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This article discusses the iconography of Luca Signorelli's Sermon and Deeds of the Antichrist (c.1502–3) in the Cappella Nuova at the cathedral of Orvieto. A combined investigation of the Antichrist's subject matter, Signorelli's literary and visual sources, as well as his discarded drawings for the entire fresco decoration of the Cappella Nuova, brings fresh insights to the thematic intentions of the artist and his advisers. Signorelli's entire view of eschatology marked a renewed interest of Italian artists in the apocalyptic sublime. It also signified a revival of the medieval tradition of the Antichrist as the arch-hypocrite, and his reign as an apocalyptic age of hypocrisy. At the same time, the artist's treatment of the subject matter indicates an ambiguous stance toward religious hypocrisy characterized by a suppression of the anti-clerical and millenarian aspects of the Antichrist myth.
First dispatched to Jamaica in 1818 by The Conversion Society, the Rev. John Stainsby became a prominent figure on the island. This article examines his intense involvement in Anglican missionary affairs to reveal how dishonesties and concealment of belief were used to expand Anglican missions in the Caribbean. Firstly, this article examines two key sites of contention between missionaries and the plantocracy – Sunday markets and baptism – where Stainsby used deception to reconcile his religious duties and colonial law. Secondly, it considers the motivations and actions of The Conversion Society and the Church Missionary Society more generally, including the heavily censored material used for religious instruction. Finally, it examines Stainsby as an enslaver, and considers the religious justifications used to support enslavement by many resident Anglican clergymen in the early nineteenth century.
In 1838, Robert and Samuel Wilberforce published, in five volumes, The Life of William Wilberforce. Although the subject of some contemporary controversy, this work, containing extensive quotations from his diaries, rapidly established itself as the principal source for subsequent biographical writings about Wilberforce and strongly influenced later interpretations. The production of a complete initial transcription of the diaries by the Wilberforce Diaries Project for the first time enables a systematic comparison between the Life and its principal source. This reveals a systematic attempt by his sons to minimize references to Wilberforce's participation in some aspects of Hanoverian sociability, his use of medication to deal with his worsening health, his close associations with and respect for Nonconformists and his own evangelical commitment and spirituality. As a consequence, the Wilberforce we know from the biography is as much a product of early Victorian myth-making as the Wilberforce of 1759–1833.
Driving capacity is affected by vestibular disorders and the medications used to treat them. Driving is not considered during medical consultations, with 92 per cent of patients attending a centre for dizziness not discussing it with the doctor.
Objective
To investigate if medical record prompts facilitate dizziness and driving conversations in ENT balance clinics.
Methods
A questionnaire was designed to reflect the current standards of practice and advice given regarding driving and dizziness during balance clinic consultations.
Results
Medical record prompts facilitated the improved frequency and recording of shared decision-making conversations about driving and dizziness in 98 per cent of consultations.
Conclusion
This study highlights the benefits of medical record prompts for documented and accurate shared decision-making conversations surrounding dizziness, vertigo, vestibular conditions and driving. This potentially improves safety for all road users, and protects the patient and clinician in the event of road traffic accidents and medico-legal investigations.
Epilepsy ranks fourth among neurological diseases, featuring spontaneous seizures and behavioural and cognitive impairments. Although anti-epileptic drugs are currently available clinically, 30 % of epilepsy patients are still ineffective in treatment and 52 % of patients experience serious adverse reactions. In this work, the neuroprotective effect of α-linolenic acid (ALA, a nutrient) in mice and its potential molecular mechanisms exposed to pentylenetetrazol (PTZ) was assessed. The mice were injected with pentetrazol 37 mg/kg, and ALA was intra-gastrically administered for 40 d. The treatment with ALA significantly reduced the overall frequency of epileptic seizures and improved the behaviour impairment and cognitive disorder caused by pentetrazol toxicity. In addition, ALA can not only reduce the apoptosis rate of brain neurons in epileptic mice but also significantly reduce the content of brain inflammatory factors (IL-6, IL-1 and TNF-α). Furthermore, we predicted that the possible targets of ALA in the treatment of epilepsy were JAK2 and STAT3 through molecular docking. Finally, through molecular docking and western blot studies, we revealed that the potential mechanism of ALA ameliorates PTZ-induced neuron apoptosis and neurological impairment in mice with seizures by down-regulating the JAK2/STAT3 pathway. This study aimed to investigate the anti-epileptic and neuroprotective effects of ALA, as well as explore its potential mechanisms, through the construction of a chronic ignition mouse model via intraperitoneal PTZ injection. The findings of this research provide crucial scientific support for subsequent clinical application studies in this field.
