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Single-ended and balanced 90–120 GHz microstrip power amplifier MMICs have been designed for cost-sensitive 5G and 6G backhaul in a commercial 6-inch, 0.1-µm GaAs process. At 108 GHz, measured output power is 20.4 and 22.5 dBm, respectively. At 120 GHz, measured output is 12.6 and 17.4 dBm, respectively. This is the highest reported for GaAs, among the highest reported to date for microstrip MMIC amplifiers at these frequencies and competitive with more expensive InP and GaN processes. Measurement is compared with simulation.
This review aims to critically evaluate the efficacy of long-chain ո-3 PUFA ingestion in modulating muscle protein synthesis (MPS), with application to maintaining skeletal muscle mass, strength and function into later life. Ageing is associated with a gradual decline in muscle mass, specifically atrophy of type II fibres, that is exacerbated by periods of (in)voluntary muscle disuse. At the metabolic level, in otherwise healthy older adults, muscle atrophy is underpinned by anabolic resistance which describes the impaired MPS response to non-pharmacological anabolic stimuli, namely, physical activity/exercise and amino acid provision. Accumulating evidence implicates a mechanistic role for n-3 PUFA in upregulating MPS under stimulated conditions (post-prandial state or following exercise) via incorporation of EPA and DHA into the skeletal muscle phospholipid membrane. In some instances, these changes in MPS with chronic ո-3 PUFA ingestion have translated into clinically relevant improvements in muscle mass, strength and function; an observation evidently more prevalent in healthy older women than men. This apparent sexual dimorphism in the adaptive response of skeletal muscle metabolism to EPA and DHA ingestion may be related to a greater propensity for females to incorporate ո-3 PUFA into human tissue and/or the larger dose of ingested ո-3 PUFA when expressed relative to body mass or lean body mass. Future experimental studies are warranted to characterise the optimal dosing and duration of ո-3 PUFA ingestion to prescribe tailored recommendations regarding n-3 PUFA nutrition for healthy musculoskeletal ageing into later life.
For migrant workers who do not have access to other means of income, the platform economy offers a viable yet exploitative alternative to the conventional labour market. Migrant workers are used as a source of cheap labour by platforms – and yet, they are not disempowered. They are at the heart of a growing platform worker movement. Across different international contexts, migrants have played a key role in leading strikes and other forms of collective action. This article traces the struggles of migrant platform workers in Berlin and London to explore how working conditions, work experiences, and strategies for collective action are shaped at the intersection of multiple precarities along lines of employment and migration status. Combining data collected through research by the Fairwork project with participant observation and ethnography, the article argues that migrant workers are more than an exploitable resource: they are harbingers of change.
Turbulent open channel flows developing above submerged canopies made of slender cylinders mounted perpendicular to the channel bed are known to be largely governed by the solidity parameter $\lambda =dh/\Delta S^2$ ($d$ and $h$ being the diameter and height of the filament, and $\Delta S$ the average spacing between filaments). When the filaments are sufficiently slender, the ratio between the height of the stems and the spacing sets the hydrodynamic regime developing inside and outside the canopy. This ratio also establishes the conditions leading to the transition from a dense to a sparse canopy flow regime (Nepf, Annu. Rev. Fluid Mech., vol. 44, 2012, pp. 123–142). In a previous, companion numerical investigation, Monti et al. (J. Fluid Mech., vol. 891, 2020, A9) used large eddy simulation (LES) to study the influence of the canopy height on the onset of the different regimes without modifying the average spacing $\Delta S$ between the stems. In that LES study, we were looking at the complementary situation in which the height of the stems is constant while the filaments’ number density of the canopy is changed. It was found that for low values of $\lambda$ (i.e. sparse or moderately dense canopies: $\lambda \lessapprox 0.26$), the flows sharing the value of the solidity obtained by either varying $h$ or $\Delta S$ are very similar. Differently, for higher values of $\lambda$ (i.e. in denser canopies), the effects of $h$ and $\Delta S$ start to diverge although sharing the same nominal value of $\lambda$. In this paper, we analyse the different physical mechanisms that come into play for dense configurations obtained by varying either $\Delta S$ or $h$. In particular, we focus on the most relevant length scales and carry out a detailed analysis of the flows using a triple decomposition approach. We show that the inner region of dense canopy flows, characterised by tall stems, is dominated by wall-normal sweeps delivering high momentum in the wall vicinity. Here, the impenetrability condition of the bed redistributes the available momentum in the wall-parallel directions re-energising an otherwise stagnating flow. Differently, in densely packed canopies, the penetration of the outer jet and the momentum transfer from the external flow are limited by the decreasing value of the wall-parallel permeabilities leading to different behaviours, including a reduction of the total drag offered by the canopy.
