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The relationship between clinical examination findings and objective nasal patency measures in structural nasal obstruction remains uncertain. This review aims to explore the relationship between clinical nasal examination findings and objective nasal patency measures using acoustic rhinometry, peak nasal inspiratory flow, rhinomanometry and rhinospirometry.
Methods
Qualitative systematic review using the Preferred Reporting Items for Systematic reviews and Meta-Analyses 2020 statement.
Results
A total of 17 articles were included in the systematic review. Several studies showed a positive relationship between objective nasal patency measures and clinical nasal examination findings, however evidence in the literature is limited and confined to cohort studies. Objective nasal patency measures using acoustic rhinometry, rhinomanometry and rhinospirometry assessment correlate positively in severe anterior septal deviation but its role in assessing middle/posterior and mild/moderate septal deviation in isolation remains uncertain. There is limited evidence in the literature to assess the relationship between peak nasal inspiratory flow and clinical examination findings.
Conclusion
Objective nasal patency measures has a limited role in supporting clinical examination findings in severe structural nasal obstruction.
Oxidative stress is present in chronic obstructive pulmonary disease (COPD); however, the effect of increased dietary antioxidants on reducing COPD risk remains unclear. The aim of this study was to investigate the association of the composite dietary antioxidant index (CDAI) with COPD in adults. This study conducted a cross-sectional investigation using data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2015 to March 2020 to explore the association between CDAI and COPD in adults. This study included 9295 participants. Three logistic regression models (crude model, partially adjusted model and fully adjusted model) and restricted cubic spline (RCS) curves were utilised to assess the association between CDAI levels and COPD risk. Subsequently, a two-sample Mendelian randomisation (MR) was employed to analyse the causal impact of antioxidant levels within CDAI on the occurrence of COPD. CDAI levels were inversely associated with COPD after adjusting for confounders (OR = 0·97, 95 % CI 0·95, 1·00), and the association was linear (P < 0·001), and the results of the RCS showed that CDAI was linearly correlated with COPD occurrence (P < 0·001). MR analysis revealed a causal relationship between vitamin C and COPD occurrence (OR = 0·99, 95 % CI 0·98, 1·00, P < 0·05). Our study indicates that dietary sources of antioxidants may reduce the risk of COPD occurrence, and the results of the MR analysis further show that vitamin C is causally associated with a reduced risk of COPD occurrence. However, further exploration is needed to understand how antioxidants prevent COPD.
The theory and practice of what has come to be called “deliberative democracy” have been revived for the modern era with a focus on deliberative microcosms selected through random sampling or “sortition.” But might it be possible to spread some of the benefits of deliberation beyond mini-publics to the broader society? Can technology assist with scaling an organized deliberative process? In particular, would those who experience such a process become more deliberative voters? Would their considered judgments from deliberation influence their voting? We draw on a larger than usual experiment with public deliberation and a one-year follow-up in the mid-term U.S. elections to suggest answers to these questions. It has implications for whether spreading an organized deliberative process could, in theory, be used to create more deliberative elections.
Natural disasters can cause widespread death and extensive physical devastation, but also harmfully impact individual and community health following a disaster event. Nature-based recovery approach can positively influence the mental health of people and community’s post-natural disasters. In response to the Australian bushfire season of 2019-2020, Zoos Victoria, in partnership with the Arthur Rylah Institute, worked with local communities in East Gippsland to support people’s recovery through experiencing, supporting, and witnessing nature’s recovery.
Methods
This mixed-method study explored how nature improved the recovery of remote and rural communities affected by the Black Summer bushfires in East Gippsland. The research studied the individuals’ feelings about being involved in nature-based community events and their lived experiences. Data were collected from June to September 2023 through a nature-based community recovery project survey and community interviews.
Results
The findings demonstrated that engagement with natural environments promotes positive psychological, mental, and general well-being of people from bushfire-affected communities. Positive feedback from participants indicated the success of the Nature-Based Community Recovery Project in East Gippsland after the Black Summer bushfire.
Conclusions
This research provides insights for future recovery projects and ensures that sustainable nature-based recovery solutions for bushfire-impacted communities can be established.
We examine the preopening process and price discovery from the offer price to the first open price in initial public offerings. The extent of price discovery during preopening is influenced by firm characteristics and preopening attributes, such as volume of shares executed in preopening, canceled orders, order imbalance, and changes in indicative price. Institutional investors cancel 4 orders for every executed order. Each phase of preopening contributes to incremental price discovery. In “hot” IPOs, almost all price discovery processes occur during preopening, whereas in “cold” IPOs, half of the price adjustment occurs after the market opens.
