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In hypersonic flight the shock wave and turbulent boundary layer interaction (STBLI) sharply increases wall heat transfer that intensifies the aerodynamic heating problems. In this work the STBLI is modelled by compression ramp flow with a Mach number of 5, a Reynolds number based on momentum thickness of 4652 and a wall to recovery temperature ratio of 0.5. The aerodynamic heat generation and transport mechanisms are investigated in the interaction based on theoretical analysis and direct numerical simulation (DNS) that agrees with previous studies. A prediction correlation of wall heat flux in STBLI is deduced theoretically and validated by some representative data including the present DNS, which improves the prediction accuracy and can be applied to a wider $Ma$ range compared with the canonical Q-P theory. The correlation indicates that the sharp increase of wall heat transfer in the STBLI can be explained by the boundary layer compression and the convection transport enhancement. Based on the DNS results, the aerodynamic heat generation and transport mechanisms are revealed in the separation, recirculation and reattachment zones in the STBLI. From this perspective, the peak heat flux can be further explained by the enhancement of near-wall turbulent energy dissipation, compression aerodynamic heat generation and the near-wall turbulent transport. The generation and transport of compression aerodynamic heat reveal the underlying mechanism of the strong correlation between the peak heat flux ratios and the pressure ratios in STBLIs.
Poverty prevention is a central concern of welfare states, and the redistribution of financial resources has been a major strategy to realise it. The differences in addressees, extent, and conditions of this redistribution have been intensively studied. The relevance of family in poverty prevention policies, though, has hardly been analysed, although all forms of welfare redistribution “factor in” family in one way or another, and particularly so in poverty prevention. We analyse how family membership impacts welfare state redistribution to the poor to identify redistributive logics in terms of family, that is the unequal redistribution of public resources to particular family types. We systematically analyse and present the similarities and differences in these redistributive logics, using the micro-simulation model EUROMOD for the countries of the EU. The results show that poor families benefit from anti-poverty measures in form of additional benefits, but family-related financial obligations often exceed these.
We present a simulation-based study of the effect of a passing wave packet on underlying fully developed turbulence. We propose a novel wave-phase-resolved simulation method inspired by Helmholtz decomposition to directly couple the turbulence simulation with instantaneous wave orbital motions without wave-phase averaging. We also introduce a boundary condition treatment for the turbulence at the wave surface, which allows the turbulence simulation to be conducted in a rectangular domain while retaining the wave-phase effect. The results obtained from the proposed method reveal considerable variations in turbulence statistics, including the enstrophy and Reynolds normal stresses, during wave packet passage. Most changes occur rapidly when the narrow bandwidth around the wave packet core passes. Further analyses of the energy spectra indicate that the enhancement of turbulence occurs across a wide range of scales, with the near-surface small-scale motions experiencing the most significant intensification. Meanwhile, large-scale motions with scales comparable to the boundary layer depth are also enhanced. The mechanisms underlying the Reynolds normal stress variation at different length scales are related to the energy transfer from the wave orbital straining to turbulence through production, the pressure–strain effect, the pressure diffusion and the wave advection. By assessing the turbulence statistics and dynamics impacted by a wave packet in detail, this study provides an improved understanding of the response of a developed turbulent flow to a transient wave field. The proposed simulation method also proves to be a promising phase-resolved approach for efficiently modelling the wave effect on turbulence.
In 2023, both Democratic and Republican elected officials supported banning official use of the gender-neutral term “Latinx.” Using a nationally representative survey sample, this study examines whether opposition to the gender-neutral term “Latinx” suggests a potential wedge issue that cuts across partisanship. We find that opposition to “Latinx” is significantly higher among Republican partisans, those who disapprove of Joe Biden as president, and those with “colder” feelings toward Democrats. Opposition to “Latinx” generally converges with factors that predict existing partisan divisions; where it diverges, it does not affect respondent evaluations of Biden or feelings about Democrats. Based on these findings, we conclude that gender-neutral language currently shows little potential as a wedge issue.
