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We derive equations for three-dimensional internal wave beams propagating over a uniform slope in a uniformly stratified fluid. Using small-amplitude expansions, linear solutions for internal waves are obtained under weakly viscous conditions. Furthermore, a set of equations is constructed for the Lagrangian mean flow induced by the weakly nonlinear internal waves, providing the corresponding Lagrangian mean flow solutions within the boundary layer. The momentum equations of the Lagrangian mean velocity show that the Lagrangian mean flow is driven by the internal wave-induced body force, with its barotropic component related to the pressure gradient force, and its baroclinic component influenced by both viscosity and buoyancy. The Lagrangian-averaged buoyancy equation demonstrates that only the horizontal velocity for the Lagrangian mean flow exists throughout a vertically stable stratification region. This study emphasises the potential role of the Lagrangian mean flow in transporting time-averaged potential vorticity and solves for the Lagrangian mean flow in the inviscid region via mean potential vorticity conservation. The main results of the internal waves and the Lagrangian mean flow are visualised, revealing that the range of the boundary layer is related to the Reynolds number and that the intensity of the Lagrangian mean flow within the boundary layer is affected by the incidence angle and the reflection obliqueness. Theoretical analysis is provided to explain these phenomena.
This work proposes an integrated pulse transmitter with polarization reconfigurability. A reconfigurable pulse-triggered network is designed and seamlessly integrated with a dual-polarized radiator within the compact transmitter structure. This integration allows the radiator to sequentially perform DC charge accumulation, pulse oscillation, and radiation during each pulse cycle. Moreover, the reconfigurable pulse-triggered network introduces two operating modes, enabling the pulse transmitter to switch between different polarization states. Experiments demonstrate that the proposed pulse transmitter can directly convert DC energy into radiated pulses with switchable polarization modes. The pulse signal with a peak-to-peak voltage of 1.6 V is received in the −45° polarization direction at 1.5 m under mode 1, and switches to +45° polarization with a peak-to-peak voltage of 1.6 V under mode 2.
We introduce a relaxation of stability, called almost sure stability, which is insensitive to perturbations by subsets of Loeb measure $0$ in a non-standard finite group. We show that almost sure stability satisfies a stationarity principle in the sense of geometric stability theory for measure-independent elements. We apply this principle to deduce the existence of squares in dense almost surely stable subsets of Cartesian products of non-standard finite groups, possibly non-abelian. Our results imply qualitative asymptotic versions for Cartesian products of finite groups. In the final section, we establish the existence of $3\times 2$-grids (and thus of L-shapes) in dense almost surely stable two-dimensional subsets of finite abelian groups of odd order.
This paper presents a novel compact substrate-integrated waveguide (SIW) antenna that can be utilized for several applications, such as fifth generation (5 G), internet of things (IoT), artificial intelligence, and medical applications. Six antennas are designed. In addition, there are single SIW, 2 × 1 arrays, and 4 × 1 arrays with and without slots. The proposed feeding method is implemented to create a slot antenna array with incorporating KS connector. The proposed designs target the 25–28 GHz band, covering up to 3 GHz of bandwidth depending on the configuration. The structures are designed and simulated using a numerical technique package (CST). The simulation results demonstrate that the SIW antenna array functions efficiently in terms of the gain, return loss, and radiation patterns. Furthermore, the proposed structures have a total volume of 62 mm × 55 mm × 0.508 mm. In conclusion, the experimental results demonstrate that the performance of the proposed antenna is in good agreement with the simulations. Moreover, the gain increased from 8.5 dBi for the single SIW antenna to 14.7 dBi for the four-element array at 26 GHz, indicating a 72.9% improvement.
This study aimed to evaluate the characteristics, difficulties, and outcomes of patients who underwent transcatheter ablation treatment due to arrhythmia with a diagnosis of CHD.
Methods:
A total of 166 patients (189 substrates) with CHD who underwent catheter ablation between November 2013 and 2023 were evaluated retrospectively. EnSite™ (St Jude Medical Inc., St Paul, MN, USA) was used in all patients.
