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In 1964, Australian writer Donald Horne observed that ‘whatever differences there are between the Australian cities are differences within a range of similarity’. He proposed that Australia had 11 major cities and yet, in general, there existed a singular national urban culture, a one-city Australia. Unpacking the story of Australian urban history, its national trends and local nuances, has been an ongoing project ever since. What follows is an analysis of the field, which suggests how historians might begin to unpack Horne’s assertion. The final section of the article explores the contribution of Australian urban history in the national and global contexts.
Brady-arrhythmia requiring pacemaker implantation remains one of the Fontan-specific complications before and after total cavopulmonary connection.
Methods:
A retrospective analysis of 620 patients who underwent total cavopulmonary connection between 1994 and 2021 was performed to evaluate the incidence of brady-arrhythmia and the outcomes after pacemaker implantation. Factors associated with the onset of brady-arrhythmia were identified.
Results:
A total of 52 patients presented with brady-arrhythmia and required pacemaker implantation. Diagnosis included 16 sinus node dysfunctions, 29 atrioventricular blocks, and 7 junctional escape rhythms. Pacemaker implantation was performed before total cavopulmonary connection (n = 16), concomitant with total cavopulmonary connection (n = 8), or after total cavopulmonary connection (n = 28, median 1.8 years post-operatively). Freedom from pacemaker implantation following total cavopulmonary connection at 10 years was 92%. Twelve patients needed revision of electrodes due to lead dysfunction (n = 9), infections (n = 2), or dislocation (n = 1). Lead energy thresholds were stable, and freedom from pacemaker lead revision at 10 years after total cavopulmonary connection was 78%. Congenitally corrected transposition of the great arteries (odds ratio: 6.6, confidence interval: 2.0–21.5, p = 0.002) was identified as a factor associated with pacemaker implantation before total cavopulmonary connection. Pacemaker rhythms for Fontan circulation were not a risk factor for survival (p = 0.226), protein-losing enteropathy/plastic bronchitis (p = 0.973), or thromboembolic complications (p = 0.424).
Conclusions:
In our cohort of patients following total cavopulmonary connection, freedom from pacemaker implantation at 10 years was 92% and stable atrial and ventricular lead energy thresholds were observed. Congenitally corrected transposition of the great arteries was at increased risk for pacemaker implantation before total cavopulmonary connection. Having a pacemaker in the Fontan circulation had no adverse effect on survival, protein-losing enteropathy/plastic bronchitis, or thromboembolic complications.
Dating organic inclusions in mortars such as charcoals is a useful alternative or complementary method to dating mortars themselves, helping to estimate the building age. To assess the limitations of this dating approach, organic inclusions were searched for in surface mortar layers of six early to late medieval buildings in the Czech Republic with relatively well-known age. Altogether, 123 samples were found. About 80% were successfully radiocarbon (14C) dated. However, only 66% originated from wood relatively young when used in lime burning. To judge which samples are relevant to the actual building date, sufficient statistics is crucial. We recommend dating at least 5–10 samples, i.e., collecting 6–12 samples, for a site with uncomplicated building history, or per building phase. Otherwise, unrealistically old or young dates might be obtained. With the recommended statistics, inclusion-based dating provides building ages with uncertainty of 50–100 years.
The author makes the case that wealth inequality ramifies in the communicative practices of policymaking in ways which produce specific forms of epistemic injustice. Relative epistemic authority between richer and poorer knowers is established by limiting some speakers to being sources of information, and elevating others to the epistemically more sophisticated role of inquirer. In its systemic form, this differentiation has the effect of re-producing and maintaining ‘tracker prejudices’ (Fricker, 2007) and ‘tracker privileges’ (Medina, 2011) which then ramify in relational and distributive inequality (Fricker, 2016). The article suggests that in a context in which the inclusion of ‘lived experience’ has come to be seen as an intrinsic good in policy discourse (Smith-Merry, 2020), the lived experience we need to amplify isn’t that of the poor, it is that of the rich. Only in centring rich voices in social policymaking can we reveal and challenge the operation of wealth privilege and advance reparatory forms of epistemic practice.1
Assume that G is a finite group, N is a nontrivial normal subgroup of G and p is an odd prime. Let $\mathrm{Irr}_p(G)=\{\chi \in \mathrm{Irr}(G) : \chi (1)=1~\mathrm{or}~ p \mid \chi (1)\}$ and $\mathrm{Irr}_p(G|N)=\{\chi \in \mathrm{Irr}_p(G) : N \not \leq \mathrm{ker}\,\chi \}$. The average character degree of irreducible characters of $\mathrm{Irr}_p(G)$ and the average character degree of irreducible characters of $\mathrm{Irr}_p(G|N)$ are denoted by $\mathrm{acd}_p(G)$ and $\mathrm{acd}_p(G|N)$, respectively. We show that if $\mathrm{Irr}_p(G|N) \neq \emptyset $ and $\mathrm{acd}_p(G|N) < \mathrm{acd}_p(\mathrm{PSL}_2(p))$, then G is p-solvable and $O^{p'}(G)$ is solvable. We find examples that make this bound best possible. Moreover, we see that if $\mathrm{Irr}_p(G|N) = \emptyset $, then N is p-solvable and $P \cap N$ and $PN/N$ are abelian for every $P \in \mathrm{Syl}_p(G)$.
