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Persistent discrimination and identity threats contribute to adverse health outcomes in minoritized groups, mediated by both structural racism and physiological stress responses.
Objective:
This study aims to evaluate the feasibility of recruiting African American volunteers for a pilot study of race-based stress, the acceptability of a mindfulness intervention designed to reduce racism-induced stress, and to evaluate preliminary associations between race-based stress and clinical, psychosocial, and biological measures.
Methods:
A convenience sample of African Americans aged 18–50 from New York City’s Tri-state area underwent assessments for racial discrimination using the Everyday Discrimination Scale (EDS) and Race-Based Traumatic Stress Symptom Scale. Mental health was evaluated using validated clinical scales measuring depression, anxiety, stress, resilience, mindfulness, resilience, sleep, interpersonal connection, and coping. Biomarkers were assessed through clinical laboratory tests, allostatic load assessment, and blood gene expression analysis.
Results:
Twenty participants (12 females, 8 males) completed assessments after consent. Elevated EDS scores were associated with adverse lipid profiles, including higher cholesterol/high-density lipoprotein (HDL) ratios and lower HDL levels, as well as elevated inflammatory markers (NF-kB activity) and reduced antiviral response (interferon response factor). Those with high EDS reported poorer sleep, increased substance use, and lower resilience. Mindfulness was positively associated with coping and resilience but inversely to sleep disturbance. 90% showed interest in a mindfulness intervention targeting racism-induced stress.
Conclusions:
This study demonstrated an association between discrimination and adverse health effects among African Americans. These findings lay the groundwork for further research to explore the efficacy of mindfulness and other interventions on populations experiencing discrimination.
A recent outbreak of cryptosporidiosis (Cryptosporidium parvum, subtype IIdA23G1) among veterinary students associated with extracurricular activities concerned with lambs is described from Norway. Although cryptosporidiosis outbreaks among veterinary students have been frequently reported, this is among the first from lamb contact. Cryptosporidium oocysts were detected in samples from two students and three lambs. A questionnaire distributed immediately after the outbreak was recognized, identified an assumed attack rate of 50% based on exposure and illness among exposed students (28 of 56), despite most reporting good or very good hygiene measures. Laboratory diagnostics confirmed infection in two of these. The illness lasted over a week in most students (up to 15 days), but contact with health services was negligible. In addition to implementing measures to reduce the likelihood of further such outbreaks among veterinary students, it is recommended that future outbreaks of diarrhoea among ruminants on the farm should be investigated for aetiological agents.
The recent history of the Ukrainian authoritarian far right is one of paradoxes. If one looks at the polls, it has performed poorly; its modest successes have been regional and short-lived. On the other hand, it has been highly successful in terms of shaping memory politics in the country. It has had a disproportional influence on history writing, having invested significant efforts into building an effective structure in the field of memory management. Radical nationalists have also come to staff senior positions as deans and vice chancellors at Ukraine’s top universities, the ministry of education, the Ukrainian Institute of National Memory (UINP), and the archives of the Ukrainian Security Service (HDA SBU). The hard right has gained a disproportionate influence on “soft issues” of identity and the shaping of “national memory” – not only by running the governmental memory institutes, but also by hands-on drafting of memory laws outlawing “disrespect” for the OUN, the Ukrainian Insurgent Army (UPA), and other historical far-right groups. This study seeks to trace and contextualize the repatriation of the ethnonationalist hard right from emigration and its role in shaping an infrastructure of memory production – in particular, under presidents Yushchenko (2005–2010) and Poroshenko (2014–2019).
Loneliness has become a major public health issue of the recent decades due to its severe impact on health and mortality. Little is known about the relation between loneliness and social anxiety. This study aimed (1) to explore levels of loneliness and social anxiety in the general population, and (2) to assess whether and how loneliness affects symptoms of social anxiety and vice versa over a period of five years.
Methods
The study combined data from the baseline assessment and the five-year follow-up of the population-based Gutenberg Health Study. Data of N = 15 010 participants at baseline (Mage = 55.01, s.d.age = 11.10) were analyzed. Multiple regression analyses with loneliness and symptoms of social anxiety at follow-up including sociodemographic, physical illnesses, and mental health indicators at baseline were used to test relevant covariates. Effects of loneliness on symptoms of social anxiety over five years and vice versa were analyzed by autoregressive cross-lagged structural equation models.
Results
At baseline, 1076 participants (7.41%) showed symptoms of social anxiety and 1537 (10.48%) participants reported feelings of loneliness. Controlling for relevant covariates, symptoms of social anxiety had a small significant effect on loneliness five years later (standardized estimate of 0.164, p < 0.001). Vice versa, there was no significant effect of loneliness on symptoms of social anxiety taking relevant covariates into account.
