Rheumatoid arthritis (RA) is characterised by chronic inflammation in joints. Obesity, stress, being women and dietary pattern are important in pathogenesis. The joint damage in RA is accelerated by oxidative stress. The aim of this study was to examine the serum total antioxidant level, nutritional status and Mediterranean diet adherence of adult women with RA. Thirty-five adult women RA patients and thirty-five healthy control participated in this study (45·4 ± 11·61 and 42·5 ± 8·50 years, respectively). Nutritional status, physical activity levels and adherence to the Mediterranean diet were questioned. Physicians assessed the disease activity score of patients with RA. Serum total antioxidant and oxidant status were analysed. The serum total antioxidant status of the control group was higher, whereas the oxidative stress index and total oxidant status were lower than that of the RA group. Dietary protein, fibre, EPA, retinol, Fe, Zn and total antioxidant intake in the RA group were lower than in the control group (P < 0·05). Individuals with higher fibre intake showed a significantly lower risk for RA after adjusting for potential confounding factors (OR = 0·845, 95 % CI = 0·773–0·923, P < 0·001). The mean physical activity level of the control group was higher than that of the RA group (1·59 ± 0·10 and 1·53 ± 0·13, respectively) (P = 0·01). In conclusion, serum antioxidant parameters and dietary antioxidant intake are decreased in patients with RA. Therefore, medical treatment for these patients should be supplemented with medical nutrition therapy to achieve optimal nutritional status.

The sulfide-free metasomatic rocks with chalcophile metals from the Nežilovo ore field, near Veles, Republic of North Macedonia belong to a rare kind of ore. The mineralogy and petrology of these rocks were studied in detail and can be considered as a standard description for ores of this type. A characteristic feature of Nežilovo-type ores is a wide variety of accessory oxide minerals containing chalcophile elements (Zn, Pb, Sb, Cu and As). The new nolanite-supergroup mineral zincorinmanite-(Zn), ideally (Fe3+2Zn)SbZnO7(OH), was discovered in the Nežilovo ore. The associated minerals are quartz, baryte, gahnite, Zn-bearing phlogopite, together with accessory hematite, almeidaite, a Pb-analogue of hydroxycalcioroméite and an insufficiently studied Sb-rich högbomite-supergroup mineral. Zincorinmanite-(Zn) forms lamellar to tabular subhedral single-crystal grains up to 0.5 mm across and up to 40 μm thick. The colour and streak are black and the lustre is submetallic. The new mineral is brittle, with the Mohs’ hardness of 6. No cleavage is observed. The fracture is uneven. The calculated density is 5.446 g·cm–3. In reflected light, zincorinmanite-(Zn) is light grey, no pleochroism is observed. The reflectance values (Rmin, %/Rmax, %/λ, nm) are: 12.6/13.7/470, 12.1/13.2/546, 11.8/12.8/589 and 11.5/12.2/650. The Raman spectrum shows bands corresponding to the O–H and Sb–O stretching vibrations and (Fe3+,M2+)–O–H bending modes. The chemical composition is (electron microprobe data, with iron divided into Fe2O3 and FeO based on the charge balance and H2O calculated from the structural data, wt.%): MgO 1.42, MnO 0.44, FeO 2.04, ZnO 22.55, Al2O3 1.95, Fe2O3 35.59, TiO2 1.51, Sb2O5 33.05, H2O 1.18, total 99.73. The empirical formula is [(Fe3+2.12Al0.18)(Zn0.32Mg0.16Fe2+0.13Mn0.03)Ti0.06]Σ3.00(Sb0.97Ti0.03)Σ1.00Zn1.00O7[(OH)0.61O0.39]Σ1.00. The crystal structure was determined using single-crystal X-ray diffraction data and refined to R = 0.0191. Zincorinmanite-(Zn) is hexagonal, space group P63mc, a = 5.9720(1), c = 9.3578(1) Å and V = 289.031(8) Å3 (Z = 2). The new mineral is isostructural with other members of the nolanite group. The strongest lines of the powder X-ray diffraction pattern [d, Å (I, %) – hkl] are: 5.176 (46) – 100; 3.473 (77) – 102; 2.989 (46) – 110; 2.674 (86) – 103; 2.520 (100) – 112; and 2.496 (42) – 201.

