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The location of parasites within individual hosts is often treated as a static trait, yet many parasite species can occur in multiple locations or organs within their hosts. Here, we apply distributional heat maps to study the within- and between-host infection patterns for four trematodes (Alaria marcianae, Cephalogonimus americanus, Echinostoma spp. and Ribeiroia ondatrae) within the amphibian hosts Pseudacris regilla and two species of Taricha. We developed heatmaps from 71 individual hosts from six locations in California, which illustrate stark differences among parasites both in their primary locations within amphibian hosts as well as their degree of location specificity. While metacercariae (i.e., cysts) of two parasites (C. americanus and A. marcianae) were relative generalists in habitat selection and often occurred throughout the host, two others (R. ondatrae and Echinostoma spp.) were highly localised to a specific organ or organ system. Comparing parasite distributions among these parasite taxa highlighted locations of overlap showing potential areas of interactions, such as the mandibular inner dermis region, chest and throat inner dermis and the tail reabsorption outer epidermis. Additionally, the within-host distribution of R. ondatrae differed between host species, with metacercariae aggregating in the anterior dermis areas of newts, compared with the posterior dermis area in frogs. The ability to measure fine-scale changes or alterations in parasite distributions has the potential to provide further insight about ecological questions concerning habitat preference, resource selection, host pathology and disease control.
Flux conditions are semi-analytical expressions that can be used to determine the flux at the grounding line of marine ice sheets. In the glaciology literature, such flux conditions have initially been established for the Weertman and Coulomb friction laws. However, the extension to more general and complex friction laws, such as the Budd friction law, for which basal friction depends on both the basal velocity and the effective pressure, is a topic of recent research. Several studies have also shown that hybrid friction laws, which consider a transition between a power-law friction far from the grounding line and a plastic behaviour close to it, were good candidates for improved modelling of marine ice sheets. In this article, we show that the flux conditions previously derived for the Weertman and Coulomb friction laws can be generalised to flux conditions for the Budd friction law with two different effective-pressure models. In doing so, we build a bridge between the results obtained for these two friction laws. We provide a justification for the existence and uniqueness of a solution to the boundary-layer problem based on asymptotic developments. We also generalise our results to hybrid friction laws, based on a parametrisation of the flux condition. Finally, we discuss the validity of the assumptions made during the derivation, and we provide additional explicit expressions for the flux that stay valid when the bedrock slopes are important or when the friction coefficients are relatively small.
Infections from prolonged use of axillary intra-aortic balloon pumps (IABPs) have not been well studied. Bloodstream infection (BSI) occurred in 13% of our patients; however, no difference in outcome was noted between those with BSI and those without. Further studies regarding protocol developments that minimize BSI risk are needed.
The CCAMLR System of Inspection has been in place for more than 30 years, but its implementation and impact have yet to be summarised and analysed. The purpose of the research is to clarify the legal basis, analyse the implementation and make suggestions for further improvements. By analysing the CAMLR Convention and historical files, the System of Inspection has been further improved and many details have been added based on some international fisheries agreements and domestic laws regulating fisheries. Article XXIV of the CAMLR Convention, various Conservation Measures and documents form the legal basis of the System of Inspection. The System is divided into two types, namely At-sea inspection and Port inspection. Combined with the annual reports of CCAMLR meetings over the past 30 years, the System has become relatively complete as a “Compliance Monitoring Mechanism” under the CCAMLR Compliance Evaluation Procedure with other monitoring, control and surveillance (MCS) tools. However, inspection data have not been stable over the years. Since 2017, the increase in catches has not led to an increase in the number of inspections in the annual reports. In addition, At-sea inspections do not cover all Subareas of the Convention. At present, the objects of inspection have been extended to Non-Member vessels, so that it should also be sanctioned through various mechanisms. In addition, the System of Inspection is different from the Compliance Evaluation Procedure and the relationship between the two needs to be confirmed in practice. Due to the change in inspection methods, the lack of inspection data and the increase in other MCS tools, At-sea inspection does not cover all Subareas of the Convention. The System of Inspection is constantly being practised and improved. The study calls on Members to continue to carry out inspections and to improve the System in order to achieve the conservation and rational use of fishery resources.
