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To evaluate the outcomes of reinnervation techniques for the treatment of adult unilateral vocal fold paralysis and bilateral vocal fold paralysis.
Methods
A literature review was conducted in the Embase and Medline databases in English, with no limitations on the publication date. The outcome parameters of interest included visual, subjective perceptual, acoustic, aerodynamic analysis and electromyography. A meta-analysis with a random-effects model and inverse variance was calculated.
Results
The systematic Preferred Reporting Items for Systematic Reviews and Meta-Analyses approach resulted in 27 studies, totalling 803 patients (747 unilateral cases and 56 bilateral cases). Thyroid cancer and/or surgery had caused unilateral vocal fold paralysis in 74.8 per cent of cases and bilateral vocal fold paralysis in 69.6 per cent of cases. Statistically significant improvements in patients were observed for voice, deglutition and decannulation (bilateral vocal fold paralysis). Meta-analysis of 10 reinnervation techniques was calculated for the maximum phonation time of 184 patients.
Conclusion
Reinnervation was shown to improve voice, swallowing and decannulation, but studies lacked control groups, limiting generalisability. Larger studies with controls are needed.
The Austrian school reforms of the 1850s and 1860s, inspired by the mindset of the democratic and civic revolutions of 1848, turned a predominantly feudal and religious school system into a modern one and brought basic education to the masses. In the following decades, literacy increased, basic knowledge spread, and the overwhelming influence of the Catholic church in school matters diminished. Yet, as an “unintended consequence,” these reforms also had great implications for the process of building what turned out to be “the Slovene nation.” This article aims to illustrate that the formation of Slovene national identity—based on the use of the Slovene language as the main marker of Slovene ethnicity—was implemented to a large extent with the help of the Austrian school system and its efforts at centralization, systematization, and modernization. Measures like the creation of a school subject for the Slovene language, Slovene reading materials in school textbooks, and statistical categorization within school administrations played a crucial role in that process.
On September 22, 2022, the Supreme Court Chamber (SCC) of the Extraordinary Chambers in the Courts of Cambodia (ECCC) pronounced its judgment against Khieu Samphan, a key figure in the Khmer Rouge regime that ruled the country in the late 1970s. The appellate SCC upheld the Trial Chamber's conviction of Khieu Samphan for war crimes and genocide, as well as all but two convictions against him for crimes against humanity. The SCC also found him responsible for additional crimes and affirmed his life sentence. On December 23, 2022, the court published the full written judgment, bringing to a close Case 002/02, the third and final trial at the ECCC.
To analyze Clostridioides difficile testing in 3 hospitals in central North Carolina to validate previous racial health-disparity findings.
Methods:
We completed a retrospective analysis of inpatient C. difficile tests from 2015 to 2021 at 3 university-affiliated hospitals in North Carolina. We calculated the number of C. difficile tests per 1,000 patient days stratified by race: White, Black, and non-White, non-Black (NWNB). We defined a unique C. difficile test as one that occurred in an inpatient unit with a matching laboratory accession ID and on differing calendar days. Tests were evaluated overall, by hospital, by year, and by positivity rate.
Results:
In total, 35,160 C. difficile tests and 2,571,850 patient days across all 3 hospitals from 2015 to 2021 were analyzed. The median number of C. difficile tests per 1,000 patient days was 13.85 (interquartile range [IQR], 9.88–16.07). Among all C. difficile tests, 5,225 (15%) were positive. White patients were administered more C. difficile tests (14.46 per 1,000 patient days) than Black patients (12.96; P < .0001) or NWNB race patients (10.27; P < .0001). Black patients were administered more tests than NWNB patients (P < .0001). White patients tested positive at a similar rate to Black patients (15% vs 15%; P = .3655) and higher than NWNB individuals (12%; P = .0061), and Black patients tested positive at a higher rate than NWNB patients (P = .0024).
Conclusion:
White patients received more C. difficile tests than Black and NWNB patient groups when controlling for race patient days. Future studies should control for comorbidities and investigate community onset of C. difficile by race and ethnicity.
Acouscapes is a software designed as a simple educational solution for the creation of soundscapes and their use in the composition of soundscape music in primary and secondary education. The software has slots in which the user must place the sounds that will make up the desired soundscape, allowing them to make different soundwalks by interacting with the graphic interface. Acouscapes allows the content of these soundscapes to be modified by means of sound and structural processing, and includes a recording function. This article aims to present the conceptual and educational foundations of Acouscapes, to describe the software technically and functionally, and to offer some applications of this software as a mediation artefact in educational processes.