Chrono-medicine considers circadian biology in disease management, including combined lifestyle and medicine interventions. Exercise and nutritional interventions are well-known for their efficacy in managing type 2 diabetes, and metformin remains a widely used pharmacological agent. However, metformin may reduce exercise capacity and interfere with skeletal muscle adaptations, creating barriers to exercise adherence. Research into optimising the timing of exercise has shown promise, particularly for glycaemic management in people with type 2 diabetes. Aligning exercise timing with circadian rhythms and nutritional intake may maximise benefits. Nutritional timing also plays a crucial role in glycaemic control. Recent research suggests that not only what we eat but when we eat significantly impacts glycaemic control, with strategies like time-restricted feeding (TRF) showing promise in reducing caloric intake, improving glycaemic regulation and enhancing overall metabolic health. These findings suggest that meal timing could be an important adjunct to traditional dietary and exercise approaches in managing diabetes and related metabolic disorders. When taking a holistic view of Diabetes management and the diurnal environment, one must also consider the circadian biology of medicines. Metformin has a circadian profile in plasma, and our recent study suggests that morning exercise combined with pre-breakfast metformin intake reduces glycaemia more effectively than post-breakfast intake. In this review, we aim to explore the integration of circadian biology into type 2 diabetes management by examining the timing of exercise, nutrition and medication. In conclusion, chrono-medicine offers a promising, cost-effective strategy for managing type 2 diabetes. Integrating precision timing of exercise, nutrition and medication into treatment plans requires considering the entire diurnal environment, including lifestyle and occupational factors, to develop comprehensive, evidence-based healthcare strategies.
Radial unstable stratification is a potential source of turbulence in the cold regions of accretion disks. To investigate this thermal effect, here we focus on two-dimensional Rayleigh–Bénard convection in an annulus subject to radially dependent gravitational acceleration $g \propto 1/r$. Next to the Rayleigh number $Ra$ and Prandtl number $Pr$, the radius ratio $\eta$, defined as the ratio of inner and outer cylinder radii, is a crucial parameter governing the flow dynamics. Using direct numerical simulations for $Pr=1$ and $Ra$ in the range from $10^7$ to $10^{10}$, we explore how variations in $\eta$ influence the asymmetry in the flow field, particularly in the boundary layers. Our results show that in the studied parameter range, the flow is dominated by convective rolls and that the thermal boundary-layer (TBL) thickness ratio between the inner and outer boundaries varies as $\eta ^{1/2}$. This scaling is attributed to the equality of velocity scales in the inner ($u_i$) and outer ($u_o$) regions. We further derive that the temperature drops in the inner and outer TBLs scale as $1/(1+\eta ^{1/2})$ and $\eta ^{1/2}/(1+\eta ^{1/2})$, respectively. The scalings and the temperature drops are in perfect agreement with the numerical data.
In June 2022, the U.S. Supreme Court’s Dobbs ruling overturned Roe v. Wade, reversing the nearly 50-year-old landmark decision that affirmed a woman’s constitutional right to abortion. Several months later, voters turned out in record numbers for the 2022 midterms, though a widely predicted “Red Wave” vote did not materialize. There has since been speculation that overturning Roe v. Wade played a crucial role in the midterms, generating a “Blue Tsunami” or “Roevember” driven largely by young, pro-choice women voting out of self-interest. We posit instead that group empathy was the key motivational mechanism in the link between opposition to Dobbs and voter mobilization in that election. Analyzing data from an original national survey, we find that opposition to overturning Roe v. Wade did not directly affect one’s likelihood to vote unless one is empathic toward groups in distress. Such opposition was actually demobilizing for those low in empathy. The findings indicate group empathy serves as a catalyst for people to act on their opposition to policies that harm disadvantaged groups, in this case women as a marginalized political minority losing their constitutional right to bodily autonomy and access to reproductive care.
