In this paper, we introduce a new class of $T_0$ spaces called wb-sober spaces, which is strictly larger than the class of open well-filtered spaces. Unlike open well-filtered spaces, wb-sober spaces are defined more intuitively by requiring certain special subsets, termed wb-irreducible closed sets, to have singleton closures. We establish several key results about these spaces, including (1) every open well-filtered space is wb-sober, but not vice versa; (2) every strongly core-coherent wb-sober space is open well-filtered; (3) a space is core-compact iff its irreducible closed sets are wb-irreducible, providing a characterization of core-compactness; (4) every core-compact wb-sober space is sober, thereby generalizing the Jia-Jung problem. In addition, we investigate the core-coherence of the Xi-Zhao model. We prove that a $T_1$ space contains finite number of isolated points iff its Xi-Zhao model is core-coherent iff its Xi-Zhao model is strongly core-coherent. Based on this result, we then propose a general approach to constructing a non-routine open well-filtered but not well-filtered dcpo.

This article discusses the importance of personal recovery in psychiatry and proposes a new socially constitutive process. The author, an expert by experience, emphasises that recovery is not only an individual endeavour but also an intersubjective one. Moreover, social relationships and external factors such as community, family, health service culture and social norms influence the recovery process. The socially constitutive process posits that support from professionals and family members is crucial, significantly reducing the burden of responsibility carried by individuals with mental illness.

In this article we explore the practical conditions of ritual practices of Hui and Uyghur Muslims in China. Ceaseless conflicts among different religious ideas and elements exist, but they are integrated into religious pluralism, which meets the needs of Muslims' daily practices. Furthermore, we probe the reasons for the resulting religious harmony through investigating the historical process of the formation of religious pluralism, and showing present ritual performances in which there is a hierarchically built ritual structure functioning to make religious integration possible, though different opinions regarding diverse religious elements occur elsewhere among Hui and Uyghur Muslims. Finally, the discussion supports the related assertion that rituals can be reliable and effective ways of understanding the sociological and psychological functions of religions, or religious beliefs, and other related socio-cultural realities.

This study aimed to explore the combined effects of serum vitamin-D level and tobacco exposure on the risk of overweight and obesity in children. This cross-sectional study analysed the data of 11 636 children aged 2–17 years from the National Health and Nutrition Examination Surveys database between 2007 and 2018. Univariable and multivariate weighted logistic regression models were used to analyse the associations of serum vitamin-D or cotinine levels with overweight and obesity in children as well as the combined effects of serum vitamin-D and cotinine on the risk of overweight and obesity in children. Subgroup analysis was performed in terms of gender, age, race and household smokers. OR with corresponding 95 % CI was presented. The elevated risk of overweight and obesity in children was found in those with serum vitamin-D < 20 ng/ml (OR = 1·44, 95 % CI: 1·29, 1·61). Also, the odds of overweight and obesity in children was 1·14 (OR = 1·14, 95 % CI: 1·01, 1·29) in children with cotinine ≥ 0·05 ng/ml. Relative to participants with serum vitamin-D ≥ 20 ng/ml and cotinine < 0·05 ng/ml, increased risk of overweight and obesity was identified in those with serum vitamin-D < 20 ng/ml and cotinine < 0·05 ng/ml (OR = 1·45, 95 % CI: 1·26, 1·68) and serum vitamin-D < 20 ng/ml and cotinine ≥ 0·05 ng/ml (OR = 1·62, 95 % CI: 1·38, 1·91). Serum vitamin-D and cotinine exposure had combined effects on the risk of overweight and obesity in children.

