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The present study was conducted with the objective of studying the genetic diversity of essential oils (EOs) in curry leaf (CL) ex-situ. Chemometric methods and pattern analysis were employed to assess the genetic diversity of EOs and to characterise diverse sets of CL germplasm into different chemotypes. The study revealed a huge genetic diversity for EO yield and its composition among the tested genotypes. Cultivated types had significantly higher EO yields and showed a greater degree of genetic divergence compared to wild types. In total, 80 different compounds were identified in the EOs of CL and classified into major (6) and minor (74) compounds. The major compounds α-pinene, γ-terpinene, and α-selinene and 14 minor compounds were highly variable among the tested genotypes. They may play an important role in the formation of different chemotypes. Other important compounds, such as trans-caryophyllene and α-humulene, were more widely distributed among the tested genotypes and indicated their predominant occurrence in the EOs of CL. Some major compounds, such as valencene and γ-terpinene, showed a significant regional correlation, indicating the role of geographic factors in the evolution of different chemotypes. Furthermore, some compounds such as α-pinene, bornyl acetate, and camphene had significantly higher concentrations in wild types compared to cultivated types, indicating the influence of domestication through human selection on the composition of EOs in CL. A total of 4 major chemotypes were characterised, of which three new chemotypes are being reported for the first time in CL.
The article was inspired by Justice Alito's selective and often misleading use of the medieval history of abortion law to justify the overturning of Roe v. Wade. Hoping to offer a corrective view of the larger conversation about abortion during the premodern era, this article hopes to drive home a number of points. First, modern authorities need to acknowledge that the word “abortion” (aborsus) meant something different then than it does now. Second, at its origins, abortion was conceived as a crime against husbands, and thus it falls into a larger body of misogynous law designed to protect men and their heirs from women who exploited their reproductive potential to trick men out of their rightful inheritance. And third, medieval laws against those who provided abortions labeled them as witches or poisoners. Medieval laws about abortion are thus intertwined with fears of the devil and of the woman's body as poison.
A tribute to the life and career of Dr Milton Diamond, a leading figure in twin studies of transsexuality and gender identity, is presented. Dr Diamond is famous for revealing the truth about the unsuccessful effort to change a monozygotic male Canadian twin into a female, following accidental ablation of his penis during circumcision. A short summary of recent twin research on human sexuality and transsexuality, focused on Dr Diamond’s contributions, is then presented. The tribute and overview are followed by research reviews involving the loss of a twin brother; oxytocin adminstration during twin delivery; models of monochorionic twinning; and twins’ brain responses to watching films. The final section of this article covers topics of human interest, including the passing of the world’s oldest conjoined twins; twins discordant for child abuse; twins married to twins; the delivery of a rare quadruplet set; questions of coincidence; and reared-apart twin valedictorians.
We introduce the concept of almost $\mathcal {P}$-numbers where $\mathcal {P}$ is a class of groups. We survey the existing results in the literature for almost cyclic numbers, and give characterisations for almost abelian and almost nilpotent numbers proving these two concepts are equivalent.
In 2020, COVID-19 modeling studies predicted rapid epidemic growth and quickly overwhelmed health systems in humanitarian and fragile settings due to preexisting vulnerabilities and limited resources. Despite the growing evidence from Bangladesh, no study has examined the epidemiology of COVID-19 in out-of-camp settings in Cox’s Bazar during the first year of the pandemic (March 2020-March 2021). This paper aims to fill this gap.
Methods
Secondary data analyses were conducted on case and testing data from the World Health Organization and the national health information system via the District Health Information Software 2.
Results
COVID-19 in Cox’s Bazar was characterized by a large peak in June 2020, followed by a smaller wave in August/September and a new wave from March 2021. Males were more likely to be tested than females (68% vs. 32%, P < 0.001) and had higher incidence rates (305.29/100 000 males vs. 114.90/100 000 female, P < 0.001). Mortality was significantly associated with age (OR: 87.3; 95% CI: 21.03-350.16, P < 0.001) but not sex. Disparities existed in testing and incidence rates among upazilas.
Conclusions
Incidence was lower than expected, with indicators comparable to national-level data. These findings are likely influenced by the younger population age, high isolation rates, and low testing capacity. With testing extremely limited, true incidence and mortality rates are likely higher, highlighting the importance of improving disease surveillance in fragile settings. Data incompleteness and fragmentation were the main study limitations.
We show that for $\mathrm {C}^*$-algebras with the global Glimm property, the rank of every operator can be realized as the rank of a soft operator, that is, an element whose hereditary sub-$\mathrm {C}^*$-algebra has no nonzero, unital quotients. This implies that the radius of comparison of such a $\mathrm {C}^*$-algebra is determined by the soft part of its Cuntz semigroup.
Under a mild additional assumption, we show that every Cuntz class dominates a (unique) largest soft Cuntz class. This defines a retract from the Cuntz semigroup onto its soft part, and it follows that the covering dimensions of these semigroups differ by at most $1$.
