Submitral aneurysm is a rare type of non-ischaemic ventricular aneurysm. We describe the case of a 26-year-old woman with progressive dyspnoea for approximately 1 year who was diagnosed with a ruptured submitral aneurysm in the left atrium with severe regurgitation. The patient underwent aneurysm correction and mitral valve repair, and post-operative echocardiography showed no residual abnormalities. The patient remains asymptomatic.

We characterize the stabilized automorphism group for odometers and Toeplitz subshifts, and then prove an invariance property of the stabilized automorphism group of these dynamical systems. Namely, we prove the isomorphism invariance of the primes for which the p-adic valuation of the period structure tends to infinity. A particular case of interest is that for torsion-free odometers, the stabilized automorphism group is a full isomorphism invariant.

The purpose of this paper is to reject what I call the entitlement model of directed obligation: the view that we can conclude from X is obligated to Y that therefore Y has an entitlement against X. I argue that rejecting the model clears up many otherwise puzzling aspects of ordinary moral interaction. The main goal is not to offer a new theory of obligation and entitlement. It is rather to show that, contrary to what most philosophers have assumed, directed obligation and entitlement are not the same normative concept seen from two different perspectives. They are two very different concepts, and much is gained by keeping them distinct.

This paper is a revised version of a plenary lecture delivered at the SLS Annual Conference held at Oxford Brookes University in June 2023. It adopts an auto-ethnographic approach, drawing on the author's long experience of participating in the UK Research Excellence Framework (REF), to assess the current state of legal research in the UK and consider the implications of the increasing importance in the research landscape of engaging in research that serves the public good. The paper explores what falls within the scope of ‘legal research’, particularly for REF purposes, and reflects on how REF-focused research sits within the broader scope of legal scholarly activities. Ideas of the public good are examined and their relation to measures of research impact probed. The paper concludes by painting a broad-brush picture of the current research landscape, identifying key elements and engines of change, and speculating on the direction in which things are going and what should most concern legal scholars going forward. Although primarily focused on legal research in the UK, the paper should be of interest to legal scholars beyond the UK, particularly those in jurisdictions where research assessment exercises are a feature of academic life.

Macauba (Acrocomia aculeata) is a palm tree native from Brazil, whose pulp is rich in oil that has a high content of oleic acid and carotenoids. Macauba pulp oil can bring health benefits due to its bioactive compounds; however, its effects on gut health are unknown. Thus, the objective of this study was to evaluate the effect of macauba pulp oil on the intestinal health in mice fed a high-fat (HF) diet. Male C57BL1/6 mice were randomly divided into three groups (10 animals/group): control diet, HF diet and HF diet with 4 % of macauba pulp oil (HFM). Concentration of short-chain fatty acids (SCFA), faecal pH and histomorphometric analysis of the colon were performed. Content of colon samples was used on microbiome analysis using 16S rRNA amplicon sequencing. Animals from the HFM group had higher butyric acid content and goblet cells number, greater circular and longitudinal muscle layer and higher α-diversity compared with the HF group. Moreover, consumption of MPO reduced Desulfobacterota phylum, Ruminococcaceae, Oscillospiraceae, Prevotellaceae, Bifidobacteriaceae family, Faecalibacterium, Prevotella, Ruminococcus and Enterorhabdus genus. Therefore, macauba pulp oil was able to modulate the gut microbiota and enhance intestinal barrier morphology, showing preventive effects on gut dysbiosis in mice fed a HF diet.

Habitat alteration and climate change are important threats to terrestrial biodiversity in the tropics. Endorsing flagship or umbrella species can help conserve sympatric biodiversity, restore degraded ecosystems and achieve United Nations Sustainable Development Goals (UN SDGs). The Ethiopian wolf (Canis simensis) is a rare and endemic Ethiopian canid. It is Africa’s most endangered canid species and is restricted to several isolated patches of Afroalpine habitats. While its behavioural ecology and conservation biology have been well studied, studies of the Ethiopian wolf’s significance for the conservation of its habitat and sympatric species are lacking. Here we use geographical range overlap and geospatial modelling to evaluate the importance of the Ethiopian wolf as a flagship and/or umbrella species. We assess whether conservation interventions targeting the Ethiopian wolf could help to restore and protect Afroalpine habitat and conserve sympatric species whilst simultaneously providing a wide range of socioeconomic and environmental benefits. We found that Ethiopian wolves share their range with 73 endemic and/or threatened vertebrate species, 68 of which are Afroalpine ecosystem species, and at least 121 endemic and/or threatened plant species. Ethiopian wolves are taxonomically distinctive and charismatic species classified as Endangered on the International Union for Conservation of Nature (IUCN) Red List. Thus, they meet both the flagship and umbrella species criteria to restore Afroalpine habitats and conserve threatened sympatric species. A conservation strategy protecting and restoring Afroalpine habitat has the potential to contribute to achieving at least five of the 17 UN SDGs. The protection of flagship and umbrella species should be integrated into broader regional biodiversity and habitat conservation.