As the Mediterranean diet (MDi) has demonstrated a powerful preventative effect on various medical conditions, a positive effect on oral health may also be speculated. Tooth loss, pain or tooth mobility may discourage the consumption of specific food types, affecting MDi adherence. The aim of this study was to investigate the association between adherence to MDi and oral health in adult populations. The study protocol was registered in Open Science Framework (https://osf.io/vxbnh/) and adhered to PRISMA-ScR guidelines. The principal research questions were: (1) Does better oral health enable adults to better adhere to MDi? and (2) Does better adherence to MDi enable adult individuals to have better oral health? The content of three databases, Clarivate Analytics’ Web of Science, Scopus and PubMed was searched without language, date or any other restrictions. The search results were imported into the Rayyan environment, and from the initial 1127 studies identified, only 20 remained after the exclusion process. Three articles composed the first group, revealing significant associations between various oral health parameters and adherence to MDi, with large variations in methodology and no safe conclusions. The studies investigating the effect of the level of adherence to MDi on various oral parameters were more numerous and revealed negative associations with the prevalence of periodontal disease and upper aero-digestive tract cancer. Further studies to explore the existence and direction of the association between oral health and MDi are needed, with public health interventions encouraging adherence to the MDi to reduce the burden of oral conditions and other non-communicable diseases.
With the over-use of tetracycline (TC) and its ultimate accumulation in aquatic systems, the demand for TC removal from contaminated water is increasing due to its severe threat to public health. Clay minerals have attracted great attention as low-cost adsorbents for controlling water pollution. The objective of the present study was to measure the adsorption behavior and mechanisms of TC on allophane, a nanosized clay mineral with a hollow spherical structure; to highlight the advantage of the allophane nanostructure, a further objective was to compare allophane with halloysite and montmorillonite, which have nanostructures that differ from allophane. Structural features and surface physicochemical properties were characterized by transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), zeta potential, N2-physisorption, and acid–base titration. The adsorption data showed that TC adsorption followed the pseudo-second order and Langmuir models. The adsorption was pH dependent, as all three clay minerals performed better under neutral to weakly alkaline conditions and maintained high adsorption performance in the presence of co-existing Na+/K+/Ca2+/Mg2+ cations. Regeneration of the adsorbent was excellent, with efficiencies exceeding 75% after five recycles. By comparison, allophane always exhibited the greatest adsorption capacity, up to 796 mg g–1 at ~pH 9. The TC adsorption on allophane and halloysite was dominated by inner-sphere complexation, together with a small amount of electrostatic adsorption, while that on montmorillonite involved mainly interlayer cation exchange. The findings provide insights into the effects of nanostructures of clay minerals on their TC adsorption performance and highlight the huge potential of allophane as an efficient and inexpensive adsorbent for TC removal.
Marsupials give birth to immunologically naïve young after a relatively short gestation period compared with eutherians. Consequently, the joey relies significantly on maternal protection, which is the focus of the present review. The milk and the pouch environment are essential contributors to maternal protection for the healthy development of joeys. In this review, we discuss bioactive components found in the marsupial pouch and milk that form cornerstones of maternal protection. These bioactive components include immune cells, immunoglobulins, the S100 family of calcium-binding proteins, lysozymes, whey proteins, antimicrobial peptides and other immune proteins. Furthermore, we investigated the possibility of the presence of plurifunctional components in milk and pouches that are potentially bioactive. These compounds include caseins, vitamins and minerals, oligosaccharides, lipids and microRNAs. Where applicable, this review addresses variability in bioactive components during different phases of lactation, designed to fulfil the immunological needs of the growing pouch young. Yet, there are numerous additional research opportunities to pursue, including uncovering novel bioactive components and investigating their modes of action, dynamics, stability and ability to penetrate the gut epithelium to facilitate systemic effects.
In this commentary on Jeremy Fantl's The Limitations of the Open Mind, I focus mainly on the book's second half and argue against Fantl's view that you should rarely engage closed-mindedly with those putting forth claims that you know are false and arguments that you know are misleading. I argue that this kind of engagement can be fruitfully exercised without problematic deception. If we are attuned to the social dimension of epistemology, and we see that false and potentially pernicious beliefs are spreading, we have good reason to engage with at least some of these believers with the aim of altering their epistemic attitudes, and to allow for more collective knowledge.
