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In this work, a near-wall model, which couples the inverse of a recently developed compressible velocity transformation (Griffin et al., Proc. Natl Acad. Sci., vol. 118, 2021, p. 34) and an algebraic temperature–velocity relation, is developed for high-speed turbulent boundary layers. As input, the model requires the mean flow state at one wall-normal height in the inner layer of the boundary layer and at the boundary-layer edge. As output, the model can predict mean temperature and velocity profiles across the entire inner layer, as well as the wall shear stress and heat flux. The model is tested in an a priori sense using a wide database of direct numerical simulation high-Mach-number turbulent channel flows, pipe flows and boundary layers (48 cases, with edge Mach numbers in the range 0.77–11, and semi-local friction Reynolds numbers in the range 170–5700). The present model is significantly more accurate than the classical ordinary differential equation (ODE) model for all cases tested. The model is deployed as a wall model for large-eddy simulations in channel flows with bulk Mach numbers in the range 0.7–4 and friction Reynolds numbers in the range 320–1800. When compared to the classical framework, in the a posteriori sense, the present method greatly improves the predicted heat flux, wall stress, and temperature and velocity profiles, especially in cases with strong heat transfer. In addition, the present model solves one ODE instead of two, and has a computational cost and implementation complexity similar to that of the commonly used ODE model.
Cinquante ans après la Conférence de Stockholm de 1972, la littérature est appelée à offrir un compte rendu sur le passé et informer les décisions à venir. Dans ce contexte, le présent essai critique propose une revue historique de la gouvernance mondiale de l'environnement, couvrant la période de 1945 à 2022. Pour ce faire, il réunit les processus et évènements marquants des dernières décennies et distingue les moments clés ayant façonné la gouvernance mondiale de l'environnement. Informé par la littérature scientifique et des documents officiels, l'article expose l’émergence, la mise à l'agenda et l'institutionnalisation de plusieurs enjeux environnementaux. Il contribue ainsi à situer les développements qu'a connus la gouvernance mondiale de l'environnement et contextualiser les processus en cours. La conclusion de l’étude invite à accorder une plus grande attention aux enjeux environnementaux et à repenser la gouvernance mondiale de l'environnement au-delà des frontières, tant étatiques que disciplinaires.
In this paper the three-dimensional finite-time Lyapunov exponent (FTLE) field of a direct numerical simulation of a flat-plate turbulent boundary layer is analysed in several wall-parallel sections. The data consider a case at a low subsonic Mach number with a moderate positive pressure gradient in the streamwise direction. In contrast to other studies mainly focusing on the maxima of the FTLE field, particular emphasis is placed on the regions of minimal stretching between the vortices and shear layers of the three-dimensional turbulent flow field. These visually appear as contiguous islands or ‘valleys’ between the ‘ridges’ of the FTLE maxima, both at forward and backward integration of the flow field in time. To clearly distinguish the structures investigated from their more common counterparts (e.g. Lagrangian coherent structures, LCS), the acronym LAMS (Lagrangian areas of minimal stretching) is proposed to denote the associated cohesive fluid regions. Consistent with intuition, the largest LAMS occur near the boundary-layer edge, where large regions of homogeneous laminar external flow coexist with upwelling turbulent structures. Compensating for turbulent regions pushing upward, they sink from there down toward the wall, becoming smaller and longer. This process is associated with an increased relative velocity of the LAMS compared with the mean flow, which is observed over the whole boundary layer in the range $y^+ \gtrsim 10$. Furthermore, it is observed that the Q4 (sweep) events contained in the LAMS clearly dominate over Q2 (ejection) events above $y^+ \approx 10$. Thereby, local maxima occur at $y^+ \approx 20$ and near the boundary-layer edge. Below $y^+ \approx 10$, the relationship reverses. Sweeping LAMS from above $y^+ \approx 10$ and ejecting LAMS from below meet in the layer where the maximal vortical activity occurs. The latter is caused by mostly streamwise oriented vortices with maximal vortex stretching in the streamwise direction. Overall, LAMS are associated with cohesive fluid regions between the surrounding vortices and shear layers that both drop down from the boundary-layer edge toward the wall in the outer region of the boundary layer and lift from the wall in the near-wall region.
When a fast droplet impacts a pool of the same fluid, a thin ejecta sheet that dominates the early-time dynamics emerges within the first few microseconds. Fluid and impact properties are known to affect its evolution; we experimentally reveal that the pool depth is a critical factor too. Whilst ejecta sheets can remain separate and subsequently fold inwards on deeper pools, they instead develop into outward-propagating lamellae on sufficiently shallow pools, undergoing a transition that we delineate by comprehensively varying impact inertia and pool depth. Aided by matching direct numerical simulation results, we find that this transition stems from a confinement effect of the pool base on the impact-induced pressure, which stretches the ejecta sheet to restrict flow into it from the droplet on sufficiently shallow pools. This insight is also applied to elucidate the well-known transition due to Reynolds number.