This paper establishes bounds on the performance of empirical risk minimization for large-dimensional linear regression. We generalize existing results by allowing the data to be dependent and heavy-tailed. The analysis covers both the cases of identically and heterogeneously distributed observations. Our analysis is nonparametric in the sense that the relationship between the regressand and the regressors is not specified. The main results of this paper show that the empirical risk minimizer achieves the optimal performance (up to a logarithmic factor) in a dependent data setting.
Critically injured patients have experienced delays in being transported to hospitals during Mass Casualty Incidents (MCIs). Extended pre-hospital times (PHTs) are associated with increased mortality. It is not clear which factors affect overall PHT during an MCI. This systematic review aimed to investigate PHTs in trauma-related MCIs and identify factors associated with delays for triaged patients at incident scenes.
Methods:
This systematic review was performed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Web of Science, CINAHL, MEDLINE, and EMBASE were searched between January and February 2022 for evidence. Research studies of any methodology, and grey literature in English, were eligible for inclusion. Studies were narratively synthesized according to Cochrane guidance.
Results:
Of the 2025 publications identified from the initial search, 12 papers met the inclusion criteria. 6 observational cohort studies and 6 case reports described a diverse range of MCIs. PHTs were reported variably across incidents, from a median of 35 minutes to 8 hours, 8 minutes. Factors associated with prolonged PHT included: challenging incident locations, concerns about scene safety, and adverse decision-making in MCI triage responses. Casualty numbers did not consistently influence PHTs. Study quality was rated moderate to high.
Conclusion:
PHT delays of more than 2 hours were common. Future MCI planning should consider responses within challenging environments and enhanced timely triage decision-making.
This article argues that Dialogue among Civilisations can be put forward as a crucial contribution to debates addressing IR’s Eurocentrism. It highlights the blurring of West/non-West, domestic/international, and imperial/post-imperial bifurcations. This is evident in three ways. First, Dialogue among Civilisations needs to be appreciated in Iran’s wider historical context and its multifaceted intellectual heritages. This demonstrates that the idea of the West as distinctly different from the East is problematic because of engagement between Iran and the so-called West. Second, Khatami’s intellectual endeavours are based on a simultaneous engagement with Western political thought, Islamic philosophy, and the idea of Ancient Iran. Finally, the notion itself reflects an internal dialogue whereby Western civilisation along with Islam and Iran’s pre-Islamic heritages are considered integral to Iranian political culture. Furthermore, it is an aspiration for how post-colonial Muslim societies can engage with colonial power while maintaining a post-colonial authenticity. Our contention is that an in-depth understanding of Iran alongside a revisiting of Khatami’s Dialogue among Civilisations can act as a means of bringing the perspective of the ‘other’ into debates on the international and our epistemological and ontological understanding of the West.
As space missions are needed in the future, the assembly volume of the space truss will become larger and larger, and the advancing path of the on-orbit cellular robot to the mission target will become more and more complicated. If the shortest moving path cannot be found in the truss environment, the climbing time of the robot on the truss will be greatly increased. To improve the speed of the cellular robot moving to the target point on the large space truss, this paper designs a cellular robot structure and configuration suitable for climbing on the truss and uses the improved sparrow algorithm to solve the problem of robot motion path planning. By establishing a mathematical model of the space truss, the improved sparrow algorithm is used to find the shortest path between the starting point and the end point in the truss environment. Finally, the data of this algorithm are compared with the data of other algorithms. The data results show that the improved sparrow algorithm is very effective in solving the optimal path of the space truss. The improved sparrow algorithm keeps the same optimal path compared with the standard sparrow algorithm, and the overall reaction time is increased by 51.60%, and the number of effective iterations is increased by about 13.87%.
The way that leaders and citizens cope with stress is under-theorised in the study of International Relations (IR). This article anchors psychological studies on coping to the literature theorising emotions in IR to clarify two unaddressed questions: (1) how do political actors – individuals and collectives – cope with both sudden crises and long-term change?; and (2) in the context of international politics, whose coping matters, and under what conditions? Our coping framework demonstrates that intersubjective appraisal of urgency from everyday stressors triggers a process that elevates individual coping to the collective level. Circulation of coping responses, a key but neglected process of scaling up, binds individuals to affective communities. Our theoretical contribution is an innovative coping framework to explore how individual pursuit of well-being is transformed into collective agency. The methodological novelty is the triangulation of emotional representation with survey data and in-depth interviews to capture the circulation of coping responses. We illustrate our conceptual framework with the overlooked case of Hong Kong. Our findings suggest coping constitutes conditions of political possibilities, in that individual Hong Kongers’ efforts to sustain emotional well-being are aggregated to create momentum for a state-building project unexpected by the former British colonisers or the Chinese Communist Party.
