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The crystal structure of palbociclib (C24H29N7O2) used as a medication for the treatment of breast cancer has been solved and refined using synchrotron radiation after density functional theory optimization. Palbociclib crystallizes in the monoclinic system (space group P21/c, #14) at room temperature with crystal parameters: a = 11.3133(2), b = 5.62626(9), c = 35.9299(9) Å, β = 101.5071(12), V = 2241.03(8) Å3, and Z = 4. The crystal structure contains infinite N–H⋯N bonded layers. The powder pattern has been submitted to ICDD for inclusion in the Powder Diffraction File™ (PDF®).
We study the question of $\mathcal {L}_{\mathrm {ring}}$-definability of non-trivial henselian valuation rings. Building on previous work of Jahnke and Koenigsmann, we provide a characterization of henselian fields that admit a non-trivial definable henselian valuation. In particular, we treat the cases where the canonical henselian valuation has positive residue characteristic, using techniques from the model theory and algebra of tame fields.
Previous studies have shown that helminth infection protects against the development of diabetes mellitus (DM), possibly related to the hygiene hypothesis. However, studies involving Stronglyoides stercoralis and its possible association with DM are scarce and have shown contradicting results, prompting us to perform this meta-analysis to obtain more precise estimates. Related studies were searched from PubMed, Google Scholar, Science Direct, and Cochrane Library until 1 August 2024. Data on the occurrence of DM in patients positive and negative for S. stercoralis were obtained. All analyses were done using Review Manager 5.4. The initial search yielded a total of 1725 studies, and after thorough screening and exclusion, only five articles involving 2106 participants (536 cases and 1570 controls) were included in the meta-analysis. Heterogeneity was assessed, and outlier studies were excluded using a funnel plot. Results showed a significant association of S. stercoralis infection with DM, suggesting that those with the infection are less likely to develop DM. Overall, the results suggest that S. stercoralis infection may decrease the likelihood of developing DM, potentially supporting the hygiene hypothesis.
This article explores the history of Japan’s municipal electricity regulation. We find that in the early phase of Japanese electrification, rights-of-way and municipal franchises remained undefined compared with these concepts in Western societies. Consequently, Japanese cities started electrification without municipal regulations. Although municipal franchises were introduced to Japan as a regulatory framework in the 1900s, they were tailored to Japan’s political and ideological context. Moreover, the Road Law of 1919 weakened the legal basis for municipal regulation. With the revision of the Electric Utility Law in 1932 and World War II, the decline of municipal regulation became inevitable.
The COVID-19 pandemic has presented multifaceted challenges globally, impacting adolescent health. Among these, food security and nutrition are intertwined closely with mental health outcomes. In Indonesia, with its diverse socio-economic landscape, these interconnections may have been exacerbated by the pandemic. This study investigated the relationship between food security, nutrition and adolescent mental health in Indonesia during COVID-19. Longitudinal data were collected from 511 adolescent boys and girls in 2021–2022 in Gunungkidul district, Yogyakarta. Food security was measured using the Household Food Insecurity Access Scale (HFIAS), and the validated Kessler-10 Psychological Distress Scale (K10) was used to measure adolescent depression. Multivariate linear regression and linear mixed-effects regression were employed to explore associations between these variables, while adjusting for sex, age, pubertal status and household income. Overall, food insecurity score was positively associated with depressive symptoms (β: 0·72, 95 % CI 0·52, 0·92), while BMI z-score was inversely associated (β: −0·31, 95 % CI 0·68, −0·03). We found an increase in strength of association between food insecurity and depressive symptoms over time (moderately food-insecure: β: 1·36 (95 % CI −0·10, 2·83) to 4·63 (95 % CI 2·17, 7·09); severely food-insecure: β: 1·89 (95 % CI 0·36, 3·41) to 3·30 (95 % CI 1·50, 5·10). Enhancing food access, improving nutritional status and providing mental health support are crucial components of adolescent health.
This paper presents a compact broad dual-band rectifier based on a transmission line matching network. This method improves the overall impedance matching performance over two bands, and improves bandwidth of the rectifier’s efficiency. A π-type direct current filter with excellent harmonic suppression performance is proposed. The multi-section transmission line used as the dual-band input impedance matching network is analyzed to achieve an arbitrary frequency ratio. A rectifier is designed and implemented using a three-stage transmission-line matching network. Simulation and experimental results show that a dual-band rectifier is successfully performed with the measured power conversion efficiency (PCE) of 75.7% and 76.3% at 0.915 and 2.45 GHz, respectively. Additionally, the rectifier exhibits bandwidths of 0.48 and 0.25 GHz when the PCE exceeds 70%. Significant enhancement of bandwidth over conventional rectifiers is demonstrated.
This introduction to the ‘Survey and Speculation’ special issue ‘Empire and Cities’ outlines how this collection came about, summarizes the six contributions and draws general conclusions.
