To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Almost 20% of children with simple or complex types of CHD have a duct-dependent circulation The systemic-to-pulmonary shunt can be performed surgically, e.g., Blalock–Taussing shunt or with a patent duct arteriosus stenting.
Using a TorqVueTM LP catheter (Abbott Medical, Plymouth, MN, USA) might be an innovative and helpful technique.
The aim of this case report was to illustrate the advantages of using TorqVueTM LP for both the angiographic and the implant phase, to reduce manipulations and complications associated with the procedure.
The concept of political knowledge is foundational to American politics, but we know little about the extent to which its two dimensions—objective knowledge and knowledge confidence—covary over time as citizens learn about the American political system. We employ a two-wave survey to study whether individuals gain both objective knowledge and knowledge confidence such that they calibrate over time when exposed to civic education coursework. We find students gain both objective knowledge and knowledge confidence over the semester and that, on average, the gap between them shrinks after taking Introduction to American Government. However, we also see evidence that a student’s initial levels of knowledge shape growth in these two concepts and whether they become more closely aligned over the semester. The results shed light on the relationship between what individuals know about politics and what they think they know, and the role of civic education in shaping an active and informed electorate.
A scheme for generating high-flux angularly uniform proton beams with high laser-to-proton energy conversion efficiency is proposed. Three laser beams are focused on a microwire array attached to a solid-density hemispheric target. The laser-driven hot electrons from the front of the microwire hemisphere generate a hot-electron sheath in the hollow behind it, so that the protons on its back are accelerated by target normal sheath acceleration. The accelerated protons are of high flux, as well as angularly and energetically uniform. The scheme should be useful for applications involving warm dense matter, such as isochoric heating and modification of materials, as well as for proton therapy and inertial confinement fusion.
The significance of Abbo of Fleury’s time in England to the intellectual life of tenth- and eleventh-century Ramsey is widely appreciated. Less well understood is what English monks knew of Fleury’s claims of Abbo’s sanctity. The present article explores knowledge of Abbo’s cult in England through a close study of Oxford, Bodleian MS Lat. misc. c. 75, a twelfth-century witness to Aimo’s Vita et miracula s. Abbonis of which the Life’s editors were unaware. The manuscript is introduced, its textual relationship to the Vita’s other witnesses is examined and a stemma for the Vita’s textual transmission is proposed. Textual interpolations made at Ramsey are then analysed for the additional information which they provide about Abbo’s legacy there before a possible context for the Vita’s transmission to Ramsey is proposed. An appendix of variants between the Ramsey witness and the Vita’s printed edition is also provided.
Trace amine-associated receptor 1 (TAAR1) agonists offer a new approach, but there is uncertainty regarding their effects, exact mechanism of action and potential role in treating psychosis.
Aims
To evaluate the available evidence on TAAR1 agonists in psychosis, using triangulation of the output of living systematic reviews (LSRs) of animal and human studies, and provide recommendations for future research prioritisation.
Method
This study is part of GALENOS (Global Alliance for Living Evidence on aNxiety, depressiOn and pSychosis). In the triangulation process, a multidisciplinary group of experts, including those with lived experience, met and appraised the first co-produced living systematic reviews from GALENOS, on TAAR1 agonists.
Results
The animal data suggested a potential antipsychotic effect, as TAAR1 agonists reduced locomotor activity induced by pro-psychotic drug treatment. Human studies showed few differences for ulotaront and ralmitaront compared with placebo in improving overall symptoms in adults with acute schizophrenia (four studies, n = 1291 participants, standardised mean difference (SMD) 0.15, 95% CI −0.05 to 0.34). Large placebo responses were seen in ulotaront phase three trials. Ralmitaront was less efficacious than risperidone (one study, n = 156 participants, SMD = −0.53, 95% CI −0.86 to −0.20). The side-effect profile of TAAR1 agonists was favourable compared with existing antipsychotics. Priorities for future studies included (a) using different animal models of psychosis with greater translational validity; (b) animal and human studies with wider outcomes including cognitive and affective symptoms and (c) mechanistic studies and investigations of other potential applications, such as adjunctive treatments and long-term outcomes. Recommendations for future iterations of the LSRs included (a) meta-analysis of individual human participant data, (b) including studies that used different methodologies and (c) assessing other disorders and symptoms.