Tea is one of the most widely consumed beverages in the world. However, the association between tea and risk of pancreatic adenocarcinoma remains controversial. This study aimed to investigate the causal relationship between tea consumption and risk of pancreatic adenocarcinoma and to explore their mediating effects. The two-sample Mendelian randomisation (MR) analysis showed an inverse causal relationship between tea intake and pancreatic adenocarcinoma (OR: 0·111 (0·02, 0·85), P < 0·04). To examine the mediating effects, we explored the potential mechanisms by which tea intake reduces the risk of pancreatic adenocarcinoma. Based on the oral bioavailability and drug-like properties in Traditional Chinese Medicine Systems Pharmacology database, we selected the main active ingredients of tea. We screened out the fifteen representative targeted genes by Pharmmapper database, and the gene ontology enrichment analysis showed that these targeted genes were related to vascular endothelial growth factor (VEGF) pathway. The two-step MR analysis of results showed that only VEGF-D played a mediating role, with a mediation ratio of 0·230 (0·066, 0·394). In conclusion, the findings suggest that VEGF-D mediates the effect of tea intake on the risk of pancreatic adenocarcinoma.

Hakite-(Cd), hakite-(Fe) and hakite-(Zn) are new minerals belonging to the tetrahedrite group and forming, along with hakite-(Hg), the hakite series. They have been discovered in samples collected from the Bytíz deposit, in the uranium and base-metal Příbram ore district, Central Bohemia, Czech Republic. They occur as anhedral grains, up to 300 μm in size, in a calcite gangue, associated with clausthalite, cadmoselite, hakite-(Hg) [for hakite-(Cd)], berzelianite, bukovite, bytízite, crookesite, chaméanite, eskebornite, příbramite, the not yet approved giraudite-(Hg) and giraudite-(Cu), hakite-(Hg), umangite, chalcopyrite, tetrahedrite-(Zn) and a new Cu–As selenide [for hakite-(Fe) and -(Zn)]. The three new species are black, with a metallic lustre. Mohs hardness is ca. 3½–4; calculated density is 6.019 (Hak-Cd), 6.011 (Hak-Fe) and 6.081 g.cm–3 (Hak-Zn). In reflected light, they are isotropic, pale grey with bluish (Hak-Cd) or brownish (Hak-Fe and Hak-Zn) shades. Empirical formulae of hakite-(Cd), hakite-(Fe), and hakite-(Zn) are Cu9.71Ag0.24Cd1.51Hg0.43Zn0.03(Sb3.94As0.13)Σ4.07Se11.35S1.57, Cu10.11Ag0.18Fe0.81Zn0.50Hg0.26(Sb3.72As0.41)Σ4.13Se12.65S0.12, and Cu10.03Ag0.24Zn0.61Fe0.53Hg0.45(Sb3.55As0.60)Σ4.15Se12.82S0.08, respectively. These formulae correspond to the end-member formulae Cu6(Cu4Cd2)Sb4Se13 (Hak-Cd), Cu6(Cu4Fe2)Sb4Se13 (Hak-Fe), and Cu6(Cu4Zn2)Sb4Se13 (Hak-Zn). All these new members of the hakite series are cubic, I$\bar{4}$3m, Z = 2, with unit-cell parameters a = 10.8860(6) Å, V = 1290.0(2) Å3 (Hak-Cd); a = 10.7983(4) Å, V = 1259.12(14) Å3 (Hak-Fe); and a = 10.8116(14) Å, V = 1263.8(5) Å3 (Hak-Zn). These species are isotypic with the other members of the tetrahedrite group, and their crystal structures have been refined on the basis of single-crystal X-ray diffraction data down to R1 values of 0.0230 (Hak-Cd), 0.0254 (Hak-Fe), and 0.0302 (Hak-Zn). These structural data allow us to describe the S-to-Se partitioning in hakite-series minerals and to understand the mechanisms avoiding too short Me–Se distances in these selenides.

This paper proposes a seat support mechanism to solve the problem of misalignment between the chest examination and probe scanning areas when the patient is bent in a seated-style echocardiography robot. To guide the patient to an appropriate body position where their chest is within the examination range of the chest examination unit while minimizing the physical load of the patient, the posture of the patient must satisfy the three following conditions. (i) The breech must be in contact with the seat surface, (ii) the legs must be vertical to the floor, and (iii) the chest and mechanism must be parallel while the probe scanning and chest examination ranges must match. The human body was modeled to derive a posture that satisfies the aforementioned conditions for the height of each individual, and a seat support mechanism with four degrees of freedom was installed to guide the user to the derived posture. By installing this mechanism, the body load of the left biceps brachii, right biceps brachii, left latissimus dorsi, and right latissimus dorsi was reduced to 64.7%, 52.7%, 86.4%, and 80.2%, respectively. The sharpness of the image contours was improved to 103.8%.