Given a Fell bundle $\mathcal {B}=\{B_t\}_{t\in G}$ over a locally compact group G and a closed subgroup $H\subset G,$ we construct quotients $C^{*}_{H\uparrow \mathcal {B}}(\mathcal {B})$ and $C^{*}_{H\uparrow G}(\mathcal {B})$ of the full cross-sectional C*-algebra $C^{*}(\mathcal {B})$ analogous to Exel–Ng’s reduced algebras $C^{*}_{\mathop {\mathrm {r}}}(\mathcal {B})\equiv C^{*}_{\{e\}\uparrow \mathcal {B}}(\mathcal {B})$ and $C^{*}_R(\mathcal {B})\equiv C^{*}_{\{e\}\uparrow G}(\mathcal {B}).$ An absorption principle, similar to Fell’s one, is used to give conditions on $\mathcal {B}$ and H (e.g., G discrete and $\mathcal {B}$ saturated, or H normal) ensuring $C^{*}_{H\uparrow \mathcal {B}}(\mathcal {B})=C^{*}_{H\uparrow G}(\mathcal {B}).$ The tools developed here enable us to show that if the normalizer of H is open in G and $\mathcal {B}_H:=\{B_t\}_{t\in H}$ is the reduction of $\mathcal {B}$ to $H,$ then $C^{*}(\mathcal {B}_H)=C^{*}_{\mathop {\mathrm {r}}}(\mathcal {B}_H)$ if and only if $C^{*}_{H\uparrow \mathcal {B}}(\mathcal {B})=C^{*}_{\mathop {\mathrm {r}}}(\mathcal {B});$ the last identification being implied by $C^{*}(\mathcal {B})=C^{*}_{\mathop {\mathrm {r}}}(\mathcal {B}).$ We also prove that if G is inner amenable and $C^{*}_{\mathop {\mathrm {r}}}(\mathcal {B})\otimes _{\max } C^{*}_{\mathop {\mathrm {r}}}(G)=C^{*}_{\mathop {\mathrm { r}}}(\mathcal {B})\otimes C^{*}_{\mathop {\mathrm {r}}}(G),$ then $C^{*}(\mathcal {B})=C^{*}_{\mathop {\mathrm {r}}}(\mathcal {B}).$
The stability of Taylor–Couette flow modulated by oscillatory wall suction/blowing is investigated using Floquet linear stability analysis. The growth rate and stability mode are obtained by numerical calculation and asymptotic expansion. By calculating the effect of wall suction/blowing on the critical mode of steady Taylor–Couette flow, it is found that for most suction/blowing parameters, the maximum disturbance growth rate of the critical mode decreases and the flow becomes more stable. Only in a very small parameter region, wall suction/blowing increases the maximum disturbance growth rate of the critical mode, resulting in flow instability when the gap between the cylinders is large. The asymptotic results for small suction/blowing amplitudes indicate that the change of flow instability is mainly due to the steady correction of the basic flow induced by the modulation. A parametric study of the critical inner Reynolds number and the associated critical wavenumber is performed. It is found that the flow is stabilized by the modulation for most of the parameter ranges considered. For a wide gap between the cylinders, it is possible for the system to be mildly destabilized by weak suction/blowing.
This paper examines the fissures within recent decolonial debates, arguing for the privileging of alternative narratives from formerly colonized groups and a shift away from centring colonialism. It calls for the recognition of decolonial struggles whose histories run deep and the need to link the struggles with indigeneity, its poetics of relations, and connectedness. Therefore, decoloniality requires thinking and doing and paying attention to social and economic well-being of hitherto marginalized indigenous communities, while giving due recognition to their poetics of relationality, reciprocity, and conviviality. Drawing on the example of #RhodesMust Fall movement in South Africa, it raises difficult questions around ownership, agency, while pointing to cracks that this contemporary movement surfaced, in spite of its claim to decoloniality.
A growing number of studies among adolescents have reported early maladaptive schemas (EMS) to associate with anxiety and depression within non-clinical samples. However, there is a gap of knowledge concerning clinical populations.
Aims:
The current study’s aim was to explore the potential association between EMS domains and anxiety and depressive symptoms within clinical sample of adolescents.
Method:
The current study included 176 adolescent psychiatry out-patients. The EMS domains were measured with the Young Schema Questionnaire-Short Form 2-Extended (YSQ). Their association with anxiety symptoms (the Overall Anxiety Severity and Impairment Scale) and depressive symptoms (the Beck Depression Inventory II) were analysed with general linear models while controlling for significant confounding factors.
Results:
Depressive symptoms were associated with three of the four EMS domains: Disconnection and Rejection (η2p=0.047, p=0.005), Impaired Autonomy and Performance (η2p=0.074, p<0.001), and Impaired Limits (η2p=0.053, p=0.003). Anxiety symptoms were associated with two EMS domains: Impaired Autonomy and Performance (η2p=0.046, p=0.005) and Excessive Responsibility and Standards (η2p=0.054, p=0.002).
Conclusions:
Various EMS domains were associated with depressive and anxiety symptoms among adolescent out-patients. Further studies are needed on the effect of EMSs on the treatment outcomes for depression and anxiety.
China is entering a deeply aging society gradually, and individual pension allocation behavior has a profound impact on the practice and effect of national strategies to actively cope with population aging. This paper constructs a dyad model based on the influence path of social network ties in individual commercial pension insurance purchasing decisions, and then validates the path by building a generalized linear mixed model (GLMM) based on Bayesian approach with the national longitudinal sample data of China. The empirical results show that, firstly, strong ties social interaction (e.g., visiting friend's house) positively influences individuals' commercial pension insurance purchase behavior; secondly, the less the frequency of individual social interaction is, the less significant the positive influence of social interaction on individual commercial pension insurance product purchase is; finally, between 2013 and 2018, the intensity and frequency of social interactions among middle-aged and elderly people in China has been changed dramatically by the shock of the popularity and development of digital social tools. The influence of strong ties social interaction on insurance purchase behavior becomes weaker and weaker, while that of weak ties becomes stronger.