This article presents a constructional analysis of the uses of left-peripheral so in Early New High German. This element is known as a resumptive element, which takes up an adverbial clause and integrates it into a main clause. While this seems a valid analysis for constructions with preposed adverbial clauses, it is not compatible when so is preceded by adverbs or main clauses.
First, a quantitatively informed picture is presented. A network is proposed that centers around a prototype in which so connects a protasis and apodosis when so follows verb-final and verb-initial clauses. Second, it is argued that so following verb-second clauses is loosely connected to this network. Finally, it is considered whether and to what degree the use of so following adverbs should be analyzed in the same way as so following adverbial clauses. It is argued that patterns with adverbs are not in paradigmatic relation with adverbial clauses. Moreover, their function is different, as they are backward-oriented and take up earlier constituents.
We propose a novel and unified sampling scheme, called the accelerated group sequential sampling scheme, which incorporates four different types of sampling scheme: (i) the classic Anscombe–Chow–Robbins purely sequential sampling scheme; (ii) the accelerated sequential sampling scheme; (iii) the relatively new k-at-a-time group sequential sampling scheme; and (iv) the new k-at-a-time accelerated group sequential sampling scheme. The first-order and second-order properties of this unified sequential sampling scheme are fully investigated with two illustrations on minimum risk point estimation for the mean of a normal distribution and on bounded variance point estimation for the location parameter of a negative exponential distribution. We also provide extensive Monte Carlo simulation studies and real data analyses for each illustration.
Tape rolls are often used for multiple patients despite recommendations by manufacturers for single-patient use. We developed a survey to query Health Care Personnel about their tape use practices and beliefs and uncovered behaviors that put patients at risk for hospital-acquired infections due to tape use.
The modern history of Tianjin, a northern port city in China, offers an intriguing urban case for scholars interested in comparative colonial practices. From the 1860s to the 1940s, Tianjin was home to up to nine foreign concessions and a sequence of different Chinese municipalities. While much scholarship on colonial history has focused on the interactive dynamics between the colonizer and the colonized, Tianjin’s colonial past draws attention to the multiplicity, multilateralism and multilayered trajectories at the heart of the colonial experiences of both imperialist powers and the Chinese. At the heart of this short survey are some reflections on the multi-imperial dimensions of the city of Tianjin. It also explains how the multi-imperial dimensions operated in Tianjin in its treaty-port incarnation and offers some considerations of how the Tianjin case contributes to broader historiographical conversations germane to the imperial–global–urban complex.
This paper examines the role of offshoring in the flattening of the ratio of female to male hours worked in the US since the early 1990s. The observed flattening coincides with a decline in the share of occupations with high offshoring potential in women’s hours worked and an increase in service offshoring. I propose a two-gender, two-sector model with a continuum of occupations. Given the higher female intensity in the service sector, the gender hours ratio declines as service offshoring increases. Quantitatively, the service offshoring plays an important role in explaining the plateau in the gender hours ratio since the 1990s.
Cognitive therapy for PTSD (CT-PTSD) is an efficacious treatment for children and adolescents with post-traumatic stress disorder (PTSD) following single incident trauma, but there is a lack of evidence relating to this approach for youth with PTSD following exposure to multiple traumatic experiences.
Aims:
To assess the safety, acceptability and feasibility of CT-PTSD for youth following multiple trauma, and obtain a preliminary estimate of its pre–post effect size.
Method:
Nine children and adolescents (aged 8–17 years) with multiple-trauma PTSD were recruited to a case series of CT-PTSD. Participants completed a structured interview and mental health questionnaires at baseline, post-treatment and 6-month follow-up, and measures of treatment credibility, therapeutic alliance, and mechanisms proposed to underpin treatment response. A developmentally adjusted algorithm for diagnosing PTSD was used.
Results:
No safety concerns or adverse effects were recorded. Suicidal ideation reduced following treatment. No participants withdrew from treatment or from the study. CT-PTSD was rated as highly credible. Participants reported strong working alliances with their therapists. Data completion was good at post-treatment (n=8), but modest at 6-month follow-up (n=6). Only two participants met criteria for PTSD (developmentally adjusted algorithm) at post-treatment. A large within-subjects treatment effect was observed post-treatment and at follow up for PTSD severity (using self-report questionnaire measures; ds>1.65) and general functioning (CGAS; ds<1.23). Participants showed reduced anxiety and depression symptoms at post-treatment and follow-up (RCADS-C; ds>.57).
Conclusions:
These findings suggest that CT-PTSD is a safe, acceptable and feasible treatment for children with multiple-trauma PTSD, which warrants further evaluation.
This study explored the prospective use of the Ages and Stages Questionnaires-3 in follow-up after cardiac surgery.