In this article, by the use of nth derivative characterization, we obtain several some sufficient conditions for all solutions of the complex linear differential equation

$$ \begin{align*}f^{(n)}+A_{n-1}(z)f^{(n-1)}+\ldots+A_1(z)f'+A_0(z)f=A_n(z) \end{align*} $$

$A_i(z) (i=0,1,\ldots ,n)$

Leveraging blockchain technology in the energy sector holds immense potential, particularly in facilitating decentralised energy systems. However, the legal and regulatory landscapes of several countries, including Malaysia and Australia, pose significant obstacles to its effective implementation. This article examines the specific legal and regulatory hurdles hindering the incorporation of P2P energy trading systems in these two jurisdictions: Malaysia and Australia. Through a comparative analysis, the authors aim to provide valuable insights for policymakers and regulators seeking to develop comprehensive frameworks that encourage blockchain adoption in the energy sector. The article highlights the need to address the under-inclusiveness of laws, legal uncertainty around novel blockchain-based concepts like smart contracts, and the obsolescence of legal frameworks designed for traditional centralised energy systems. By examining Malaysia’s and Australia’s unique challenges, the article seeks to contribute to a broader understanding of the complexities of adapting legal and regulatory frameworks to accommodate this transformative technology.

Research on female leadership has documented that female-led firms tend to engage in lower risk-taking activities than male-led firms and attributed it to females' higher propensity for risk aversion. Nevertheless, this claim and its associated findings have been increasingly challenged. In this article, we address the unclear pattern of females' risk preference in leadership by contextualizing the effect of chair gender on corporate acquisitions in the context of state-owned enterprises (SOEs) in China. Drawing on expectancy violation theory, we propose that female chairs are more inclined to take risks when they operate in contexts that encourage female agency. We further explore self-affirmation mechanisms through two moderators: gender stereotype threats and self-efficacy. An analysis of chairs of 1,265 publicly listed SOEs in China from 2008 to 2020 supports predictions that female chairs are more likely than male chairs to engage in firm acquisitions. The effects are amplified under low levels of female executive representation and high levels of political appointments held by female chairs. The study shows that context determines how extensively gender affects risk-taking. It offers new insights into when and why female leaders exhibit higher levels of risk-taking in Chinese SOEs.

We report the case of a 16-year-old female with previously diagnosed bilateral sub-segmental pulmonary emboli who presented in cardiogenic shock from depressed biventricular function with cardiac MRI demonstrating concern for microvascular coronary injury. She was ultimately diagnosed with catastrophic antiphospholipid antibody syndrome-induced ischaemic cardiomyopathy, potentially associated with an underlying autoimmune connective tissue disease.

In the late twelfth century, four Chinese stonemasons migrated to Japan from the Chinese coastal city of Ningbo. They participated in the most important contemporary building project in Japan—the reconstruction of the prestigious Tōdaiji monastery in Nara following the Genpei War. Drawing on Chinese and Japanese textual records, archaeological evidence from the quarry sites, and the existing stone works, this study investigates the network that facilitated the movement of the artisans and their materials between China and Japan and sheds light on the relationship between artisans and religious monuments from a transnational perspective. This study explores how the migrant artisans’ expertise and connections enabled them to establish roots in a new society. Additionally, it examines the timing of the artisans’ migration within the broader context of Japan’s societal transformations, aiming to highlight the connectivity fostered by maritime networks in premodern East Asia.

Colorectal cancer (CRC), the third most common cancer globally, causes over 900 000 deaths annually. Although vitamin D is observed to have potential anti-carcinogenic properties, research findings on its preventable effect against CRC remain inconclusive. Notably, different subsites within the colon and rectum may be associated with distinct risk factors. While some studies have explored this relationship with circulating 25-hydroxyvitamin D (25(OH)D), the results remain contradictory. Our study employed a nested case–control design, involving 775 CRC cases matched with 775 cancer-free controls based on age, region of living and the time of blood sampling. The study was conducted within the Norwegian Women and Cancer post-genome cohort, which comprises approximately 50 000 women. We measured pre-diagnostic circulating plasma 25(OH)D status 5–13 years before diagnosis. Adjustment variables were based on self-administered questionnaires and included BMI, physical activity level, smoking, intake of processed meat, calcium, alcohol and fibre. An increase of 5 nmol/l in 25(OH)D reduced the risk of proximal colon cancer by 6 % (OR = 0·94, 95 % CI 0·89, 0·99). Furthermore, a sensitivity analysis revealed a 62 % increased risk among the women with 25(OH)D levels below 50 nmol/l compared with sufficient levels, ≥ 50 to < 75 nmol/l (OR = 1·62, 95 % CI 1·01, 2·61). No association was found with CRC, colon or distal colon cancer. We observed a subsite-specific association between 25(OH)D and CRC, highlighting the need for further investigation to elucidate the potential underlying mechanisms and clinical implications.