To examine time trends of hospital-associated infections (HAIs) in people living in the Brussels–Capital Region, and to evaluate the consequences for hospitals and long-term care facilities (LTCFs).
Design:
Cross-sectional analyses of yearly hospital administrative data.
Setting:
All Belgian hospitals and discharge destinations, focusing on LTCFs.
Participants:
All individuals from the Brussels–Capital Region hospitalized for >1 day throughout Belgium between 2008 and 2020 (N = 1,915,572).
Methods:
We calculated HAI prevalences and then, adjusting for confounders, the odds of being discharged to a LTCF or being readmitted within 30 days postdischarge after an HAI. HAIs included hospital-associated bloodstream infections, hospital-associated urinary tract infections, hospital-associated pneumonia, ventilator-associated pneumonia, and surgical-site infections.
Results:
Between 2008 and 2020, we identified 77,004 HAIs. Changes in time trends occurred. We observed a decrease of all HAIs from 2012 to 2014 from 5.17% to 2.19% (P < .001) and an increase from 2019 to 2020 from 3.38% to 4.06% (P < .001). Among patients with HAIs, 24.36% were discharged to LTCFs and 13.51% underwent early readmission. For stays ≥4 days, HAIs were associated with higher odds of LTCF discharge (adjusted odds ratio [aOR], 1.25; 95% confidence interval [CI], 1.22–1.28), but with lesser odds of early readmission (aOR, 0.88; 95% CI, 0.85–0.90).
Conclusions:
Administrative data can be useful to detect HAIs trends, but they seem to underestimate the burden compared to surveillance systems. Risk factors of readmission should be identified during hospital stays to ensure continuity of care. Considering the results from 2020 coinciding with the COVID-19 pandemic, monitoring the impact of HAIs should continue.
A single common pulmonary vein is a rare anomaly, mostly occurring with asplenia. We wanted to report our case because it co-exists with polysplenia and ciliary dyskinesia.
A baby girl about 2 months old with respiratory arrest was admitted to the emergency room of our hospital. She responded to pulmonary resuscitation. We ascertained from her medical history that she had been hospitalised twice because of recurrent lung infections. After the initial check and treatment, we applied imaging modalities to detect underlying problems of recurrent lung infection. Echocardiographic evaluation was suboptimal because of the widespread pulmonary infiltration. Still, we noticed a single common pulmonary vein without obstruction at the junction of the left atrium. Subsequently, a chest CT scan with contrast was performed. It revealed a single common pulmonary vein entering the left atrium with a single orifice, atrial septal defect, two lobes in both lungs, hepatic veins draining directly into the right atrium, and polysplenia. When the flow of a single common pulmonary vein goes directly to the right atrium through the defect, it may cause right heart dilatation as it did in our case. Therefore, patients may need to undergo surgery at an earlier age.
We study the spectral energy transfer due to wave–triad interactions in the Garrett–Munk spectrum of internal gravity waves based on a numerical evaluation of the collision integral in the wave kinetic equation. Our numerical evaluation builds on the reduction of the collision integral on the resonant manifold for a horizontally isotropic spectrum. We evaluate directly the downscale energy flux available for ocean mixing, whose value is in close agreement with the finescale parameterization. We further decompose the energy transfer into contributions from different mechanisms, including local interactions and three types of non-local interactions, namely parametric subharmonic instability, elastic scattering (ES) and induced diffusion (ID). Through analysis on the role of each mechanism, we resolve two long-standing paradoxes regarding the mechanism for forward cascade in frequency and zero ID flux for the GM76 spectrum. In addition, our analysis estimates the contribution of each mechanism to the energy transfer in each spectral direction, and reveals new understanding of the importance of local interactions and ES in the energy transfer.