Tight budgets often limit the scope of test campaigns within the development programmes of small uncrewed air vehicles (UAVs). This paper explores a range of combinations of instrumentation suites and protocols for both wind tunnel and flight evaluation, focusing on the key aspect of drawing up the drag curve of the airframe. Through extensive testing of a 5kg maximum take-off mass, fixed wing, twin motor, richly instrumented test platform, we show that automated glides over a range of airspeeds and the slow down manoeuvre are effective ways of determining power-off drag, while estimating thrust from propeller speed, and voltage and current sensing based methods work well for the power-on case. We also seek the most time-efficient and robust mix of the above manoeuvres to yield a given drag curve accuracy level and we find wind condition impacts the manoeuvre makeup of the optimal strategy.
Most human studies investigating the relationship between maternal diet in pregnancy and infant epigenetic state have focused on macro- and micro-nutrient intake, rather than the whole diet. This makes it difficult to translate the evidence into practical prenatal dietary recommendations.
To review the evidence on how the prenatal diet relates to the epigenetic state of infants measured in the first year of life via candidate gene or genome-wide approaches.
Following the PRISMA guidelines, this systematic literature search was completed in August 2020, and updated in August 2021 and April 2022. Studies investigating dietary supplementation were excluded. Risk of bias was assessed, and the certainty of results was analysed with consideration of study quality and validity.
Seven studies were included, encompassing 6852 mother-infant dyads. One study was a randomised controlled trial and the remaining six were observational studies. There was heterogeneity in dietary exposure measures. Three studies used an epigenome-wide association study (EWAS) design and four focused on candidate genes from cord blood samples. All studies showed inconsistent associations between maternal dietary measures and DNA methylation in infants. Effect sizes of maternal diet on DNA methylation ranged from very low (< 1%) to high (> 10%). All studies had limitations and were assessed as having moderate to high risk of bias.
The evidence presented here provides very low certainty that dietary patterns in pregnancy relate to epigenetic state in infants. We recommend that future studies maximise sample sizes and optimise and harmonise methods of dietary measurement and pipelines of epigenetic analysis.
Paediatric cardiologists and nurse practitioners lack structured education tools focused on basic cardiac surgery principles. However, non-surgical specialties caring for surgical patients require this knowledge for comprehensive clinical care. We created a cardiac surgical educational curriculum focused on improving knowledge and attitudes towards communication for non-surgical trainees and advanced practice providers.
Methods:
Over one academic year, six paediatric cardiology fellows and seven paediatric cardiac surgery nurse practitioners at Seattle Children’s Hospital participated in this study. With surgical supervision, six lectures were prepared by each fellow and delivered monthly. Sessions were hybrid and recorded for later viewing. Pre- and post-intervention survey of attitudes regarding surgical topics and pre- and post- test-based knowledge assessments were administered.
Results:
Participants positively rated the usefulness of the lecture series (4.2/5) and would recommend it to a colleague (4.5/5). Self-reported confidence discussing surgical concepts with patients increased from 2.3 to 3.4 among paediatric cardiology fellows (p < 0.001) and from 2.8 to 3.9 among nurse practitioners (p < 0.001), out of 5. In both groups, knowledge assessment scores improved from 54 to 79% post-intervention (p < 0.001).
Conclusions:
After a six-part educational series taught by paediatric cardiology fellows, both paediatric cardiology fellows and paediatric cardiac surgery nurse practitioners demonstrated improved knowledge and reported increased comfort counselling families on basic cardiac surgery topics. Structured, active-learning lessons taught by fellows for non-surgical audiences can improve attitudes and build clinically relevant knowledge. Creating an effective level-appropriate multidisciplinary curriculum accessible to various types of medical providers could enhance comprehensive care of complex congenital cardiac surgery patients.
To evaluate the feasibility and safety of employing a Eustachian tube video endoscope with a supporting balloon as a viable treatment and examination option for patients with Eustachian tube dysfunction.
