear-rated bilateral telerobotic systems, Telbot and Dexter, focusing on critical performance metrics such as effort transparency, stiffness, and backdrivability. Despite the absence of standardized evaluation methodologies for these systems, this study identifies key gaps by experimentally assessing the quantitative performance of both systems under controlled conditions. The results reveal that Telbot exhibits higher stiffness, but at the cost of greater effort transmission, whereas Dexter offers smoother backdrivability. Furthermore, positional discrepancies were observed during the tests, particularly in nonlinear positional displacements. These findings highlight the need for standardized evaluation methods, contributing to the development, manufacturing, and procurement processes of future bilateral telerobotic systems.
We show that there exists a recursive coloring function c such that any $\Pi ^0_3$ set is not a solution to c for Hindman’s theorem. We also show that there exists a recursive coloring function c such that any $\Delta ^0_3$ set is not a solution to c for Hindman’s theorem restricted to sums of at most three numbers.
To explore relationships between spatial distributions of northern shrimp Pandalus eous and environmental factors along the coastline of Honshu Island in the Sea of Japan, we built delta-type two-step generalized additive models (delta-GAM) based on bottom trawl surveys conducted in 2013–2022. The models provide the first quantitative analysis of the species’ habitat, showing that its distribution is associated with bottom sediment type, depth, slope and topographic position index (TPI) alongside the effects of year and region. From the delta-GAM response plots, species habitat preferences in the Sea of Japan were estimated as follows: seafloor deeper than 283 m; muddy rather than sandy bottoms; gently sloped to flat bottoms (<0.8° in slope); and valleys rather than ridges (TPI < 0.9). These results were reviewed in detail along with previously reported distribution records of northern shrimp. Standardized density (s-density) per fishing grid cell (10′ square latitude–longitude mesh) estimated from the delta-GAM results indicated that this species is widely distributed on the continental slope along the coast of Honshu Island. To test plausibility of the s-density analysis, we compared s-density per fishing grid cell with nominal CPUE (kg per haul) per fishing grid cell based on official logbook data from large offshore trawl fisheries. The two were generally positively correlated by year, and the delta-GAM results were assumed to be fairly robust. Finally, potential fishing grounds were explored based on the delta-GAM results.
This study presents the first Korean records of two subtropical fish species, Pseudojuloides paradiseus and Diplogrammus xenicus, collected around Jeju-do Island, as well as one boreal fish species, Erilepis zonifer, collected in Busan (approximately 200 km away from Jeju-do Island). In this study, we discuss the implications of the species’ habitat range expansion. Previously, P. paradiseus was known as an endemic species of Japan, while D. xenicus was known to inhabit the Eastern Indian Ocean and the Pacific Ocean excluding around the equator, and E. zonifer was only known to inhabit the Pacific Ocean between eastern Japan and the western USA. Their habitat range expansions might be attributed to the expansion of the Tsushima Warm Current at the surface layer and/or the North Korean Cold Current at the bottom layer. Our findings may suggest that habitat of marine fish is being changed continuously by climate change or oceanic currents. Therefore, it needs to conduct integrated and systematic monitoring of fish fauna to response changing marine biodiversity.
Although mesopelagic fish dominate the oceanic ecosystem, they remain one of the least investigated components. From the vertically stratified sample collections, we investigated community structure, vertical distribution and diel/ontogenetic vertical migration covering four seasons for larval and juvenile/adult mesopelagic fish at the time-series station K2 in the Western Subarctic Gyre of the North Pacific. We collected 10 and 20 species of larval and juvenile/adult fish, respectively. Among the larval fish community, Leuroglossus schmidti was the most abundant; total abundances except L. schmidti were low throughout the year; species richness of myctophids were low. Among the 20 species of juvenile/adult fish, larvae of only six species were collected; thus, most mesopelagic fish species do not use the Western Subarctic Gyre as their nursery. In the juvenile/adult fish community, Stenobrachius leucopsarus and Stenobrachius nannochir were abundant. Species diversity and total abundance in the warm seasons (summer and autumn) were higher than in the cold seasons (winter and spring). The decreasing of species diversity and total abundance during the cold seasons was probably affected by horizontal migrations of fish for reproduction toward the southern transition or subarctic slope areas. Stenobrachius leucopsarus was distributed at shallow depths with opportunistic diel vertical migration (DVM); in contrast Stenobrachius nannochir occurred at greater depths, without DVM. The distribution depths of S. leucopsarus during day and those of S. nannochir changed seasonally and synchronously; shallowest in autumn, deepest in spring.