The gravity flow of a granular material between two vertical walls separated by a width $2W$ is simulated using the discrete element method (DEM). Periodic boundary conditions are applied in the flow (vertical) and the other horizontal directions. The mass flow rate is controlled by specifying the average solids fraction $\bar {\phi }$, the ratio of the volume of the particles to the volume of the channel. A steady fully developed state can be achieved for a narrow range of $\bar {\phi }$, $\bar {\phi }_{max} \geq \bar {\phi } \geq \bar {\phi }_{cr}$, and the material is in free fall for $\bar {\phi } < \bar {\phi }_{min}$. For an intermediate range of $\bar {\phi }$ ($\bar {\phi }_{cr} > \bar {\phi } \geq \bar {\phi }_{min}$), there are oscillations in the horizontal coordinate of the centre of mass, velocity components and stress. As $\bar {\phi }$ decreases in the range $\bar {\phi }_{cr} > \bar {\phi } \geq \bar {\phi }_{min}$, the amplitude of the oscillations increases proportional to $\sqrt {\bar {\phi }_{cr} - \bar {\phi }}$ and the frequency appears to tend to a non-zero value as $\bar {\phi } \rightarrow \bar {\phi }_{cr}$, indicating a supercritical Hopf bifurcation. The relation between the dominant frequency and the higher harmonics of the position, velocity and stress fluctuations are explained using the momentum balance. It is found that dissipation in the inter-particle and particle–wall contacts is critical for the presence of an oscillatory state.
In Renaissance Italy, the political power of authorities found one of its expressions in material symbols of sovereignty. The placing of inscriptions, sculptures and columns and the commissioning of frescoes in streets, piazzas and public spaces, for example, were essential ways of communicating political or spiritual authority to the populace. Sometimes perceived as representations of a top-down form of communication, in the urban context these same material emblems of power became political objects through which to express dissent, as in the case of public loggias, speaking statues or graffiti on walls and civic palaces. Presenting case-studies from various cities in northern Italy, this article investigates the dialectics between the people and the authorities in the urban fabric, especially in everyday life. Combining a spatial and a material approach to politics, this article reveals the dynamic and relational nature of political public spaces.
The turbulent wake past a square-back Ahmed body in close proximity to the ground experiences random side-to-side switching between two asymmetric positions, a phenomenon known as bi-modality. It has been observed to be sensitive to the dynamics of the upstream boundary layers formed along the body surfaces. Close to the body fore end, these separate and reattach, with hairpin vortices emanating from the reattachment points and growing along the surfaces before breaking down upstream of the base. This study uses wall-resolved large eddy simulations to investigate the effect of using suction to suppress these upstream boundary layer separations on the wake bi-modality. It is seen that, in the unforced flow (in the absence of suction), the smaller top and side surface vortices resulting from breakdown interact as they convect downstream. Steady suction is confirmed to suppress the boundary layer separations on the different body surfaces. When the boundary layer separations on the two side (vertical) surfaces are suppressed, it is found that horizontal bi-modality is completely inhibited with weak vertical asymmetry preserved. The interaction of the small top/side surface vortices is interrupted, damping boundary layer fluctuations just upstream of the base. Applying suction on different combinations of side/top/bottom boundary layer separations is found to have different effects on the underbody flow and the wake vertical balance, with bi-modality suppression dependent on side surface suction. This confirms that bi-modality is triggered, at least in part, by boundary layer disturbances on the surfaces perpendicular to the switching direction.
The rapid development of the digital economy has highlighted the crucial role of data in economic growth. This study investigates the impact of two types of innovation on long-term growth by incorporating data into a model of creative destruction and knowledge accumulation. Unlike traditional factors, data exhibit nonrivalry between the two research and development (R&D) sectors, thereby influencing the growth rate of economic outputs simultaneously without interference. Our findings reveal the existence of a balanced growth path (BGP) in both the decentralized economy and the social planner’s economy. In horizontal innovation, data can be transformed into digital knowledge to promote the economic growth [Cong et al. (2021)]. In addition to horizontal innovation, the utilization of data in vertical innovation also enhances the success rate of innovation, with a gradual decrease in per capita data usage on the BGP. Moreover, as agents accumulate human capital, the economy achieves higher output levels, effectively addressing consumer privacy concerns. However, along the transitional path, insufficient data provision by both R&D sectors leads to lower economic growth rates or more intense economic fluctuations, necessitating policy interventions.