In this paper, we propose a numerical model to simulate gas–liquid–solid interaction problems, coupling the lattice Boltzmann method and discrete element method (LBM–DEM). A cascaded LBM is used to simulate the liquid–gas flow field using a pseudopotential interaction model for describing the liquid–gas multiphase behaviour. A classical DEM resorting to fictitious overlaps between the particles is used to simulate the multiple-solid-particle system. A multiphase fluid–solid two-way coupling algorithm between LBM and DEM is constructed. The model is validated by four benchmarks: (i) single disc sedimentation, (ii) single floating particle on a liquid–gas interface, (iii) sinking of a horizontal cylinder and (iv) self-assembly of three particles on a liquid–gas interface. Our simulations agree well with the numerical results reported in the literature. Our proposed model is further applied to simulate droplet impact on deformable granular porous media at pore scale. The dynamic droplet spreading process, the deformation of the porous media (composed of up to 1277 solid particles) as well as the invasion of the liquid into the pores are well captured, within a wide range of impact Weber number. The droplet spreading dynamics on particles is analysed based on the energy budget, which reveals mechanisms at play, showing the evolution of particle energy, surface energy and viscous dissipation energy. A scaling relation based on the impact Weber number is proposed to describe the maximum spreading ratio.
To improve contact tracing for healthcare workers, we built and configured a Bluetooth low-energy system. We predicted close contacts with great accuracy and provided an additional contact yield of 14.8%. This system would decrease the effective reproduction number by 56% and would unnecessarily quarantine 0.74% of employees weekly.
The article explores the connection between the rule of law and the right to freedom of thought, conscience, and religion from an empirical and theoretical perspective. The author posits that the two are not merely interdependent, but that freedom of thought, conscience, and religion is foundational for embedding the rule of law because a state needs to facilitate freedom of thought, conscience, and religion to encourage the exploration of virtue to inform consensus around society’s common norms. This virtue-building role of freedom of thought, conscience, and religion gives the human right its foundational role for creating the conditions required for embedding the rule of law. This conclusion is drawn from Martin Krygier’s analysis of the sociological conditions necessary to embed the rule of law and a comparison of the worldwide rule of law, religious freedom, and happiness indexes. To support a universal approach to the human right and to underpin the identified essentiality of it, the author proposes a theoretical approach grounded in the theory of common grace; Rowan Williams’s other-regarding communal approach to rights; and the framework for plural living together proposed by Herman Dooyeweerd. The author posits that this approach could be adapted with a plural metanarrative to accommodate dialogue around virtue building and dispute resolution within societies with very different outlooks.
This article investigates the transformation of the body of a female child murderer as she passed through specific spatial configurations in the urban setting of the seventeenth-century capital of Denmark–Norway. By using the case of Gertrud Nielsdatter, we explore the significance of public urban spaces in the bodily and material transformation of a woman from a condemned sinner to an object of scientific wonder. This transformation was facilitated by practices in diverse public spaces – controlled or influenced by government, city, church, as well as academic authorities and stakeholders – such as the city court, the place of execution, the university and, not least, the book shops across Europe selling books containing the print representing internal organs of Gertrud Nielsdatter. The case demonstrates how the physical body of an ordinary – yet outlawed – Copenhagener was repeatedly transformed in interaction with public spaces and the material culture of buildings, fixtures and fittings.
Cold-water immersion (e.g. adapted cold showers, partial or whole-body immersion, cold swimming) are nowadays increasingly being used as an adjunctive procedure to enhance the effects of primary treatment of various clinical conditions, including depressive and anxiety disorders. This brief article reviews the evidence regarding the beneficial effects of cold-water immersion on clinical depression and anxiety and outlines potential therapeutic mechanisms underlying the intervention. Promising avenues for future research and best practice recommendations are also discussed to improve the clinical effectiveness of cold-water immersion.
To systematically identify the complications associated with balloon Eustachian tuboplasty and their frequency of occurrence. This study will also highlight the measures that can be employed to avoid these complications and perform this procedure more safely.
Methods
Systematically reviewed relevant papers published until January 2023. Each reference was checked and evaluated for any potential manuscripts. There was no registered protocol; the Preferred Reporting Items for Systematic Reviews and Meta-Analyses was used.
Results
Sixty-nine publications were found, from which 14 publications met our inclusion criteria: 2 randomised clinical trials, 5 retrospective studies, 2 systematic reviews, 2 case series and 3 case reports. Studies with balloon Eustachian tuboplasty procedure only were included, regardless of ethnicity, gender and age. All studies were excluded in which more than one procedure was performed.
Conclusion
Balloon Eustachian tuboplasty is a relatively safe procedure with an overall complication risk of 1.66 per cent. Major complication rate was 0.43 per cent. Surgical emphysema was the most common, around 0.40 per cent.