Materials and Method:
For children undergoing cardiac surgery at 5 United Kingdom centres, the Ages and Stages Questionnaires-3 were administered 6 months and 2 years later, with an outcome based on pre-defined cut-points: Red = 1 or more domain scores >2 standard deviations below the normative mean, Amber = 1 or more domain scores 1–2 standard deviations below the normal range based on the manual, Green = scores within the normal range based on the manual.
Results:
From a cohort of 554 children <60 months old at surgery, 306 participated in the postoperative assessment: 117 (38.3%) were scored as Green, 57 (18.6%) as Amber, and 132 (43.1%) as Red. Children aged 6 months at first assessment (neonatal surgery) were likely to score Red (113/124, 85.6%) compared to older age groups (n = 32/182, 17.6%). Considering risk factors of congenital heart complexity, univentricular status, congenital comorbidity, and child age in a logistic regression model for the outcome of Ages and Stages score Red, only younger age was significant (p < 0.001). 87 children had surgery in infancy and were reassessed as toddlers. Of these, 43 (49.2%) improved, 30 (34.5%) stayed the same, and 13 (16.1%) worsened. Improved scores were predominantly in those who had a first assessment at 6 months old.
Discussion:
The Ages and Stages Questionnaires results are most challenging to interpret in young babies of 6 months old who are affected by complex CHD.
The relation between perception and production in social meaning is often taken to be transparent, with social meaning associations learned from observations of language use. However, recent work has suggested that this relation is often more complex than previously thought. Here, we present new data comparing the social meaning of realized variable liaison in spoken French, couched within the framework of the pragmatic sociology of critique. We recall data from a recent matched guise experiment showing that listeners associate the realization of liaison with meanings like “professionalism”, specifically in social situations where efficacy and expertise are at issue. Basing ourselves on this finding, we use a production task, presenting these same social situations to amateur and professional actors. We find that our participants do not exploit the social meaning potential of variable liaison, producing liaison at lexically-determined rates on a par with previous corpus studies. We discuss this discrepancy between perception and production, which suggests that the link between the two is dependent on the linguistic variable under investigation.
Anti-reclamation movements are common in Indonesia, but their effectiveness varies. Such movements, which oppose the infilling of coastal waters and wetlands, consistently draw support from environmentalists, fisherfolk, and coastal residents. To succeed, however, they must transcend these constituencies and mobilize broad coalitions. In this paper, I apply the concept of political opportunity to explain variation in the ability of anti-reclamation movements to achieve this goal. Specifically, I argue that the opportunity to build broad coalitions depends on the positioning of political, economic, and communal elites. Disagreement among these groups creates opportunities for activists to recruit some of them as allies in the construction of economically diverse, cross-class coalitions. Consensus, by contrast, excludes elites as potential allies, forcing activists to build geographically expansive but class-based coalitions. To develop my argument, I draw on local news archives and primary source documents to compare similarly situated anti-reclamation movements in Bali and Makassar. In Bali, the movement flourished by cultivating an alliance with communal elites and local businesses. In Makassar, the movement withered because public officials, local businesses, and communal elites all welcomed reclamation. My findings imply that anti-reclamation movements are most likely to succeed when they emphasize communal identities with cross-class appeal. Yet such tactics alienate parallel movements from one another and undermine national activism. As a result, anti-reclamation movements fight the same battles over and over without achieving national reforms that would empower coastal communities to participate in coastal planning. Under such conditions, reclamation deepens the vulnerability of coastal communities to climate change.
Clostridioides difficile (C. difficile) is one of the most common causes of healthcare-associated infections (HAIs). Elimination of C. difficile spores is difficult as they are resistant to common hospital-grade disinfectants. Copper-impregnated surfaces provide continuous reduction of multiple pathogens, potentially lowering the risk of infections. This manuscript aims to evaluate the efficacy of copper-impregnated surfaces on C. difficile spores.
Methods:
Control (no copper) coupons and copper coupons containing 20% copper-oxide were inoculated with C. difficile spore loads ranging from 105 to 107 spores, with or without 5% fetal bovine serum soil load. After 4 hours of contact time, the C. difficile spores were recovered, plated on C. difficile growth media, and colony forming units were counted. The efficacy of copper (log10 kill) was estimated using a Bayesian latent variables model.
Results:
After 4 hours, unsoiled copper bedrail and copper table coupons at mean spore inoculation resulted in a 97.3% and 96.8% reduction in spore count (1.57 and 1.50 log10 kill, respectively). That of soiled bedrail and table coupons showed a 91.8% and 91.7% reduction (1.10 and 1.10 log10 kill, respectively).
Conclusions:
Copper coupons can substantially reduce C. difficile spores after 4 hours, but results vary depending on the initial spore concentration and presence or absence of organic material. Higher initial spore loads or excess organic material may prevent spores from contact with copper surfaces, thus decreasing kill efficacy. Continuous sporicidal effect of copper-impregnated surfaces may decrease spore burden and help prevent transmission of spores.