Conclusions
Findings provided evidence that symptoms of social anxiety are predictive for loneliness. Thus, prevention and intervention efforts for loneliness need to address symptoms of social anxiety.
Accelerator mass spectrometry (AMS) is a worldwide recognized method for radiocarbon (14C) dating. The advantageous aspects of this method include the variety of materials and the small sample size (1 mg of carbon) that can be measured. However, these pose several challenges in the laboratory, such as developing appropriate chemical pretreatment methods. In the summer of 2022, the Radiocarbon and Mass Spectrometry Laboratory in Gliwice, Poland, launched the MICADAS accelerator spectrometer. The report on background and reference materials measurement results for the period from September 2022 to July 2024 is presented in this publication. Quality assurance and quality control processes are extremely important to guarantee the high quality of the results obtained in the laboratory. Hence, our Radiocarbon and Mass Spectrometry Laboratory in Gliwice took part in the Glasgow International Radiocarbon Inter-Comparison (GIRI) program. The radiocarbon ages for wood, bone, humic acid, and barley mash samples were determined and compared with reported values. The resulting data confirmed that our Laboratory is capable of dating samples across a spectrum of materials and ages ranging from contemporary to the limits of the radiocarbon method, achieving precision on par with that of other laboratories.
The adoption of policies promoting healthier restaurant food environments is contingent on their acceptability. Limited evidence exists regarding individual characteristics associated with restaurant food environment policy acceptability, especially health-related characteristics. This study examined associations between health characteristics and restaurant food environment policy acceptability among urban Canadians.
Design:
Links between health characteristics and complete agreement levels with selected policies were examined using data in the cross-sectional Targeting Healthy Eating and Physical Activity survey study, that is, a large pan-Canadian study on policy acceptability. For each policy, several logistic multilevel regression analyses were conducted.
Setting:
Canada’s seventeen most populated census metropolitan areas.
Participants:
Urban Canadian adults responded to the survey (n 27 162).
Results:
Body mass index was not associated with acceptability after adjustments for other health and sociodemographic characteristics were made. Across all policies and analyses, those reporting excellent or very good health statuses were more likely to be in complete agreement with targeted policies than those with good health statuses. For selected policies and analyses, those reporting poor health statuses were also more likely to be in complete agreement than those describing their health status as good. For all policies and analyses, both those consuming restaurant-prepared foods daily and those never consuming these foods were more likely to be in complete agreement than those consuming these foods once per week.
Conclusions:
More research is needed to explain discrepancies in acceptability according to health characteristics. Bringing this study’s findings to the attention of policymakers may help build momentum for policy enactment.
Let $(X,\mathcal {B},\mu ,T)$ be a probability-preserving system with X compact and T a homeomorphism. We show that if every point in $X\times X$ is two-sided recurrent, then $h_{\mu }(T)=0$, resolving a problem of Benjamin Weiss, and that if $h_{\mu }(T)=\infty $, then every full-measure set in X contains mean-asymptotic pairs (that is, the associated process is not tight), resolving a problem of Ornstein and Weiss.
Recently, Kurisu and Otsu (2022b, Econometric Theory 38(1), 172–193) derived the uniform convergence rates for the nonparametric deconvolution estimators proposed by Li and Vuong (1998, Journal of Multivariate Analysis 65(2), 139–165). This article shows that faster uniform convergence rates can be established for their estimators under the same assumptions. In addition, a new class of deconvolution estimators based on a variant of Kotlarski’s identity is also proposed. It is shown that in some cases, these new estimators can have faster uniform convergence rates than the existing estimators.
The Hong Kong Colonial Cemetery, established in 1845, served as both an exemplary burial space and a refuge from the ‘degenerative’ tropical urban environment for the British during the second half of the nineteenth century. This article argues that what constitutes the sacredness of the cemetery was not merely Christian values, but a mixture of personal emotional meanings and imperialist sentiments. The sacredness of the site during the nineteenth century also rested upon the exclusion of the Chinese ‘other’, even though such boundaries were often volatile due to the diverse and unfixed nature of the colonial community, and the rising influences of the Chinese elites.
Stigma of mental health conditions hinders recovery and well-being. The Honest, Open, Proud (HOP) program shows promise in reducing stigma but there is uncertainty about the feasibility of a randomized trial to evaluate a peer-delivered, individual adaptation of HOP for psychosis (Let's Talk).