Conclusions
This co-produced, international triangulation examined the available evidence and developed recommendations for future research and clinical applications for TAAR1 agonists in psychosis. Broader challenges included difficulties in assessing the risk of bias, reproducibility, translation and interpretability of animal models to clinical outcomes, and a lack of individual and clinical characteristics in the human data. The research will inform a separate, independent prioritisation process, led by lived experience experts, to prioritise directions for future research.
The perspective article explores systemic issues in psychiatric care, particularly the barriers to timely treatment and the ethical dilemmas involved in involuntary interventions. It further examines the impact of anosognosia—lack of disease insight—on treatment, noting the difficulties in managing care for those unaware of their illness, and scrutinizes training materials from international organizations that might mislabel necessary psychiatric practices as human rights violations, thereby complicating the care landscape. The discussion extends to the legal and societal implications of psychiatric interventions, using Massachusetts’ Rogers Guardianship as a case study to highlight the consequences of legalistic approaches to mental health treatment.
The article calls for destigmatizing psychiatric treatment and integrating robust, evidence-based practices to improve patient outcomes and healthcare equity. The global mental health policy landscape is urged to recognize the critical role of psychiatric care in restoring health and dignity to individuals with serious mental illnesses, advocating for a more nuanced understanding and application of human rights in mental health.
Drowning remains a significant cause of mortality among children world-wide, making prevention strategies crucial. The World Health Organization (WHO) recommends training children in safe rescue techniques, including the use of basic skills such as throwing floating objects. This study aims to address a knowledge gap regarding the throwing capabilities of children aged six to twelve using conventional and alternative water rescue materials.
Method:
A total of 374 children aged six to twelve years participated in the study, including both males and females. A randomized crossover approach was used to compare throws with conventional rescue material (ring buoy and rescue tube) to an alternative material (polyethylene terephthalate [PET]-bottle). Throwing distance and accuracy were assessed based on age, sex, and the type of rescue tools used.
Results:
Children of all ages were able to throw the PET-bottle significantly farther than both the ring buoy (P <.001; d = 1.19) and the rescue tube (P <.001; d = 0.60). There were no significant differences (P = .414) in the percentage of children who managed to throw each object accurately.
Conclusion:
Conventional rescue materials, particularly the ring buoy, may not be well-suited for long-distance throws by children. In contrast, lighter and smaller alternatives, such as PET-bottles, prove to be more adaptable to children’s characteristics, enabling them to achieve greater throwing distances. The emphasis on cost-effective and easily accessible alternatives should be implemented in drowning prevention programs or life-saving courses delivered to children.
We show that linearly repetitive weighted Delone sets in groups of polynomial growth have a uniquely ergodic hull. This result applies in particular to the linearly repetitive weighted Delone sets in homogeneous Lie groups constructed in the companion paper [S. Beckus, T. Hartnick and F. Pogorzelski. Symbolic substitution beyond Abelian groups. Preprint, 2021, arXiv:2109.15210] using symbolic substitution methods. More generally, using the quasi-tiling method of Ornstein and Weiss, we establish unique ergodicity of hulls of weighted Delone sets in amenable unimodular locally compact second countable groups under a new repetitivity condition which we call tempered repetitivity. For this purpose, we establish a general sub-additive convergence theorem, which also has applications concerning the existence of Banach densities and uniform approximation of the spectral distribution function of finite hopping range operators on Cayley graphs.
Designers rely on many methods and strategies to create innovative designs. However, design research often overlooks the personality and attitudinal factors influencing method utility and effectiveness. This article defines and operationalizes the construct design mindset and introduces the Design Mindset Inventory (D-Mindset0.1), allowing us to measure and leverage statistical analyses to advance our understanding of its role in design. The inventory’s validity and reliability are evaluated by analyzing a large sample of engineering students (N = 473). Using factor analysis, we identified four underlying factors of D-Mindset0.1 related to the theoretical concepts: Conversation with the Situation, Iteration, Co-Evolution of Problem–Solution and Imagination. The latter part of the article finds statistical and theoretically meaningful relationships between design mindset and the three design-related constructs of sensation-seeking, self-efficacy and ambiguity tolerance. Ambiguity tolerance and self-efficacy emerge as positively correlated with design mindset. Sensation-seeking, which is only significantly correlated with subconstructs of D-Mindset0.1, is both negatively and positively correlated. These relationships lend validity D-Mindset0.1 and, by drawing on previously established relationships between the three personality traits and specific behaviors, facilitate further investigations of what its subconstructs capture.
