Cylicospirura is a genus of spirocercid nematodes infecting felids around the globe. Eleven species have been characterised, with C. felineus and C. subaequalis being reported in jaguarundis, Herpailurus yagouaroundi, from Brazil. Herein, we described spirocercid reddish worms collected from three jaguarundis from Costa Rica by using hierarchical clustering and dendrogram plots of morphological characters reported from our specimens and compared to other Cylicospirura spp., histopathological observations of associated lesions, and phylogenetic analyses of both mitochondrial and ribosomal loci. Nematodes were found within stomach nodules located in the submucosa causing a pyogranulomatous, multifocal, nodular, and sclerosing gastritis. In addition, the collected worms differed from their congeners by having a longer body and smaller muscular and glandular oesophagus, subsequently showing lower total oesophagus to body length percentage and ratio of glandular to muscular oesophagus. Cytochrome oxidase subunit 1 and internal transcribed spacer 1 analyses revealed that worms were 8.33 to 8.66% different from C. felineus, C. subaequalis, or C. petrowi and 15.2 to 15.4% different from C. petrowi, respectively. Moreover, sequences derived from collected worms clustered separately from other Cylicospirura spp. available in GenBank® in the phylogenetic trees. By using an integrative taxonomy approach, the nematodes collected from stomach nodules of jaguarundis were described as a new taxon, for which the name Cylicospirura wishkai sp. nov. is proposed.

The lower limb exoskeleton is a typical wearable robot designed to assist human motion. However, its system stability and performance are often compromised due to unknown model parameters and inadequate control strategies. Therefore, it is crucial to explore the parametric identification of the exoskeleton and the design of corresponding control strategies for human-exoskeleton cooperative motion. First, an exoskeleton platform is developed to provide experimental validation. Simultaneously, a two-degree-of-freedom (2-DOF) exoskeleton model is constructed using the Lagrange method. The neighborhood field optimization (NFO) technique is then applied to identify the unknown model parameters of the exoskeleton. Additionally, the excitation trajectories for the exoskeleton are developed by the NFO method, incorporating several motion constraints to enhance the accuracy of model identification. An admittance controller is implemented to enable active control of the exoskeleton, allowing it to align with human intention and thereby improving the wearability and comfort of the device. Finally, both simulation and experimental results are compared and verified on the platform. These results demonstrate that the NFO method achieves superior identification accuracy compared to particle swarm optimization (PSO) and genetic algorithm (GA).

Individuals with severe mental illness face a significantly reduced life expectancy compared to the general population. Addressing key modifiable risk factors is essential to reduce these alarming rates of mortality in this population. Nutritional psychiatry has emerged as an important field of research, highlighting the important role of nutrition on mental health outcomes. However, individuals with severe mental illness often encounter barriers to healthy eating, including poor diet quality, medication-related side effects such as increased appetite and weight gain, food insecurity and limited autonomy over food choices. While nutrition interventions play a key role in improving health outcomes and should be a standard part of care, their implementation remains challenging. Digital technology presents a promising alternative support model, with the potential to address many of the structural and attitudinal barriers experienced by this population. Nonetheless, issues such as digital exclusion and low digital literacy persist. Integrating public and patient involvement, along with behavioural science frameworks, into the design and delivery of digital nutrition interventions can improve their relevance, acceptability and impact. This review discusses the current and potential role of digital nutrition interventions for individuals with severe mental illness, examining insights, challenges and future directions to inform research and practice.

Despite the recent methodological advancements in causal panel data analysis, concerns remain about unobserved unit-specific time-varying confounders that cannot be addressed by unit or time fixed effects or their interactions. We develop a Bayesian sensitivity analysis (BSA) method to address the concern. Our proposed method is built upon a general framework combining Rubin’s Bayesian framework for model-based causal inference (Rubin [1978], The Annals of Statistics 6(1), 34–58) with parametric BSA (McCandless, Gustafson, and Levy [2007], Statistics in Medicine 26(11), 2331–2347). We assess the sensitivity of the causal effect estimate from a linear factor model to the possible existence of unobserved unit-specific time-varying confounding, using the coefficients of the treatment variable and observed confounders in the model for the unobserved confounding as sensitivity parameters. We utilize priors on these coefficients to constrain the hypothetical severity of unobserved confounding. Our proposed approach allows researchers to benchmark the assumed strength of confounding on observed confounders more systematically than conventional frequentist sensitivity analysis techniques. Moreover, to cope with convergence issues typically encountered in nonidentified Bayesian models, we develop an efficient Markov chain Monte Carlo algorithm exploiting transparent parameterization (Gustafson [2005], Statistical Science 20(2), 111–140). We illustrate our proposed method in a Monte Carlo simulation study as well as an empirical example on the effect of war on inheritance tax rates.

This study offers a phenomenological exploration of unchosen pregnancy as a distinct temporal experience. By bracketing the traditionally dominant concept of pregnancy as culminating in birth, this study unveils the unique temporal contours of early pregnancy, particularly when it is not chosen. Through a critical phenomenology analysis, this study demonstrates how unchosen pregnancy is characterized by extreme temporal disorientation, a heightened experience of multiple temporal layers, and a profound loss of temporal grounding. This description of unchosen pregnancy is intended to open new pathways of thought on the ethical issue of abortions and expand the phenomenological understanding of pregnancy.

