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In late May, 2023, a 25’ long mobile veterinary clinic was mobilized to Ukraine from the US to provide emergency veterinary response for the animals of Ukraine. Due to effects of the Russian invasion, many pets and other animals were suffering from neglect, starvation and injuries, and many veterinary practices had been forced to close, greatly decreasing access to care. Prior to the mobilization of the mobile clinic, an initial response to care for pets of Ukraine refugees had been set up at the Ukraine-Romania border in early March 2022, soon after the invasion begun. This presentation will describe the initial challenges that arose when 6 million refugees, some with pets, migrated from Eurasia to Eastern and Westen Europe with the focus on potential zoonotic disease transmission, barriers to travelling to the EU with pets, and the strong bonds that the Ukraine people had with their pets. The main focus of the presentation will be on the many logistical challenges that arose with the transport and mobilization of the mobile veterinary clinic from the US to Ukraine, and operational issues related to security, travel logistics, language barriers, stocking drugs and medical supplies, pet overpopulation and many other challenges.
To study the clinicopathological features of collision tumours of the thyroid and to develop a logical management regimen in view of the rarity of these tumours.
Methods
A retrospective study on collision tumours of the thyroid, diagnosed over the previous 15 years in a tertiary cancer care centre. The inclusion criteria were proven cases of collision tumours of medullary thyroid carcinoma with papillary thyroid carcinoma and/or follicular thyroid carcinoma.
Results
Among the 470 patients with medullary thyroid carcinoma, 24 were found to harbour collision tumours (5.1 per cent). Amongst 18 patients (75 per cent) with lymph node metastases, 88.8 per cent originated from medullary thyroid carcinoma and 22.2 per cent from the papillary thyroid carcinoma component. Two patients (8.3 per cent) presented with distant metastases. Eight patients underwent radioactive iodine scan, of whom seven demonstrated neck uptake and received radioactive iodine therapy. Fifteen patients (62.5 per cent) were disease free, eight patients (33.33 per cent) harboured biochemical and/or structural residual disease, and one patient died due to an unrelated aetiology.
Conclusion
Thyroid collision tumours are relatively rare entities and are usually undiagnosed pre-operatively. The prognosis of the disease primarily depends on tumour aggressiveness the of medullary thyroid carcinoma component. A combined follow up with tumour markers and imaging, including positron emission tomography/computed tomography molecular imaging approaches should be adopted.
To promote cooperation among stakeholders in different jurisdictions to facilitate coordinated insolvency proceedings, the United Nations Commission on International Trade Law (UNCITRAL) adopted the Model Law on Cross-Border Insolvency (MLCBI) in 1997. The MLCBI harmonises certain procedural aspects of the cross-border insolvency process, though states may choose to make modifications when adopting the MLCBI in their own legal systems. This was completed in Singapore in 2017, and the Singapore Model Law (SML) can now be found in the Third Schedule to the Insolvency, Restructuring and Dissolution Act 2018 (2020 Rev Ed) (IRDA 2018). One topic that has been the subject of much debate internationally is whether foreign solvent proceedings can be recognised under the MLCBI or the corresponding provisions in various jurisdictions: the Nevada Bankruptcy Court first answered this question in the affirmative, but this was explicitly rejected by the High Court of England and Wales (EWHC) in Re Sturgeon Central Asia Balanced Fund Ltd (in liquidation) (No 2) (Re Sturgeon). In Ascentra Holdings, Inc (in official liquidation) v SPGK Pte Ltd (Ascentra), the Singapore Court of Appeal (SGCA) held that foreign proceedings concerning solvent companies may be recognised under the SML. This commentary addresses the salient points of the SGCA's judgment and highlights the positive impact of this gradual harmonisation of the approaches taken in different jurisdictions to the MLCBI. Through a comparative analysis of the conflicting Re Sturgeon decision, three additional justifications based on the preparatory documents pertaining to the MLCBI, relevant authorities in the UK and a purposive reading of the MLCBI are provided for the approach in Ascentra. It is contended in closing that these reasons support the argument for definitively overruling the Re Sturgeon decision in the UK.