It is a classic result of Segerberg and Maksimova that a variety of $\mathsf {S4}$-algebras is locally finite iff it is of finite depth. Since the logic $\mathsf {MS4}$ (monadic $\mathsf {S4}$) axiomatizes the one-variable fragment of $\mathsf {QS4}$ (predicate $\mathsf {S4}$), it is natural to try to generalize the Segerberg–Maksimova theorem to this setting. We obtain several results in this direction. Our positive results include the identification of the largest semisimple variety of $\mathsf {MS4}$-algebras. We prove that the corresponding logic $\mathsf {MS4_S}$ has the finite model property. We show that both $\mathsf {S5}^2$ and $\mathsf {S4}_u$ are proper extensions of $\mathsf {MS4_S}$, and that a direct generalization of the Segerberg–Maksimova theorem holds for a family of varieties containing the variety of $\mathsf {S4}_u$-algebras. Our negative results include a translation of varieties of $\mathsf {S5}_2$-algebras into varieties of $\mathsf {MS4_S}$-algebras of depth 2, which preserves and reflects local finiteness. This, in particular, shows that the problem of characterizing locally finite varieties of $\mathsf {MS4}$-algebras (even of $\mathsf {MS4_S}$-algebras) is at least as hard as that of characterizing locally finite varieties of $\mathsf {S5}_2$-algebras—a problem that remains wide open.
The Being Human Festival, celebrating its tenth anniversary in 2024, is the UK’s national humanities research festival, held every November to engage local communities with creative and participatory events that are free to attend. Over its first decade, Being Human has helped transform UK public engagement practices in the humanities, strengthened community ties, and inspired academic and public participants alike. Looking back on 10 years of Being Human, the director of the festival takes readers behind-the-scenes to see who makes it happen, how, and why. Looking forward, the festival aims to further transform public engagement infrastructure, support vernacular knowledge, and expand globally, advocating for the humanities’ indispensability in a democratic society.
Rather than leading to the emergence of a problem, some processes contribute to limiting their scope and impeding agenda-setting. These “nonproblems” are situations that could have led to social mobilizations or public intervention but end up neither being publicized nor subject to strong policy. We use occupational health in France to illustrate these mechanisms. The social invisibility of work-related ill-health is linked to the joint contribution of two processes. Firstly, from the perspective of research on ignorance and undone science, scientific knowledge is under-developed compared to other public health issues. And even available knowledge is rarely used by policy-makers. Secondly, policies use underestimated numbers from the occupational diseases compensation system. This specific configuration of knowledge/ignorance and official counting plays a central role in the production of occupational health issues as a nonproblem. Their invisibility contributes to the production of inertia and public inaction that characterize public policy in this field.
Modern fluvial sediments provide important information about source-to-sink process and regional tectono-magmatic events in the source area, but many factors, e.g., chemical weathering, sedimentary cycles and source-rock types, can interfere with the establishment of the source-sink system. The Lalin River (LR) and the Jilin Songhua River (JSR) are two important tributaries of the Songhua River in the Songnen Plain in NE China. They have similar flow direction, topography and identical climate backgrounds, but have notably different parent-rock types in the headwater, which provides an opportunity to explore the influencing factors of river sediment composition. To this end, the point bar sediments in the two rivers were sampled for an analysis of geochemistry (including element and Sr-Nd isotopic ratios), heavy mineral and detrital zircon U-Pb dating. The results are indicative of the fact that the two rivers have the similar geochemical composition (e.g., elements and Sr isotopes) as well as chemical weathering (CIA = 51.41–57.60, CIW = 59.68–66.11, PIA = 51.95–60.23, WIP = 56.00–65.47, Rb/Sr = 0.38–0.42) and recycling (SiO2/Al2O3 = 5.79 and 5.03, ICV = 1.0 and 1.2, CIA/WIP = 0.81–1.03) characteristics, showing a major control of climate on the low-level weathering and recycling of the river sediments. However, there are significant differences in the detrital zircon U-Pb age (a significant Mesozoic age peak for the LR but an additional Precambrian peak for the JSR), Nd isotope ratio (−6.2812–8.5830 and −8.1149–10.2411 for the LR and the JSR, respectively) and to a certain extent heavy mineral composition (e.g., for the < 63 μm fraction, a dominance of hornblende and magnetite in the LR, but haematite-limonite in the JSR) in the two river sediments, indicating that source rocks largely control the composition of the river sediments. Some of the major tectono-magmatic events (e.g., crustal growth and cratonisation of the North China Craton, closure of the Paleo-Asian Ocean, subduction and rollback of the Paleo-Pacific plate) occurring in the eastern Songnen Plain are well documented in the JSR sediments but not in the LR, the difference of which is largely regulated by the source rocks in the source area.
