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The increasing demand for food and especially proteins leads to the search for alternative protein sources. Meat co-products, which are available but little used in human food, provide a potential solution to this challenge. The present study aimed to evaluate the nutritional quality of two beef protein ingredients (greasy greaves recovered proteins (GGRP) and water recovered proteins (WRP)), both co-products of the fat rendering process. Their true ileal digestibility (TID), digestible indispensable amino acid score (DIAAS) and kinetics of plasma amino acids (AA) were measured in ten growing pigs, each fed the two co-products and a protein-free diet. Titanium dioxide was used as an indigestible marker. Digesta samples were collected for 9 h after meal ingestion, and blood samples were collected at ten time points during the same period. Total nitrogen (N) and AA contents were determined. Data were statistically analysed using linear mixed models. The TID of total N was not different between WRP and GGRP (81–84 %, P > 0·05). The first-limiting AA was Trp for both ingredients, with a DIAAS much higher for GGRP than for WRP (74 and 10 % for adults, respectively; P < 0·001). Postprandial plasma AA concentration peaked earlier for WRP (3 h) than for GGRP (5 h). Plasma concentrations of total and essential AA were higher (P < 0·001) with GGRP diet than WRP diet. Overall, GGRP has a nutritional quality suitable to meet the needs of adults for AA, while WRP needs to be supplemented with other protein sources to fulfil the dietary requirements.
This article addresses whether responses to COVID-19 created opportunities for future policy change. We explore this matter by presenting a framework rooted in political economy and the literature on pandemics. We argue that the opportunities created by emergency responses are context-specific and that narratives, policy tools, and pro-equity state actors are variables that mediate emergency responses and future opportunities. We ground our analytical contribution on the emergency cash transfers deployed during 2020 following the COVID-19 outbreak in two contrasting Central American countries, Costa Rica and Guatemala. The paper promotes further policy discussion on the opportunities for progressive change in unequal contexts.
Medical ethics education is crucial for medical students and trainees, helping to shape attitudes, beliefs, values, and professional identities. Exploration of ethical dilemmas and approaches to resolving them provides a broader understanding of the social and cultural contexts in which medicine is practiced, as well as the ethical implications of medical decisions, fostering critical thinking and self-reflection skills imperative to providing patient-centered care. However, exposure to medical ethics topics and their clinical applications can be limited by curricular constraints and the availability of institutional resources and expertise. Podcasts, among other Free Open Access Medical Education (FOAMed) resources, are a novel educational tool that offers particular advantages for self-directed learning, a process by which learners engage in asynchronous educational opportunities outside of traditional academic or clinical settings. Podcasts can be readily distributed to wide audiences and played at any time, reducing barriers to access and offering a level of flexibility that is not possible with traditional forms of education and is well-suited to busy schedules. Podcasts can also use real voices and storytelling to make the content memorable and eminently human. This paper describes the development, production process, and impact of Core IM’s “At the Bedside,” a podcast focusing on issues in medical ethics and the medical humanities, intending to supplement standard bioethics curricula in an accessible, relevant, and engaging way. The authors advocate for broad incorporation of podcasts into medical ethics education.
Many bioethicists have recently shifted from using “physician-assisted suicide” (PAS) to “medical aid-in-dying” (MAID) to refer to the act of voluntarily hastening one’s death with the assistance of a medical provider. This shift was made to obscure the practice’s connection to “suicide.” However, as the charge of “suicide” is fundamental to arguments against the practice, “MAID” can only be used by its proponents. The result has been the fragmentation of the bioethical debate. By highlighting the role of human agency—as opposed to natural processes—in causing death, the term “PAS” makes it easier both to perceive potential risks to vulnerable populations and to affirm suicide as a potentially autonomous choice. As such, “PAS” thus more transparently expresses the arguments of both supporters and opponents of the “right to die,” while avoiding the unnecessary stigmatization of suicide and suicidal people which is a result of the usage of “MAID.”
