To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Phytosterols/phytostanols are bioactive compounds found in vegetable oils, nuts and seeds and added to a range of commercial food products. Consumption of phytosterols/phytostanols reduces levels of circulating LDL-cholesterol, a causative biomarker of CVD, and is linked to a reduced risk of some cancers. Individuals who consume phytosterols/phytostanols in their diet may do so for many years as part of a non-pharmacological route to lower cholesterol or as part of a healthy diet. However, the impact of long term or high intakes of dietary phytosterols/phytostanols has not been on whole-body epigenetic changes before. The aim of this systematic review was to identify all publications that have evaluated changes to epigenetic mechanisms (post-translation modification of histones, DNA methylation and miRNA expression) in response to phytosterols/phytostanols. A systematic search was performed that returned 226 records, of which eleven were eligible for full-text analysis. Multiple phytosterols were found to inhibit expression of histone deacetylase (HDAC) enzymes and were also predicted to directly bind and impair HDAC activity. Phytosterols were found to inhibit the expression and activity of DNA methyl transferase enzyme 1 and reverse cancer-associated gene silencing. Finally, phytosterols have been shown to regulate over 200 miRNA, although only five of these were reported in multiple publications. Five tissue types (breast, prostate, macrophage, aortic epithelia and lung) were represented across the studies, and although phytosterols/phytostanols alter the molecular mechanisms of epigenetic inheritance in these mammalian cells, studies exploring meiotic or transgenerational inheritance were not found.
This study details the Masjid-i Jami‘ of Urmiya, the earliest surviving mosque in the West Azerbaijan province in Iran. The building suggests the expansion of constructing Saljuq-domed mosques outside central Iran in the mid-sixth/twelfth century, embellished with a stunning Ilkhanid mihrāb (prayer niche) in the seventh/thirteenth century. This study provides as much information as possible for recognizing the structure's main features. While the mosque is comprised of various parts, this paper mainly focuses on its dome chamber as the earliest surviving structure. Several new inscriptions and drawings in the mosque's decoration are published for the first time in this article.
Gender pluralism has become a rich scholarly topic in Southeast Asia, especially with the rise of LGBT mobilisations across the region in the past decade. Transgender ritual specialists dominate the field of study, with a growing body of literature on Southeast Asian queer expressive cultures. However, queer performances in several classical performing arts are often excluded from the scholarship due to the field's association with the “traditional”. In this article, I address this scholarly gap by examining the social lives of queer men in Thai classical string music. I focus on a strategy called kep aakaan or “keeping condition” in which the musicians in question carefully articulate and disarticulate their femininity to render their gender nonconformity ambiguous under the heteronormative gaze. Using ethnographic methods to investigate the lived experience of queer male musicians on and off the stage, I show that “keeping condition” is not just about managing the display of queer potential but is also closely intertwined with morality and citizenship. Drawing on the ideas of tacit subjects and contextual sensitivities, I argue that “keeping condition” exposes the fluidity in which queer musicking bodies move between queerness and heteronormativity in ways that are more reconciliatory than confrontational. By focusing on the complicities of queerness and heteronormativity, I argue that non-normative classical performing arts can be a productive site for critical gender, sexuality, and queer studies in Southeast Asia, cutting through the “traditional” and “modern” divide that looms large in the region.
Campaigns on behalf of Russian political prisoners stretch from the revolutionary “nihilists” of the 1880s to the dissidents of the 1970s. While the efforts of political émigrés and their Western sympathizers – to promote awareness, raise funds, and pressure governments – met with decidedly mixed success, there were several watershed moments. This article examines how one such breakthrough, the compilation and publication of Letters from Russian Prisons in 1925, resulted in the formation of the International Committee for Political Prisoners (ICPP) as the first ever transnational amnesty NGO. Along with 300 pages of harrowing accounts of Soviet prisons, camps, and exile, the book featured endorsements by “Twenty-Two Well-Known European and American Authors”. The disputatious process of this volume's compilation and the controversy greeting its issuance show the challenges of extending civil liberties advocacy to include criticism of the Soviet Union among left and liberal figures in the interwar period. In establishing a new field of endeavor – universalist transnational activism to aid political detainees – the ICPP navigated a complex network of relationships among a diverse array of political and intellectual figures.