Moringa oleifera, a traditional Indian herb, is widely known for its capacity to induce antioxidant, anti-inflammatory and other chemoprotective effects in a broad range of biomedical models. These perspectives have led to an extensive number of studies using various moringa extracts to evaluate its capacity to protect biological systems from oxidative stress and to explore whether it could be used to slow the onset of numerous age-related conditions and diseases. Moringa extracts have also been applied to prevent damage to plants from oxidative and saline stresses, following hormetic dose–response patterns. The present paper provides the first integrated and mechanistically based assessment showing that moringa extracts commonly induce hormetic dose responses and that many, perhaps most, of the beneficial effects of moringa are due to its capacity to act as an hormetic agent.
where $\Omega =\mathbb {R}^N$ or $\mathbb {R}^N\setminus \Omega$ is a compact set, $\rho >0$, $V\ge 0$ (also $V\equiv 0$ is allowed), $p\in (2,2+\frac 4 N)$. The existence of a positive solution $\bar u$ is proved when $V$ verifies a suitable decay assumption (Dρ), or if $\|V\|_{L^q}$ is small, for some $q\ge \frac N2$ ($q>1$ if $N=2$). No smallness assumption on $V$ is required if the decay assumption (Dρ) is fulfilled. There are no assumptions on the size of $\mathbb {R}^N\setminus \Omega$. The solution $\bar u$ is a bound state and no ground state solution exists, up to the autonomous case $V\equiv 0$ and $\Omega =\mathbb {R}^N$.
The response to harmonic horizontal oscillations of a stably stratified fluid-filled two-dimensional square container is examined as the forcing amplitude is increased. For the studied forcing frequency, the response flow at very small forcing amplitudes is a synchronous periodic flow with piecewise-constant vorticity in regions delineated by the characteristics emanating from the corners of the container, regularized by viscosity. The second temporal harmonic of the forced response flow resonantly excites an intrinsic mode of the stratified container, whose magnitude grows as the square of the forcing amplitude. Above a critical forcing amplitude, a sequence of pairs of other container modes are excited via triadic resonances with the second-harmonic-driven mode. The flows are computed from the Navier–Stokes–Boussinesq equations and the ensuing dynamics is analysed using Fourier techniques, providing a comprehensive picture of the transition to internal wave turbulence.
In this work, we study an elliptic problem involving an operator of mixed order with both local and nonlocal aspects, and in either the presence or the absence of a singular nonlinearity. We investigate existence or nonexistence properties, power- and exponential-type Sobolev regularity results, and the boundary behaviour of the weak solution, in the light of the interplay between the summability of the datum and the power exponent in singular nonlinearities.
The tragic Andrée balloon expedition of 1897 serves as a haunting reminder of the dangers posed by ice drift during polar exploration. This paper examines Andrée’s initial decision after his balloon flight to march towards Cape Flora in Franz Josef Land, despite its much greater distance compared to the Sjuøyane archipelago. The rationale behind this choice remains unclear, but potential factors include stored supplies, the demonstrated winter survival in Franz Josef Land and the scientific interest in unexplored regions. By analysing historical accounts and employing scenario analyses, this study contributes to a better understanding of Andrée’s perception of ice drift and its impact on their ill-fated journey. The paper explores major forces affecting ice drift, reviews the historical development of understanding ice drift in the area, and presents an analysis of Andrée’s understanding and decision-making. The overall conclusion is that Andrée probably was unaware of the substantial deflection to the right of the direction of the wind that ice drift in the Arctic on average is characterised of due to the Earth’s rotation (the Coriolis effect). Without this deflection, the decision to march towards Cape Flora would have made sense under the assumption of continued northerly winds.
In this article, we prove that a complete Noetherian local domain of mixed characteristic $p>0$ with perfect residue field has an integral extension that is an integrally closed, almost Cohen–Macaulay domain such that the Frobenius map is surjective modulo p. This result is seen as a mixed characteristic analog of the fact that the perfect closure of a complete local domain in positive characteristic is almost Cohen–Macaulay. To this aim, we carry out a detailed study of decompletion of perfectoid rings and establish the Witt-perfect (decompleted) version of André’s perfectoid Abhyankar’s lemma and Riemann’s extension theorem.
Charles and Singleton have explained why Cassius Dio's claim (60.21.2) that elephants were among the equipment prepared for use in Britain during the Claudian invasion of a.d. 43 is probably untrue, if one assumes that by ‘elephant’ he means the animal of that name. It is argued here that the best explanation of this apparent error is that Dio preserves a reference to a type of military machine, probably a siege-tower, rather than to the animal of this name.