Methods
A multi-site, Prospective Randomized Open Blinded Evaluation (PROBE) design, feasibility randomised controlled trial (RCT) comparing the peer-delivered intervention (Let's Talk) to treatment as usual (TAU). Follow-up was 2.5 and 6 months. Randomization was via a web-based system, with permuted blocks of random size. Up to 10 sessions of the intervention over 10 weeks were offered. The primary outcome was feasibility data (recruitment, retention, intervention attendance). Primary outcomes were analyzed by intention to treat. Safety outcomes were reported by as treated status. The study was prospectively registered: https://doi.org/10.1186/ISRCTN17197043.
Results
149 patients were referred to the study and 70 were recruited. 35 were randomly assigned to intervention + TAU and 35 to TAU. Recruitment was 93% of the target sample size. Retention rate was high (81% at 2.5 months primary endpoint), and intervention attendance rate was high (83%). 21% of 33 patients in Let's talk + TAU had an adverse event and 16% of 37 patients in TAU. One serious adverse event (pre-randomization) was partially related and expected.
Conclusions
This is the first trial to show that it is feasible and safe to conduct a RCT of HOP adapted for people with psychosis and individual delivery. An adequately powered trial is required to provide robust evidence.
We use the universe of probate and vital registers from England between 1838 and 2018 to document the status of the Irish in England. We identify the “Irish” in the records as those individuals with distinctively Irish surnames. From at least the mid-nineteenth century to 2018, we find that the Irish in England have persisted as an underclass, being on average 50 percent poorer than the English. Infant mortality was about 25 percent higher for the Irish between the 1830s and the mid-twentieth century but has subsequently equalized. Sorting, both to urban areas and to the North of England, are important elements in the Irish experience. We discuss the potential roles of selective migration, social mobility, and discrimination in this and signpost directions for future research.
In practice, nondestructive testing (NDT) procedures tend to consider experiments (and their respective models) as distinct, conducted in isolation, and associated with independent data. In contrast, this work looks to capture the interdependencies between acoustic emission (AE) experiments (as meta-models) and then use the resulting functions to predict the model hyperparameters for previously unobserved systems. We utilize a Bayesian multilevel approach (similar to deep Gaussian Processes) where a higher-level meta-model captures the inter-task relationships. Our key contribution is how knowledge of the experimental campaign can be encoded between tasks as well as within tasks. We present an example of AE time-of-arrival mapping for source localization, to illustrate how multilevel models naturally lend themselves to representing aggregate systems in engineering. We constrain the meta-model based on domain knowledge, then use the inter-task functions for transfer learning, predicting hyperparameters for models of previously unobserved experiments (for a specific design).
Children born growth-restricted are well recognized to be at an increased risk of poor neurodevelopmental outcomes. This prospective study examined the influence of chest-to-head circumference ratio at birth on neurodevelopment in the first three years among children enrolled in the Japan Environment and Children’s Study. We analyzed information of 84,311 children (43,217 boys, 41,094 girls). Children were divided into low, normal, and high chest-to-head circumference ratio groups. Neurodevelopment was assessed every six months (from 6 months to 3 years) using the Ages and Stages Questionnaire (Japanese translation), with delays defined as scores below 2 standard deviations from the mean. Additionally, we evaluated the contributions of chest and head circumference to the observed association. Linear mixed-effect regression revealed increased risk of delays in communication, gross motor, fine motor, problem-solving, and personal-social skills in the low-ratio group compared to the normal-ratio group. Adjusted risk ratios were in the range of 1.14 – 1.39 in boys and 1.16 – 1.37 in girls, with no such increase observed in the high-ratio group. The heightened risk in the low-ratio group was likely associated with a relatively narrow chest rather than a large head. The area under the ROC curves in predicting any developmental delay at three years for newborn measurements ranged from 0.513 to 0.526 in boys and 0.509 to 0.531 in girls. These findings suggest that a low chest-to-head circumference ratio may indicate children who are at risk for neurodevelopmental deficits. However, the ability to predict poor neurodevelopmental outcomes at three years of age is limited.
A Decentralised Autonomous Organisation (DAO) is a new form of digital enterprise that operates on blockchain networks. It enables a new model of collaboration through diverse capital contributions and equitable sharing of benefits and risks. This paper explores the legal dimensions of DAO token transferability, a vital aspect for the expansion of DAO operations. First, it evaluates how property law (including the proposal by the Law Commission of England and Wales for a third category of digital asset ownership) might apply to DAO tokens so as to mitigate legal risks and ensure smooth transferability. Secondly, it investigates the potential for DAO software protocols to implement contractual transferability restrictions and examines their technological design. Finally, it looks at the legal enforceability of such restrictions and the policies needed to support their legal recognition.