It is well known that marginalized communities of color, particularly young Black men, are more likely to experience police-initiated contact that other groups. Research suggests that these events contribute to legal cynicism, or the belief that the law and its agencies are ineffective, unwilling to help, and untrustworthy. In turn, cynical orientations limit one’s willingness to call the police to help. However, recent work on marginalized women suggests that despite holding cynical attitudes towards the police, their immediate needs for safety and services supersede these beliefs. The current study examines the racialized and gendered linkages between police-initiated contact and help-seeking outcomes (reporting crime, calling for an emergency, and seeking help from police for non-emergencies). Using data from the Police Public Contact Survey (from the Police Public Contact Survey–2020) results indicate that Black and Hispanic participants were less likely than White participants to seek help. However, Black and Hispanic women were more likely than their male counterparts for calls for help regarding a crime or disturbance. Across all outcomes, police-initiated contact was associated with higher rates of help-seeking. Perceived illegitimacy of street stops reduced the odds of reporting crimes to the police. However, perceived traffic stop illegitimacy was not related to help-seeking. Police initiated contacts and perceptions of legitimacy did not moderate the relationships between demographic variables and help-seeking outcomes. Implications for theories on legal socialization and the impact of police-initiated contacts on help-seeking are discussed.
It is unclear whether larval infestations of Rhagoletis pomonella (Walsh) (Diptera: Tephritidae) in earlier (softer) apple (Rosaceae) cultivars are greater than in later (firmer) apple cultivars in Washington State, United States of America, where flies were introduced and are quarantine pests of apple. Here, a field survey of apples in a noncommercial setting in Washington and experiments testing whether earlier apples are more suitable than later apples for Washington-origin R. pomonella were conducted. Early season ‘Gala’ and ‘Golden Delicious’, midseason ‘Red Delicious’, and late-season ‘Granny Smith’ and ‘Fuji’ were exposed to flies reared from early and midseason apples in laboratory experiments and to wild flies in apple trees in field experiments. The field survey provided evidence for softer apples being more infested and suitable. Likewise, most of the laboratory and field experimental data showed that ‘Gala’ and ‘Golden Delicious’, two of the softer apples tested, produced the most larvae and were most suitable, regardless of whether test apples were conventional or organic and ripe or unripe. To optimise fly trapping protocols in Washington, trapping in early apple trees near ‘Gala’ and ‘Golden Delicious’ orchards should be prioritised over trapping near mid- or late-season apple cultivar orchards.
Youth self-harm (SH) is viewed as a public health concern and one of the main reasons for urgent psychiatry assessment. This systematic review sought to establish prevalence of SH among youth in Ireland.
Methods:
A systematic review using pre-defined search terms was conducted (Jan 1980–March 2024).
Results:
From a total of 204 papers identified, 18 were included. Significant variation in rates of SH was found. Limiting data to adolescent years (15–18), best estimates for overall lifetime rates of SH ranged from 1.5% (when rates of SH were reported based on a two-stage study design), to 23% (where SH was limited to non-suicidal SH). SH was typically higher in females, impulsive in nature, and occurred in the home setting. Whilst almost half of youth sought help before (43.7%) or after (49.8%) the SH episode, this was most often to a friend or family member. Overall rates of professional help seeking were low.
Conclusions:
Robust studies using clear definitions of terms, separately capturing SH with and without suicidal intent, and distinguishing SH in the context of a mental illness, are required to inform service developments. Given the frequent occurrence of SH among youth accompanied by predominance of help seeking via friends and family, it is imperative that psychoeducation is delivered to families and peers. Out of hours community and specialist mental health services are essential to address this important issue.
We prove a local gradient estimate for positive eigenfunctions of the $\mathcal {L}$-operator on conformal solitons given by a general conformal vector field. As an application, we obtain a Liouville type theorem for $\mathcal {L} u=0$, which improves the one of Li and Sun [‘Gradient estimate for the positive solutions of $\mathcal Lu = 0$ and $\mathcal Lu ={\partial u}/{\partial t}$ on conformal solitons’, Acta Math. Sin. (Engl. Ser.)37(11) (2021), 1768–1782]. We also consider applications where manifolds are special conformal solitons and obtain a better Liouville type theorem in the case of self-shrinkers.