Adverse pressure gradient (APG) turbulent boundary layers (TBL) require an understanding of the details of the pressure gradient, or history effect, to characterize the associated variation of spatiotemporal turbulent statistics. The streamwise-varying mean pressure gradient is reflected in the streamwise developing mean flow field and thus resolvent analysis, which captures the amplification of the Navier–Stokes equations linearized about the turbulent mean, can be used to understand linear amplification in APG TBLs. In particular, by using a biglobal approach in which the amplification is characterized by a temporal frequency and spanwise wavenumber, the streamwise and wall-normal inhomogeneities of the APG TBL can be resolved and related to the APG history. The linear response is able to identify multiscale phenomena, identifying a near-wall peak with $\lambda _{z}^+\approx 100$ for zero pressure gradient TBLs and mild to moderate APG TBLs as well as large-scale modes whose amplification increases with APG strength and Reynolds number. It is shown that the monotonic growth in the turbulent statistics with increasing APG is reflected in the linear growth in the associated resolvent amplification. Collapse in the Reynolds stresses is obtained through an augmented hybrid velocity scale, which replaces the local APG strength measure in the hybrid velocity scale presented in Romero et al. (Intl J. Heat Fluid Flow, vol. 93, 2022, 108885) with a velocity that encapsulates the pressure gradient history. While this resolvent approach is applicable to any APG TBL, it is shown from a scaling analysis of the linearized Navier–Stokes equations that the linear growth observed in the resolvent amplification with the history effect is limited to near-equilibrium APG TBLs.
Turbulent boundary layers on immersed objects can be significantly altered by the pressure gradients imposed by the flow outside the boundary layer. The interaction of turbulence and pressure gradients can lead to complex phenomena such as relaminarization, history effects and flow separation. The angular momentum integral (AMI) equation (Elnahhas & Johnson, J. Fluid Mech., vol. 940, 2022, A36) is extended and applied to high-fidelity simulation datasets of non-zero pressure gradient turbulent boundary layers. The AMI equation provides an exact mathematical equation for quantifying how turbulence, free-stream pressure gradients and other effects alter the skin friction coefficient relative to a baseline laminar boundary layer solution. The datasets explored include flat-plate boundary layers with nearly constant adverse pressure gradients, a boundary layer over the suction surface of a two-dimensional NACA 4412 airfoil and flow over a two-dimensional Gaussian bump. Application of the AMI equation to these datasets maps out the similarities and differences in how boundary layers interact with favourable and adverse pressure gradients in various scenarios. Further, the fractional contribution of the pressure gradient to skin friction attenuation in adverse-pressure-gradient boundary layers appears in the AMI equation as a new Clauser-like parameter with some advantages for understanding similarities and differences related to upstream history effects. The results highlight the applicability of the integral-based analysis to provide quantitative, interpretable assessments of complex boundary layer physics.
Dilated cardiomyopathy is an expected manifestation and common cause of death in patients with Duchenne muscular dystrophy. We present an unusually rapid progression of cardiomyopathy in a boy with Duchenne muscular dystrophy. Expanded genetic testing revealed a contiguous Xp21 deletion involving dystrophin and XK genes, responsible for Duchenne muscular dystrophy and McLeod neuroacanthocytosis syndrome, respectively, resulting in a more severe cardiac phenotype.
This paper documents that 56% of nonprofessional social media investment analysts (SMAs) are skilled and declare beliefs that generate positive abnormal returns (ABRs), while 44% produce negative ABRs. 13% of all SMAs are high-skill type and produce a 1-week 3-factor alpha of 61 bps, while the remaining 87% generate only 6 bps. The distinctive features of high-skill SMAs are primarily firm and industry specializations. Although SMAs tend to extrapolate and herd, their expectations are not systematically wrong. For higher-skilled SMAs compared to the less-skilled ones, extrapolation fades more quickly, and herding is lower, consistent with theory.
Aqueous suspensions of cornstarch abruptly increase their viscosity on raising either shear rate or stress, and display the formation of large-amplitude waves when flowing down inclined channels. The two features have been recently connected using constitutive models designed to describe discontinuous shear thickening. By including time-dependent relaxation and spatial diffusion of the frictional contact density responsible for shear thickening, an analysis of steady sheet flow and its linear stability is presented. The inclusion of such effects is motivated by the need to avoid an ill-posed mathematical problem in thin-film theory and the resulting failure to select any preferred wavelength for unstable linear waves. Relaxation, in particular, eliminates an ultraviolet catastrophe in the spectrum of unstable waves and furnishes a preferred wavelength at which growth is maximized. The nonlinear dynamics of the unstable waves is briefly explored. It is found that the linear instability saturates once disturbances reach finite amplitude, creating steadily propagating nonlinear waves. These waves take the form of a series of steep, shear-thickened steps that translate relatively slowly in comparison with the mean flow.
