This study evaluated the effects of chenodeoxycholic acid (CDCA), a farnesoid X receptor (FXR) potential activator, on growth performance, antioxidant capacity, glucose metabolism and inflammation in largemouth bass (Micropterus salmoides) (initial body weight: 5·45 ± 0·02 g) fed a high-carbohydrate diet. Experimental diets included a positive control (5 % α-starch), a negative control (10 % α-starch) and two diets containing 10 % α-starch supplemented with either 0·05 % or 0·10 % CDCA. After 8 weeks, the high-carbohydrate diet reduced growth performance and increased hepatosomatic and viscerosomatic indexes, which were mitigated by 0·10 % CDCA supplementation. The high-carbohydrate diet also increased hepatic glycogen and crude lipid content, both of which were reduced by 0·10 % CDCA. Furthermore, the high-carbohydrate diet-induced oxidative stress, histopathological changes and reduced liver lysozyme activity, which were ameliorated by CDCA supplementation. Molecular analysis showed that the high-carbohydrate diet suppressed FXR and phosphorylated AKT1 (p-AKT1) protein expression in the liver, downregulated insulin signalling (ira, irs, pi3kr1 and akt1), gluconeogenesis (pepck and g6pc) and glycolysis genes (gk, pk and pfkl). CDCA supplementation upregulated fxr expression, activated shp, enhanced the expression of insulin signalling and glycolytic genes (gk, pk and pfkl) and inhibited gluconeogenesis. Additionally, CDCA reduced inflammatory markers (nf-κb and il-1β) and restored anti-inflammatory mediators (il-10, iκb and tgf-β). In conclusion, 0·10 % CDCA improved carbohydrate metabolism and alleviated liver inflammation in largemouth bass fed a high dietary carbohydrate, partially through FXR activation.

Considered a staple of the French press since at least the nineteenth century, the fait divers—a catch-all category for short, often sensational news items such as murders, petty crimes, and suicides—has been taken up and transformed in West African cultural production. This essay focuses on the transformations and transpositions of the fait divers tradition in the work of Senegalese writer Aminata Maïga Ka (1940–2005), arguing that her short stories and novels inflect earlier treatments of the journalistic genre while staging a broader critique of the liberalization of the media in Senegal during the 1970s and 1980s. Ka’s works offer a window onto the entangled histories of postcolonial literary production and the emergent popular press in Senegal. Specifically, she updates and expands Ousmane Sembène’s rescripting of the French fait divers in his short story “La Noire de …” (1961/1962) and the landmark film from 1966 by the same title.

The concept of ritual has been all too loosely applied to violence and atrocity with assumptions of repetitiveness, mythic symbolism, and religious overtones. This paper examines a selection of modern cases of atrocity for specific ritual elements: attention to body and spaces as frames for meaning; a prescripted mode of action; and performative enaction of a new millennial or transgressive order. Focal cases include American lynching (nineteenth–twentieth centuries) and militia atrocities in Sierra Leone and Liberia (1990s), while examples of gendered atrocity in ritualized forms (perpetrated by Bosnian Serbs and the Islamic State) are broached in the conclusion. Ritualization is not typical to modern atrocities but allows perpetrating groups to experience meaningfulness in the violent acts they assemble, often in situations of crisis.

Forty years into Botswana’s AIDS epidemic, amidst persistently low rates of marriage across southern Africa, an unexpected uptick in weddings appears to be afoot. Young people orphaned in the worst years of the epidemic are crafting creative paths to marriage where—and perhaps because—their parents could not. Taking the lead of a pastor’s assertion that the wife is mother of her husband, I suggest these conjugal creativities turn on an understanding of marriage as an intergenerational relationship. Casting marriage in intergenerational terms is an act of ethical (re)imagination that creates experimental possibilities for reworking personhood, pasts, and futures in ways that respond closely to the specific crises and loss the AIDS epidemic brought to Botswana. This experimentation is highly unpredictable and may reproduce the crisis and loss to which it responds; the multivalences of marriage-as-motherhood can be sources of failure and violence, as well as innovation and life. But it also recuperates and reorients intergenerational relationships, retrospectively and prospectively, regenerating persons and relations, in time. While different crises might invite different sorts of ethical re-imagination, marriage gives us a novel perspective on how people live with, and through, times of crisis. And marriage emerges as a crucial if often overlooked practice by which social change is not only managed but sought and produced.