The purpose of this study was to examine the perspectives of support staff, health care professionals, and care coordinators working in or referring to a community-based, slow-stream rehabilitation, hospital-to-home transition program regarding gaps in services, and barriers and facilitators related to implementation and functioning of the program. This was a qualitative descriptive study. Recruitment was conducted through purposive sampling, and 23 individuals participated in a focus groups or individual semi-structured interview. Transcripts were analyzed by six researchers using inductive thematic analysis. Themes that emerged were organized based on a socio-ecological framework. Themes were categorized as: (1) macro level, meaning gaps while waiting for program, limited program capacity, and gaps in service post-program completion; (2) meso level, meaning lack of knowledge and awareness of the program, lack of specific referral process and procedures, lack of specific eligibility criteria, and need for enhanced communication among care settings; or (3) micro level, meaning services provided, program participant benefits, person-centred communication, program structure constraints, need for use of outcome measures, and follow-up or lack of follow-up. Implementation of seamless patient information sharing, documentation, use of specific referral criteria, and use of standardized outcome measures may reduce the number of unsuitable referrals and provide useful information for referral and program staff.
Two-dimensional simulations are conducted to investigate the direct initiation of cylindrical detonation in hydrogen/air mixtures with detailed chemistry. The effects of hotspot condition and mixture composition gradient on detonation initiation are studied. Different hotspot pressures and compositions are first considered in the uniform mixture. It is found that detonation initiation fails for low hotspot pressures and the critical regime dominates with high hotspot pressures. Detonation is directly initiated from the reactive hotspot, whilst it is ignited somewhere beyond the non-reactive hotspots. Two cell diverging patterns (i.e. abrupt and gradual) are identified and the detailed mechanisms are analysed. Moreover, cell coalescence occurs if many irregular cells are generated initially, which promotes the local cell growth. We also consider non-uniform detonable mixtures. The results show that the initiated detonation experiences self-sustaining propagation, highly unstable propagation and extinction in mixtures with a linearly decreasing equivalence ratio along the radial direction, i.e. 1 → 0.9, 1 → 0.5 and 1 → 0. Moreover, the hydrodynamic structure analysis shows that, for the self-sustaining detonations, the hydrodynamic thickness increases at the overdriven stage, decreases as the cells are generated and eventually becomes almost constant at the cell diverging stage, within which the sonic plane shows a ‘sawtooth’ pattern. However, in the detonation extinction cases, the hydrodynamic thickness continuously increases, and no ‘sawtooth’ sonic plane can be observed.
After the coup attempt on July 15, 2016, the Turkish state started to produce a new official history of the event as a narrative of popular resistance against a military coup for the sake of democracy. This narrative with a religious aura was supported by “democracy watch” meetings and new commemoration days, museums, and monuments across Turkey. It was based on four concepts, symbolized by the Rabia sign: one nation, one homeland, one flag, and one state. However, the use of the Rabia sign has fallen from grace recently, creating a critical gap or “glitch” in the mnemonic infrastructure. This paper offers a visual categorization of July 15 monuments across Turkey and positions them in the historiography of Turkish national monuments. Finally, Rabia monuments are analyzed as a case study to show part of the complex (trans)national narratives of the “New Turkey.”
To systematically review the methodology, performance, and generalizability of diagnostic models for predicting the risk of healthcare-facility–onset (HO) Clostridioides difficile infection (CDI) in adult hospital inpatients (aged ≥18 years).
Background:
CDI is the most common cause of healthcare-associated diarrhea. Prediction models that identify inpatients at risk of HO-CDI have been published; however, the quality and utility of these models remain uncertain.
Methods:
Two independent reviewers evaluated articles describing the development and/or validation of multivariable HO-CDI diagnostic models in an inpatient setting. All publication dates, languages, and study designs were considered. Model details (eg, sample size and source, outcome, and performance) were extracted from the selected studies based on the CHARMS checklist. The risk of bias was further assessed using PROBAST.
Results:
Of the 3,030 records evaluated, 11 were eligible for final analysis, which described 12 diagnostic models. Most studies clearly identified the predictors and outcomes but did not report how missing data were handled. The most frequent predictors across all models were advanced age, receipt of high-risk antibiotics, history of hospitalization, and history of CDI. All studies reported the area under the receiver operating characteristic curve (AUROC) as a measure of discriminatory ability. However, only 3 studies reported the model calibration results, and only 2 studies were externally validated. All of the studies had a high risk of bias.
Conclusion:
The studies varied in their ability to predict the risk of HO-CDI. Future models will benefit from the validation on a prospective external cohort to maximize external validity.