This article presents a little-known story of Jewish-Muslim coexistence in Germany after World War Two. Using an ethnographic case study of Frankfurt am Main’s train-station district (Bahnhofsviertel), the analysis investigates long-term and partially forgotten Jewish-Muslim narratives, relations, and neighborhood encounters, paying particular attention to the changing political, spatial, and temporal dimensions that have blurred or closed symbolic boundaries between Jews and Muslims since the late 1960s. Bringing together the scholarship on symbolic boundaries and urban diversity, the theoretical discussion contributes to a more nuanced understanding of the variegated processes of Jewish-Muslim boundary-making and un-making over time, as well as the macro- and micro-level influences which shape these negotiations and outcomes. Studying Jewish-Muslim relations at the neighborhood level by adopting a boundary-related approach brings out more clearly the tensions over groupism and fluidity in theoretical debates and removes the current exceptionalism around Jewish-Muslim themes, making them more easily compared with other boundary processes within everyday life.
Evidence indicates that ketamine is highly effective, has a lower side effect profile and is better tolerated compared to many augmentation strategies for refractory depression. This, combined with data on psychiatric treatment outcome mediators, suggests that earlier intervention with ketamine could improve outcomes for patients suffering from refractory depression.
The current study examined how happiness is affected by optimism, self-efficacy, and occupational compromise (OC), among young workers (aged 20–30 years) in the post-Covid-19 pandemic period. A sample of 211 young people (aged 20–30 years) who were currently or formerly employed participated in the study. The research findings indicate negative correlations between (a) the optimism and self-efficacy of the employees to their OC and (b) between their OC to their sense of happiness. In addition, as hypothesized, positive correlations were found between (a) feelings of optimism and self-efficacy to the degree of happiness and (b) between optimism and self-efficacy. Finally, the study tested a mediation model that indicated optimism as a mediating variable in the relationships of self-efficacy and OC with happiness. In light of these findings, several conclusions emerged from the study. First, according to general trends in the Israeli economy, even among young workers, who make up the new generation of workers in the post-Covid-19 period, there is a reduction in the degree of OC in order to achieve happiness. But this depends on several personality elements, such as their feelings of optimism and self-efficacy. Second, in accordance with the mediation model tested in the study, it seems that optimism has a central role in enhancing happiness among young workers in the post-Covid-19 era, at the beginning of their career path. Eventually, it appears that the reduced OC and elevated happiness among young workers in the post-pandemic period, has the potential to shape the future job market as filled with content employees that can also improve their organizations’ economic output.
Commercial Electronic Health Record (EHR) systems in the U.S. are hospital-centric and are optimized for billing and insurance processes and liability risk management. Operational medicine has completely different medical record requirements, with dynamic and unpredictable environments and a focus on field triage, emergent patient needs, logistical coordination, and ultimately, the efficient transfer of care. The DHS Office of Health Security’s Medical Information Exchange (MIX) and the DHA’s Joint Operational Medicine Information Systems (JOMIS) programs have been exploring EHR solutions which anticipate and support the multilateral collaborations and fluid circumstances of field-based medical care using a no-code (drag and drop) solution that can be tailored to requirements in real time, can scale down to mobile devices, and can retain full functionality even while offline.