Results:
The mean age was 14.8 ± 7.9 years (2.9–43 years). The most common CHD’s were Ebstein anomaly (n: 40), tetralogy of Fallot (n: 31), atrial septal defect (n: 25), ventricular septal defect (n: 22), great artery transposition (D/L TGA, n: 12), and complex CHD in single ventricle physiology (n: 9). The most common arrhythmia mechanisms were Wolf-Parkinson-White syndrome (WPW, n: 50), intraatrial reentrant tachycardia (IART, n: 39), typical atrioventricular nodal reentrant tachycardia (AVNRT, n: 37), and ventricular tachycardia-ventricular extrasystoles (VT/VES, n: 23). There was more than one arrhythmia in 23 patients and multiple manifest accessory pathways in 10 patients. The average procedure time was 174 ± 69.3 minutes, and the average fluoro time was 8.3 minutes. While successful ablation was performed in 176/189 (acute success 93.1%) substrates, the procedure was unsuccessful in five patients and suboptimal in eight patients. Recurrence was observed in 11 patients (6.4%) during a mean follow-up period of 49.2 ± 30.1 months. A second ablation was performed on 13 patients. Acute success was achieved in all except one patient. A total of 11 patients are being followed up with medical treatment.
Conclusion:
Despite the complex anatomy, age, operations, and limited vascular access possibilities in patients diagnosed with CHD, transcatheter ablation treatment with advances in electrophysiology, the introduction of different energy types, special ablation catheters, multipolar mapping catheters, and 3D nonfluoroscopic mapping systems seems to be a safe and effective option.
Reverse osmosis (RO) is an efficient desalination approach, but the widely used solution-diffusion model was challenged for failing to explain field-dependent permeabilities, particularly when the continuum theory may break down in Ångström scale. Here we developed a non-equilibrium statistical theory, supported by molecular dynamics simulations that captures the field-dependent water and ion permeabilities through a single Ångström-scale channel. Surprisingly, our simulation reveals a counterintuitive negative differential flow resistance (NDFR) effect, where the flow velocity decreases with increasing pressure. This phenomenon arises from ion trapping at the nanotube entrance, caused by dielectric and dehydration barriers and hydrodynamic friction. The NDFR effect significantly reduces water permeability and may be a predominant factor constraining the selectivity-permeability trade-off in RO. Our statistical theory is based on a bidirectional escape framework that predicts the pressure- and size-dependent permeabilities and explains the NDFR effect. Our findings offer molecular-level insights into RO and can be extended to broader transport phenomena in confined systems.
The hydrodynamics of wetting involves a singularity of viscous stress, and its microscopic regularisation ultimately determines the speed at which contact lines move over a surface. In a recent paper, Luo & Gao (J. Fluid Mech., vol. 1019, 2025, A52) explore a new analytical solution, based on which they construct a model for ‘slippery wedge flow’. This lucid approach provides an accurate description of viscous wetting flows in the presence of slip, without the usual restriction to small contact angles, and offers a quantitative multiscale formalism for slippery contact lines.
We present a novel approach to harness the oscillation energy from cilia in chaotic flow to enhance scalar transport, addressing limitations of the laminar boundary layer. In contrast to the scallop theorem, where reciprocal motion yields negligible transport, coordinated rigid cilium oscillations in chaotic flow trigger boundary-layer resonance, significantly boosting scalar transport at specific frequencies. Under relatively high rigidity, the cilia undergo only small elastic deformations at the driving frequency, and their strokes remain nearly time symmetric. Nevertheless, unlike the classical expectation that reciprocal motion yields negligible transport, coordinated rigid cilium oscillations in chaotic flow trigger boundary-layer resonance, producing a sharp, frequency-selective boost in transport. At low to medium frequencies, cilium-driven fluid displacement enhances transport via vertical mixing. Above a critical frequency, rapid cilium motion induces unstable shear flow, generating coherent vortical structures that amplify mixing in chaotic flow regimes. These vortices, which interact with the inherent coherent structures of the chaotic flow, dramatically improve the efficiency of transport. Our findings reveal a dynamic coupling between cilium-driven resonance and chaotic flow coherent structures, providing a paradigm for optimising transport in thermal systems through active flow control.
This study has investigated the relationship between the gut microbiota composition and the growth performance in pigs from birth to the finishing stage, focusing on nutrient metabolism. Of fifty-nine crossbred pigs [(Landrace × Large Yorkshire) × Duroc] from seven sows, individuals with high and low daily gain (DG) were assigned to high DG (HDG, n 11) and low DG (LDG, n 8) groups. Faecal samples collected at weaning (21 d), growing (95–106 d) and finishing (136–152 d) stages were analysed for amino acids, SCFA and microbial composition using 16S rRNA sequencing. Although birth and weaning weights were similar in both groups, the HDG group had significantly higher weights in the growing and finishing stages (P < 0·01). The microbial composition of the LDG group revealed a higher abundance of f_Lachnospiraceae;__ at weaning (P < 0·05), whereas the HDG group contained a higher abundance of g_Streptococcus and g_Prevotella 7 at the finishing stage (P < 0·05). Functional analysis revealed increased amino acid metabolism in the HDG group at the finishing stage (P < 0·05). During the growing stage, total free faecal amino acid content was low in the HDG group (P < 0·05); at weaning, levels of isobutyric and isovaleric acids, key amino acid fermentation products (P < 0·05, P < 0·01), were higher. These findings indicate growth stage-specific differences in the gut microbiota and metabolic profiles between groups with different growth performance, suggesting that microbial and metabolic characteristics may influence growth performance.