In transonic flow conditions, buffeting associated with finite-amplitude lift fluctuations can limit the operational envelope of an aircraft. For both airfoils and wings, these oscillations have been linked to global flow instabilities that arise from a Hopf bifurcation. We employ a combination of numerical simulations and global stability analysis to investigate the near-critical behaviour of the oscillatory buffet-onset instability on airfoils. The flow is governed by the unsteady Reynolds-averaged Navier–Stokes equations, with a basic state provided by a steady-state solution. In the weakly nonlinear formulation, the disturbance amplitude is described by the Landau equation. The linear growth rate can be determined from either the simulations or the stability analysis, and the Landau constant is derived from simulations resulting in finite-amplitude equilibrium states. The results show that the Landau constant is nearly independent of Mach number and angle of attack for a given airfoil. Using the Landau constant derived from a small number of simulations, the stability analysis can be employed to efficiently capture the essential finite-amplitude behaviour needed to estimate the buffet-onset boundary. The stability analysis is shown to capture the envelope of lift oscillations during a continuous pitch of an airfoil, from pre-buffet through post-buffet lift levels.
Do inputs need to be restricted on a language-specific basis? Classic Optimality Theory claims that they do not: the rich base is filtered by constraints that yield full contrast, complementary distributions or positional neutralisation depending on the ranking. The problem arises when positional neutralisation affects a gappy contrast. In Russian, voicing neutralisation works on all obstruents alike, including non-contrastively voiceless ones – but it creates voiced allophones that are otherwise disallowed. In the popular OT account of positional neutralisation, analysing these cases requires handling voicing twice: once for all segments, then again for gaps. I argue that the solution is to relax the rich base assumption by ruling gaps out at the UR level through morpheme structure constraints (Halle 1959 et seq.).
Supportive public policies are suggested as ways to lessen gentrification’s impact for older adults. While explicit policies designed to help older adults with gentrification are rare, literature on age-friendly cities is a close proxy. We utilized three North American cases undergoing gentrification: New York City, NY, and Denver, CO, in the United States and Hamilton, in Ontario, Canada, to present existing neighbourhood-based policies as social determinants of health in housing, resource access, healthcare, transportation, and communal places. Age-friendly policy application gap examples and COVID-19’s impact were included. Using a qualitative comparative case study method, we found policies were not specifically designed to address older adults’ gentrification needs. With the call for age-friendly designations, the role of gentrification in neighbourhoods with older populations must be included. We call for gentrification-specific policies for older adults to provide greater safeguards especially when events such as COVID-19 compete for existing, over-stretched resources.
Legislation is a powerful tool for facilitating mental healthcare. Gender is an important social determinant of physical and mental health. Many jurisdictions are in the process of revising their mental health law, to align with human rights commitments. Consideration of gender in these revisions could enhance the mental healthcare received by women, transgender and non-binary individuals.
Aim:
This paper examines gender-based provisions in mental health law published in English.
Methods:
Countries that use English as an official language were identified. Jurisdictions in these countries with stand-alone mental health laws were included. Legislation was reviewed for gender-specific provisions.
Results:
Seventy-five countries were evaluated; 71 jurisdictions were included. Thirty-eight jurisdictions had 88 gender-specific provisions. These addressed ten key areas, including: general gender-based protections, female representation on boards and review panels, protections during searching and restraint, gender separated facilities, protections in relation to parenting, fertility, sterilisation and termination. Fiji, Ghana, India, and the Australian jurisdictions had the highest number of gender-specific laws. However, gender-specific provisions are highly heterogeneous and are drafted from a cisnormative perspective and fail to adequately address the specific needs of individuals outside of that framework.
Conclusion:
Gender-specific provisions can enhance the protections afforded by mental health law. However, as legislation can be a blunt instrument, careful consideration must be given to potential unintended consequences. During revisions of mental health law consideration should be given to gender-specific provisions and legislation must be inclusive of individuals identifying as transgender, non-binary and other genders.