Anomalous left coronary artery from the pulmonary artery is a rare CHD. It is the most common type of anomalous coronary origin. It may cause myocardial ischaemia or infarction, mitral regurgitation, congestive heart failure, and early death in infancy if left untreated. Surgery is the only treatment for anomalous left coronary artery from the pulmonary artery. In recent years, with advancements in surgical techniques and the widespread utilisation of extracorporeal cardiac assist devices such as extracorporeal membrane oxygenation, the treatment outcomes for anomalous left coronary artery from the pulmonary artery have demonstrated significant improvements. However, the surgical indications and methods of anomalous left coronary artery from the pulmonary artery, especially the surgical methods of anomalous left coronary artery from the pulmonary artery with intramural coronary artery, and whether to treat mitral regurgitation at the same time are still controversial. The long-term complications and prognosis remain discouraging simultaneously, with significant variations in outcomes across different centres. The present review specifically addresses these aforementioned concerns. Based on the literature published at home and abroad, we found that no matter what type of anomalous left coronary artery from the pulmonary artery patients, even asymptomatic patients, regardless of the collateral circulation between the left and right coronary arteries, should immediately undergo surgical treatment to promote the recovery of left ventricular function. Based on different coronary artery anatomical morphology and preoperative cardiac function, the long-term follow-up results of individualised surgical treatment of anomalous left coronary artery from the pulmonary artery children show good prognosis, and most children have significant improvement in cardiac function. Patients with moderate to severe mitral regurgitation should undergo mitral valve operation at the same time as anomalous left coronary artery from the pulmonary artery repair. Mitral valvuloplasty can quickly improve mitral regurgitation and promote the early recovery of cardiac function after operation, and does not increase the risk of operation. Mechanical circulatory support is a safe and effective means of early postoperative transition for children with severe anomalous left coronary artery from the pulmonary artery. Anomalous left coronary artery from the pulmonary artery with intramural coronary artery is a rare anomaly. According to different anatomical types, different surgical methods can be used for anatomical correction, and satisfactory early and mid-term results can be obtained.
Fungal metabolites are known to have potent and diverse properties such as antiviral, antidiabetic, antitumour, antioxidant, free radical scavenging, and antibacterial effects which can be utilized to treat diseases. In this study, we investigated the functional activity of stereumamide A (StA) derived from a culture broth of Trichaptum fuscoviolaceum during the in vitro fertilization (IVF) of pig oocytes, to determine its effects on sperm penetration. Oocytes matured in vitro were fertilized in the absence or presence of varying concentrations of StA (0-50 μg/ml StA). When StA was directly added into the IVF medium, significantly lower fertilization rates were seen with the 20 or 50 μg/ml StA (2.0–17.5%) treatments compared with those of 10 μg/ml StA or the controls (60.9–62.3%), whereas StA had no influence on the survival of oocytes and spermatozoa throughout the IVF process. For evaluating the control of sperm entry, mature oocytes were pre-incubated in a medium containing 20 μg/ml StA for 1 h, and then IVF was subsequently performed. The incidence of polyspermy was significantly reduced when oocytes were pre-incubated with StA (15.0% vs. 50.4–57.5% in controls). In conclusion, sperm penetration was inhibited in the medium in the presence of StA during IVF, while StA did not affect sperm motility and fertility competence. Fertilization was controlled when mature oocytes were incubated with StA prior to IVF, suggesting the possible use of the fungal metabolite in assisted reproductive technology for humans and animals.
Repetition is a critical issue in interpreting the work of Herodotus. Detlev Fehling, for one, has pointed to recurrence of motif and scene as evidence of the historian’s ‘free invention’. Words that occur twice in Herodotus are an efficient way to consider pressing issues at the centre of how and why Herodotus put together his narrative in the way he has. Pairs where the uses are close together in stories with a lot in common suggest that we may be seeing Herodotus’ ‘habit of presentation’, especially when phrasal repetition is also found. Where pairs are found further apart, the issue of deliberate linkage between discrete episodes may be indicated through the strategic redeployment of a key term. Finally, with Xerxes’ invasion, recurring terms help us to see how Herodotus could operate over large portions of text, deliberately linking one episode to another through the deployment of twice-occurring words, thereby also connecting the whole account of the campaign to the largest project of the History.