In Canada, there is interest in expanding medical assistance in dying (MAID) to include advance requests (AR) for people living with dementia (PLWD). However, operationalizing the intolerable suffering criterion for MAID in ARs for PLWD is complicated by the Canadian legal context—in which MAID is understood as a medical intervention and suffering is conceptualized as subjective—and the degenerative nature of dementia. ARs that express a wish to receive MAID when the PLWD develops pre-specified impairments are problematic because people are unlikely to accurately predict the conditions that will cause intolerable suffering. ARs that express a wish to receive MAID when the PLWD exhibits pre-specified behaviors that likely represent suffering are problematic because they are inconsistent with the subjective conceptualization of suffering. Further research is required to determine whether adopting an objective conceptualization of suffering is justified in these cases and, if so, how to reliably identify intolerable suffering in PLWD.
The article examines the role of Hegel's theory of finite cognition in Marx's critique of classical political economy. I argue that Hegel's distinction of finite cognition between analytic and synthetic in the Science of Logic constitutes the methodological framework through which Marx delineates the different stages of the development of political economy. Focusing on the Grundrisse, I reveal the Hegelian influence behind Marx's statements on previous political economists’ methods. Thus, Marx's immanent critique of the classical political economy is construed as undertaken from the level of the systematic dialectical method of Capital, and is modelled on Hegel's immanent critique of analytic and synthetic cognition from the perspective of absolute cognition. In this context, and focusing on Marx's critique of Ricardo's method, I argue that the latter's limitations are associated with the deficiencies of synthetic cognition as presented by Hegel. Therefore, the article sheds light on an important yet underexplored topic of the Hegel-Marx relationship. By indicating the centrality of Hegel's theory of finite cognition in Marx's methodological underpinnings, the article provides a new perspective on Hegel-Marx scholarship.
To test the transmission of mental health difficulties from mother to child, we examined mediation through emotion reminiscing conversations and child language. Maternal depression symptoms were measured at 9 months post-partum, and child mental health outcomes were measured at age 8 years. Emotion reminiscing conversations between 1,234 mother-child pairs (624 boys, 610 girls) were recorded as part of a large, diverse, longitudinal cohort Growing Up in New Zealand. The 1,234 reminiscing conversations were transcribed and coded for maternal elaboration and emotion resolution quality (mother and child). The coded reminiscing variables did not mediate the pathway from maternal depression to child mental health outcomes; however, each maternal reminiscing variable together with child language skill serially mediated the relationship from maternal depression symptoms to child-reported anxiety and depression symptoms, and parent-reported child externalizing symptoms. Language as a skill and it’s use as a tool for making shared meaning from past events are highlighted as possible mechanisms for the intergenerational transmission of mental health difficulties. These findings point to potential opportunities for early interventions, including prevention of and support for postnatal depression, family intervention in reminiscing training, and supporting child language development.
High-temperature non-equilibrium effects are prominent in scramjet nozzle flows at high Mach numbers. Hence, the thermochemical non-equilibrium gas model incorporating the vibrational relaxation process of molecules in the hydrocarbon-air reaction is developed to numerically simulate the flow of a hydrocarbon fuel scramjet nozzle at Mach 10. Besides, the results computed by the models of the thermally perfect gas, chemically non-equilibrium gas, and thermally non-equilibrium chemically frozen gas are applied for comparative studies. Results indicate that chemical non-equilibrium effects are more significant for the flow-field structure and parameters compared to thermal non-equilibrium effects. Meanwhile, vibrational relaxation and chemical reactions interact in the flow-field. The heat released from the chemical reactions in the flow-field of the thermochemical non-equilibrium gas model makes the thermal non-equilibrium effects weaker compared to the thermally non-equilibrium chemically frozen gas model; the chemical reactions in the thermochemical non-equilibrium gas model are more intense than in the chemically non-equilibrium gas model. Due to the slow relaxation of vibrational energy, the thermal non-equilibrium models predicted nozzle thrust lower than the thermal equilibrium models by approximately 1.11% to 1.33%; when considering the chemical reactions, the chemical non-equilibrium models predicted nozzle thrust higher than the chemical frozen models by approximately 7.30% to 7.54%. Hence, the structural design and performance study of the high Mach numbers scramjet nozzle must consider thermochemical non-equilibrium effects.