Records of the Nubian Bustard Nubotis nuba range across the drier northern component of the Sahel zone in Africa from Mauritania through Mali, Niger, and Chad to Sudan. Reports of significant hunting pressure have caused it to be treated as IUCN “Near Threatened” for almost 40 years, but information relating to distribution and population trends remains scattered, anecdotal, and unevaluated. All accessible evidence bearing on its conservation is therefore assembled and reviewed here. The lack of records from Mauritania since 1984, Mali since 1974, and Sudan since 1988 suggests that populations there may now be very small and perhaps entirely extinguished. Records from Niger and Chad remain many, thanks largely to the assiduous reporting of observations on the West African Bird DataBase (WABDaB) by researchers involved in ungulate conservation. The national nature reserves of Aïr and Ténéré (RNNAT) and Termit and Tin-Toumma (RNNTT) in Niger and the Ouadi Rimé–Ouadi Achim Faunal Reserve (RFOROA) in Chad emerge as vital to the long-term survival of the Nubian Bustard, given the accumulating evidence in both countries of (1) widespread habitat degradation and conversion, as human populations and their livestock expand in numbers and range in the Sahel, and (2) intensifying persecution, as highly mobile and well-armed local poachers plus Gulf state hunters gain increasing vehicular access to the remotest regions, depleting all huntable wildlife (a Sahel-wide bird study, 2011–2019, encountered just 16 bustards of four species – none Nubian – in 487 observation days). Populations of Nubian Bustard must now be greatly fragmented and depleted, with many entirely lost, so targeted programmes to minimise disturbance, persecution, and damage to habitat in the three key reserves (including the exclusion of powerlines) are urgently needed. Ultimately however the survival of this and other endemic Sahelian species can only be secured via a huge programme of ecologically and economically sustainable management practices.
A key theme throughout Maimon’s works is a circularity he diagnoses at the heart of Kant’s response to Hume. The objective validity of Kant’s category of causality ultimately rests, Maimon argues, upon the logical status of the hypothetical judgement – on its inclusion among the forms of pure general logic. In turn, however, the inclusion of the hypothetical within pure general logic itself rests upon the objective validity of causal judgements. This article examines Maimon’s diagnosis and traces it back to a debate that has its origins in Wolff’s German Logic, concerning the relationship between categorical and hypothetical judgements.
To map Greek academic otolaryngologists, and assess gender, age and location-related differences in their rank and academic productivity.
Methods
A pre-established database of local and diaspora scientists was used, after adjustment and updating for otolaryngology. The following data were recorded: age, gender, academic rank, country of work, total citations and h-index of December 2022.
Results
A total of 276 Greek academic otolaryngologists were identified in the Scopus database. Of Greek otolaryngologists, 15.9 per cent are women. Of all academic otolaryngologists, 27.1 per cent have a university post, but only 4 per cent of them are women. There is an almost linear correlation between university post ranking and citations. Otolaryngologists based in Greece accounted for 3 out of the 10 most cited Greek otolaryngologists.
Conclusion
There are significant age, gender and location-related differences in academic output. The representation of women and the full use of their potential in medicine require proactive measures, to lift the burdens limiting their participation.