Constraining the timing and extent of Quaternary glaciations in the Tibetan Plateau (TP) is significant for the reconstruction of paleoclimatic environment and understanding the interrelationships among climate, tectonics, and glacial systems. We investigated the late Quaternary glacial history of the Qinggulong and Juequ valleys in the Taniantaweng Mountains, southeastern TP, using cosmogenic 10Be surface exposure dating. Four major glacial events were identified based on 26 10Be ages. The exposure ages of the oldest late Quaternary glaciation correspond to Marine Oxygen Isotope Stage (MIS) 6. The maximum glacial extent was dated to 48.5–41.1 ka (MIS 3), during the last glaciation, and was more advanced than that of the last glacial maximum (LGM). Geochronology and geomorphological evidence indicate that multiple glacial fluctuations occurred in the study area during the Early–Middle Holocene. These glacial fluctuations likely were driven by the North Atlantic climate oscillations, summer solar insolation variability, Asian summer monsoon intensity, and CO2 concentration.
I examine Kant’s claim in part one of Religion within the Boundaries of Mere Reason that moral reform requires both a ‘change of heart’ and gradual reformation of one’s sense (R, 6: 47). I argue that Kant’s conception of moral reform is neither fundamentally obscure nor is it as vulnerable to serious objections as several commentators have suggested. I defend Kant by explaining how he can maintain both that we can choose our moral disposition via an intelligible choice and that we become good through a continuous struggle. I then provide an interpretation of how moral reform occurs in the phenomenal realm.
Bimbowrieite, NaMgFe3+5(PO4)4(OH)6⋅2H2O, is a new mineral found in a mineralogically zoned rare-element bearing pegmatite at the White Rock No.2 quarry, Bimbowrie Conservation Park, South Australia, Australia. Crystals are dark olive green to greenish brown and are bladed with dimensions of up to 150 μm. Crystals occur as aggregates up to 0.4 mm across associated with ushkovite, bermanite, leucophosphite and sellaite. Bimbowrieite is pleochroic, biaxial (+), with α = 1.785(5), β = 1.795(5), γ = 1.805(5) and 2V(meas.) = 89.4(5)°. The average of 28 chemical analyses gave the empirical formula: (Na0.81Ca0.19)Σ1.00(Mg0.75Mn2+0.19Fe2+0.05)Σ0.99(Fe3+4.99Al0.01)Σ5.00(PO4)3.97(OH)5.88⋅2.05 H2O based on 24 oxygen atoms. Bimbowrieite is monoclinic, space group C2/c with a = 25.944(5), b = 5.1426(10), c = 13.870(3 Å, β = 111.60(3)°, V = 1720.4(7) Å3 and Z = 4. The crystal structure was refined to R1 = 1.97% for 1060 observed reflections with F0 > 4σ(F0). Bimbowrieite is isostructural with dufrénite. The structure is based on a trimer of face-sharing octahedra in which an M2 octahedra shares two trans faces with two M4 octahedra. Trimers link in the c-direction by sharing corners with two M3 octahedra and with T1 and T2 tetrahedra. Linkage in the a-direction is via corner-sharing M1 octahedra and linkage in the b-direction is via corner-sharing T1 and T2 tetrahedra.
Executive clemency is a discretionary power to grant legal mercy and is rarely given. Using data from contemporary clemency hearings in four states, I explore how state actors use commutation hearings as sites to exert social control and communicate hegemonic ideology. Clemency board members use hearings as sites to communicate the behaviors and attitudes they desire from applicants, aiming to generate compliance and consent. These state actors use the ritual of the clemency process and the hope afforded by the possibility of legal mercy as tools to motivate desired behaviors and beliefs among those in prison both explicitly and implicitly in these hearings. Such behaviors and beliefs, accordingly, are those that serve to reinforce the control and power of the state.
Purity is known as an ideal of proof that restricts a proof to notions belonging to the ‘content’ of the theorem. In this paper, our main interest is to develop a conception of purity for formal (natural deduction) proofs. We develop two new notions of purity: one based on an ontological notion of the content of a theorem, and one based on the notions of surrogate ontological content and structural content. From there, we characterize which (classical) first-order natural deduction proofs of a mathematical theorem are pure. Formal proofs that refer to the ontological content of a theorem will be called ‘fully ontologically pure’. Formal proofs that refer to a surrogate ontological content of a theorem will be called ‘secondarily ontologically pure’, because they preserve the structural content of a theorem. We will use interpretations between theories to develop a proof-theoretic criterion that guarantees secondary ontological purity for formal proofs.