Methods
A study involving nine fresh human cadaver heads was conducted to investigate the potential of balloon dilatation Eustachian tuboplasty using a Eustachian tube video endoscope and a supporting balloon catheter. The Eustachian tube cavity was examined with the Eustachian tube video endoscope during the procedure, which involved the dilatation of the cartilaginous portion of the Eustachian tube with the supporting balloon catheter.
Results
The utilisation of the Eustachian tube video endoscope in conjunction with the supporting balloon catheter demonstrated technical ease during the procedure, with no observed damage to essential structures, particularly the Eustachian tube cavity.
Conclusion
This newly introduced method of dilatation and examination of the Eustachian tube cavity using a Eustachian tube video endoscope and the supporting balloon is a feasible, safe procedure.
A rarely seen arrhythmia is the p-wave asystole also mentioned ventricular asystole, ventricular standstill, or third-degree atrioventricular block with no ventricular escape rhythm. It is the result of the lack of impulse formation in ventricles (absence of idioventricular automaticity) or the failure of impulse transmission to ventricles (conduction disturbance)(1). As the name implies, the ventricles stop pumping, resulting in no effective cardiac output during the phenomenon. It is a potentially fatal rhythm disorder and need immediate diagnosis and treatment. We planned to present a case of p-wave asystole, which developed after tetralogy of Fallot total correction surgery
Childhood adversity is one of the strongest predictors of adolescent mental illness. Therefore, it is critical that the mechanisms that aid resilient functioning in individuals exposed to childhood adversity are better understood. Here, we examined whether resilient functioning was related to structural brain network topology. We quantified resilient functioning at the individual level as psychosocial functioning adjusted for the severity of childhood adversity in a large sample of adolescents (N = 2406, aged 14–24). Next, we examined nodal degree (the number of connections that brain regions have in a network) using brain-wide cortical thickness measures in a representative subset (N = 275) using a sliding window approach. We found that higher resilient functioning was associated with lower nodal degree of multiple regions including the dorsolateral prefrontal cortex, the medial prefrontal cortex, and the posterior superior temporal sulcus (z > 1.645). During adolescence, decreases in nodal degree are thought to reflect a normative developmental process that is part of the extensive remodeling of structural brain network topology. Prior findings in this sample showed that decreased nodal degree was associated with age, as such our findings of negative associations between nodal degree and resilient functioning may therefore potentially resemble a more mature structural network configuration in individuals with higher resilient functioning.
Reasoning with quantifier expressions in natural language combines logical and arithmetical features, transcending strict divides between qualitative and quantitative. Our topic is this cooperation of styles as it occurs in common linguistic usage and its extension into the broader practice of natural language plus ‘grassroots mathematics’.
We begin with a brief review of $\mathsf {FO}(\#)$, first-order logic with counting operators and cardinality comparisons. This system is known to be of very high complexity, and drowns out finer aspects of the combination of logic and counting. We therefore move to a small fragment that can represent numerical syllogisms and basic reasoning about comparative size: monadic first-order logic with counting, $\mathsf {MFO}(\#)$. We provide normal forms that allow for axiomatization, determine which arithmetical notions can be defined on finite and on infinite models, and conversely, we discuss which logical notions can be defined out of purely arithmetical ones, and what sort of (non-)classical logics can be induced.
Next, we investigate a series of strengthenings of $\mathsf {MFO}(\#)$, again using normal form methods. The monadic second-order version is close, in a precise sense, to additive Presburger Arithmetic, while versions with the natural device of tuple counting take us to Diophantine equations, making the logic undecidable. We also define a system $\mathsf {ML}(\#)$ that combines basic modal logic over binary accessibility relations with counting, needed to formulate ubiquitous reasoning patterns such as the Pigeonhole Principle. We prove decidability of $\mathsf {ML}(\#)$, and provide a new kind of bisimulation matching the expressive power of the language.
As a complement to the fragment approach pursued here, we also discuss two other ways of lowering the complexity of $\mathsf {FO}(\#)$ by changing the semantics of counting in natural ways. A first approach replaces cardinalities by abstract but well-motivated values of ‘mass’ or other mereological aggregating notions. A second approach keeps the cardinalities but generalizes the meaning of counting to work in models that allow dependencies between variables.
Finally, we return to our starting point in natural language, confronting the architecture of our formal systems with linguistic quantifier vocabulary and syntax, as well as with natural reasoning modules such as the monotonicity calculus. In addition to these encounters with formal semantics, we discuss the role of counting in semantic evaluation procedures for quantifier expressions and determine, for instance, which binary quantifiers are computable by finite ‘semantic automata’. We conclude with some general thoughts on yet further entanglements of logic and counting in formal systems, on rethinking the qualitative/quantitative divide, and on connecting our analysis to empirical findings in cognitive science.