We investigated the effects of two-dimensional sharp-edged rectangular bumps on Tollmien–Schlichting (TS) wave evolution using direct numerical simulation. The bump height, $h$, ranged from 5 % to 40 % of the local displacement thickness, $\delta ^*$. Behind the bump, a recirculating flow region could be formed whose length increased nonlinearly with $h$. The bump height effect on the TS wave, which was the dominant, scaled super-exponentially with $h$. We also showed a substantial effect of the $\delta ^*$-based Reynolds number, ${\textit {Re}} _{\delta ^*}$. Firstly, the bump wake extended with ${\textit {Re}} _{\delta ^*}$, promoting larger TS wave growth rates. The second effect is related to proximity to the upper branch of the instability loop, accounting for the influence of the TS frequency, as well. It dictates the bump impact increases as it gets closer to transition, either by the bump moving downstream or the transition moving upstream. For a 40 % high bump, for example, changing the ${\textit {Re}} _{\delta ^*}$ at the bump location from 1500 to 2000 increased $\Delta N$ by a factor of 2 ($\Delta N$ represents a measure of a surface irregularity effect on the smooth plate N-factor). We also found that $(\Delta N)_{max}$ increases linearly with ${\textit {Re}} _{hh}$. Results in the subsonic regime showed that the bump impact attenuates with Mach number up to 0.7 but above it, stabilisation is surpassed by the destabilising effect caused by the recirculation lengthening. This is mostly associated with the bump wake that extends with the pressure gradient which increases substantially towards the sonic speed. This is enhanced if the surface is adiabatic rather than isothermal.
A Christian approach to suffering, sin, and evil cannot offer now a full theodicy. We now ‘know in part’ only regarding divine purposes in allowing suffering, sin, and evil. We can clarify instead how God interacts in righteousness with people as their God of promise and voucher in the midst of suffering, sin, and evil. To that end, this article illuminates a divine effort toward human reconciliation with God in righteousness and resurrection, despite our gaps in explaining suffering, sin, and evil. It identifies current reconciliation with God and resurrection by God that do not fully explain suffering, sin, and evil, but can be a voucher now in human experience and life for eventual eschatological reparations promised by God. If the Spirit of God can be such a voucher, so also can the reconciliation and resurrection now empowered by that Spirit. This article recognizes a special role for the divine ‘fruit of the Spirit’ identified by Paul. It also explains how this role figures in spiritual resurrection with Christ now, in advance of any resurrection of the body. The article contends that the spiritual resurrection in question emerges through reconciliation with God now in volitional cooperation with God’s unique moral personality traits.
We investigate a turbulent boundary layer (TBL) under uniform pressure force variations, focusing on understanding its response to local pressure force, local pressure force variation (local disequilibrating effect) and upstream history. The flow starts as a zero-pressure-gradient (ZPG) TBL, followed by a uniform increase in the ratio of pressure force to turbulent force in the outer region and concludes with a uniform decrease of the same magnitude. This last zone includes a subzone with a diminishing adverse pressure gradient (APG), followed by an increasing favourable pressure gradient (FPG). In both subzones, the impact remains the same: mean momentum gain and turbulence reduction. In the outer region, the mean flow responds to force balance changes with a considerable delay. The accumulated flow history leads to a FPG TBL at the domain's end with a momentum defect comparable to APG TBLs. Below $y^+=10$, the mean flow responds almost instantaneously to pressure force changes. In the overlap layer, velocity profiles deviate from the conventional logarithmic law of ZPG TBL. Outer-layer turbulence decays more slowly than it increases initially, the latter turbulence increase persisting even after the pressure force begins to decrease. As a result of the slow turbulence decay, the FPG TBL at the domain's end exhibits unusually high outer turbulence levels. Near the wall, turbulence responds with a delay to pressure force changes, partly due to the influence of large-scale turbulence. All these significant cumulative effects of continuous pressure force variation indicate that parameters based solely on local variables cannot fully describe the physics of non-equilibrium TBLs.
JOMIS Delivering Interoperable Medical Information Technology Capabilities to the Warfighter. My presentation is about the advances we have made in software development and delivery. Will speak to how we are positioning ourselves to better transition innovations and technology from the services into our products to 1) address our backlog and 2) share lessons learned about various innovations.