The knowledge of students’ quality of life and post-traumatic stress disorder levels, investigation of the relationship between them, and taking measures are essential in terms of guiding the necessary interventions. This study was conducted to determine the quality of life and post-traumatic stress disorder levels of midwifery students experiencing an earthquake.
Methods
This descriptive and correlational study was conducted with 363 midwifery students who had experienced the Kahramanmaras, Türkiye earthquake. Data were obtained using a Descriptive Information Form, the PTSD-Brief Scale, and the World Health Organization Quality of Life Scale (WHOQOL-BREF).
Results
The rate of post-traumatic stress disorder in the sample studied (n = 363), which consisted of midwifery students who would work in the field of health, was 21.5% 2 months after the earthquake. The multiple linear regression analysis indicated that factors predicting post-traumatic stress disorder following the earthquake were quality of life score related to physical and environmental domains, damage status of the house, presence of family history of depression, and smoking status.
Conclusions
This study, which was conducted 2 months following the earthquakes, showed that living spaces had an impact on the occurrence of post-traumatic stress disorder symptoms.
We present an experimental study on the drag reduction by polymers in Taylor–Couette turbulence at Reynolds numbers ($Re$) ranging from $4\times 10^3$ to $2.5\times 10^4$. In this $Re$ regime, the Taylor vortex is present and accounts for more than 50 % of the total angular velocity flux. Polyacrylamide polymers with two different average molecular weights are used. It is found that the drag reduction rate increases with polymer concentration and approaches the maximum drag reduction (MDR) limit. At MDR, the friction factor follows the $-0.58$ scaling, i.e. $C_f \sim Re^{-0.58}$, similar to channel/pipe flows. However, the drag reduction rate is about $20\,\%$ at MDR, which is much lower than that in channel/pipe flows at comparable $Re$. We also find that the Reynolds shear stress does not vanish and the slope of the mean azimuthal velocity profile in the logarithmic layer remains unchanged at MDR. These behaviours are reminiscent of the low drag reduction regime reported in channel flow (Warholic et al., Exp. Fluids, vol. 27, no. 5, 1999, pp. 461–472). We reveal that the lower drag reduction rate originates from the fact that polymers strongly suppress the turbulent flow while only slightly weaken the mean Taylor vortex. We further show that polymers steady the velocity boundary layer and suppress the small-scale Görtler vortices in the near-wall region. The former effect reduces the emission rate of both intense fast and slow plumes detached from the boundary layer, resulting in less flux transport from the inner cylinder to the outer one and reduces energy input into the bulk turbulent flow. Our results suggest that in turbulent flows, where secondary flow structures are statistically persistent and dominate the global transport properties of the system, the drag reduction efficiency of polymer additives is significantly diminished.
We model transient mushy-layer growth for a binary alloy solidifying from a cooled boundary, characterising the impact of liquid composition and thermal growth conditions on the mush porosity and growth rate. We consider cooling from a perfectly conducting isothermal boundary, and from an imperfectly conducting boundary governed by a linearised thermal boundary condition. For an isothermal boundary we characterise different growth regimes depending on a concentration ratio, which can also be viewed as characterising the ratio of composition-dependent freezing point depression versus the temperature difference across the mushy layer. Large concentration ratio leads to high porosity throughout the mushy layer and an asymptotically simplified model for growth with an effective thermal diffusivity accounting for latent heat release from internal solidification. Low concentration ratio leads to low porosity throughout most of the mushy layer, except for a high-porosity boundary layer localised near the mush–liquid interface. We identify scalings for the boundary-layer thickness and mush growth rate. An imperfectly conducting boundary leads to an initial lag in the onset of solidification, followed by an adjustment period, before asymptoting to the perfectly conducting state at large time. We develop asymptotic solutions for large concentration ratio and large effective heat capacity, and characterise the mush structure, growth rate and transition times between the regimes. For low concentration ratio the high porosity zone spans the full mush depth at early times, before localising near the mush–liquid interface at later times. Such variation of porosity has important implications for the properties and biological habitability of mushy sea ice.
Studies have shown that some covertly conscious brain-injured patients, who are behaviorally unresponsive, can reply to simple questions via neuronal responses. Given the possibility of such neuronal responses, Andrew Peterson et al. have argued that there is warrant for some covertly conscious patients being included in low-stakes medical decisions using neuronal responses, which could protect and enhance their autonomy. The justification for giving credence to alleged neuronal responses must be analyzed from various perspectives, including neurology, bioethics, law, and as we suggest, philosophy of mind. In this article, we analyze the warrant for giving credence to neuronal responses from two different views in philosophy of mind. We consider how nonreductive physicalism’s causal exclusion problem elicits doubt about interpreting neural activity as indicating a conscious response. By contrast, such an interpretation is supported by the mind-body powers model of neural correlates of consciousness inspired by hylomorphism.