This article investigates geosocial patterns of marriage strategies among the leadership of Hasidism, arguably the most prominent socio-religious movement of modern Jewry, known for its unique network of charismatic leaders organized in hereditary dynasties. The article’s core premise is that grasping the network structure of the Hasidic movement’s dynasties, which has been under-researched, is crucial to understanding the movement’s social and cultural dynamics. The study employs social network analysis (SNA) and spatial analysis to examine marital unions among these leaders (2,375 cases), from the early stages of the movement in the eighteenth century until the early twenty-first century. The article explains, for the first time, how Hasidic dynasties expanded, eroded, and negotiated their status within the network of other dynasties. More specifically, we analyze the position of the dynasties within a wider context of social and spatial interconnection patterns, the significance of endogamy, the impact of territorial factors on marriage preferences, and the creation of dynastic clusters. A significant conclusion of this article is that, rather than a set of unrelated dynasties, Hasidic leadership gradually became a web of interconnected families with explicable patterns of organization. These findings can help explain historical processes in Hasidism, such as its persistence through historical crises. It can also illuminate leadership processes in other religions in which, as in Hasidism, the social structure of charismatic leadership is based on clans.

In recent years, the number of migrant deaths and disappearances in the Mediterranean and on the Atlantic coasts has risen steadily. The arrival of small boats with migrants on board on the Spanish and Italian coasts has received a lot of media attention, and European Governments are investing more than in the past to stop unauthorized arrivals on their shores. Certain narratives from governments and officials of international organizations attribute these deaths to “smugglers” and the dangerous routes they take. However, this article provides evidence that the higher mortality rates are the result of changes in border controls following bilateral agreements between the European Union and Morocco after 2018. By analyzing data from official statistics, microdata, and data provided by NGOs up to 2024, it shows how the increase in the mortality rate of migrants in the Western Mediterranean is the result of changes in the management of sea rescues, the militarization and externalization of the border, and the way in which migrants attempting to cross the sea are taking more dangerous routes than in the past.

This study was designed to explore the mediating role of serum 25-hydroxyvitamin D (25(OH) D) in Triglyceride–glucose (TyG) index and hypertension (HTN). Study participants were selected from the 2001 to 2018 National Health and Nutrition Examination Survey. Firstly, we estimated the association between TyG index and serum 25(OH)D with HTN using a weighted multivariable logistic regression model and restricted cubic spline. Secondly, we used a generalised additive model to investigate the correlation between TyG index and serum 25(OH)D. Lastly, serum 25(OH)D was investigated as a mediator in the association between TyG index and HTN. There were 14 099 subjects in total. TyG index was positively and linearly associated with HTN risk, while serum 25(OH)D had a U-shaped relationship with the prevalence of HTN. When the serum 25(OH)D levels were lower than 57·464 mmol/l, the prevalence of HTN decreased with the increase of serum 25(OH)D levels. When serum 25(OH)D levels rise above 57·464 mmol/l, the risk of HTN increases rapidly. Based on the U-shaped curve, serum 25(OH)D concentrations were divided into two groups: < 57·464 and ≥57·464 mmol/l. According to the mediation analysis, when serum 25(OH)D levels reached < 57·464 mmol/l, the positive association between the TyG index and incident HTN was increased by 25(OH)D. When serum 25(OH)D levels reached ≥ 57·464 mmol/l, the negative association between the TyG index and incident HTN was increased by 25(OH)D. There was a mediation effect between the TyG index and HTN, which was mediated by 25(OH)D. Therefore, we found that the association between serum 25(OH)D levels and TyG index may influence the prevalence of HTN.

In the United States, New Delhi metallo-beta-lactamase (NDM)-producing carbapenem-resistant Enterobacterales (CRE) are frequently associated with healthcare encounters. From September 2021 to September 2022, 21 patients with NDM-CRE identified from urine and without healthcare exposure were reported to the Centers for Disease Control and Prevention. Isolates were genetically similar to healthcare-associated strains.

We establish sharp upper bounds for shifted moments of quadratic Dirichlet L-function under the generalized Riemann hypothesis. Our result is then used to prove bounds for moments of quadratic Dirichlet character sums.

This paper expresses extensive agreement with Michael Bergmann’s position in Radical Skepticism and Epistemic Intuition, but (i) offers a simpler response to the skeptic, (ii) takes issue with Bergmann’s strong claim that an “evil demon” hypothesis is as good an explanation of our sensory experiences as is the natural realist explanation, and (iii) corrects a misunderstanding about explanationists’ canons of theory preference.

This paper is concerned with the growth rate of susceptible–infectious–recovered epidemics with general infectious period distribution on random intersection graphs. This type of graph is characterised by the presence of cliques (fully connected subgraphs). We study epidemics on random intersection graphs with a mixed Poisson degree distribution and show that in the limit of large population sizes the number of infected individuals grows exponentially during the early phase of the epidemic, as is generally the case for epidemics on asymptotically unclustered networks. The Malthusian parameter is shown to satisfy a variant of the classical Euler–Lotka equation. To obtain these results we construct a coupling of the epidemic process and a continuous-time multitype branching process, where the type of an individual is (essentially) given by the length of its infectious period. Asymptotic results are then obtained via an embedded single-type Crump–Mode–Jagers branching process.