This study provides the first records of the upside-down jellyfish Cassiopea andromeda (Forskål, 1775) in the eastern Atlantic supported by molecular analysis. Specimens were observed, recorded, and sampled in an inland aquaculture facility in September 2023 in Tenerife Island (Canary Islands). This new record officially demonstrates the geographical expansion of C. andromeda, and the introduction of a new potential invasive species in the Macaronesia oceanic island system.
Management of paediatric non-tuberculous mycobacteria cervicofacial lymphadenitis (NTMCL) is variable without standard practice in the U.K. We undertook a survey to evaluate current U.K. practice in tertiary paediatric units.
Methods
A survey of twenty-one tertiary paediatric centres to evaluate NTMCL management.
Results
We received over 90% response rate. Only 21% have local guidelines, with the majority believing that written national guidance would improve management. Surgery is the most common management choice (69%), with a more limited procedure if skin is involved and/or in proximity to important structures. Observation alone is favoured (32%) when there is no skin involvement but in close proximity to the facial nerve. When treated medically, rifampicin and clarithromycin for 3 months was the commonest choice. Over 25% of respondents state their management has changed following previous adverse outcomes within their own practice or department.
Conclusion
This survey consolidates the current management of NTMCL in U.K. tertiary paediatric units.
Epidemiological evidence suggests that a higher intake of sugar during pregnancy is associated with a higher risk of childhood asthma and atopy. However, randomised trial evidence supporting such a link is lacking. This study aimed to examine whether a low glycaemic index (GI) dietary intervention during pregnancy decreases the risk of childhood asthma and eczema. This is a secondary analysis of 514 children from the ROLO trial. Healthy women were randomised to receive an intervention of low GI dietary advice or routine care from early pregnancy. Mothers reported current doctor-diagnosed eczema in their children at 2 years (n 271) and current doctor-diagnosed asthma and eczema in their children at 5 (n 357) and 9–11 years (n 391) of age. Multivariable logistic regression models were used test the effect of the intervention on child outcomes overall and stratified by maternal education. There was a suggestion of a reduction in asthma at 5 years of age in children whose mothers received the low GI dietary intervention during pregnancy compared with usual care (adjusted OR 0·46 (95 % CI 0·19, 1·09); P = 0·08). In stratified adjusted analyses, the intervention was associated with a reduced risk of asthma at 5 years of age in children born to mothers with incomplete tertiary level education but not in those with complete tertiary level education (OR 0·14 (95 % CI 0·02, 0·69); P = 0·010 and OR 1·03 (95 % CI 0·34, 3·13); P = 0·94, respectively). A low GI diet in pregnancy may reduce the risk of developing asthma in childhood, particularly amongst children born to mothers with lower educational attainment.
In Northeast Brazil, the poorest region of the country, indigenous communities face critical health care challenges. Despite legal entitlements to the Unified Health System (SUS), systemic barriers persist, exacerbating health disparities and mortality. This ecological study analyzed mortality trends and causes of death within the Special Indigenous Sanitary District (DSEI) Alagoas-Sergipe over a decade.
Methods
Data on deaths from 2012 to 2022 were obtained from the Indigenous Health Secretariat. Causes of death were classified into 13 categories. Mortality rates per 1,000 indigenous inhabitants were calculated, and trends were analyzed using the Mann-Kendall test. The study also compared causes of death by age group.
Results
Mortality rates ranged from 3.3 to 5.2 per 1,000, showing a moderate upward trend over time (τ = 0.5, p = 0.042). Predominant causes included heart and vascular disorders (24.3%), external causes (12.4%), respiratory issues (11.1%), and infections (10.9%). About one-third of pediatric deaths were associated with general neonatal complications.
Conclusions
This study highlights increasing mortality in indigenous communities in Northeast Brazil. The predominant causes of death reflect broader public health concerns. These trends emphasize the urgency for more effective, culturally sensitive public health policies and improved health care access.