The Aerospace Integration Research Centre (AIRC) at Cranfield University offers industry and academia an open environment to explore the opportunities for efficient integration of aircraft systems. As a part of the centre, Cranfield University, Rolls-Royce, and DCA Design International jointly have developed the Future Systems Simulator (FSS) for the purpose of research and development in areas such as human factors in aviation, single-pilot operations, future cockpit design, aircraft electrification, and alternative control approaches. Utilising the state-of-the-art modularity principles in simulation technology, the FSS is built to simulate a diverse range of current and novel aircraft, enabling researchers and industry partners to conduct experiments rapidly and efficiently. Central to the requirement, a unique, user-experience-centred development and design process is implemented for the development of the FSS. This paper presents the development process of such a flight simulator with an innovative flight deck. Furthermore, the paper demonstrates the FSS’s capabilities through case studies. The cutting-edge versatility and flexibility of the FSS are demonstrated through the diverse example research case studies. In the final section, the authors provide guidance for the development of an engineering flight simulator based on lessons learned in this project.

For given $\epsilon>0$ and $b\in \mathbb {R}^m$, we say that a real $m\times n$ matrix A is $\epsilon $-badly approximable for the target b if

$$ \begin{align*}\liminf_{q\in\mathbb{Z}^n, \|q\|\to\infty} \|q\|^n \langle Aq-b\rangle^m \geq \epsilon,\end{align*} $$

$\langle \cdot \rangle $

$\epsilon $

$\epsilon $

$\epsilon $

The objective of this study was to investigate the effects of different cockpit primary flight display (PFD) interface designs on pilot cognitive efficiency and cognitive load. This study designed five optimised PFD interfaces and conducted interface cognition experiments to assess cognitive responses across six different PFD interface designs, including the original design. It compared various subjective and objective metrics across different interface designs and evaluated the impact of each design factor on cognitive task performance. The experimental results show that the PFD interface in the original interface design performs better under different flight symbol designs, and the interface with 50% increase in font size performs better among interface designs with different font sizes with relatively lower cognitive load. This study provides experimental support and optimization suggestions for the optimal design of cockpit PFD interface, which can help improve pilots’ perception and operational capabilities, and thus enhance task performance efficiency and flight safety. Future research can investigate the effects of various design factors on the cognitive effects of the interface to enhance the ongoing improvement and optimisation of interface design.

Relying upon an original (country-sector-year) measure of robotic capital ($RK$), we investigate the degree of complementarity/substitutability between robots and workers at different skill levels. We employ nonparametric methods to estimate elasticity of substitution patterns between $RK$ and skilled/unskilled labor over the period 1995–2009. We show that: i) on average, $RK$ exhibits less substitutability with skilled workers compared to unskilled workers, indicating a phenomenon of “RK-Skill complementarity”. This pattern holds in a global context characterized by significant heterogeneity; ii) the dynamic of “RK-Skill complementarity” has increased since the early 2000s; iii) the observed strengthening is more prominent in OECD countries, as opposed to non-OECD countries, and in the Manufacturing sector, compared to non-Manufacturing industries.

We evaluate the impact of the 2017 Tax Cuts & Jobs Act (TCJA) pension tax break on sponsor contributions to defined-benefit retirement plans. We exploit cross-sectional variation in ex-ante exposure to the tax break. We find that the tax break induced an extra $2.8 billion of sponsor contributions to medium- and large-scale plans in 2017. However, we find strong evidence of reversal, both in terms of sponsor contributions and plan funding ratios by 2018. Our contributions model indicates that this reversal is consistent with more binding financial constraints in 2018 relative to 2019. Our results suggest that the TCJA did not have a long-lasting impact on corporate defined-benefit pension funds.

The pth ($p\geq 1$) moment exponential stability, almost surely exponential stability and stability in distribution for stochastic McKean–Vlasov equation are derived based on some distribution-dependent Lyapunov function techniques.