Treating inertial measurement unit (IMU) measurements as inputs to a motion model and then preintegrating these measurements have almost become a de facto standard in many robotics applications. However, this approach has a few shortcomings. First, it conflates the IMU measurement noise with the underlying process noise. Second, it is unclear how the state will be propagated in the case of IMU measurement dropout. Third, it does not lend itself well to dealing with multiple high-rate sensors such as a lidar and an IMU or multiple asynchronous IMUs. In this paper, we compare treating an IMU as an input to a motion model against treating it as a measurement of the state in a continuous-time state estimation framework. We methodically compare the performance of these two approaches on a 1D simulation and show that they perform identically, assuming that each method’s hyperparameters have been tuned on a training set. We also provide results for our continuous-time lidar-inertial odometry in simulation and on the Newer College Dataset. In simulation, our approach exceeds the performance of an imu-as-input baseline during highly aggressive motion. On the Newer College Dataset, we demonstrate state-of-the art results. These results show that continuous-time techniques and the treatment of the IMU as a measurement of the state are promising areas of further research. Code for our lidar-inertial odometry can be found at: https://github.com/utiasASRL/steam_icp.
This study aimed to develop and validate the modified irritant gas syndrome agent (IGSA) criteria, utilizing readily available triage information and epidemiologic data to efficiently segregate patients based on the severity of hydrofluoric acid (HFA) exposure.
Methods
A retrospective analysis of 160 patients exposed to HFA was performed to develop the criteria and assess the criteria’s efficacy, focusing on age, respiratory rate, and compliance with IGSA standards. The criteria’s validity was assessed by comparing clinical outcomes between patients meeting the modified IGSA (mIGSA) criteria and those who did not as external and internal.
Results
The mIGSA criteria (or AIR criteria) consisting of the 3 clusters of age greater than 49, IGSA criteria satisfied, and respiratory rate greater than 19 was developed. The area under curve of receiver operating characteristic curve for prediction of the risk of confirmed HFA injury according to AIR criteria was 0.8415 at the external validation.
Conclusions
The mIGSA criteria offer a significant improvement in the triage of HFA exposure incidents, facilitating rapid identification and prioritization of patients with potentially severe outcomes. Future research should aim to further validate these criteria across diverse emergency scenarios, reinforcing their utility in global health emergency preparedness.
This systematic literature review explores the applications of social network platforms for disaster health care management and resiliency and investigates their potential to enhance decision-making and policy formulation for public health authorities during such events.
Methods
A comprehensive search across academic databases yielded 90 relevant studies. Utilizing qualitative and thematic analysis, the study identified the primary applications of social network data analytics during disasters, organizing them into 5 key themes: communication, information extraction, disaster Management, Situational Awareness, and Location Identification.
Results
The findings highlight the potential of social networks as an additional tool to enhance decision-making and policymaking for public health authorities in disaster settings, providing a foundation for further research and innovative approaches in this field.
Conclusions
However, analyzing social network data has significant challenges due to the massive volume of information generated and the prevalence of misinformation. Moreover, it is important to point out that social network users do not represent individuals without access to technology, such as some elderly populations. Therefore, relying solely on social network data analytics is insufficient for effective disaster health care management. To ensure efficient disaster management and control, it is necessary to explore alternative sources of information and consider a comprehensive approach.
This study aimed to investigate the prevalence and nature of cognitive impairment among severely ill COVID-19 patients and the effectiveness of the Montreal Cognitive Assessment (MoCA) in detecting it.
Method:
We evaluated cognition in COVID-19 patients hospitalized during the first wave (March to June 2020) from six Dutch hospitals, nine months post-discharge, using a comprehensive multi-domain neuropsychological test battery. Test performance was corrected for sex, age, and education differences and transformed into z-scores. Scores within each cognitive domain were averaged and categorized as average and above (z-score ≥ −0.84), low average (z-score −1.28 to −0.84), below average (z-score −1.65 to −1.28), and exceptionally low (z-score < −1.65). Patients were classified with cognitive impairment if at least one domain’s z-score fell below −1.65. We assessed the MoCA’s accuracy using both the original cutoff (<26) and an “optimal” cutoff determined by Youden’s index.
Results:
Cognitive impairment was found in 12.1% (24/199) of patients, with verbal memory and mental speed most affected (6.5% and 7% below −1.65, respectively). The MoCA had an area under the curve of 0.84. The original cutoff showed sensitivity of 83% and specificity of 66%. Using the identified optimal cutoff of <24, maintained sensitivity while improving specificity to 81%.
Conclusions:
Cognitive impairment prevalence in initially hospitalized COVID-19 patients is lower than initially expected. Verbal memory and processing speed are primarily affected. The MoCA is a valuable screening tool for these impairments and lowering the MoCA cutoff to <24 improves specificity.