Content analysis is a valuable tool for analysing policy discourse, but annotation by humans is costly and time consuming. ChatGPT is a potentially valuable tool to partially automate content analysis for policy debates, largely replacing human annotators. We evaluate ChatGPT’s ability to classify documents using pre-defined argument descriptions, comparing its performance with human annotators for two policy debates: the Universal Basic Income debate on Dutch Twitter (2014–2016) and the pension reforms debate in German newspapers (1993–2001). We use the API (GPT-4 Turbo) and user interface version (GPT-4) and evaluate multiple performance metrics (accuracy, precision and recall). ChatGPT is highly reliable and accurate in classifying pre-defined arguments across datasets. However, precision and recall are much lower, and vary strongly between arguments. These results hold for both datasets, despite differences in language and media type. Moreover, the cut-off method proposed in this paper may aid researchers in navigating the trade-off between detection and noise. Overall, we do not (yet) recommend a blind application of ChatGPT to classify arguments in policy debates. Those interested in adopting this tool should manually validate bot classifications before using them in further analyses. At least for now, human annotators are here to stay.

As historic drought conditions become more common in western North America, Late Quaternary hydroclimate records become vital for putting present anthropogenic conditions into a longer-term context. Here, we establish a high-resolution record of drought for the eastern Sierra Nevada (California) using lacustrine carbonates from well-dated sediment cores. We used oxygen and carbon stable-isotope ratios, combined with high-resolution scanning X-ray fluorescence counts of calcium (Ca) and titanium (Ti), to reconstruct the drought record over the last 4600 years in June Lake. We found elevated δ18O and δ13C carbonate isotope values coinciding with peaks in both total inorganic carbon and Ca/Ti, suggesting enhanced carbonate precipitation in response to evaporative concentration of lake water. At least six intervals of prolonged (centennial-scale) carbonate deposition were identified, including three pulses during the Late Holocene Dry Period (LHDP; ~3500–2000 cal yr BP), the Medieval Climate Anomaly (~1200–800 cal yr BP), and the Current Warm Period, which began around 100 cal yr BP. This record highlights the complexities of the LHDP, an interval that was more variable at June Lake than has been previously described in regional records.

This paper explores the genre of the botanical gothic, a derivative of the fin de siècle adventure novel in which (generally male) British explorers engage in combat with fictitious killer vegetation from the colonial periphery. I argue that the carnivorous plant of the botanical gothic is intimately entangled with another “man-eating” figure: that of the New Woman. Through a reading of H. G. Wells's “The Flowering of the Strange Orchid” (1894), Algernon Blackwood's “The Man Whom the Trees Loved” (1912), and Beatrice Grimshaw's “The Tale of the Scarlet Butterflies” (1908), I demonstrate the extent to which the monstrous plant is implicitly gendered as threateningly female and depicted as a sort of exoticized vegetal femme fatale that lures weak-minded men to their demise. This, I argue, builds upon contemporaneous anxieties surrounding feminine sexual independence and the destabilization of gender roles in order to create an excessively sensualized feminine plant “rival” to supplant—and indeed queer—the normatively gendered dynamic of the local, domestic space. Male subjects in such narratives are emasculated under the threateningly penetrative agencies of the carnivorous plant that becomes a vegetal stand-in, I suggest, for the deviant and “man-eating” sexuality attributed to the New Woman figure herself.

This essay focuses on the ethical considerations and implications of providing a universal multi-cancer screening test as the best approach to reduce societal cancer burden in a society with limited funds, resources, and infrastructure. With 1.9 million cancer diagnoses each year in the United States, with 86% of all cancers diagnosed in individuals over the age of 50, and with screening tools approved for only four cancer types (breast, cervical, colorectal, and lung cancer), it seems that a multi-cancer screening test to detect most cancer early that is easy to administer, and is accurate and cost-effective, would be worth considering. Whole-body magnetic resonance imaging and a multi-marker blood test are the two main technologies that we will discuss as a universal screening test. However, to understand and appreciate the societal and clinical breakthrough of such a screening test, we must first consider the accessibility and efficacy of current screening methods. We conclude with a closer examination of the ethical implications of implementing the Galleri test as a multi-cancer detection screening tool as adamantly advocated by the company that developed this blood-based test.

This study examines the amendatory activities of the majority and opposition parties in the Italian 18th legislature (2018–2022) in response to the COVID-19 pandemic crisis. Following the rally around the flag hypothesis, we test whether both sides exhibited similar legislative behaviour during emergencies. We exploit an original database covering amendments tabled by Italian legislators on bills converting decree-laws. Results reveal that the COVID-19 pandemic affected amendment activities without aligning majority and opposition behaviours. In other words, the opposition did not pull in the same direction of the government legislation. This can be explained by contingent factors and pre-existing party polarization.