Multiple reviews have examined the impact of nutritional interventions in patients with burn injuries; however, discrepancies among results cast doubt about their validity. We implemented this review to assess the impact of various nutritional interventions in adult patients with burn injuries. We conducted a thorough search of PubMed, Scopus and Web of Science databases until 1 August 2024, to identify relevant meta-analyses of intervention trials, examining the impact of nutritional interventions on burn patients. We adopted the random-effect models to determine the pooled effect sizes while employing the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) to examine evidence certainty. Thirty-three original intervention trials from eleven meta-analyses were entered in our review. Early enteral nutrition could substantially reduce overall mortality (relative risk (RR): 0·36, 95 % CI: 0·19, 0·68, GRADE = moderate certainty), hospital stay (mean difference (MD): −15·3, 95 % CI: −20·4, −10·2, GRADE = moderate certainty) and sepsis risk (RR: 0·23, 95 % CI: 0·11, 0·45, GRADE = moderate certainty). Glutamine showed a notable decrease in the length of hospital stay (MD: −6·23, 95 % CI: −9·53, −2·94, GRADE = low certainty). However, other nutritional interventions, including combined immunonutrition, branched-chain amino acids, fish oil, ornithine α-ketoglutarate and trace elements, did not significantly affect the assessed clinical outcomes. Early enteral nutrition might impose a beneficial effect on mortality, hospital stay length and incidence of sepsis with moderate evidence. Lower length of hospital stay was also seen in burn patients supplemented with glutamine, although the evidence was weak.
In Latin American comparative politics, a tension exists between North Americanization and parochialism. While certain academic scholarship is published in Scopus-indexed journals that engage with “mainstream” Global North literature, other works are found in non-indexed outlets, focusing solely on their home countries and fostering parochial scientific communities. To assess this tension in graduate program curricula, we compiled an original dataset of comparative politics readings from 21 universities across nine Latin American countries. Our network analysis reveals a centralized structure influenced by mainstream readings, challenging the expectation of parochialism. In addition to the mainstream content, universities tend to incorporate readings from regional journals to facilitate cross-case comparisons. However, these materials are inconsistently shared, resulting in fragmentation of content from Latin American sources. Our findings contribute to and challenge the North Americanization versus parochialism debate, showing that future scholars receive similar mainstream training but encounter diverse regional materials during their PhD studies.
The accuracy of electromagnetic (EM) exposure assessments depends mainly on the resolution of a voxel human body model. The resolution of the conventional human body model is limited to a few millimeters. In the millimeter wave (mmWave) frequency range, EM waves are absorbed by the superficial tissues in the human body. Therefore, resolution and skin thickness of the human body model are important for accuracy of the EM wave exposure metrics recommended by international human safety guidelines. Realistic thickness modeling of the skin tissue on the human body may provide greater accuracy in the EM exposure assessment, especially at mmWave frequency range. In this paper, effects of the skin thickness on the EM exposure metrics in one-dimensional multi-layered models obtained from different regions of the body model are investigated using the dispersive algorithm based on the finite-difference time-domain method over the frequency range from 1 to 100 GHz. Furthermore, effects of eyelid tissue in a human eye on the EM exposure metrics are studied over the frequency range. The EM exposure metrics such as absorbed power density, heating factor, and power transmission coefficient are calculated up to 100 GHz to evaluate the limits of EM wave exposure.
In this article, we study rational matrix representations of VZ p-groups (p is any prime). Using our findings on VZ p-groups, we explicitly obtain all inequivalent irreducible rational matrix representations of all p-groups of order $\leq p^4$. Furthermore, we establish combinatorial formulae to determine the Wedderburn decompositions of rational group algebras for VZ p-groups and all p-groups of order $\leq p^4$, ensuring simplicity in the process.