We study the energy stability of pressure-driven laminar magnetohydrodynamic flow in a rectangular duct with a transverse homogeneous magnetic field and electrically insulating walls. For sufficiently strong fields, the laminar velocity distribution has a uniform core and convex Hartmann and Shercliff boundary layers on the walls perpendicular and parallel to the magnetic field. The problem is discretized by a double expansion in Chebyshev polynomials in the cross-stream coordinates. The linear eigenvalue problem for the critical Reynolds number depends on the streamwise wavenumber, Hartmann number and the aspect ratio. We consider the limits of small and large aspect ratios in order to compare with stability models based on one-dimensional base flows. For large aspect ratios, we find good numerical agreement with results based on the quasi-two-dimensional approximation. The lift-up mechanism dominates in the limit of a zero streamwise wavenumber and provides a linear dependence between the critical Reynolds and Hartmann numbers in the duct. As the aspect ratio is reduced away from unity, the duct results converge to Orr's original energy stability result for spanwise uniform perturbations imposed on the plane Poiseuille base flow. We also examine different possible symmetries of eigenmodes as well as the purely hydrodynamic case in the duct geometry.
The values of the signal-to-noise ratio are determined, at which the method of processing X-ray diffraction data reveals reflections with intensity less than the noise component of the background. The possibilities of the method are demonstrated on weak reflections of α-quartz. The method of processing X-ray diffraction data makes it possible to increase the possibilities of X-ray phase analysis in determining the qualitative phase composition of multiphase materials with a small (down to 0.1 wt.%) content of several (up to eight) phases.
A recent article of Chernikov, Hrushovski, Kruckman, Krupinski, Moconja, Pillay, and Ramsey finds the first examples of simple structures with formulas which do not fork over the empty set but are universally measure zero. In this article we give the first known simple $\omega $-categorical counterexamples. These happen to be various $\omega $-categorical Hrushovski constructions. Using a probabilistic independence theorem from Jahel and Tsankov, we show how simple $\omega $-categorical structures where a formula forks over $\emptyset $ if and only if it is universally measure zero must satisfy a stronger version of the independence theorem.
The property of countable metacompactness of a topological space gets its importance from Dowker’s 1951 theorem that the product of a normal space X with the unit interval $[0,1]$ is again normal iff X is countably metacompact. In a recent paper, Leiderman and Szeptycki studied $\Delta $-spaces, which is a superclass of the class of countably metacompact spaces. They proved that a single Cohen real introduces a ladder system $ L$ over the first uncountable cardinal for which the corresponding space $X_{ L}$ is not a $\Delta $-space, and asked whether there is a ZFC example of a ladder system $ L$ over some cardinal $\kappa $ for which $X_{ L}$ is not countably metacompact, in particular, not a $\Delta $-space. We prove that an affirmative answer holds for the cardinal $\kappa =\operatorname {\mathrm {cf}}(\beth _{\omega +1})$. Assuming $\beth _\omega =\aleph _\omega $, we get an example at a much lower cardinal, namely $\kappa =2^{2^{2^{\aleph _0}}}$, and our ladder system L is moreover $\omega $-bounded.
The later career of British prehistorian Peggy Piggott, latterly Guido, is evaluated in this article, in a bid to further develop our understanding of women's participation in twentieth-century British archaeology. After WWII, when her husband Stuart Piggott was appointed to the Abercromby Chair in Edinburgh, she worked to assist his role. By the early 1950s, she had co-directed and published eight hillfort excavations, advancing our understanding of prehistoric architecture before the advent of radiocarbon dating. The authors consider Peggy Piggott's contribution as a fieldworker, promoting open-area excavation and influencing the next generation. We also consider her thinking, as an early advocate for continuity and Childe's diffusionism, in contrast to the invasionist views of Christopher Hawkes and Stuart Piggott. The authors reflect on the role her marriage played in enabling and restricting her career, her work in 1960s Italy, her expertise in ancient glass beads, and her activity in retirement.