A data-driven turbulence model for coarse-grained numerical simulations of two-dimensional Rayleigh–Bénard convection is proposed. The model starts from high-fidelity data and is based on adjusting the Fourier coefficients of the numerical solution, with the aim of accurately reproducing the kinetic energy spectra as seen in the high-fidelity reference findings. No assumptions about the underlying partial differential equation or numerical discretization are used in the formulation of the model. We also develop a constraint on the heat flux to guarantee accurate Nusselt number estimates on coarse computational grids and high Rayleigh numbers. Model performance is assessed in coarse numerical simulations at $Ra=10^{10}$. We focus on key features including kinetic energy spectra, wall-normal flow statistics and global flow statistics. The method of data-driven modelling of flow dynamics is found to reproduce the reference kinetic energy spectra well across all scales and yields good results for flow statistics and average heat transfer, leading to computationally cheap surrogate models. Large-scale forcing extracted from the high-fidelity simulation leads to accurate Nusselt number predictions across two decades of Rayleigh numbers, centred around the targeted reference at $Ra=10^{10}$.
To investigate epidermal growth factor, transforming growth factor-α and interleukin-8 production in nasal mucosa irrigated with hypertonic 2.3 per cent solution with algae extracts, in comparison to 0.9 per cent NaCl during the first two weeks after surgery for nasal polyposis, in relation to symptoms and local findings.
Methods
This prospective study included 20 nasal polyposis patients postoperatively irrigated with hypertonic solution and 20 nasal polyposis patients postoperatively irrigated with isotonic solution. We evaluated nasal symptom score, endoscopic score and mediator levels in nasal secretions before and after irrigation.
Results
Following treatment, nasal symptom score and endoscopic score were significantly lower in the hypertonic solution group (p = 0.023; p < 0.001, respectively). The increase in the epidermal growth factor and the decrease in the transforming growth factor-α and interleukin-8 concentration were higher in the hypertonic group (p < 0.001 for all mediators).
Conclusion
Irrigation with a hypertonic solution was found to be more effective than an isotonic solution in nasal mucosa reparation.
This work investigates the effect of surface roughness on cylinder flows in the postcritical regime and reexamines whether the roughness Reynolds number ($Re_{k_s}$) primarily governs the aerodynamic behaviour. It has been motivated by limitations of many previous investigations, containing occasionally contradictory findings. In particular, many past studies were conducted with relatively high blockage ratios and low cylinder aspect ratios. Both of these factors appear to have non-negligible effects on flow behaviour, and particularly fluctuating quantities such as the standard deviation of the lift coefficient. This study employs a 5 % blockage ratio and a span-to-diameter ratio of 10. Cylinders of different relative surface roughness ratios ($k_s/D$), ranging from $1.1\times 10^{-3}$ to $3\times 10^{-3}$, were investigated at Reynolds numbers up to $6.8 \times 10^5$ and $Re_{k_s}$ up to 2200. It is found that the base pressure coefficient, drag coefficient, Strouhal number, spanwise correlation length of lift and the standard deviation of the lift coefficient are well described by $Re_{k_s}$ in postcritical flows. However, roughness does have an effect on the minimum surface pressure coefficient (near separation) that does not collapse with $Re_{k_s}$. The universal Strouhal number proposed by Bearman (Annu. Rev. Fluid Mech., vol. 16, 1984, pp. 195–222) appears to be nearly constant over the range of $Re_{k_s}$ studied, spanning the subcritical through postcritical regimes. Frequencies in the separating shear layers are found to be an order of magnitude lower than the power law predictions for separating shear layers of smooth cylinders.
The main objective measure to assess the health of the Fontan circulation is the pressure measurement of the superior vena cava or pulmonary arteries. We reviewed the literature for benefits of measuring resting pressure in the Fontan circuit and explored whether dynamic measurement by volume loading or exercise has the potential to refine this diagnostic tool.
Methods:
PubMed was searched for articles showing a relationship between resting post-operative central venous pressure or pulmonary artery pressure and Fontan failure. Relationships between post-operative central venous pressure or pulmonary artery pressure and volume loading changes, such as during exercise or volume loading during cardiac catheterization, were also queried.