This study systematically evaluates the effects of probiotic interventions on gut microbiota and clinical outcomes in diabetic patients to determine the optimal target population and conditions for effective use, with an emphasis on precision treatment. A comprehensive search was performed across PubMed, Web of Science, Cochrane Library, Embase, China National Knowledge Internet (CNKI), and Wanfang databases until April 2024. Randomized controlled trials (RCTs) assessing probiotics as adjunctive therapy for diabetes were included. The control group received standard care, and the intervention group received probiotics alongside standard care. Data were managed with Endnote and Excel, and analyses were conducted using Revman 5.3 and Stata 16. Twelve RCTs involving 1113 participants were included. Probiotics significantly increased fecal Lactobacillus (standardized mean difference (SMD) 1.42, P < 0.0001, I2 = 95 %) and Bifidobacterium levels (SMD 1.27, P < 0.0001, I2; = 90 %) and reduced fasting plasma glucose (SMD −0.35, P = 0.004). Subgroup analysis showed that shorter intervention durations (≤ 3 months) improved FPG, HbA1c, and Bifidobacterium levels, while younger patients (≤ 60 years) experienced the most significant improvements in Bifidobacterium levels. In conclusion, probiotics improve gut microbiota and clinical outcomes in diabetic patients, with intervention duration and patient age as key factors influencing treatment effectiveness.
One of the challenges in measuring the adsorption of metal cations is that they may form metal hydroxide compounds at certain pH ranges. This becomes problematic when adsorption is quantified in terms of measuring a decrease in metal ions in solution, because metal hydroxy complexes are removed from solution through precipitation, leading to erroneously high determinations of adsorption. Within this context, the present study aimed to analyze the pH-dependent adsorption behavior of Ni2+ ions onto sepiolite, a naturally occurring magnesium silicate clay mineral, while simultaneously accounting for the precipitation of nickel compounds during the process. For this purpose, zeta potential, ion exchange capacity, and the adsorption behavior of 2.5×10–3 mol L–1 nickel (II) sulfate hexahydrate onto relatively high-quality sepiolite were investigated. Kinetic studies and thermodynamic assessments were delineated to enhance the understanding of adsorption isotherms, both for future research and practical applications in environmental remediation. The results showed that the adsorption of Ni2+ ions onto sepiolite before the onset of precipitation is governed by an ion exchange process involving the release of Mg2+ ions from the sepiolite matrix and the uptake of Ni2+ ions from the solution. Above the threshold of pH ~8 where Ni-hydroxide complexes begin to form, ~97% of nickel ions were present in the forms of NiOH+, Ni(OH)2, and Ni(OH)3–. Isotherms for total Ni2+ removal were constructed to distinguish true adsorption from precipitation phenomena. The calculated and experimental values for true adsorption were found to be in good agreement.
A better understanding of calcitonin gene-related peptide (CGRP) inhibitor use is in migraine treatment needed.
Methods:
A retrospective, observational, population-based cohort study was conducted using administrative data. Adults (≥18 years) who received ≥1 prophylactic CGRP inhibitor in Canada (six provinces) between 2018 (first approved) and 2023 were identified. CGRP inhibitor use was described; migraine-related acute medication and healthcare use were compared pre–post CGRP inhibitor initiation (independent and paired t-tests).
Results:
12,851 adults were identified. CGRP inhibitor use increased from 11.8 (incident/prevalent) to 22.4 (incident) and 57.3 (prevalent) per 100,000 adults. Erenumab use decreased over time, as use of newer agents increased. During the 1-year period after CGRP inhibitor initiation, 57.4% had concomitant use with a different prophylactic migraine medication class (onabotulinumtoxinA injection: 23.2%; oral non-CGRP inhibitor: 34.2%), and 30.4% stopped use (21.3% switched to a different prophylactic migraine medication class; 9.1% discontinued all prophylactic migraine medication). During the 1-year period after CGRP inhibitor initiation (versus before), days of supply for migraine-related acute medication was lower (mean [standard deviation]: 129 [191] versus 145 [197] days; mean difference [95% confidence interval]: −16: [−22, −11] days), as were the number of healthcare visits (7.36 [8.70] versus 9.18 [10.10]; −1.82 [−2.06, −1.58]).