In this paper, we analyze a polling system on a circle. Random batches of customers arrive at a circle, where each customer, independently, obtains a location that is uniformly distributed on the circle. A single server cyclically traverses the circle to serve all customers. Using mean value analysis, we derive the expected number of waiting customers within a given distance of the server. We exploit this to obtain closed-form expressions for both the mean batch sojourn time and the mean time to delivery.
Gradual typing provides a model for when a legacy language with less precise types interacts with a newer language with more precise types. Casts mediate between types of different precision, allocating blame when a value fails to conform to a type. The blame theorem asserts that blame always falls on the less-precisely typed side of a cast. One instance of interest is when a legacy language (such as Java) permits null values at every type, while a newer language (such as Scala or Kotlin) explicitly indicates which types permit null values. Nieto et al. in 2020 introduced a gradually typed calculus for just this purpose. The calculus requires three distinct constructors for function types and a non-standard proof of the blame theorem; it can embed terms from the legacy language into the newer language (or vice versa) only when they are closed. Here, we define a simpler calculus that is more orthogonal, with one constructor for function types and one for possibly nullable types, and with an entirely standard proof of the blame theorem; it can embed terms from the legacy language into the newer language (and vice versa) even if they are open. All results in the paper have been mechanized in Coq.
In May 2017, whole-genome sequencing (WGS) became the primary subtyping method for Salmonella in Canada. As a result of the increased discriminatory power provided by WGS, 16 multi-jurisdictional outbreaks of Salmonella associated with frozen raw breaded chicken products were identified between 2017 and 2019. The majority (15/16) were associated with S. enteritidis, while the remaining outbreak was associated with S. Heidelberg. The 16 outbreaks included a total of 487 cases with ages ranging from 0 to 98 years (median: 24 years); 79 hospitalizations and two deaths were reported. Over the course of the outbreak investigations, 14 frozen raw breaded chicken products were recalled, and one was voluntarily withdrawn from the market. After previous changes to labelling and the issuance of public communication for these products proved ineffective at reducing illnesses, new industry requirements were issued in 2019, which required the implementation of measures at the manufacturing/processing level to reduce Salmonella to below detectable amounts in frozen raw breaded chicken products. Since implementation, no further outbreaks of Salmonella associated with frozen breaded chicken have been identified in Canada, a testament to the effectiveness of these risk mitigation measures.
Through the provision of drinking and agricultural irrigation water, groundwater resources fundamentally underpin the existence of modern human society across large regions of the world. Despite this, decades of unsustainable exploitation have led to acute degradation of groundwater quantity and quality, creating pressing challenges that society must address if we are to maintain viable access to this crucial resource for future generations. Taking stock of the current situation, in this contribution we begin by reviewing some of the major global groundwater resource pressures, before exploring a range of technological, engineering, societal and nature-based solutions to address these challenges. We look at examples of emerging groundwater resource threats and potential innovative solutions to tackle them, before concluding with a forward look at future research opportunities that can ultimately enhance our management of this vital resource.
Reading difficulties (RD) frequently co-occur with attention-deficit/hyperactivity disorder (ADHD), and children with both RD + ADHD often demonstrate greater challenges in reading and executive functions (EF) than those with RD-only.
Methods:
This study examined the effect of a 4-week EF-based reading intervention on behavioral and neurobiological correlates of EF among 8–12 y.o. English-speaking children with RD + ADHD (n = 19), RD-only (n = 18), and typically developing children (n = 18). Behavioral and resting-state fMRI data were collected from all participants before and after 4 weeks of the EF-based reading computerized program. Group (RD + ADHD, RD-only, typical readers) x Test (pre- and post-intervention) repeated measures ANOVAs were conducted for reading, EF, and brain functional connectivity (FC) measures.
Results:
Across groups, reading (fluency, comprehension) and EF (inhibition, speed of processing) behavioral performance improved following the intervention. Exploratory subgroup comparisons revealed that children with RD + ADHD, but not RD-only, showed significant gains in reading comprehension, whereas inhibition improved in both RD groups, but not among typical readers. Furthermore, across groups, FC between the frontoparietal (FP) and cingulo-opercular (CO) networks decreased following the intervention. Exploratory subgroup comparisons revealed that children with RD + ADHD, but not RD-only, showed a significant decrease in FC of FP-CO and FP-dorsal attention network.
Conclusions:
These results support the differential response to an EF-based reading intervention of children with RD with and without comorbid ADHD at brain and behavioral levels.