When placed at the surface of a volatile liquid, a sphere of hot dense non-volatile material remains suspended until it cools sufficiently. The duration of this ‘inverse Leidenfrost’ phenomenon depends on the Nusselt number $Nu$ of the sphere, itself determined by flow in the film of vapour separating particle and liquid. It is shown that provided the Nusselt number is large, it can be calculated numerically using only the Laplace relation and the equations governing the thin film; patching to a solution for the outer thick film is not necessary. This method is demonstrated by using it to determine $Nu$ for a sphere sufficiently small that in the governing equations, the acceleration due to gravity is negligible except where multiplied by the density of the sphere. Numerical results giving $Nu$ as a function of a dimensionless measure of sphere weight are supplemented with analysis showing that, when the weight is of the order of the maximum supportable by surface tension alone, the film consists of a spherical bubble cap bounded by its contact rim. The solutions for these regions are coupled: although the apparent contact angle $\chi$ for the cap is determined within the rim, its value depends on the flow rate arriving from the cap as well as on the additional evaporation from the rim. The latter acts to reduce $\chi$ from the value it would otherwise have, thereby reducing the thickness of the entire cap. For the example treated here, the value of $Nu$ is doubled by this mechanism.
The 1984 election of David Penman as Anglican Archbishop of Melbourne was surprising, coming at the end of a controversial process in which two better-known candidates had consistently been the front runners. His election disrupted the longstanding power base of Melbourne Diocese represented by the two men passed over. But his election disrupted more than that – it disrupted the stalemate preventing the ordination of women in the Anglican Church of Australia. His election was crucial to the struggle to have women ordained in the Australian church. As Melbourne Diocesan Synod prepares to elect its next archbishop in 2025, it is timely to re-visit the 1984 election.
It is widely agreed that Thucydides’ Melian dialogue presents the Athenian invasion of Melos, and the Athenian justification, in a negative light. Attention tends to focus on the immorality of ‘the rule of the stronger’ that the Athenians present in the dialogue. This essay argues that another feature of the dialogue triggering negative judgements of the Athenians is their criticism of the Melians’ resistance: it is voiced by the Athenians themselves and therefore provokes in readers a ‘speaker-relative’ normative judgement of the Athenians. Philosophers have explored how our normative judgements about statements often depend on the speaker. Because the Athenians have deliberately put the Melians into their perilous situation, and because part of Athenian self-mythology was heroic resistance against overwhelming numbers in the Persian Wars, Athenian criticism of the Melians is hypocritical and applies an asymmetrical ethics to the Athenians and the Melians. Reaction against these features of the dialogue exacerbates the moral abhorrence of the Athenians felt by many readers. Hence I disagree with Bosworth’s view of the dialogue as primarily critical of the Melians. Instead we see Thucydides here condemning not only the Athenian imperial project but also the rhetoric used to defend and sustain it.
We consider the two-dimensional Rayleigh–Bénard convection problem between Navier-slip fixed-temperature boundary conditions, and present a new upper bound for the Nusselt number (${\textit {Nu}}$). The result, based on a localization principle for the Nusselt number and an interpolation bound, exploits the regularity of the flow. On one hand our method yields a shorter proof of the celebrated result of Whitehead & Doering (Phys. Rev. Lett., vol. 106, 2011, 244501) in the case of free-slip boundary conditions. On the other hand, its combination with a new, refined estimate for the pressure gives a substantial improvement of the interpolation bounds in Drivas et al. (Phil. Trans. R. Soc. A, vol. 380, issue 2225, 2022, 20210025) for slippery boundaries. A rich description of the scaling behaviour arises from our result: depending on the magnitude of the Prandtl number (${\textit {Pr}}$) and slip length, our upper bounds indicate five possible scaling laws (where ${\textit {Ra}}$ is the Rayleigh number): ${\textit {Nu}}\sim (L_s^{-1}\,{\textit {Ra}})^{{1}/{3}}$, ${\textit {Nu}}\sim (L_s^{-2/5}\,{\textit {Ra}})^{{5}/{13}}$, ${\textit {Nu}}\sim {\textit {Ra}}^{{5}/{12}}$, ${\textit {Nu}}\sim {\textit {Pr}}^{-1/6}(L_s^{-4/3}\,{\textit {Ra}})^{{1}/{2}}$ and ${\textit {Nu}}\sim {\textit {Pr}}^{-1/6}(L_s^{-1/3}\,{\textit {Ra}})^{{1}/{2}}$.