Modern careers are enacted in turbulent and stressful environments and workers face increasing uncertainty in navigating their careers. Therefore, it is essential to support workers in coping with stress by enhancing their resilience. We propose that strengths-based leaders help their workers to find their own unique pathway to developing resilience by building upon their pre-existing strengths. In turn, we propose that resilience allows workers to transform the support and opportunities provided by their strengths-based leader into the active state of work engagement. We conducted a two-wave time-lagged survey among a representative sample of 1,095 Dutch employees. Results of our structural equation modelling indicated that T1 strengths-based leadership was positively related to T2 employee work engagement and that T2 employee resilience mediated the relationship between strengths-based leadership (T1) and employee work engagement (T2). We conclude that strengths-based leadership might be a tool to develop a resilient and engaged workforce and make suggestions for developing strengths-based leadership.
Pulmonary valve replacement and right ventricular outflow tract reconstruction with valved conduits have been the shortcomings of paediatric cardiac surgeons in the treatment of CHD. In recent decades, encouraging achievements have been made in right ventricular outflow tract technology. Since Klinner reported the first right ventricle-to-pulmonary artery connection using unvalved conduits made of autologous pericardium in 1964, various right ventricle-to-pulmonary artery conduits have gradually been used in the treatment of various complex CHD. Compared with other materials, valved homograft conduit (VHC) is more consistent with physiological characteristics, better haemodynamics, easy suture and good haemostasis, anti-calcification, anti-infection, and without the need for lifelong anticoagulation, which makes VHC the best material for reconstruction of right ventricular outflow tract. However, due to the shortage of donor sources, other alternative conduits such as polytetrafuoroethylene valved conduits have been developed, and the results are not inferior to VHC in clinical application. The emerging tissue engineering technology is expected to utilise recipient-derived endothelial cells for implantation onto the decellularized VHC or degradable synthetic materials in order to construct a recipient-specific tissue-engineered valved conduit. This advancement holds great potential as an ideal biological transplant material and valve replacement for CHD. It will completely solve the problems of immune rejection and the growth of the conduit that cannot adapt to the physical growth of children. This review provides a comprehensive review of the clinical indications for right ventricle-to-pulmonary artery conduits application, optimal timing for surgery, current practices in utilising various types of external conduits, and considerations for re-replacement.
To assess the face and content validity of artificial temporal bone dissection in surgical training in the UK.
Methods
Expert and non-expert groups participated in artificial temporal bone dissection at the Queen Elizabeth Hospital, Birmingham, UK. Face and content validity were assessed by a validated post-dissection questionnaire.
Results
The median content validity score was 34 out of 35 (interquartile range 32.00–35.00). Mean face validity score compared to human was 45.76 out of 65 (95 per cent CI 42.57–48.94). Face validity compared to cadaveric models demonstrated equivalence (95 per cent CI 25.30–30.70, crossing equivalence value 27.00). Experts rated face validity less favourably than non-experts (p = 0.012 and 0.042, respectively). Content validity was equivalent between experts and non-experts (p = 0.052). There were no significant differences in total content (p = 0.606) and face validity (p = 0.133, p = 0.105) scores between different artificial bones.
Conclusion
The high content and face validity suggests ENT training programs should consider formally incorporating artificial models into mastoid surgery training pathways.
This article reframes understandings of pluralism in democratic theory by showing that the management of late and post-colonial identitarian conflict was integral to its incorporation into twentieth-century political science. It does so by reconstructing the central but underexamined place of theories of consociational democracy in efforts to reform South Africa’s apartheid constitution in the 1970s and 80s. Consociational democratic theory offered such promising resources for apartheid reform, it contends, because it entwined (a) a conception of social pluralism that redescribed apartheid’s racial hierarchy as identitarian difference with (b) a conception of institutional pluralism that curtailed the most transformative possibilities of decolonization through universal suffrage. Recovering pluralism’s colonial genealogies clarifies the conditions under which the recognition of identitarian diversity can function as a disavowal of racial domination, positioning democratic theory as an adjunct to projects of neo-colonial order.