How do peacebuilding institutions affect political behavior? This article studies the historic victory of the Colombian left in the 2022 presidential elections in light of the implementation of local peacebuilding programs through the 2016 Peace Accords. Using a quasi-experimental design, we show that the Development Plans with a Territorial Focus (PDET), a central component of the 2016 Peace Accords between the government and the FARC, increased the vote share for the leftist coalition, Pacto Histórico, in the 2022 elections by increasing voter turnout in PDET regions. In a departure from existing literature, we find that the explanatory effect of violence on vote share is significantly reduced when we include an indicator for PDET implementation and additional covariates. While there is a substantial body of work examining the effects of conflict violence and the presence of armed actors on elections, there has been relatively little focus on how the peacebuilding has affected vote choice and political behavior. We see our project as a bridge to fill this gap in the literature.
This work studies the three-dimensional flow dynamics around a rotating circular cylinder of finite length, whose axis is positioned perpendicular to the streamwise direction. Direct numerical simulations and global stability analyses are performed within a parameter range of Reynolds number $Re=DU_\infty /\nu <500$ (based on cylinder diameter $D$, uniform incoming flow velocity $U_\infty$), length-to-diameter ratio ${\small \text{AR}}=L/D\leq 2$ and dimensionless rotation rate $\alpha =D\varOmega /2U_\infty \leq 2$ (where $\varOmega$ is rotation rate). By solving Navier–Stokes equations, we investigated the wake patterns and explored the phase diagrams of the lift and drag coefficients. For a cylinder with ${\small \text{AR}}=1$, we found that when the rotation effect is weak ($0\leq \alpha \lesssim 0.3$), the wake pattern is similar to the unsteady wake past the non-rotating finite-length cylinder, but with a new linear unstable mode competing to dominate the saturation state of the wake. The flow becomes stable for $0.3\lesssim \alpha \lesssim 0.9$ when $Re<360$. When the rotation effect is strong ($\alpha \gtrsim 0.9$), new low-frequency wake patterns with stronger oscillations emerge. Generally, the rotation effect first slightly decreases and then sharply increases the $Re$ threshold of the flow instability when $\alpha$ is relatively small, but significantly decreases the threshold at high $\alpha$ ($0.9<\alpha \leq 2$). Furthermore, the stability analyses based on the time-averaged flows and on the steady solutions demonstrate the existence of multiple unstable modes undergoing Hopf bifurcation, greatly influenced by the rotation effect. The shapes of these global eigenmodes are presented and compared, as well as their structural sensitivity, visualising the flow region important for the disturbance development with rotation. This research contributes to our understanding of the complex bluff-body wake dynamics past this critical configuration.
The recent Lagrangian relaxation towards equilibrium (LaRTE) approach (Fowler et al., J. Fluid Mech., vol. 934, 2022, A44) is a wall model for large-eddy simulations (LES) that isolates quasi-equilibrium wall-stress dynamics from non-equilibrium responses to time-varying LES inputs. Non-equilibrium physics can then be modelled separately, such as the laminar Stokes layers that form in the viscous region and generate rapid wall-stress responses to fast changes in the pressure gradient. To capture additional wall-stress contributions due to near-wall turbulent eddies, a model term motivated by the attached eddy hypothesis is proposed. The total modelled wall stress thus includes contributions from various processes operating at different time scales (i.e. the LaRTE quasi-equilibrium plus laminar and turbulent non-equilibrium wall stresses) and is called the multi-time-scale (MTS) wall model. It is applied in LES of turbulent channel flow subject to a wide range of unsteady conditions from quasi-equilibrium to non-equilibrium. Flows considered include pulsating and linearly accelerating channel flow for several forcing frequencies and acceleration rates, respectively. We also revisit the sudden spanwise pressure gradient flow (considered in Fowler et al., J. Fluid Mech., vol. 934, 2022, A44) to review how the newly introduced model features affect this flow. Results obtained with the MTS wall model show good agreement with direct numerical simulation data over a vast range of conditions in these various non-equilibrium channel flows. To further understand the MTS model, we also describe and test the instantaneous-equilibrium limit of the MTS wall model. In this limit, good wall-stress predictions are obtained with reduced model complexity but providing less complete information about the wall-stress physics.