Conclusion:
CGRP inhibitor use increased from 2018 to 2023. After CGRP inhibitor initiation, most patients had concomitant use with a different prophylactic migraine medication class, and some stopped use; migraine-related acute medication and healthcare use were lower (versus before). Findings provide a real-world description of the evolving landscape of CGRP inhibitor use in Canada.
The effect of the Japanese diet on cancer incidence remains unclear. The purpose of this study was to examine the association between the Japanese diet and the risk of all-cause and site-specific cancer. We analysed 14-year follow-up data from the Osaki Cohort study of 25 570 Japanese men and women aged 40–79 years. The Japanese diet was evaluated using a thirty-nine-item FFQ at baseline. Based on a previous study, we used eight food items to calculate the Japanese Diet Index score: rice, miso soup, seaweed, pickles, green and yellow vegetables, seafood, green tea and beef and pork. The participants were divided into quartiles based on their Japanese Diet Index scores. The Cox proportional hazards model was used to estimate the hazard ratios and 95 % CI of cancer incidence. During the mean 10·4 years of follow-up, we identified 3161 incident cases of all-cause cancer. Multivariable analysis showed that the Japanese Diet Index score was not associated with cancer incidence. In comparison with Q1 (the lowest), the multivariable hazard ratios and 95 % CI were 1·01 (0·92, 1·12) for Q2, 0·94 (0·85, 1·04) for Q3 and 1·06 (0·95, 1·18) for Q4 (the highest). Furthermore, separate analyses of nine common cancer sites demonstrated no association with the Japanese Diet Index score. The results were consistent even after a sensitivity analysis using multiple imputation. This prospective study showed that the Japanese diet was not associated with cancer incidence. The results suggest that the Japanese diet could contribute to a person’s overall health and well-being without increasing cancer risk.
The present article aims to assess the relationship between the mass exodus of Iranian Christians and the Hispanic world, widening the analytical lens on early 20th-century Iranian migrations. Specifically, the study draws parallels between the humanitarian efforts of the Spanish diplomats during the Turkish occupation of northwestern Persia in 1918 and the subsequent arrival and settlement of Assyrians and Armenians in Argentina in the early decades of the twentieth century. Although numerous publications address the early Iranian diaspora and Iran during the World War I, little scholarly work examines Spain’s humanitarian role in this context or the history of the Iranian diaspora in Latin America. This finding underscores the notion that, in addition to the prominent international actors that have historically been the focus of scholarly inquiry—namely, the United States, France, Great Britain, Germany, and Russia—smaller countries also played a significant role in the events that transpired in Iran during those years. Furthermore, this study highlights the Iranian diaspora’s expansion to distant regions, such as Argentina, which has not been extensively researched in the context of Iranian studies. This comprehensive approach serves to broaden our understanding of the global history of Iran in the early twentieth century.
Beliefs in evil spirits and the practice of deliverance from supernatural forces have been widespread throughout history. Many psychological and physical afflictions have been attributed to involuntary demonic possession. Traditional remedies, for those reporting inhabitation by evil spirits, can involve exorcism believed to expel such forces. Similar beliefs may be symptomatic of major mental illness and treatments namely medication and psychotherapy, are frequently recommended. An increasingly secular western world is also seeing growth in non-denominational Christian churches and other faiths, who accept spirit possession and exorcism. Culturally competent mental health professionals, seeking to understand their patients’ world view, may struggle with exorcism, seeing it as an interference to conventional treatment. They may be being unwilling thus to attempt differentiation between possession and mental illness. This paper explores the diversity of views on this topic and points of contention and overlap. The risks and cautions necessary in approaching this issue are stressed.