This study analyzes disparities in initial health care responses in Turkey and Syria following the 2023 earthquakes.
Methods
Using Humanitarian Data Exchange, Crude Mortality Rates (CMR) and injury rates in both countries were calculated, and temporal trends of death tolls and injuries in the first month post- catastrophe were compared. World Health Organization (WHO) Flash Appeal estimated funding requirements, and ratios of humanitarian aid personnel in Urban Search and Rescue (USAR) teams per population from ReliefWeb and MAPACTION data were used to gauge disparities.
Results
56 051 096 individuals were exposed, with Turkey having 44 million vs 12 million in Syria. Turkey had higher CMR in affected areas (10.5 vs. 5.0 per 10,000), while Syria had higher CMR in intensely seismic regions (9.3 vs. 7.7 per 1,000). Turkey had higher injury rates (24.6 vs. 9.9 per 10 000). Death and injury rates plateaued in Syria after 3 days, but steadily rose in Turkey. Syria allocated more funding for all priorities per population except health care facilities’ rehabilitation. Turkey had 219 USAR teams compared to Syria’s 6, with significantly more humanitarian aid personnel (23 vs. 2/100,000).
Conclusions
Significant disparities in the initial health care response were observed between Turkey and Syria, highlighting the need for policymakers to enhance response capabilities in conflict-affected events to reduce the impact on affected populations.
Narrative Abstract
The 2023 Turkish-Syrian earthquakes, the most devastating in the region since 1939, heightened challenges in Syria’s health care system amid ongoing conflict, disrupting Gaziantep’s humanitarian aid supply route. The initial health care responses post-earthquakes in Turkey and Syria were analyzed through a descriptive study, where Crude Mortality Rates (CMR) and injury rates during the first week were calculated. The World Health Organization’s funding priorities and the ratio of humanitarian aid personnel in Urban Search and Rescue teams per population were assessed. Turkey had 4-fold higher earthquake exposure and experienced higher CMR and injuries per population, while Syria had higher CMR in intensely seismic regions. Temporal trends showed plateaued death and injury rates in Syria within 3 days, while Turkey’s continued to increase. Syria required more funding across nearly all priorities while Turkey had more humanitarian aid personnel per population. Significant health care response disparities were observed, emphasizing the imperative for policymakers to enhance initial responses in conflict-affected events.
The collapse of a vapour bubble over a material surface has been widely studied over the past few decades, but a comprehensive and quantitative analysis of the cavitation dynamics and its effects on solid materials at the mesoscale (nanometre up to micrometre), which would be of particular interest in applications exploiting cavitation power, is still lacking. In this work, we adopt a diffuse interface model to describe the microbubble dynamics, and a dynamic plasticity model for the solid. The former is particularly suited to studying the rich phenomenology characterising bubble collapse at the mesoscale, which comprises transitions to supercritical conditions, emission and propagation of shock waves, generation of liquid microjets and topological transitions, whereas the latter is used to characterise the permanent plastic deformation caused by the bubble collapse, and has been augmented to consider inertial effects, to assess whether or not an interaction between elastic and plastic waves may influence the resulting deformation. Results concerning the collapse of a microbubble at different liquid overpressures and initial standoff ratios are discussed, and the elastoplastic wave propagation in the solid, together with plastic deformation, is studied for different cases, depending on elastic and plastic material parameters.
Cet article vise à élucider la nature de l'enquête. Je présente tout d'abord les desiderata communs à toute théorie de l'enquête. Je catégorise ensuite l'enquête comme un processus structuré en me concentrant sur ses composantes essentielles : des attitudes de questionnement guidant des actions. Enfin, je me penche sur l'objection récente selon laquelle les attitudes de questionnement ne sont pas nécessaires à l'enquête. Je défends la thèse selon laquelle l'enquête est un processus structuré essentiellement constitué d'attitudes de questionnement ayant deux rôles fonctionnels précis, soit d'initier et de guider le déploiement de capacités cognitives en vue d'un but épistémique.