n-3 PUFA delivered by fish oil supplements alter the number and functions of circulating extracellular vesicles (EV), but consumption of oily fish does not reproduce this effect. In order to assess the effects of fish oil supplements and oily fish, at a level achievable in the diet, on EV numbers, composition and procoagulant activity in healthy human volunteers, forty-two healthy subjects were assigned to one of three treatment groups: (i) fish oil supplements plus white fish meals, (ii) control supplements plus oily fish meals or (iii) control supplements plus white fish meals for 12 weeks in a randomised, double-blind, placebo-controlled, parallel trial; circulating EV were enumerated and their procoagulant activity assessed using thrombin generation and fibrinolysis assays. Our results showed that fish oil supplements decreased circulating EV numbers and reduced EV-stimulated thrombin generation, but the consumption of oily fish at half the dose of EPA had no effect on either EV number or thrombogenic capacity. Consumption of both oily fish and fish oil supplements increased the EPA and DHA contents of EV, and the proportion of EPA in circulating EV was strongly associated with EV-stimulated thrombin generation. This study revealed that the additional 1 g/d EPA delivered in the fish oil supplements is required to decrease the numbers and thrombogenic capacity of EV, since oily fish at a level achievable in the diet had no effect. Increasing EPA intake beyond current guidelines for oily fish consumption may therefore be required for cardiovascular benefits relating to EV.

A reconfigurable leaky-wave antenna and its application capable of electronically steering the beam within the entire hemisphere is presented. The original antenna is designed as a 1D array of conducting patches on a dielectric substrate coupled by varactors in series with interdigital capacitors. The beam of this antenna is driven by a DC bias that controls the capacitances of the varactor diodes over a frequency range from 8 to 8.2 GHz. Simulations showed a change in the direction of the main radiation pattern within 55° at 8 GHz by varying the varactor capacitances in the range of 0.1 to 1 pF. The maximum gain is 10 dBi and the side lobe level is -10 dB. The fabricated antenna sample operates at an applied DC voltage between 0 and 12 V, which corresponds to varactor capacitances controlled in the range of 1 to 0.15 pF. This gives a range of elevation angles equal to 40°. The application of the antenna in a reconfigurable star-type structure is proposed. The direction of the main lobe of the radiation pattern in azimuth is controlled by switching between the centrally excited eight antenna arrays using PIN diodes. The direction of radiation in elevation is controlled by the DC bias of the varactors of a particular array switched to “ON”. This complex beam steering throughout the hemisphere represents a novel character of the presented antenna. The antenna has a planar structure. Low-cost printed circuit board technology was used for its fabrication.

Vanishing twin syndrome is a miscarriage of multiples where one or more fetuses ‘vanishes’ (i.e., partial or full resorption or via calcification) during pregnancy, often before detection via ultrasound. It affects 30−50% of multifetal pregnancies, with most cases resulting in full resorption within the first trimester. Despite its recognition since 1945 and rising occurrence in both natural and assisted pregnancies, standardized clinical guidelines remain inadequate, leading to inconsistent diagnosis, counseling, and communication from healthcare providers. This study examines the experiences of mothers and gestational carriers diagnosed with VTS, focusing on patient-provider communication, risks, and symptom disclosure. A global online survey collected qualitative and quantitative data from 153 participants across 17 countries. Results show that most patients with formal diagnoses experienced negative interactions with healthcare providers, with an average sentiment score of −0.7 (on a scale from −2 to 2). Over 53.4% rated their communication experience as −1, and the average satisfaction score for the amount of information received was 3.5/10. Additionally, 43% of respondents were not informed about chorionicity, a key factor affecting fetal outcomes. Significant discrepancies in care were observed across different countries. The findings highlight major gaps in patient-provider communication and inconsistent clinical practices regarding VTS. Addressing these issues through improved education, clearer protocols, and standardized guidelines could enhance patient experiences and decision-making. Future research should focus on provider training and evidence-based strategies to improve the management of VTS and other types of miscarriage and death of multiples during pregnancy and postpartum.

We prove that any compact R-analytic group is linear when R is a pro-p domain of characteristic zero.

Scholars of gender have long realized that questions regarding gender, women, and politics require a multi-method, nuanced approach. When a plurality of white women voted for Donald Trump over Hillary Clinton in the 2016 presidential election, social scientists increasingly began to recognize the urgency of undertaking new approaches to understanding gender, race, and voting behavior in the United States.1 Since then, researchers have helped us understand why so many white women support right-wing candidates and policies that aim to suppress their autonomy, offering explanations such as the influence of belief in traditional gender roles (Christley 2022), “possessive investments in white heteropatriarchy” (Strolovitch, Wong, and Proctor 2017, 354), and “gendered nationalism” in American politics (Deckman and Cassese 2021, 278). In more recent years — as election results and polling suggest growing numbers of men of color have shifted rightward — there has been increased interest in employing an intersectional approach to analyze the gulf between men and women of color.

There has been substantial recent renewed interest and investment to assess the therapeutic potential of psychedelic compounds in addiction disorders. This editorial discusses the available evidence from randomised trials and future research directions in the field, together with potential implications for patients, professionals and the wider addiction treatment system.

This article examines the impact of informal intergovernmental relations on the Kenyan government’s handling of the COVID-19 pandemic. It argues that although informality in governance has been perceived negatively by many governance scholars, it nevertheless has the capacity to enhance the effectiveness and legitimacy of government. By virtue of informality’s adaptability and recognition of the centrality of context, it can enhance efficacy particularly in unpredictable circumstances as occurred in the pandemic. Notwithstanding this reality, until recently, literature on informality, mainly informed by Eurocentric colonial perspectives on governance, has focussed on its negative elements, criticizing it for diverse governance ailments. Through the prism of the negotiated order theory, this article challenges this dominant narrative using an analysis of informal intergovernmental relations during the COVID-19 pandemic in Kenya. It argues that though informality was at times applied negatively, overall, it ensured vibrant intergovernmental relations, thus positively impacting health service delivery and enhancing the government’s legitimacy in the management of the pandemic.

We show that dualising transfer maps in Hochschild cohomology of symmetric algebras over complete discrete valuations rings commutes with Tate duality. This is analogous to a similar result for Tate cohomology of symmetric algebras over fields. We interpret both results in the broader context of Calabi–Yau triangulated categories.

There is a longstanding belief amongst scholars of psychophysiology that activation is positively associated with attention. However, recent work on news avoidance suggests that activation from negative content is linked to decreased attention. The current study seeks to investigate these different expectations and suggests that both increased and decreased activation can be linked to both attention and avoidance. Using an experiment that employs skin conductance levels and heart rate to evaluate subjects’ media selection choices, the author finds that even as deactivation is most likely to precede the decision to turn away from content, roughly 30% of the time activation precedes turning away. These findings confirm prior conclusions from the psychophysiological communications literature, and in the news avoidance literature, but it also highlights the need for more nuanced expectations where activation and media selection are concerned.