The aim of this study was to evaluate whether high-fat (HF) diet intake during puberty can program obesity as well as generate glucose imbalance and hepatic metabolic dysfunctions in adult life. Male Wistar rats were randomly assigned into two groups: rats fed standard chow (NF) and rats fed a HF from postnatal 30-day-old (PND30) until PND60. Then, both groups were fed a standard chow from PND60 until PND120. Euthanasia and samples collections occurred at PND120. HF animals were overweight (+11%) and had increased adiposity, hyperphagia (+12%), hyperglycaemia (+13%), hyperinsulinemia (+69%), and hypertriglyceridemia (+34%). Plasma glucose levels during intravenous glucose tolerance test (ivGTT) and intraperitoneal insulin tolerance test (ipITT) were also higher in the HF group, whereas Kitt was significantly lower (–34%), suggesting reduced insulin sensitivity. In the same sense, HF animals present pancreatic islets hypertrophy and high β-cell mass. HF animals also had a significant increase in blood glucose levels during pyruvate tolerance test, indicating increased gluconeogenesis. Hepatic morphology analyses showed an increase in lipid inclusion in the HF group. Moreover, PEPCK and FAS protein expression were higher in the livers of the HF animals (+79% and + 37%, respectively). In conclusion, HF during puberty causes obese phenotype leading to glucose dyshomeostasis and nonalcoholic fatty liver disease, which can be related to the overexpression of proteins PEPCK and FAS.

The crystal structure of L-5-methyltetrahydrofolate calcium trihydrate has been solved and refined using synchrotron X-ray powder diffraction data and optimized using density functional techniques. Calcium levomefolate trihydrate crystallizes in space group P212121 (#19) with a = 7.1706(6), b = 6.5371(5), c = 53.8357(41) Å, V = 2523.58(26) Å3, and Z = 4. The structure is characterized by alternating hydrophobic and hydrophilic layers along the c-axis. The Ca cations are 7-coordinate, and share edges to form chains along the b-axis. Each of the water molecules acts as a donor in two hydrogen bonds. The coordinated water molecule makes two strong intermolecular O–H⋯O hydrogen bonds to carboxyl and carbonyl groups. The two zeolitic water molecules form weaker hydrogen bonds, to carbonyl O atoms, ring N atoms, and aromatic C atoms. Several N–H⋯O/N hydrogen bonds, as well as C–H⋯O hydrogen bonds, also contribute to the lattice energy.

Before the mid-seventeenth century when a developing understanding of probability transformed gambling, English gaming took place in the community rather than in dedicated institutions like casinos and so represented and interacted with more general social behavior. Different communities gambled differently; they had different status under the law. This article considers gentlemen's gambling, arguing that in the absence of other constraints, notions of honor had a key role in shaping that activity. Contemporary accounts such as Sir John Harington's “Treatise on Playe” suggest that high-stakes wagering fell into the anthropological category of deep play, whereby gamesters staked excessive sums to win renown for their daring; secondly, it appears that such behavior was seen as a young man's activity, with older men condemning immoderate wagering as their ideas about what was honorable shifted as they matured and became integrated into the community. In addition to age-related changes of attitude to gambling, a tension existed between Elizabethan ideals of gentlemen's gambling behaviors and individual gamesters’ real circumstances. Some had limited money for wagering, others little time; youths from gentle families were sometimes indentured as apprentices or otherwise in situations that altered their relationships to time, money, and regulation. Consequently, even within this single sector of Elizabethan society, attitudes to gambling acquired a high level of complexity.

The dual-user training system is essential for fostering motor skill learning, particularly in complex operations. However, the challenge lies in the optimal tradeoff between trainee ability and engagement level. To address this problem, we propose an intelligent agent that coordinates trainees’ control authority during real task engagement to ensure task safety during training. Our approach avoids the need for manually set control authority by expert supervision. At the same time, it does not rely on pre-modeling the trainee’s skill development. The intelligent agent uses a deep reinforcement learning (DRL) algorithm based on trainee performance to adjust adaptive engagement during the training process. Our investigation aims to provide reasonable engagement for trainees to improve their skills while ensuring task safety. Our results demonstrate that this system can seek the policy to maximize trainee participation while guaranteeing task safety.