Substance use disorders and addictions are mental disorders deeply interconnected with other psychiatric conditions – and this connection is of fundamental importance. Although addictions are formally recognized as mental health disorders, they are often not addressed as such in research or clinical practice. Psychiatric research, clinical care, and treatment development remain largely organized along traditional diagnostic boundaries. While diagnostic classifications provide structure and clinical utility, it is increasingly evident that psychiatric diagnoses are neither fully separable nor independent entities. Despite extensive discussion on comorbidity, addictions are frequently excluded from broader conceptualizations of the intertwined nature of mental disorders. Yet, they share substantial commonalities with other psychiatric conditions across clinical presentation, psychopathology, genetic vulnerability, neurobiological mechanisms, socioenvironmental risk factors, and treatment strategies. Maintaining a conceptual divide between addictions and other psychiatric disorders reinforces diagnostic “tunnel vision,” constraining our understanding of neuropsychopathology and contributing to persistent gaps in care and treatment accessibility. This narrative review examines the overlapping risk factors, clinical features, and therapeutic approaches that link addictions with other mental disorders. We argue that advancing psychiatric research and nosology requires a deliberate acknowledgement of these transdiagnostic overlaps and shared mechanisms. The challenge is particularly evident in the understanding and treatment of dual disorders. Progress will depend on integrative, collaborative frameworks that bridge scientific and clinical perspectives and foster dynamic feedback between empirical research and clinical practice. Recognizing mental disorders as interdependent systems may offer a more coherent and effective foundation for understanding and treatment.
Due to the high prevalence of depression among young adults, identifying prevention strategies during young adulthood are crucial. Dietary polyphenols have been associated with depression in older cohorts; however, the association remains unclear, particularly in young adults. This study aimed to assess the prospective association between the intake of total polyphenols, polyphenol classes, and polyphenol subclasses with depressive symptoms in young adults. Data from 1,484 Raine Study Generation 2 participants [52.7% female; baseline mean age (SD): 20 (0.5)] at the -20, -22, and -27 year follow-ups (N = 964, 979, and 1,094, respectively), with overlap across follow-ups, were used. Energy-adjusted polyphenol intake was estimated from food frequency questionnaire data using our expansion of the AUSNUT 2011-13 and Phenol-Explorer to include polyphenol content data and categorised into quartiles. The primary outcome was self-reported depressive symptoms assessed via the 21-item Depression, Anxiety, and Stress Scale averaged across the three timepoints. Linear mixed-effects models were used to assess the association between the polyphenol intake exposures and depressive symptoms. Sociodemographic characteristics and lifestyle- and health-related behaviours were adjusted for. Participants in the highest quartiles for flavonol and hydroxybenzoic acid intake had lower depressive symptoms across time than participants in the lowest quartiles [flavonols (Q4 v Q1 mean difference: -1.41, 95%CIs: -2.51, -0.31); hydroxybenzoic acids (Q4 v Q1: -1.42, 95%CIs: -2.54, -0.29)]. We found no evidence of a highest versus lowest association for all other polyphenol categories. Future studies are required to investigate whether increasing polyphenol intake could protect against depression in young adults.
Total energy expenditure (TEE) is estimated as the product of BMR and a spinal cord injury (SCI)-specific factor. The agreement between TEE and total energy intake (TEI) was just established. The findings suggested the existence of positive and negative energy balance distributions. Forty-two males with chronic SCI underwent BMR followed by a detailed metabolic profile after an overnight fast. TEI and macronutrients of 3-d dietary logs were analysed using the Nutrition Data System for Research software. Energy surplus was calculated as TEE minus TEI. Body composition assessment was conducted using dual-energy X-ray absorptiometry. 57 % of SCI participants were classified as negative energy surplus with an average TEI of 1284 (sd 422) compared with 2197 (sd 553) kcal/d in the positive energy group (P = 0·0002). Negative energy group had a higher BMR (9 %; P = 0·02), greater body weight (P = 0·03) and greater total body lean mass (P = 0·03) and consumed a greater percentage of protein compared with the positive energy group. Percentage macronutrients of protein explained 27 % of the variance of energy surplus in a multivariate regression model (r2 0·27; P = 0·008). TEI adjusted to fat-free mass explained 87 % of the variance in energy surplus, and an intake of 34·7 kcal/kg per d was recommended to balance TEI with TEE. Persons with SCI are either classified into negative or positive energy surplus groups. Larger body weight and greater protein intakes are among the major characteristics of the negative energy group. Clinicians may need to consider the spectrum of energy balance before starting a dietary regimen after SCI.
This paper argues that, far from supporting, an oft-cited passage of the Phenomena and Noumena chapter (A247/B303) instead belies, Allison’s influential thesis that Kant’s transcendental idealism is not an ‘alternative ontology’ but a methodological or meta-epistemological ‘alternative to ontology’ that is devoid of specific metaphysical content. Following a programmatic sketch of Kant’s system of principles as a regional ontology of nature, it is argued that the precise wording and original punctuation of that passage suggest that the transcendentally realist ontologies of the past are to ‘give way’ to just such an immanent ontology of the world of outer experience.