Given a cocycle on a topological quiver by a locally compact group, the author constructs a skew product topological quiver and determines conditions under which a topological quiver can be identified as a skew product. We investigate the relationship between the ${C^*}$-algebra of the skew product and a certain native coaction on the ${C^*}$-algebra of the original quiver, finding that the crossed product by the coaction is isomorphic to the skew product. As an application, we show that the reduced crossed product by the dual action is Morita equivalent to the ${C^*}$-algebra of the original quiver.
This paper defends an interpretation of Fanon's theory of recognition as revolving around his claim that we have a basic right to demand human behaviour from the other. Developing key Hegelian ideas in a novel direction, I argue that Fanon's theory of recognition employs a concretely universal concept of humanity as a normative orientation for establishing what he calls a ‘world of reciprocal recognitions’, which he equates with the creation of a ‘human reality’. In the first section, I take up the three passages from Hegel's Phenomenology of Spirit cited by Fanon in Black Skin, White Masks to outline three key features of Fanon's theory of recognition. In section two, I argue that there are three senses of ‘universal humanity’ operative in Fanon's work: a false universal, an abstract universal, and a concrete universal. Whereas the first two are critical, pejorative uses, the third provides the normative orientation for his account of recognition and social struggle. In the third section, I show how Fanon combines features of Hegel's concrete universal with features of Sartre's existential humanism in order to avoid an essentialist or ahistorical approach to human nature. Specifically, I argue that the ideas of self-transcendence and a universal human condition shed light on what Fanon refers to as the right of reciprocal recognition to demand human behaviour from the other, and our one human duty to not renounce our freedom.
The invasive pea leaf weevil, Sitona lineatus (Linnaeus) (Coleoptera: Curculionidae), damages field peas, Pisum sativum Linnaeus (Fabaceae), and faba beans, Vicia faba Linnaeus (Fabaceae), on the Canadian prairies. We used semiochemical-baited pitfall traps to monitor and detect S. lineatus range expansion and capture associated predaceous ground beetles (Coleoptera: Carabidae) in pulse-growing regions across Alberta. Traps captured male and female S. lineatus in all pulse-growing regions in the spring and fall, including a first record of S. lineatus in the Peace River region of northwestern Alberta. Pheromone-baited traps captured more weevils than unbaited traps did, and the addition of host plant volatiles did not increase the catch. More weevils were captured in traps in pea fields compared to in faba bean fields. Rubber septa lures released more pheromones and attracted a similar number or more weevils to traps than microcentrifuge tube lures did. Ground beetle capture was not affected by semiochemical baits targeting S. lineatus. Ground beetle diversity varied by region and collection period, but the most frequently collected species was Pterostichus melanarius, a potential predator of S. lineatus. This study shows that pitfall traps baited with rubber septa pheromone lures can be used to monitor new and expanding S. lineatus populations, as well as potential natural enemy communities.
Research on mobile-assisted language learning (MALL) has revealed that high rates of attrition among users can undermine the potential benefits of this learning method. To explore this issue, we surveyed 3,670 adult MALL users based on the Unified Theory of Acceptance and Use of Technology (UTAUT) and also conducted an in-depth analysis of their historical app usage data. The results of hierarchical k-means cluster analysis and recurrent event survival analysis revealed three major findings. First, three distinct profiles of learners were characterized by different MALL acceptance and engagement experiences. Second, those with greater MALL acceptance displayed more intense, frequent, and durable app usage (behavioral engagement). Lastly, high levels of MALL acceptance were associated with more frequent pauses in app usage but also (a) longer active usage, (b) shorter breaks before returning to the app, and, ultimately, (c) fewer dropouts. We argue that persistence is a multidimensional process involving cyclical phases of engagement, disengagement, dormancy, and reengagement, with each aspect, like intensity, frequency, and duration, building up cumulatively over time. Implications for promoting persistent MALL engagement are discussed.