Nineteenth-century Italian opera scholars used to be the cool kids in town. During the 1990s, we swanned through annual meetings of the American Musicological Society, delighted that our field of study, long situated at the periphery of the discipline, was heading straight toward the centre. My decision to write a dissertation about Italian opera performers was not prompted by the siren song of potential trendiness; nevertheless, it was thrilling to be among the contributors to a collective effort that was perceived as being on the cutting edge, or at least as cutting edge as musicology could get at the time. It didn’t hurt either that this endeavour entailed touching down in Italy every now and again for some of the best parties (ahem, I mean, conferences) ever convened. I know I am idealising the past, but these thoughts came rushing back to me in a rosy hue a few months ago when a colleague approached me with this whopper: ‘Remember when nineteenth-century studies were hip? We’re the old-fashioned ones now.’ True, studies of Rossini, Donizetti, Bellini, Verdi and their contemporaries are no longer in the vanguard, but books by Emanuele Senici, Mary Ann Smart and Francesca Vella demonstrate that there is still a lot of life left in the world of nineteenth-century Italian opera studies. We’re still very cool.
Given its role as a legal instrument not only to try superiors but also to prevent both them and their subordinates from committing grave international crimes, the correct understanding and proper application of the doctrine of superior responsibility is of paramount importance. This article aims to illuminate specific and some controversial aspects of the third element of the doctrine—the failure to adopt necessary and reasonable measures—and obtain a clearer and more comprehensive understanding on the superiors’ duties, its limits and main prerequisites under the doctrine. For this purpose, an interdisciplinary study was conducted to investigate whether basic principles and business aspects of corporate governance and compliance management may be applied for a better understanding and refinement of the doctrine. The underlying analysis in corporate governance and compliance covers American (U.S.), German, and international standards.
Comeback prime ministers (CBPMs), who return to office after a break, have been a notable, but conspicuously understudied, feature of several parliamentary democracies. This article provides the first ever comparative study of CBPMs. To make sense of the varying frequency of CBPMs in 18 established democracies from 1945 to 2024, we refer to competing party rationales of (re-)selecting prime ministers in different contexts, with the latter shaping the former. Apart from powerful presidents in semi-presidential regimes, the frequency of early replacements of prime ministers, the scope of alternations of the prime minister’s party, and the degree of intraparty personalization offer plausible explanations for the cross-national and temporal variation of prime-ministerial returns. While CBPMs have become less common since 1990, the remaining cases include some particularly powerful party leaders, underscoring the continuing importance of this neglected feature for understanding chief executive selection in established parliamentary democracies and beyond.
Group A streptococcal or Streptococcus pyogenes infections have been increasing post-COVID-19 pandemic. We describe the epidemiology of S. pyogenes pharyngitis and invasive disease in Alberta, Canada 2018–2023. Positive pharyngitis specimens were identified from throat swabs collected from pharyngitis patients. Invasive S. pyogenes was defined as the isolation of S. pyogenes from a normally sterile site or severe skin infection. S. pyogenes isolates were emm typed. Pharyngitis and invasive disease displayed seasonal trends preceding the COVID-19 pandemic followed by a sharp decrease during COVID-19 intervention measures. After the lifting of interventions, rates of pharyngitis and invasive disease rose. There were 182 983 positive pharyngitis specimens between 2018 and 2023 for a positivity rate of 17.6%. The highest rates occurred in the 0–9 age group in 2023 (41.5%). Invasive disease increased in 2022–2023 driven by emm1 and 12 types. M1UK strain was the most frequent M1 type associated with invasive disease (59% of M1 isolates sequenced). Notably, out of 182 983 pharyngitis cases, there were 111 cases of invasive S. pyogenes detected for an invasive disease rate of 0.06%. This descriptive epidemiology of S. pyogenes pharyngitis and invasive S. pyogenes disease highlights the rapid increase in cases of S. pyogenes occurring in western Canada and illustrates the critical need for a vaccine.