Sarcopenia, the age-related decline in muscle mass and strength, is a contributor to frailty and reduced quality of life. Emerging evidence suggests an emerging role of the gut microbiome in modulating skeletal muscle through microbial species and metabolites, such as short-chain fatty acids (SCFAs), potentially influencing inflammation, nutrient absorption, and glucose and protein metabolism. This review considers the potential of probiotics, prebiotics, and synbiotics as interventions to mitigate sarcopenia based on animal and human studies, while providing a critique of present barriers that need to be addressed. Preclinical models, including germ-free mice and faecal microbiota transplantation, demonstrate that gut microbiota from healthy or young donors may enhance overall muscle health via reductions in inflammatory and muscle atrophy markers. Limited human studies show that probiotics such as Lactobacillus and Bifidobacterium could improve branched-chain amino acid (BCAA) bioavailability and potentially sarcopenia indices, although findings have been inconsistent. Particularly, challenges including inconsistent microbial assessments, lack of dietary control and interindividual variability due to diet, age, genetics, comorbidities and medications may hinder progress in this field. Delivery methods (e.g. capsules, fermented foods or fortified products) could further complicate efficacy through probiotic stability and dietary restrictions in older adults. Standardised protocols [e.g. Strengthening The Organisation and Reporting of Microbiome Studies (STORMS) checklist] and multi-omics approaches may be critical to address these limitations and identify microbial signatures linked to sarcopenia outcomes. While preclinical evidence highlights mechanistic pathways pertinent to amino acid metabolism, translating findings to humans requires rigorous experimental trials.

This article examines the national and international context within which Colombian immigration policy developed in the mid-twentieth century. Focussing on Republican refugees from the Spanish Civil War, it traces how and why policymakers and public opinion began to see these groups as potentially harmful to society. It argues that Colombian immigration policy emerged at the intersection of multiple, evolving discourses of race which both helped frame and were shaped by anxieties over a mass influx from Spain. By exploring the stories of several Republicans who tried to come to Colombia, the article also reveals how they helped shape immigration policy.

This study examines the interplay between welfare stigma and need in the decision to claim social welfare benefits in Hong Kong, a liberal welfare city where self-reliance and family obligations are highly valued. Our interviews with seventeen low-income parents, suggest that first, their availability and ability to work influence their self-perceived ‘deservingness’ of aid. This, in turn, affects their anticipated self-stigma and their assessment of needs. Second, having children influences parents’ decisions to claim social welfare benefits through both anticipated stigma and childcare needs. Finally, low-income parents are trapped in an impossible triangle of being a ‘good’ parent, caught between fulfilling parental responsibilities, providing for their children financially, and modeling self-reliance to protect them from welfare stigma. Claiming benefits fulfills the first two but sacrifices self-reliance, while choosing not to claim fulfills the latter two but sacrifices parental responsibilities. Both choices carry emotional consequences that can undermine parent-child relationships.

The Taiwan Incident of 1874 – a prolonged Sino-Japanese confrontation over the killing of Ryukyu castaways, whom Japan claimed as its subjects – marked the full maturation of a new mode of Qing war preparation. This mode was characterized by global coordination, domestic and international competition, and the swift mobilization of personal connections to secure foreign weapons and loans – resources that were often interconnected. Facilitated by the efforts of various actors, this internationalized approach became a standard practice during the empire’s final decades. As the empire could no longer rely on domestic self-sufficiency in arms and funding, Qing military operations came to reflect the broader influence of global military and financial resources. The Qing empire’s capacity to mobilize global resources in pursuit of national objectives helps explain its resilience in an era dominated by imperial powers.

Holocene environmental changes on the Paraty coastal plain in southeastern Brazil unfolded under dynamic sea-level fluctuations and shifting sedimentary regimes. Continental and marine palynomorph analyses, combined with calibrated radiocarbon dating from two sediment cores (JBS1 and JBS2), reveal a continuous depositional record spanning approximately 7800 to 1000 cal yr BP. Sandy mud and muddy sand sequences reflect variable coastal energy conditions through out the mid to late Holocene. Dinoflagellate cyst assemblages indicate a transition from open marine to marginal marine environments, with maximum marine influence between 7000 and 5000 cal yr BP. Terrestrial palynomorphs show a concurrent shift from grassland-dominated landscapes to mixed vegetation including ombrophilous forest taxa. A marked increase in pollen concentration in the upper stratigraphic layer suggests coastal progradation, enhanced continental input, and reduced marine influence during the late Holocene regression. Bayesian age-depth models demonstrate uninterrupted but variable sedimentation rates, with no evidence for erosional surfaces or depositional hiatuses. The results align with regional sea-level reconstructions and under score the role of transgressive-regressive processes and delta infilling in shaping vegetation dynamics. This integrated micropalaeontological and chronostratigraphic approach offers a robust framework for interpreting Holocene palaeoenvironmental evolution in tropical coastal settings.

Pseudoaneurysm after valve-sparing aortic root replacement is uncommon but potentially life-threatening. We report an unusual case of spontaneous resolution of an aortic root pseudoaneurysm that developed in a 14-year-old boy with Marfan syndrome following valve-sparing aortic root replacement. This case suggests that, in carefully selected situations, non-surgical management with intensive follow-up may be beneficial.