Results:
A total of 44 articles mentioned relationships between resting central venous pressure or pulmonary artery pressure and Fontan failure. Only 26 included an analysis between the variables and only seven of those articles found pressure to be predictive of Fontan failure. Ten articles examined the relationship between exercise or volume loading and outcomes and demonstrated a large individual variation of pressures under these dynamic conditions.
Conclusions:
Based on current literature, there is not a lot of strong evidence to show that elevated resting central venous pressure or pulmonary artery pressure is predictive of Fontan failure. Some individuals experience dramatic increases in central venous pressure or pulmonary artery pressure under increased loading conditions with exercise or bolus fluid infusion, while others experience increases closer to that of a healthy control population. Further studies are needed to examine whether more dynamic and continuous monitoring of systemic venous pressures might better predict outcomes in patients with Fontan circulation.
While sin-based responses to divine hiddenness arguments are a road less travelled, they do nonetheless have a number of defenders in the contemporary divine hiddenness literature. I begin this article by exploring the various strategies that have been employed to attempt to motivate such accounts. What none of these strategies seem to take into account, however, is a cluster of facts about the correlation (or lack thereof) between a person's propositional attitudes about God and the degree to which that person displays the relevant moral and intellectual virtues. This article aims to fill this lacuna by mapping out the options available to defenders of sin-based responses in trying to cope with this cluster of facts. I argue that there may be resources available for preserving some aspects of the sin-based approach, but that taking stock of the aforementioned facts will ultimately require the positing of causal factors besides sin in order to generate a sufficient explanation of the phenomenon of non-belief.
Scholars studying the electoral breakthroughs of right-wing illiberalism have arrived at two general conclusions: while they largely rejected the hypothesis that this phenomenon is grounded in voters’ attitudinal shift, they have shown that those voting for the illiberal Right have distinguishing socio-economic and attitudinal characteristics. My analysis reconciles these two sets of findings by documenting the gradual emergence and transformation of the right-wing electorate in Poland in the period 1993–2018 and points to the consolidation of a right-wing partisanship as an organizing factor of the “illiberal moment.” Using the POLPAN panel dataset I find that populist and authoritarian attitudes indeed emerge in Poland in the twenty-first century to distinguish those supporting the Right more and more centered around the PiS party. These attitudes, however, have been incorporated in the context of partisan rivalry—right-wing voters, for example, are more supportive of limiting democratic procedures but only when the Right is in power. In the first decade of the twenty-first century PiS also politicized the lack of partisan consensus on the expansion of the welfare state. PiS incorporated this demand in its stance legitimizing the expansion of the welfare state through what was available in its ideological repertoire: national solidarity, national victimhood, and the idea of a sovereign nation-state joined under the umbrella of Catholic symbolism. This post-consensus polarization and asymmetrical political radicalization resembles the “illiberal moment” in Western Europe that followed the convergence between center-left and center-right parties but they lack a crystallized class-based political identity and social-democratic understanding of political economy to build on.
A spread-out lattice animal is a finite connected set of edges in $\{\{x,y\}\subset \mathbb{Z}^d\;:\;0\lt \|x-y\|\le L\}$. A lattice tree is a lattice animal with no loops. The best estimate on the critical point $p_{\textrm{c}}$ so far was achieved by Penrose (J. Stat. Phys. 77, 3–15, 1994) : $p_{\textrm{c}}=1/e+O(L^{-2d/7}\log L)$ for both models for all $d\ge 1$. In this paper, we show that $p_{\textrm{c}}=1/e+CL^{-d}+O(L^{-d-1})$ for all $d\gt 8$, where the model-dependent constant $C$ has the random-walk representation
where $U^{*n}$ is the $n$-fold convolution of the uniform distribution on the $d$-dimensional ball $\{x\in{\mathbb R}^d\;: \|x\|\le 1\}$. The proof is based on a novel use of the lace expansion for the 2-point function and detailed analysis of the 1-point function at a certain value of $p$ that is designed to make the analysis extremely simple.