Embryos of optimal development reach blastocyst stage 116 ± 2 h after insemination. Usable D7 blastocysts represent nearly 5% of embryos in IVF with acceptable pregnancy and live birth rates, however data are still limited. Therefore, this study aimed to analyze the ongoing pregnancy rate (OPR) of D7 blastocysts in single euploid frozen embryo transfer (FET) cycles. An observational study was performed including 1527 FET cycles with blastocysts biopsied on D5 (N = 855), D6 (N = 636) and D7 (N = 36). Blastocysts were classified as good (AA/AB/BA), fair (BB) or poor (AC/BC/CC/CA/CB) (Gardner scoring). FETs were performed in natural cycles (NC) or hormone replacement therapy (HRT) cycles. Patient’s age differed significantly between D5, D6 and D7 blastocysts FET cycles (33.2 ± 5.6, 34.4 ± 5.3 and 35.9 ± 5.2, P < 0.001). OPRs were higher when D5 euploid blastocysts were transferred compared with D6 and D7 (56.0% vs. 45.3% and 11.1%, P < 0.001). Poor quality blastocysts were predominant in D7 blastocyst FET cycles (good quality: 35.4%, 27.2%, 5.6%; fair quality: 52.1%, 38.5%, 11.1%; poor quality: 12.5%, 34.3%, 83.3%, P < 0.001 for D5, D6 and D7 blastocysts; respectively). OPR was significantly reduced by D7 blastocyst FETs (OR = 0.23 [0.08;0.62], P = 0.004), patient’s BMI (OR = 0.96 [0.94;0.98], P < 0.001), HRT cycles (OR = 0.70 [0.56;0.88], P = 0.002) and poor quality blastocysts (OR = 0.33 [0.24;0.45], P < 0.001). OPR is significantly reduced with D7 compared with D5/D6 euploid blastocysts in FET cycles. The older the patient, the more likely they are to have an FET cycle with blastocysts biopsied on D7, therefore culturing embryos until D7 can be a strategy to increase OPR outcomes in patients ≥38 years.

This article examines and further develops the relationship between the theory of uneven and combined development (UCD), recently taken up by International Relations (IR) scholars to furnish a social theory of ‘the international’, and the Gramscian concept of ‘passive revolution’, which refers to a molecular process of top-down revolution and state formation that preserves ruling-class power by transforming its social base. To this end, the paper: (1) advances a productive distinction between ‘societal’ and ‘(geo)political’ multiplicity, increasing the transdisciplinary potential of UCD and challenging dominant state-centric approaches to IR; (2) demonstrates that UCD is central to creating the conditions for passive revolution; and, (3) argues that UCD illuminates the distinct spatial dimensions of passive revolution, for which the succession of ‘classes’ in time requires the expansion of capitalist social relations in space. To illustrate these claims, the article demonstrates how the American Civil War is best understood as an inter-societal conflict, exacerbated by the coexistence of two social formations within a single state, leading to war. It then shows how, upon victory, the North’s abolition of enslaved labour and the subsequent attempt to re-subsume the South within a single sovereign polity constituted a radical instance of passive revolution.

Is the current Power Resources Approach (PRA) of trade unions capable enough to cope with the global socio-economic and geopolitical structural transformation resulting from automation, pandemic-induced economic fallout, and the Russia-Ukraine war? If so, then why are millions of workers living in extreme poverty, and why do we have a double-digit rate of global job gaps? To survive in this challenging period of the global labour market, trade unions have to trigger the fifth power’s resources, denoted as ‘ethical power’. This new dimension of PRA might facilitate the trade unions’ efforts to secure decent industrial relations and social justice in the workplace. Historically, gaining ‘institutional power’ and ‘societal power’ was subject to ethical confrontation, which is rightly omitted while defining the PRA. Therefore, this study coined the term ‘ethical power’ as a supplement to existing power resources theory and found that the application of ethics to the attainment and exercise of PRA is not something new but rather unrecognised.

The increase of human presence in the subsea and seabed environments necessitates the development of more capable and highly dexterous, innovative underwater manipulators. Biomimetic soft-robot arms represent a promising candidate for such manipulation systems. However, the well-known modeling techniques and control theories of traditional rigid robots do not apply to soft robots. The challenges of kinematic and dynamic modeling of soft robots with infinite degrees of freedom require the development of dedicated modeling methods. A novel procedure for representing soft-robotic arms and their motion in a rigid-body simulation environment is proposed in this paper. The proposed procedure relies on the piecewise constant curvature approach to simplify the very complex model of hyper-redundant soft-robotic arms, making it suitable for real-time applications. The proposed method is implemented and verified to be used in model-mediated teleoperation of the soft arms of a biomimetic robotic squid designed for underwater manipulation as a case study.

In this paper, we study compactifications of the moduli of smooth del Pezzo surfaces using K-stability and the line arrangement. We construct K-moduli of log del Pezzo pairs with sum of lines as boundary divisors, and prove that for $d=2,3,4$, these K-moduli of pairs are isomorphic to the K-moduli spaces of del Pezzo surfaces. For $d=1$, we prove that they are different by exhibiting some walls.